Article
Biochemistry & Molecular Biology
Ioana Alesutan, Laura A. Henze, Beate Boehme, Trang T. D. Luong, Daniel Zickler, Burkert Pieske, Kai-Uwe Eckardt, Andreas Pasch, Jakob Voelkl
Summary: Medial vascular calcification is common in CKD and is closely linked to hyperphosphatemia. This study reveals the role and mechanisms of periostin in promoting vascular smooth muscle cell calcification.
Article
Biochemistry & Molecular Biology
Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K. Semple, Ian G. Ganley, Vicky E. MacRae
Summary: Arterial calcification, a characteristic of cardiovascular disease, shares similarities with skeletal mineralization but the cellular mechanisms are not fully understood. This study found that vascular smooth muscle cell (VSMC) calcification is associated with elongated mitochondria, increased reactive oxygen species production, and reduced mitophagy. The protein expressions of OPA1 and DRP1, key regulators of mitochondrial fusion and fission, respectively, were also altered. Additionally, p53-induced mitochondrial fusion was found to underlie cellular senescence in VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Angelina Pavlic, Nasim Bahram Sangani, Johanna Kerins, Gerry Nicolaes, Leon Schurgers, Chris Reutelingsperger
Summary: Vascular calcification is the pathological deposition of calcium salts in blood vessel walls and is a risk factor for cardiovascular events and mortality. Vascular smooth muscle cells (VSMCs) play a crucial role in this process by releasing extracellular vesicles (EVs), but the underlying mechanisms are not fully understood. Understanding the molecular factors and mechanisms of EV release is essential for developing targeted pharmacological treatments for vascular calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Ioana Alesutan, Trang T. D. Luong, Nadeshda Schelski, Jaber Masyout, Susanne Hille, Markus P. Schneider, Delyth Graham, Daniel Zickler, Nicolas Verheyen, Misael Estepa, Andreas Pasch, Winfried Maerz, Andreas Tomaschitz, Stefan Pilz, Norbert Frey, Florian Lang, Christian Delles, Oliver J. Mueller, Burkert Pieske, Kai-Uwe Eckardt, Juergen Scherberich, Jakob Voelkl
Summary: The study found that uromodulin can reduce vascular calcification in CKD patients, possibly by interfering with cytokine-dependent pro-calcific signaling pathways. In CKD, decreased levels and carbamylation of uromodulin may contribute to vascular pathology.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ploingarm Petsophonsakul, Mathias Burgmaier, Brecht Willems, Sylvia Heeneman, Nadina Stadler, Felix Gremse, Sebastian Reith, Kathrin Burgmaier, Florian Kahles, Nikolaus Marx, Ehsan Natour, Elham Bidar, Michael Jacobs, Barend Mees, Chris Reutelingsperger, Malgorzata Furmanik, Leon Schurgers
Summary: This study investigates the effects of nicotine on vascular smooth muscle cell calcification and its underlying mechanisms. The results show that calcification is more common in carotid plaques of smokers, and nicotine induces calcification and increases the expression of calcification-related genes and extracellular vesicle secretion in vascular smooth muscle cells. The pro-calcifying effects of nicotine are mediated by Ca2+-dependent Nox5, and Nox5 expression is higher in carotid arteries of smokers.
CARDIOVASCULAR RESEARCH
(2022)
Article
Oncology
Nikolaos T. Skenteris, Till Seime, Anna Witasp, Eva Karlof, Grzegorz B. Wasilewski, Marina A. Heuschkel, Armand M. G. Jaminon, Loureen Oduor, Robert Dzhanaev, Malin Kronqvist, Mariette Lengquist, Frederique E. C. M. Peeters, Magnus Soderberg, Rebecka Hultgren, Joy Roy, Lars Maegdefessel, Hildur Arnardottir, Eva Bengtsson, Isabel Goncalves, Thomas Quertermous, Claudia Goettsch, Peter Stenvinkel, Leon J. Schurgers, Ljubica Matic
Summary: Recent studies have found a correlation between plasma and tissue levels of osteomodulin (OMD) and cardiovascular calcification, suggesting the potential of OMD as a clinical biomarker. OMD was found to be present in calcified cardiovascular tissues and was induced by pro-inflammatory and pro-osteogenic stimuli. Furthermore, the presence of OMD in the extracellular environment attenuated smooth muscle cell (SMC) calcification.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yin Zhang, Naiwang Tang, Jinjie Zhou
Summary: The study revealed that IMD1-47 inhibits HP-induced VSMC calcification by regulating the Wnt/beta-catenin signaling pathway. This finding is significant for understanding the mechanisms of VSMC calcification.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biophysics
Jia-yan Chen, You-xiang Wang, Ke-feng Ren, Yun-bing Wang, Guo-sheng Fu, Jian Ji
Summary: This study found that the osteogenesis of vascular SMCs is influenced by substrate stiffness, with cells on the intermediate substrate stiffness (0.909 MPa) showing the highest extent of osteogenesis. Transforming growth factor-beta 1 and autophagy were involved in this stiffness-dependent process.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cardiac & Cardiovascular Systems
Sang-Ho Woo, Dongsoo Kyung, Seung Hyun Lee, Kyu Seong Park, Minkyu Kim, Kibyeong Kim, Hyo-Jung Kwon, Young-Suk Won, Inpyo Choi, Young-Jun Park, Du-Min Go, Jeong-Seop Oh, Won Kee Yoon, Seung Sam Paik, Ji Hyeon Kim, Yong-Hwan Kim, Jae-Hoon Choi, Dae-Yong Kim
Summary: This study reveals that TXNIP plays a regulatory role in the osteochondrogenic transition of vascular smooth muscle cells (VSMCs) and affects the occurrence of atherosclerotic calcification. The effects of TXNIP were analyzed through the phenotypes of Txnip(-/-) mice, Tagln-Cre; Txnip(flox/flox) mice, and mice transplanted with the bone marrow of Txnip(-/-) mice. The downregulation of TXNIP in human calcified atherosclerotic plaques was also confirmed through reanalysis of a public single-cell RNA-sequencing dataset. In vitro experiments showed that suppression of TXNIP promotes osteodifferentiation of VSMCs. These findings suggest that TXNIP regulates atherosclerotic calcification by suppressing bone morphogenetic protein signaling and inhibiting the transition of VSMCs toward an osteochondrogenic phenotype.
CIRCULATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Xunjia Li, Chengxuan Liu, Ying Li, Weijian Xiong, Deyu Zuo
Summary: The current study aimed to investigate the effects of erythropoietin (EPO) on vascular calcification under inflammatory conditions and the molecular regulator involved. The findings suggest that high-dose EPO and inflammation can exacerbate vascular calcification by activating p38 and increasing reactive oxygen species (ROS) levels.
Article
Cell Biology
Till Seime, Asim Cengiz Akbulut, Moritz Lindquist Liljeqvist, Antti Siika, Hong Jin, Greg Winski, Rick H. van Gorp, Eva Karlof, Mariette Lengquist, Andrew J. Buckler, Malin Kronqvist, Olivia J. Waring, Jan H. N. Lindeman, Erik A. L. Biessen, Lars Maegdefessel, Anton Razuvaev, Leon J. Schurgers, Ulf Hedin, Ljubica Matic
Summary: Calcification is a key feature of late-stage atherosclerosis, and recent research has shown that the expression of PRG4 is correlated with vascular remodeling and intimal calcification. Experimental models suggest that PRG4 plays a role in SMC function and osteogenic phenotype, impacting atherosclerotic plaque stability. Further investigations are needed to better understand the mechanisms behind PRG4's effects on calcification and SMC behavior.
Article
Veterinary Sciences
Saroj K. Shrestha, Se-Woong Kim, Yunjo Soh
Summary: The study found that Kalkitoxin (KT) can inhibit calcification in vascular smooth muscle cells, reducing vascular calcification. This finding provides a basis for the development of new therapies for vascular calcification and arteriosclerosis.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Cell Biology
Armand M. G. Jaminon, Asim C. Akbulut, Niko Rapp, Rafael Kramann, Erik A. L. Biessen, Lieve Temmerman, Barend Mees, Vincent Brandenburg, Robert Dzhanaev, Willi Jahnen-Dechent, Juergen Floege, Jouni Uitto, Chris P. Reutelingsperger, Leon J. Schurgers
Summary: The BioHybrid assay is a novel approach to determine individual's vascular calcification propensity, which is more sensitive in detecting differences in calcification propensity and can discriminate between individuals with different coronary artery calcification indexes.
Article
Cell Biology
Jin Niu, Chen Wu, Min Zhang, Zhen Yang, Zhenhua Liu, Feng Fu, Jun Li, Na Feng, Xiaoming Gu, Shumiao Zhang, Yali Liu, Rong Fan, Juan Li, Jianming Pei
Summary: In this study, it was found that the selective kappa-opioid receptor agonist U50,488H can inhibit calcification of rat vascular smooth muscle cells (VSMCs) by reducing PFKFB3 expression and lactate content. These findings suggest a potential drug target and strategy for the clinical treatment of vascular calcification.
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Dongwon Yi, Ah Reum Khang, Hye Won Lee, Seok Man Son, Yang Ho Kang
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2017)
Article
Endocrinology & Metabolism
Dongwon Yi, Ah Reum Khang, Hye Won Lee, Seok Man Son, Yang Ho Kang
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2018)
Article
Endocrinology & Metabolism
Ah Reum Khang, Hye Won Lee, Dongwon Yi, Yang Ho Kang, Seok Man Son
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2019)
Article
Multidisciplinary Sciences
Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang
Summary: This study investigated the association between relative hand grip strength and glycemic status. The results showed that individuals with lower relative hand grip strength had a higher risk of both diabetes and impaired fasting glucose. This association was stronger in younger adults compared to older adults.
Article
Endocrinology & Metabolism
Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
Summary: Hyperuricemia and abdominal obesity synergistically increase the risk of hypertriglyceridemia and low HDL-C in both sexes.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Dongwon Yi, Min Jin Lee, Ah Reum Khang, Yang Ho Kang
Summary: The study found a significant inverse correlation between serum uric acid levels and relative hand grip strength in women, indicating that higher uric acid levels are associated with lower grip strength. This association remained even after adjusting for age and metabolic syndrome components.
OSTEOPOROSIS AND SARCOPENIA
(2022)
Article
Endocrinology & Metabolism
Ah Reum Khang, Min Jin Lee, Dongwon Yi, Yang Ho Kang
Summary: This study investigates the predictive factors of arterial stiffness and sub-clinical atherosclerosis in type 2 diabetes mellitus patients using the eGFR(cystatin C)/eGF(Rcreatinine) ratio. The findings suggest that an eGFR(cystatin C)/eGF(Rcreatinine) ratio of less than 0.9 is associated with an increased risk of high baPWV and carotid plaque.
DIABETES & METABOLISM JOURNAL
(2023)
Letter
Endocrinology & Metabolism
Dongwon Yi, Min Jin Lee, Ah Reum Khang, Yang Ho Kang
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Engineering, Biomedical
Woong Bi Jang, Dongwon Yi, Thanh Mien Nguyen, Yujin Lee, Eun Ji Lee, Jaewoo Choi, You Hwan Kim, Eun-Jung Choi, Jin-Woo Oh, Sang-Mo Kwon
Summary: This study demonstrates the use of an artificial neural processing-based bioelectronic nose to accurately diagnose diabetes and classify diabetic types and their complications. Using neural pattern separation, the M13 phage-based e-nose achieves a classification success rate of over 86% for four conditions in mice, namely, type 1 diabetes, type 2 diabetes, diabetic cardiomyopathy, and cardiomyopathy. This research is significant for early diagnosis and treatment of diabetes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Letter
Endocrinology & Metabolism
Dongwon Yi
DIABETES & METABOLISM JOURNAL
(2020)
Letter
Endocrinology & Metabolism
Dongwon Yi
DIABETES & METABOLISM JOURNAL
(2018)