Generating Cartilage Repair from Pluripotent Stem Cells

Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen

(2013) Uri Ben-David et al.   Cell Stem Cell

Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

(2013) Marina E. Emborg et al.   Cell Reports

Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets

(2012) Kavitha Sivasubramaniyan et al.   Annals of the New York Academy of Sciences

Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells

(2012) B. O. Diekman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β-Superfamily Signaling Regulates Embryonic Stem Cell Heterogeneity: Self-Renewal as a Dynamic and Regulated Equilibrium

(2012) Katherine E. Galvin-Burgess et al.   STEM CELLS

Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression

(2012) Shufang Zhang et al.   STEM CELLS AND DEVELOPMENT

Rehabilitation After Autologous Chondrocyte Implantation for Isolated Cartilage Defects of the Knee

(2011) Anja Hirschmüller et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells

(2011) Min-Jeong Kim et al.   ARTHRITIS AND RHEUMATISM

Large-scale production of murine embryonic stem cell-derived osteoblasts and chondrocytes on microcarriers in serum-free media

(2011) Roz Alfred et al.   BIOMATERIALS

Engineering articular cartilage with spatially-varying matrix composition and mechanical properties from a single stem cell population using a multi-layered hydrogel

(2011) Lonnissa H. Nguyen et al.   BIOMATERIALS

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

(2011) Bin-Kuan Chou et al.   CELL RESEARCH

Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

(2011) Kunihiko Hiramatsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells

(2010) Wei Seong Toh et al.   BIOMATERIALS

Chondrogenesis in perfusion bioreactors using porous silk scaffolds and hESC-derived MSCs

(2010) R. Seda Tığlı et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

SOX9 determines RUNX2 transactivity by directing intracellular degradation

(2010) Aixin Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9

(2010) Y. Takigawa et al.   JOURNAL OF CELL SCIENCE

Direct and progressive differentiation of human embryonic stem cells into the chondrogenic lineage

(2010) Guochun Gong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months

(2010) Shigeyuki Wakitani et al.   Journal of Tissue Engineering and Regenerative Medicine

Directed differentiation of human embryonic stem cells toward chondrocytes

(2010) Rachel A Oldershaw et al.   NATURE BIOTECHNOLOGY

Autologous chondrocyte implantation versus ACI using 3D-bioresorbable graft for the treatment of large full-thickness cartilage lesions of the knee

(2009) Christoph Erggelet et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Induction of chondrogenesis from human embryonic stem cells without embryoid body formation by bone morphogenetic protein 7 and transforming growth factor β1

(2009) Toshiyuki Nakagawa et al.   ARTHRITIS AND RHEUMATISM

The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells

(2009) Jeffrey C. Mohr et al.   BIOMATERIALS

Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation

(2009) Gro Vatne Røsland et al.   CANCER RESEARCH

Autologous chondrocyte implantation to repair knee cartilage injury: ultrastructural evaluation at 2 years and long-term follow-up including muscle strength measurements

(2009) Sverre Løken et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Treatment of Osteoarthritis of the Knee with Microfracture and Rehabilitation

(2009) YI-MENG YEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Is arthroscopic surgery a beneficial treatment for knee osteoarthritis?

(2009) Richard W Nutton   Nature Reviews Rheumatology

Surgical options for patients with osteoarthritis of the knee

(2009) Jörg Lützner et al.   Nature Reviews Rheumatology

Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation

(2009) Ali Fathi et al.   PROTEOMICS

Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines

(2009) Melissa A. Baxter et al.   Stem Cell Research

Human Embryonic Stem Cell–Derived Mesoderm-like Epithelium Transitions to Mesenchymal Progenitor Cells

(2009) Nolan L. Boyd et al.   TISSUE ENGINEERING PART A

A Newly Developed Chemically Crosslinked Dextran–Poly(Ethylene Glycol) Hydrogel for Cartilage Tissue Engineering

(2009) Jojanneke M. Jukes et al.   TISSUE ENGINEERING PART A

Embryonic Stem Cells: Overcoming the Immunological Barriers to Cell Replacement Therapy

(2009) Kathy Lui et al.   Current Stem Cell Research & Therapy

Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States

(2008) Katsuhiko Hayashi et al.   Cell Stem Cell

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/ -catenin, Activin/Nodal and BMP signaling

(2008) T. Sumi et al.   DEVELOPMENT

Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality

(2008) E.J. Koay et al.   OSTEOARTHRITIS AND CARTILAGE

Derivation of Chondrogenically-Committed Cells from Human Embryonic Cells for Cartilage Tissue Regeneration

(2008) Nathaniel S. Hwang et al.   PLoS One

In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells

(2008) N. S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrogenic Derivatives of Embryonic Stem Cells Seeded into 3D Polycaprolactone Scaffolds Generated Cartilage Tissue In Vivo

(2008) Christopher Fecek et al.   TISSUE ENGINEERING PART A

Critical Steps toward a Tissue-Engineered Cartilage Implant Using Embryonic Stem Cells

(2008) Jojanneke M. Jukes et al.   TISSUE ENGINEERING PART A

Chondrogenic Differentiation of Human Mesenchymal Stem Cells on Oriented Nanofibrous Scaffolds: Engineering the Superficial Zone of Articular Cartilage

(2008) Joel K. Wise et al.   TISSUE ENGINEERING PART A

Chondrogenic differentiation of mouse embryonic stem cells promoted by mature chondrocytes

(2008) Feng Xie et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Multiple Mesoderm Subsets Give Rise to Endothelial Cells, Whereas Hematopoietic Cells Are Differentiated Only from a Restricted Subset in Embryonic Stem Cell Differentiation Culture

(2007) Takumi Era et al.   STEM CELLS