Review
Oncology
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Summary: This review explores the use of molecular and viral biomarkers for early detection and prediction of HPV-induced cervical lesions that may progress to CC. The study found an association between high-risk HPV-induced cervical lesions and overexpression of markers of oxidative DNA damage and other proteins, as well as dysregulation of certain markers and high methylation levels in advanced cervical lesions, indicating a higher risk of progression to CC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Mayumi Kobayashi Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
Summary: This study investigated the clinical characteristics, diagnosis, treatment, and prognosis of brain metastases from uterine cervical carcinoma and uterine endometrial carcinoma. The findings highlight factors influencing treatment selection and prognosis, with specific high-risk factors and poor prognostic indicators identified for each type of carcinoma. Despite limited evidence, further research is needed to better understand brain metastases from uterine cancer.
Article
Endocrinology & Metabolism
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The study revealed that dysregulated expression of miR-146b and androgen receptor (AR) played critical roles in the tumorigenesis of papillary thyroid carcinoma (PTC). It was confirmed that miR-146b expression was significantly inversely correlated with AR expression. Further experiments showed that AR might bind to the androgen receptor element on the promoter region of miR-146b, leading to repression of miR-146b expression and reduction of PTC tumor aggressiveness. PTC patients with low AR/high miR-146b expression were associated with advanced tumor characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Juanhong Zhao, Haixia Li, Miao Yuan
Summary: High expression of EGR1 is significantly associated with low survival rates of cervical cancer (CC) and serves as an independent prognostic biomarker. EGR1 promotes stemness and enhances proliferation and invasion of CC cells, with SOX9 playing a crucial role in this process. The EGR1-SOX9 axis may be a potential drug target for treating CC.
Review
Obstetrics & Gynecology
Antonio Raffone, Antonio Travaglino, Diego Raimondo, Manuela Maletta, Valentino De Vivo, Umberto Visiello, Paolo Casadio, Renato Seracchioli, Fulvio Zullo, Luigi Insabato, Antonio Mollo
Summary: A systematic review and meta-analysis showed that compared to SC and CCC, UCS has a significantly worse prognosis with a 1.5-1.6-fold increased risk of death. This suggests the need for more aggressive treatment for UCS compared to SC and CCC. Further studies are necessary to define the prognostic impact of different molecular subgroups.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Youngji Kwak, Sung Yoon Jang, Joon Young Choi, Hyunjun Lee, Dong Seung Shin, Yeon Hee Park, Ji-Yeon Kim, Jin-Seok Ahn, Byung Joo Chae, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jai Min Ryu
Summary: Although ER expression levels affect the prognosis of breast cancer, studies about PR expression levels are insufficient. This study found that low PR expression is associated with worse clinicopathologic features and increased risk of recurrence, metastasis, and death. Therefore, low PR may be a prognostic factor of ER-positive/HER2-negative YBC breast cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Se Ik Kim, Joo Yeon Chung, Haerin Paik, Aeran Seol, Soon Ho Yoon, Taek Min Kim, Hee Seung Kim, Hyun Hoon Chung, Jeong Yeon Cho, Jae-Weon Kim, Maria Lee
Summary: Measuring waist skeletal muscle volume using CT scans and artificial intelligence may serve as a novel prognostic biomarker in endometrial cancer patients. Low volumetric skeletal muscle index was identified as an independent poor prognostic factor for progression-free survival and overall survival.
INSIGHTS INTO IMAGING
(2021)
Article
Oncology
Agnes J. Eide, Mari K. Halle, Njal Lura, Kristine E. Fasmer, Kari Wagner-Larsen, David Forsse, Bjorn I. Bertelsen, Oyvind Salvesen, Camilla Krakstad, Ingfrid S. Haldorsen
Summary: This study reveals the relationship between abdominal fat distribution and clinicopathologic characteristics, survival, and tumor gene expression in uterine cervical cancer (CC). High visceral fat percentage is associated with high-risk clinical features and reduced survival, and is also linked to upregulated inflammatory tumor signaling.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhifang Chen, Di Dong, Yuejie Zhu, Nannan Pang, Jianbing Ding
Summary: In HPV positive cervical cancer patients, high levels of Tim-3 and Galectin-9 are associated with disease progression by promoting Treg cells to inhibit the cytotoxic function of Th1 and CD8+ T cells. The Tim-3/Galectin-9 pathway may serve as a new immunotherapy target for patients with HPV positive cervical cancer.
Article
Cell Biology
Suna Zhou, Xuequan Wang, Jiapei Ding, Haihua Yang, Youyou Xie
Summary: This study revealed that ATG5 plays a crucial role in regulating EMT and predicting poor prognosis in cervical cancer. The survival rate of cervical cancer patients was influenced by ATG5, and functional experiments confirmed its importance in the EMT process. Analysis of TCGA data and functional enrichment results highlighted the significant association of ATG5 with cancer-related pathways in cervical cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kun Zhu, Chunling Deng, Pan Du, Taorui Liu, Junjie Piao, Yingshi Piao, Meng Yang, Liyan Chen
Summary: G6PC plays a key role in the progression of cervical cancer, and overexpressed G6PC is closely related to patient LN metastasis, clinical stage, recurrence, and shortened survival. G6PC promotes cervical cancer proliferation, invasion, migration, EMT progression, and angiogenesis, partially through activating the PI3K/AKT pathway.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Oncology
Chen Xu, Tie Ma, Hongzan Sun, Xiaohan Li, Song Gao
Summary: For individuals with cervical cancer, factors such as cervical stromal invasion depth, lymphovascular space invasion (LVSI), human papilloma virus (HPV-16), Glut1, D-dimer, SUVmax, and SUVpeak were found to be significant in predicting progression-free survival (PFS). SUVpeak level (>= 7.63 g/cm3) and HPV-16 negative status were identified as independent risk factors. A nomogram based on these factors showed satisfactory performance in predicting PFS and can aid in personalized clinical decision-making for patients with cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Manganaro, Yulia Lakhman, Nishat Bharwani, Benedetta Gui, Silvia Gigli, Valeria Vinci, Stefania Rizzo, Aki Kido, Teresa Margarida Cunha, Evis Sala, Andrea Rockall, Rosemarie Forstner, Stephanie Nougaret
Summary: The ESUR female pelvic imaging working group updated their recommendations in 2019 based on >= 80% consensus among experts, highlighting the main role of MRI in initial staging, response monitoring, and evaluation of disease recurrence, while emphasizing the importance of whole-body FDG-PET in detecting lymph nodes and distant metastases.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Qiuping Mo, Yongzhen Wang, JinLan Shan, Xiaochen Wang
Summary: The purpose of this study was to investigate the prognostic value of postoperative radiotherapy in patients with localized pure mucinous breast cancer. The results showed that the addition of postoperative radiotherapy after lumpectomy significantly reduced the incidence of breast cancer death compared to non-radiotherapy. Therefore, postoperative radiotherapy is recommended for the treatment of localized pure mucinous breast cancer.
RADIATION ONCOLOGY
(2022)
Article
Cell Biology
Preetiparna Parida, Shirley Lewis, Krishna Sharan, Mehta Vedant Kamal, Naveena A. N. Kumar, Vishwapriya M. Godkhindi, Sooryanarayana Varambally, Vivek M. Rangnekar, Mahadev Rao, Rama Rao Damerla
Summary: The C1orf74 gene is found to be highly expressed in cervical cancer patients and is associated with poor prognosis. HPV-positive tumors and metastatic tissues have higher expression of C1orf74. The promoter methylation levels of the C1orf74 gene in cervical cancer tissues are lower.