Harnessing the Parathyroid Hormone, Wnt, and Bone Morphogenetic Protein Signaling Cascades for Successful Bone Tissue Engineering

Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women

(2011) Matthew T. Drake et al.   BONE

Endogenous tissue engineering: PTH therapy for skeletal repair

(2011) Masahiko Takahata et al.   CELL AND TISSUE RESEARCH

Smad1 plays an essential role in bone development and postnatal bone formation

(2011) M. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

(2011) Joana Caetano-Lopes et al.   PLoS One

Activation of the Hh Pathway in Periosteum-Derived Mesenchymal Stem Cells Induces Bone Formation in Vivo

(2010) Qun Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Parathyroid hormone and bisphosphonate have opposite effects on stress fracture repair

(2010) Ashley V. Sloan et al.   BONE

Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair

(2010) Yan Yiu Yu et al.   BONE

Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model

(2010) David G. Reynolds et al.   BONE

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial

(2010) Hiroshi Kawaguchi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

EP1−/− mice have enhanced osteoblast differentiation and accelerated fracture repair

(2010) Minjie Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women

(2010) Matthew T. Drake et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of Intermittent Systemic Administration of Recombinant Parathyroid Hormone (1-34) on Mandibular Fracture Healing in Rats

(2010) Henry H. Rowshan et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Opposite Spectrum of Activity of Canonical Wnt Signaling in the Osteogenic Context of Undifferentiated and Differentiated Mesenchymal Cells: Implications for Tissue Engineering

(2010) Natalina Quarto et al.   TISSUE ENGINEERING PART A

Enhanced Bone Morphogenetic Protein-2-Induced Ectopic and Orthotopic Bone Formation by Intermittent Parathyroid Hormone (1–34) Administration

(2010) Diederik H.R. Kempen et al.   TISSUE ENGINEERING PART A

Does osteocytic SOST suppression mediate PTH bone anabolism?

(2010) Ina Kramer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Anabolic Therapies

(2010) Nancy E. Lane et al.   Current Osteoporosis Reports

Effect of 1,25-dihydroxy vitamin D3 on fracture healing and bone remodeling in ovariectomized rat femora

(2009) Lingjie Fu et al.   BONE

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells

(2009) Stefan Bajada et al.   BONE

Intermittent PTH(1–34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures

(2009) Magnus Tägil et al.   BONE

Temporal pattern of gene expression and histology of stress fracture healing

(2009) L.J. Kidd et al.   BONE

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing

(2009) Simon Graham et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Parathyroid Hormone Upregulates BMP-2 mRNA Expression Through Mevalonate Kinase and Rho Kinase Inhibition in Osteoblastic MC3T3-E1 Cells

(2009) H. Takase et al.   HORMONE AND METABOLIC RESEARCH

Secreted frizzled related protein 1 is a target to improve fracture healing

(2009) Tripti Gaur et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Parathyroid Hormone (1-34) Augments Spinal Fusion, Fusion Mass Volume, and Fusion Mass Quality in a Rabbit Spinal Fusion Model

(2009) Padhraig F. O’Loughlin et al.   SPINE

Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1–34) in metaphyseal bone healing

(2008) Elise F. Morgan et al.   BONE

Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts

(2008) Robert L. Jilka et al.   BONE

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

Differentiation and Proliferation of Periosteal Osteoblast Progenitors Are Differentially Regulated by Estrogens and Intermittent Parathyroid Hormone Administration

(2008) Mami Ogita et al.   ENDOCRINOLOGY

Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications

(2008) Jeffrey O. Hollinger et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing

(2008) Amish A Naik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair

(2008) Carmen E. Macsai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE