Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Signe Abitz Winther, Miia Maininki Mannerla, Marie Frimodt-Moller, Frederik Persson, Tine Willum Hansen, Markku Lehto, Sohvi Hoerkkoe, Michael Blaut, Carol Forsblom, Per-Henrik Groop, Peter Rossing
Summary: Gastrointestinal dysbiosis is common in individuals with type 1 diabetes (T1D), and fecal biomarkers and short-chain fatty acid concentrations differ between T1D patients and healthy controls, suggesting altered fatty acid metabolism in T1D and DN patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
William H. Hoffman, Stephen A. Whelan, Norman Lee
Summary: Diabetic ketoacidosis (DKA) is a serious complication of Type 1 diabetes (T1D) caused by insulin deficiency and insulin resistance. The metabolic and immunologic dysregulation in DKA leads to oxidative stress, inflammation, and the development of brain edema (BE). Changes in the tryptophan (TRP)/kynurenine pathway (KP) metabolites may play a role in the pathogenesis of DKA/BE.
Article
Endocrinology & Metabolism
Charlotte Loh, Paul Weihe, Nicole Kuplin, Kerstin Placzek, Susann Weihrauch-Blueher
Summary: The study analyzed the impact of the COVID-19 lockdown on children with diabetes mellitus, showing that the lockdown resulted in younger age and more severe DKA symptoms in children with new-onset diabetes, leading to longer hospital stays.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
Lingwen Ying, Yong Zhang, Jun Yin, Yufei Wang, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou
Summary: This study aimed to explore the immunological characteristics and cytokine profiles in the early stage of type 1 diabetes. The results showed that patients with fulminant type 1 diabetes mellitus (FT1DM) had significantly higher levels of inflammation markers and leukocytes, with an increase in neutrophil% and a decrease in lymphocyte%, indicating that FT1DM may have a more abrupt and serious onset compared to classic type 1 diabetes mellitus (T1ADM).
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raul Navarro-Gil, Gibet Benejam, Montse Vizcarro, Marc Baget-Bernaldiz
Summary: This study compared the differences in multifocal electroretinogram between type 1 diabetes and type 2 diabetes patients. The findings suggest that the retinas of type 1 diabetes patients are more sensitive to changes in HbA1c levels, while the duration of diabetes affects both types of patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Hafeez Shaka, Maria Aguilera, Maria Aucar, Zain El-Amir, Farah Wani, Chukwudi Charles Muojieje, Asim Kichloo
Summary: This study analyzed the 2018 Nationwide Readmission Database to describe rates and characteristics of nonelective 30-day readmission among adult patients with T1DM hospitalized for DKA, as well as identify predictors of readmission. The study found a high readmission rate for DKA in T1DM patients, with most patients having DKA as the principal diagnosis on readmission. Predictors of readmission included a Charlson Comorbidity Index (CCI) score of 3 or greater, hypertension, female sex, and being discharged against medical advice.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Hafeez Shaka, Maria Aguilera, Maria Aucar, Zain El-Amir, Farah Wani, Chukwudi Charles Muojieje, Asim Kichloo
Summary: This study found a high 30-day readmission rate for patients with Type 1 diabetes hospitalized for DKA, with female sex, a Charlson Comorbidity Index of 3 or greater, and discharge against medical advice being significant predictors of readmission.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Giada Bianchetti, Luca Viti, Andrea Scupola, Mauro Di Leo, Linda Tartaglione, Andrea Flex, Marco De Spirito, Dario Pitocco, Giuseppe Maulucci
Summary: The study suggests that altered erythrocyte membrane fluidity in T1DM patients may serve as a marker for retinopathy, potentially resulting from various factors such as nonenzymatic glycosylation of proteins, oxidative stress, and lipid peroxidation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Abbas Alshami, Tiffany Purewal, Steven Douedi, Mohammed Alazzawi, Mohammad A. Hossain, Raquel Ong, Shuvendu Sen, Jennifer Cheng, Swapnil Patel
Summary: This study utilized the HCUP-NIS database in 2017 to show that compared to insulin injections, insulin pump use did not predict a lower incidence of DKA in hospitalized patients in the United States.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Elizabeth T. Jensen, Jeanette M. Stafford, Sharon Saydah, Ralph B. D'Agostino, Lawrence M. Dolan, Jean M. Lawrence, Santica Marcovina, Elizabeth J. Mayer-Davis, Catherine Pihoker, Arleta Rewers, Dana Dabelea
Summary: The prevalence of DKA at or near type 1 diabetes diagnosis has increased from 2010 to 2016, with a 2% annual increase. This increase does not seem to be attributed to changes in sociodemographic factors over time.
Article
Biochemistry & Molecular Biology
Fabiola Marino, Nadia Salerno, Mariangela Scalise, Luca Salerno, Annalaura Torella, Claudia Molinaro, Antonio Chiefalo, Andrea Filardo, Chiara Siracusa, Giuseppe Panuccio, Carlo Ferravante, Giorgio Giurato, Francesca Rizzo, Michele Torella, Maria Donniacuo, Antonella De Angelis, Giuseppe Viglietto, Konrad Urbanek, Alessandro Weisz, Daniele Torella, Eleonora Cianflone
Summary: Diabetic cardiomyopathy (DCM) is a major cause of cardiovascular complications in diabetes mellitus (DM). Two different types of diabetes, type 1 and type 2, exhibit different effects on cardiac structure, function and gene expression. Animal models induced by different glucose regulators have been used to compare and study these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)