Journal
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 4, Pages 287-293Publisher
TOHOKU UNIV MEDICAL PRESS
DOI: 10.1620/tjem.217.287
Keywords
Long-chain fatty acid-CoA ligase 4; metabolic syndrome; depression; fatty acid; delta-5 fatty acid desaturase
Funding
- IGA Ministry of Health of Czech Republic [8806-3]
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The composition of polyunsaturated fatty acids (PUFAs) in cell membranes and body tissues is altered in metabolic syndrome (MetS) and depressive disorder (DID). Within the cell, fatty acid coenzyme A (CoA) ligases (FACLs) activate PUFAs by esterifying with CoA. The FACL4 isoform prefers PUFAs (arachidonic and eicosapentaenoic acid) as substrates, and the FACL4 gene is mapped to Xq23. We have analyzed the association between the common single nucleotide polymorphism (SNP) (rs1324805, C to T substitution) in the first intron of the FACL4 gene and MetS or DID. The study included 113 healthy subjects (54Males/59Females), 56 MetS patients (34M/22F) and 41 DID patients (7M/34F). In MetS group, T-carriers and patients with CC or CO (CC/C0) genotype did not differ in the values of metabolic indices of MetS and M/F ratio. Nevertheless, in comparison with CC/C0, the T-allele carriers were characterized by enhanced unfavorable changes in fatty acid metabolism typical for MetS: higher content of dihomogammalinolenic acid (P < 0.05) and lower content of arachidonic acid in plasma phosphatidylcholine (PC) (P = 0.052), lower index of Delta 5 desaturation (P < 0.01) and unsaturation index (UI) (P < 0.001). In contrast, DID patients had higher concentrations of plasma glucose, insulin, conjugated dienes and index of insulin resistance, but showed no significant association with the studied SNP. The present study shows that the common SNP (C to T substitution) in the first intron of the FACL4 gene is associated with altered FA composition of plasma phosphatidylcholines in patients with MetS.
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