Hydrogels for the Repair of Articular Cartilage Defects

A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells

(2011) Chelsea S. Bahney et al.   FASEB JOURNAL

RGD-Conjugated chitosan-pluronic hydrogels as a cell supported scaffold for articular cartilage regeneration

(2011) Kyung Min Park et al.   MACROMOLECULAR RESEARCH

Mechanical evaluation of poly(vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement

(2010) Julianne L. Holloway et al.   Acta Biomaterialia

Effects of TGF-β3 and preculture period of osteogenic cells on the chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in a bilayered hydrogel composite

(2010) X. Guo et al.   Acta Biomaterialia

Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels

(2010) G.D. Nicodemus et al.   Acta Biomaterialia

Repair of Chronic Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells in an Ovine Model

(2010) Matthias Zscharnack et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair

(2010) Jie Jiang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Anisotropic dynamic changes in the pore network structure, fluid diffusion and fluid flow in articular cartilage under compression

(2010) George W. Greene et al.   BIOMATERIALS

Multi-lineage differentiation of hMSCs encapsulated in thermo-reversible hydrogel using a co-culture system with differentiated cells

(2010) Ji Sun Park et al.   BIOMATERIALS

Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells

(2010) Wei Seong Toh et al.   BIOMATERIALS

A versatile pH sensitive chondroitin sulfate–PEG tissue adhesive and hydrogel

(2010) Iossif Strehin et al.   BIOMATERIALS

Biomimetic hydrogels for chondrogenic differentiation of human mesenchymal stem cells to neocartilage

(2010) Shao Qiong Liu et al.   BIOMATERIALS

Effect of temporally controlled release of dexamethasone on in vivo chondrogenic differentiation of mesenchymal stromal cells

(2010) Soon Eon Bae et al.   JOURNAL OF CONTROLLED RELEASE

Preparation of TGF-β1-conjugated biodegradable pluronic F127 hydrogel and its application with adipose-derived stem cells

(2010) Hong Hee Jung et al.   JOURNAL OF CONTROLLED RELEASE

Design of semi-degradable hydrogels based on poly(vinyl alcohol) and poly(lactic-co-glycolic acid) for cartilage tissue engineering

(2010) Kara L. Spiller et al.   Journal of Tissue Engineering and Regenerative Medicine

Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months

(2010) Shigeyuki Wakitani et al.   Journal of Tissue Engineering and Regenerative Medicine

Self-Assembly-Peptide Hydrogels as Tissue-Engineering Scaffolds for Three-Dimensional Culture of Chondrocytes in vitro

(2010) Jingping Liu et al.   MACROMOLECULAR BIOSCIENCE

Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes

(2010) P.W. Kopesky et al.   MATRIX BIOLOGY

Supramolecular design of self-assembling nanofibers for cartilage regeneration

(2010) Ramille N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Chondrogenesis: Potential and Limitations of SOX9 Gene Transfer and Mechanical Stimulation for Cartilage Tissue Engineering

(2010) Laszlo Kupcsik et al.   TISSUE ENGINEERING PART A

Controlled Delivery of Transforming Growth Factor β1 by Self-Assembling Peptide Hydrogels Induces Chondrogenesis of Bone Marrow Stromal Cells and Modulates Smad2/3 Signaling

(2010) Paul W. Kopesky et al.   TISSUE ENGINEERING PART A

Porous Poly(Vinyl Alcohol)-Hydrogel Matrix-Engineered Biosynthetic Cartilage

(2010) David A. Bichara et al.   TISSUE ENGINEERING PART A

The Effects of Insulin-Like Growth Factor-1 and Basic Fibroblast Growth Factor on the Proliferation of Chondrocytes Embedded in the Collagen Gel Using an Integrated Microfluidic Device

(2010) Yuancheng Li et al.   TISSUE ENGINEERING PART C-METHODS

Additive manufacturing forin siturepair of osteochondral defects

(2010) Daniel L Cohen et al.   Biofabrication

Thermosensitive chitosan–Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration

(2009) Kyung Min Park et al.   Acta Biomaterialia

Unconfined compression properties of a porous poly(vinyl alcohol)–chitosan-based hydrogel after hydration

(2009) Si-Yuen Lee et al.   Acta Biomaterialia

Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model

(2009) Xuan Guo et al.   Acta Biomaterialia

Catabolic Responses of Chondrocyte-Seeded Peptide Hydrogel to Dynamic Compression

(2009) John D. Kisiday et al.   ANNALS OF BIOMEDICAL ENGINEERING

Effect of Swelling Ratio of Injectable Hydrogel Composites on Chondrogenic Differentiation of Encapsulated Rabbit Marrow Mesenchymal Stem Cells In Vitro

(2009) Hansoo Park et al.   BIOMACROMOLECULES

Induction of cartilage integration by a chondrocyte/collagen-scaffold implant

(2009) Moreica B. Pabbruwe et al.   BIOMATERIALS

Injectable chitosan-based hydrogels for cartilage tissue engineering

(2009) R. Jin et al.   BIOMATERIALS

Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering

(2009) Esther Wenk et al.   BIOMATERIALS

In vitro generation of an osteochondral construct using injectable hydrogel composites encapsulating rabbit marrow mesenchymal stem cells

(2009) Xuan Guo et al.   BIOMATERIALS

Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering

(2009) Huaping Tan et al.   BIOMATERIALS

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells

(2009) Cindy Chung et al.   BIOMATERIALS

The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cells

(2009) Saey T.B. Ho et al.   BIOMATERIALS

Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-β pathway

(2009) Zhen Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Influence of dynamic load on friction behavior of human articular cartilage, stainless steel and polyvinyl alcohol hydrogel as artificial cartilage

(2009) Feng Li et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Cell encapsulation within PVA-based hydrogels via freeze-thawing: a one-step scaffold formation and cell storage technique

(2009) N. E. Vrana et al.   Journal of Tissue Engineering and Regenerative Medicine

Strategies for Zonal Cartilage Repair using Hydrogels

(2009) Travis J. Klein et al.   MACROMOLECULAR BIOSCIENCE

Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels

(2009) G.D. Nicodemus et al.   OSTEOARTHRITIS AND CARTILAGE

The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels

(2009) T. Hao et al.   OSTEOARTHRITIS AND CARTILAGE

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Fibrin Sealants from Fresh or Fresh/Frozen Plasma as Scaffolds for In Vitro Articular Cartilage Regeneration

(2009) Emma V. Dare et al.   TISSUE ENGINEERING PART A

Addition of Hyaluronic Acid to Alginate Embedded Chondrocytes Interferes with Insulin-like Growth Factor-1 Signaling In Vitro and In Vivo

(2009) Diana M. Yoon et al.   TISSUE ENGINEERING PART A

Differential Maturation and Structure–Function Relationships in Mesenchymal Stem Cell- and Chondrocyte-Seeded Hydrogels

(2009) Isaac E. Erickson et al.   TISSUE ENGINEERING PART A

Collagen Type II Enhances Chondrogenesis in Adipose Tissue–Derived Stem Cells by Affecting Cell Shape

(2009) ZuFu Lu et al.   TISSUE ENGINEERING PART A

Dynamic Mechanical Loading Enhances Functional Properties of Tissue-Engineered Cartilage Using Mature Canine Chondrocytes

(2009) Liming Bian et al.   TISSUE ENGINEERING PART A

Passaged Adult Chondrocytes Can Form Engineered Cartilage with Functional Mechanical Properties: A Canine Model

(2009) Kenneth W. Ng et al.   TISSUE ENGINEERING PART A

A Newly Developed Chemically Crosslinked Dextran–Poly(Ethylene Glycol) Hydrogel for Cartilage Tissue Engineering

(2009) Jojanneke M. Jukes et al.   TISSUE ENGINEERING PART A

Chondrogenesis of Human Bone Marrow Mesenchymal Stem Cells in Fibrin–Polyurethane Composites Is Modulated by Frequency and Amplitude of Dynamic Compression and Shear Stress

(2009) Zhen Li et al.   TISSUE ENGINEERING PART A

Strategies for Articular Cartilage Lesion Repair and Functional Restoration

(2009) Tamer A.E. Ahmed et al.   TISSUE ENGINEERING PART B-REVIEWS

Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells

(2008) S.D. Thorpe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydrolytically Degradable Hyaluronic Acid Hydrogels with Controlled Temporal Structures

(2008) Sujata Sahoo et al.   BIOMACROMOLECULES

In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration

(2008) T.Y. Hui et al.   BIOMATERIALS

The differential effect of scaffold composition and architecture on chondrocyte response to mechanical stimulation

(2008) Taly P. Appelman et al.   BIOMATERIALS

Poly(vinyl alcohol)–acrylamide hydrogels as load-bearing cartilage substitute

(2008) Hatice Bodugoz-Senturk et al.   BIOMATERIALS

Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit

(2008) Hideyuki Koga et al.   CELL AND TISSUE RESEARCH

Autologous chondrocyte implantation—Technique and long-term follow-up

(2008) Mats Brittberg   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation

(2008) G.D. Nicodemus et al.   JOURNAL OF BIOMECHANICS

Transforming growth factor β-3 bound with sulfate polysaccharide in synthetic extracellular matrix enhanced the biological activities for neocartilage formationin vivo

(2008) Ji Sun Park et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Autologous chondrocyte implantation in a novel alginate-agarose hydrogel

(2008) T. A. S. Selmi et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Present status of and future direction for articular cartilage repair

(2008) Shigeyuki Wakitani et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Tissue engineering of cartilages using biomatrices

(2008) James Melrose et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

(2008) Xiaoqin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Static and dynamic compressive strains influence nitric oxide production and chondrocyte bioactivity when encapsulated in PEG hydrogels of different crosslinking densities

(2008) I. Villanueva et al.   OSTEOARTHRITIS AND CARTILAGE

Designing 3D Photopolymer Hydrogels to Regulate Biomechanical Cues and Tissue Growth for Cartilage Tissue Engineering

(2008) Stephanie J. Bryant et al.   PHARMACEUTICAL RESEARCH

Immune response to biologic scaffold materials

(2008) Stephen F. Badylak et al.   SEMINARS IN IMMUNOLOGY

Differential Behavior of Auricular and Articular Chondrocytes in Hyaluronic Acid Hydrogels

(2008) Cindy Chung et al.   TISSUE ENGINEERING PART A

Influence of Three-Dimensional Hyaluronic Acid Microenvironments on Mesenchymal Stem Cell Chondrogenesis

(2008) Cindy Chung et al.   TISSUE ENGINEERING PART A

Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties

(2007) Kara L. Spiller et al.   Acta Biomaterialia

Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel

(2007) Yuji Hirano et al.   JOURNAL OF BIOTECHNOLOGY

Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells

(2007) Fei Chang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures

(2007) John D. Kisiday et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells

(2007) Shyni Varghese et al.   MATRIX BIOLOGY

Poly(vinyl alcohol) Hydrogel as a Biocompatible Viscoelastic Mimetic for Articular Cartilage

(2006) Colin Grant et al.   BIOTECHNOLOGY PROGRESS