Use of Perfusion Bioreactors and Large Animal Models for Long Bone Tissue Engineering

Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep

(2013) A. Berner et al.   Acta Biomaterialia

Dynamic perfusion bioreactor system for 3D culture of rat bone marrow mesenchymal stem cells on nanohydroxyapatite/polyamide 66 scaffoldin vitro

(2013) Xu Qian et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

A novel bidirectional continuous perfusion bioreactor for the culture of large-sized bone tissue-engineered constructs

(2013) Leandro S. Gardel et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Bioactive starch-based scaffolds and human adipose stem cells are a good combination for bone tissue engineering

(2012) A.I. Rodrigues et al.   Acta Biomaterialia

Human mesenchymal stem cell position within scaffolds influences cell fate during dynamic culture

(2012) Andrew B. Yeatts et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flow dynamics characterisation of a novel perfusion-type bioreactor for bone tissue engineering

(2012) Y. Knapp et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor

(2012) Masanori Nishi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Perfusion regulation of hMSC microenvironment and osteogenic differentiation in 3D scaffold

(2011) Junho Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioreactor Systems for Bone Tissue Engineering

(2011) Juliane Rauh et al.   TISSUE ENGINEERING PART B-REVIEWS

The efficacy of allogeneic mesenchymal precursor cells for the repair of an ovine tibial segmental defect

(2011) J. R. Field et al.   VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY

Effect of flow perfusion conditions in the chondrogenic differentiation of bone marrow stromal cells cultured onto starch based biodegradable scaffolds

(2010) Alexandra Gonçalves et al.   Acta Biomaterialia

Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold

(2010) Michael B. Keogh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bone tissue engineering bioreactors: Dynamic culture and the influence of shear stress

(2010) Andrew B. Yeatts et al.   BONE

No effect of dynamic loading on bone graft healing in femoral segmental defect reconstructions in the goat

(2010) Pieter H.J. Bullens et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Computational modeling of flow-induced shear stresses within 3D salt-leached porous scaffolds imaged via micro-CT

(2010) Roman Voronov et al.   JOURNAL OF BIOMECHANICS

Cell-scaffold transplant of hydrogel seeded with rat bone marrow progenitors for bone regeneration

(2010) Dror Ben-David et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

Tissue-engineered constructs based on SPCL scaffolds cultured with goat marrow cells: functionality in femoral defects

(2010) Márcia T. Rodrigues et al.   Journal of Tissue Engineering and Regenerative Medicine

Laryngotracheal reconstruction with porous titanium in rabbits: are vascular carriers and mucosal grafts really necessary?

(2010) Luuk M. Janssen et al.   Journal of Tissue Engineering and Regenerative Medicine

Enhanced osteoblastic differentiation of mesenchymal stem cells seeded in RGD-functionalized PLLA scaffolds and cultured in a flow perfusion bioreactor

(2010) Jose F. Alvarez-Barreto et al.   Journal of Tissue Engineering and Regenerative Medicine

Osteogenic Protein-1 Associated with Mesenchymal Stem Cells Promote Bone Allograft Integration

(2010) Claudia Di Bella et al.   TISSUE ENGINEERING PART A

A Perfusion Bioreactor for Engineering Bone Constructs: An In Vitro and In Vivo Study

(2010) Bertrand David et al.   TISSUE ENGINEERING PART C-METHODS

Tubular Perfusion System for the Long-Term Dynamic Culture of Human Mesenchymal Stem Cells

(2010) Andrew B. Yeatts et al.   TISSUE ENGINEERING PART C-METHODS

Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma

(2009) Manitha B. Nair et al.   Acta Biomaterialia

The challenge of establishing preclinical models for segmental bone defect research

(2009) Johannes C. Reichert et al.   BIOMATERIALS

Bone regeneration in long-bone defects: tissue compartmentalisation? In vivo study on bone defects in sheep

(2009) Kaj Klaue et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Bone formation in trabecular bone cell seeded scaffolds used for reconstruction of the rat mandible

(2009) H. Schliephake et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

A Novel Flow-Perfusion Bioreactor Supports 3D Dynamic Cell Culture

(2009) Alexander M. Sailon et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Bone healing of the sheep tibia shaft after carbon dioxide laser osteotomy: histological results

(2009) Johannes J. Kuttenberger et al.   LASERS IN MEDICAL SCIENCE

Engineering anatomically shaped human bone grafts

(2009) Warren L. Grayson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Flow Shear Stress and Mass Transport on the Construction of a Large-Scale Tissue-Engineered Bone in a Perfusion Bioreactor

(2009) Deqiang Li et al.   TISSUE ENGINEERING PART A

Xenogenic Transplantation of Human Mesenchymal Stem Cells in a Critical Size Defect of the Sheep Tibia for Bone Regeneration

(2009) Philipp Niemeyer et al.   TISSUE ENGINEERING PART A

Bone Grafts Engineered from Human Adipose-Derived Stem Cells in Perfusion Bioreactor Culture

(2009) Mirjam Fröhlich et al.   TISSUE ENGINEERING PART A

Long Bone Defect Models for Tissue Engineering Applications: Criteria for Choice

(2009) Elizabeth A. Horner et al.   TISSUE ENGINEERING PART B-REVIEWS

The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine

(2009) George F. Muschler et al.   TISSUE ENGINEERING PART B-REVIEWS

Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds

(2008) Lea Bjerre et al.   BIOMATERIALS

3D culture of osteoblast-like cells by unidirectional or oscillatory flow for bone tissue engineering

(2008) Dajiang Du et al.   BIOTECHNOLOGY AND BIOENGINEERING

Use of bioreactors in maxillofacial tissue engineering

(2008) Rita Depprich et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

Nonunions and the Potential of Stem Cells in Fracture-Healing

(2008) Susan S. Tseng et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Selection and Development of Preclinical Models in Fracture-Healing Research

(2008) Padhraig F. OʼLoughlin et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Review of Nonprimate, Large Animal Models for Osteoporosis Research

(2008) Susan Reinwald et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodeling in the sheep tibia

(2008) Wolfgang Schneiders et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Computer-Guided CO2-Laser Osteotomy of the Sheep Tibia: Technical Prerequisites and First Results

(2008) Johannes J. Kuttenberger et al.   PHOTOMEDICINE AND LASER SURGERY

Hypoxia in Static and Dynamic 3D Culture Systems for Tissue Engineering of Bone

(2008) Elias Volkmer et al.   TISSUE ENGINEERING PART A

Effects of Initial Seeding Density and Fluid Perfusion Rate on Formation of Tissue-Engineered Bone

(2008) Warren L. Grayson et al.   TISSUE ENGINEERING PART A

Oscillatory perfusion seeding and culturing of osteoblast‐like cells on porous beta‐tricalcium phosphate scaffolds

(2007) Dajiang Du et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds

(2007) Michael J. Jaasma et al.   JOURNAL OF BIOTECHNOLOGY

Effects of Oxygen Transport on 3-D Human Mesenchymal Stem Cell Metabolic Activity in Perfusion and Static Cultures: Experiments and Mathematical Model

(2005) Feng Zhao et al.   BIOTECHNOLOGY PROGRESS