Article
Biotechnology & Applied Microbiology
Xiang Li, Shiao Li, Jiatian Qian, Yancheng Chen, Yiqin Zhou, Peiliang Fu
Summary: The study demonstrated that type I collagen-based MACT is an effective treatment for improving functionality and pain levels. Histological evidence confirmed hyaline cartilage induction and showed that repaired cartilage tended to emerge from the deep to the superficial layer. The quantitative MRI T2 mapping test indicated that there still was a difference between the transplanted cartilage and the surrounding hyaline cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
David Grevenstein, Andreas Mamilos, Volker H. Schmitt, Tanja Niedermair, Willi Wagner, C. James Kirkpatrick, Christoph Brochhausen
Summary: The study analyzed histological and immunohistological findings from five patients who underwent spheroid-based autologous chondrocyte transplantation after traumatic lesions of the knee, showing excellent histological results in terms of hyaline articular cartilage regeneration. This indicates that spheroid-based autologous chondrocyte transplantation is a promising strategy for treating traumatic lesions of the knee's articular cartilage.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Review
Biotechnology & Applied Microbiology
Yanxi Liu, Karan M. Shah, Jian Luo
Summary: Articular cartilage is avascular and has limited ability to repair itself, leading to degenerative joint diseases. Current clinical treatments often result in mechanically inferior cartilage. Understanding factors affecting cartilage homeostasis and exploring emerging regenerative approaches are crucial for future treatment options.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
H. Binder, L. Hoffman, L. Zak, T. Tiefenboeck, S. Aldrian, C. Albrecht
Summary: This retrospective study aimed to compare short-term clinical outcomes among four different types of matrix-associated autologous chondrocyte transplantation (MACT) for full-thickness chondral lesions of the tibiofemoral joint. The study found that two years postoperatively, there were no significant differences in terms of outcomes, demonstrating that MACT resulted in good clinical improvement regardless of the implants used for localized tibiofemoral defects.
BONE & JOINT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Zelong Dou, Daniel Muder, Marta Baroncelli, Ameya Bendre, Alexandra Gkourogianni, Lars Ottosson, Torbjorn Vedung, Ola Nilsson
Summary: The study found that perichondrium and periosteum transplanted into articular cartilage defects can be transformed into cartilaginous articular surfaces. Perichondrium transplants developed into an articular-like, hyaline cartilage, while periosteum transplants produced a less resilient fibro-cartilage.
Article
Biochemistry & Molecular Biology
Po-Chih Shen, Cheng-Chang Lu, Shih-Hsiang Chou, Zi-Miao Liu, Shu-Jem Su, Yin-Chun Tien
Summary: This study compared stratified chondrocyte sheets (S-CS) and heterogeneous chondrocyte sheets (H-CS) in terms of expression and therapeutic effects, revealing that the S-CS group exhibited higher cell viability, proliferation rate, expression of chondrogenic markers, secretion of tissue inhibitor of metalloproteinase, and GAG production level. The mini-pigs articular cartilage defect model showed that the S-CS group had a higher International Cartilage Repair Society (ICRS) macroscopic score and displayed a zonal structure closer to native cartilage.
Article
Orthopedics
Drake G. LeBrun, Benedict U. Nwachukwu, Stephanie S. Buza, Simone Gruber, William A. Marmor, Elizabeth R. Dennis, Beth E. Shubin Stein
Summary: In the management of symptomatic patellar cartilage defects, both PJAC and MACI were cost-effective compared to nonoperative management. PJAC was more cost-effective than MACI when they were considered equally effective, due to the need for only one surgery and less costly graft material.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Orthopedics
Lukas Zak, Anne Kleiner, Christian Albrecht, Brigitte Tichy, Silke Aldrian
Summary: The 2-year follow-up of patients who received third-generation ACI using the Igor scaffold at the knee joint showed improvements in clinical and radiological outcomes, with a decrease in pain, an increase in activity, and the majority of patients reporting good results.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Kyoung-Ho Yoon, Jae Doo Yoo, Chong-Hyuk Choi, Jungsun Lee, Jin-Yeon Lee, Sang-Gyun Kim, Jae-Young Park
Summary: The study compared the efficacy and safety of CCP-ACI and MFx for knee articular cartilage defects. The outcomes indicated that CCP-ACI group had significantly better MOCART scores, cartilage integrity, and functional improvements compared to the MFx group.
Article
Orthopedics
John R. Matthews, Joseph M. Brutico, Daniel T. Abraham, Jeremy C. Heard, Bradford S. Tucker, Fotios P. Tjoumakaris, Kevin B. Freedman
Summary: This study compares the clinical and patient-reported outcomes of autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss. The results suggest that ACI provides similar outcomes to OCA in all lesion locations and may have a lower revision rate for multifocal and condylar lesions.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Filippo Migliorini, Hanno Schenker, Nicola Maffulli, Joerg Eschweiler, Philipp Lichte, Frank Hildebrand, Christian David Weber
Summary: This study evaluated the outcomes of Autologous Matrix Induced Chondrogenesis (AMIC) as a revision procedure for failed AMIC surgery in treating talus osteochondral defects. The results showed that AMIC could be a viable option for revision surgery in recurrent symptomatic osteochondral defects of the talus. Patients were moderately satisfied with the procedure, and there was a significant improvement in the postoperative Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. A deeper understanding of prognostic factors and patient selection is crucial to prevent surgery failures.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Weirong Xing, Sheila Pourteymoor, Yian Chen, Subburaman Mohan
Summary: Studies show that targeted deletion of the Cldn12 gene in mice increases articular cartilage, potentially by promoting articular chondrocyte phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Virginie Philippe, Alexis Laurent, Philippe Abdel-Sayed, Nathalie Hirt-Burri, Lee Ann Applegate, Robin Martin
Summary: This study demonstrates that hPL can be a functional equivalent and alternative to aHS for cultured HAC batch preparation, potentially easing pressure on clinical and manufacturing bottlenecks in cell therapy approaches for cartilage regeneration.
Article
Biology
Fan Zhang, Yuanyuan Wang, Ying Zhao, Manqi Wang, Bin Zhou, Xianpeng Ge, Di Chen
Summary: NFATc1 is a crucial regulator of articular chondrocyte differentiation, expressed in the early stage of joint development. It negatively regulates the transcriptional activity of the COL2A1 gene in articular cartilage progenitors, determining the differentiation of articular chondrocytes. These findings highlight the important role of NFATc1 in articular cartilage development.
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Meeting Abstract
Orthopedics
G. G. Schulze-Tanzil, J. Badendick, O. Godkin, B. Kohl, M. Jagielski, S. Arens
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Orthopedics
K. Ruschke, C. Meier, M. Ullah, A. -C. Krebs, K. Silberreis, B. Kohl, P. Knaus, M. Jagielski, S. Arens, G. Schulze-Tanzil
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Materials Science, Biomaterials
Gioacchino Conoscenti, Tobias Schneider, Katharina Stoelzel, Francesco Carfi Pavia, Valerio Brucato, Clemens Goegele, Vincenzo La Carrubba, Gundula Schulze-Tanzil
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Anke Lohan, Benjamin Kohl, Carola Meier, Gundula Schulze-Tanzil
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Silke Schwarz, Clemens Goegele, Benjamin Ondruschka, Niels Hammer, Benjamin Kohl, Gundula Schulze-Tanzil
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Tobias Haase, Vikram Sunkara, Benjamin Kohl, Carola Meier, Patricia Bussmann, Jessica Becker, Michal Jagielski, Max von Kleist, Wolfgang Ertel
Article
Multidisciplinary Sciences
Anika Rettig, Tobias Haase, Alexandr Pletnyov, Benjamin Kohl, Wolfgang Ertel, Max von Kleist, Vikram Sunkara
Article
Biochemistry & Molecular Biology
Gundula Schulze-Tanzil, Philipp Arnold, Clemens Goegele, Judith Hahn, Annette Breier, Michael Meyer, Benjamin Kohl, Michaela Schroepfer, Silke Schwarz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Stefan Stich, Michal Jagielski, Anja Fleischmann, Carola Meier, Patricia Bussmann, Benjamin Kohl, Julia Schmidt, Jan-Philipp Krueger, Michaela Endres, Mario Cabraja, Kolja Reimann, Dominik Laue, Wolfgang Ertel, Michael Sittinger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Erman Popowski, Benjamin Kohl, Tobias Schneider, Joachim Jankowski, Gundula Schulze-Tanzil
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Samira Ira Zabaneh, Linda Josephine Voss, Agnieszka J. Szczepek, Heidi Olze, Katharina Stoelzel
Summary: This study compared SVV in MD patients and healthy participants, finding significant differences in SVV scores when using the analog bucket test and C-SVV(R) goggles, but not with the digital bucket test. The analog bucket test showed higher accuracy, and the intake of betahistine did not influence SVV scores.
Article
Cell Biology
Sandeep Silawal, Benjamin Kohl, Georg Girke, Tobias Schneider, Gundula Schulze-Tanzil
Summary: This in vitro study investigated the effects of leukocytes on tenocytes in an inflammatory scenario, with TNF alpha playing a crucial role in complement regulation. Time-dependent effects of leukocyte activation on CRP gene expression were observed, indicating a complex interplay between TNF alpha and complement regulation in tenocytes.
INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sandeep Silawal, Benjamin Kohl, Jingjian Shi, Gundula Schulze-Tanzil
Summary: The study found that C5a stimulation did not affect cell survival, but had a significant impact on the gene expression of C5aR, CRPs, and inflammatory cytokines at different stages. C5a may directly contribute to cell activation, thereby being involved in tendon healing and tendinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Mohamed Mahmoud, Maria Kokozidou, Clemens Goegele, Christian Werner, Alexander Auffarth, Benjamin Kohl, Ingo Mrosewski, Gundula Gesine Schulze-Tanzil
Summary: Interveretebral disc degeneration is a common cause of low back pain in diabetes mellitus type 2 (T2DM) patients. The effect of vitamin K2 on this disease is unclear. This study used male Zucker Diabetes Fatty (ZDF) rats to investigate the impact of vitamin K2 on IVD degeneration in T2DM. The results showed that T2DM rats exhibited histopathological IVD degeneration, and vitamin K2 had an influence on stress-associated markers in IVD cells of diabetic rats.
Correction
Orthopedics
Jessica Badendick, Owen Godkin, Benjamin Kohl, Carola Meier, Michal Jagielski, Zhao Huang, Stephan Arens, Tobias Schneider, Gundula Schulze-Tanzil
CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS
(2016)