Article
Chemistry, Multidisciplinary
Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan
Summary: The Am-PNCage is a novel protein nanocarrier with dual-targeting properties, allowing for effective drug loading and promoting drug penetration and accumulation in tumors in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Niaz Ali Khan, Amjad Khan, Rooh Ullah, Majeed Ullah, Amal Alotaibi, Riaz Ullah, Adnan Haider
Summary: The aim of this study was to prepare and characterize a sustained-release matrix tablet containing a high-dose hydrophobic drug using HPMC as the matrix-forming polymer. The results showed that HPMC successfully sustained drug release for 24 hours, and the physical parameters and drug content of the tablets were within the pharmacopeial limits.
Article
Chemistry, Multidisciplinary
Wenjin Wang, Zhiwu Chen, Xiaodong Lian, Zhaoxiang Yang, Bin Fu, Yapei Wang
Summary: A strain-manipulated surface modification strategy was proposed to obtain an anti-icing coating with adjustable hydrophilic/hydrophobic hybrid components. The performance of the coating in anti-icing was closely related to the proportion of hydrophilic and hydrophobic hybrids. The material with the optimal components showed a longer icing delay time and lower ice adhesion strength.
Article
Environmental Sciences
Qing Wen, Xinni Xie, Qidong Ren, Yuguo Du
Summary: This study investigates the effects of PBDE 99 on adipocyte commitment and adipogenesis. PBDE 99 was found to enhance adipocyte commitment and promote adipogenesis in MSCs, possibly through inhibiting Hedgehog signaling.
Article
Materials Science, Multidisciplinary
Ping Du, Xuelian Tao, Kun Liu, Jiao Lin, Yue Shi, Kwideok Park, Hsien-Yeh Chen, Chao-Po Lin, Junlei Chang, Raymond Cb Wong, Haobo Pan, Peng-Yuan Wang
Summary: The study suggests that human platelet lysate has a significant impact on the bioenergetics and differentiation of mesenchymal stem cells, promoting cell proliferation and osteogenic capability. It alters metabolic pathways and functional properties of MSCs, highlighting its potential as a biological material for stem cell engineering and regenerative medicine.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Lingxiao Liu, Cihui Luo, Jinhuan Zhang, Xiao He, Ying Shen, Bing Yan, Yu Huang, Fan Xia, Lei Jiang
Summary: This study designs a biomimetic solid-state nanochannel with hydrophilic DNA probes at the inner wall and hydrophobic coating at the outer surface, which significantly reduces the limit of detection and improves sensitivity through the synergistic effect. Nanomolar detection of Hg2+ in human serum and in vivo fish muscle is achieved.
Article
Chemistry, Physical
Nan Zhang, Yue-Ting Du, Pei-Qi Yao, Hui-Yi Huang, Li-Rong Zhang, Feng-Shou Zhang, Jun-Jie Liu
Summary: This study used molecular dynamics simulations to investigate the inhibition of natural methane hydrate growth by hyperactive insect antifreeze protein (TmAFP) and its mutants. The simulations revealed that the synergistic effect of hydrophobic and hydrophilic groups in threonine residues played a crucial role in binding to hydrates and inhibiting their growth. This study provides guidance for the design of more effective hydrate inhibitors.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Cell Biology
Chengxiao Ma, Wen Zhang, Wengcong Wang, Jiabing Shen, Kefu Cai, Mei Liu, Maohong Cao
Summary: Parkinson's disease is a common neurodegenerative disease. Cell transplantation can mitigate damage to dopaminergic neurons by enhancing self-autophagy, potentially offering a promising therapeutic option for improving neuron survival and function.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Mengke Fan, Huiying Shi, Hailing Yao, Weijun Wang, Yurui Zhang, Chen Jiang, Rong Lin
Summary: Our previous study showed that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) promotes functional enteric nerve regeneration in denervated mice but not through direct transdifferentiation. Homeostasis of the adult enteric nervous system (ENS) is maintained by enteric neural precursor cells (ENPCs). Whether ENPCs are a source of regenerated nerves in denervated mice remains unknown.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aisha Ishaque, Asmat Salim, Shabana Usman Simjee, Irfan Khan, Durriyyah Sharifah Hasan Adli
Summary: This study analyzes the effect of alpha terpineol (AT) on the differentiation of rat bone marrow derived mesenchymal stem cells (BM-MSCs) towards neuronal lineage and explores the regulation of differentiation through the Wnt pathway. The results show that AT efficiently induces neuronal differentiation of BM-MSCs by regulating the Wnt signaling pathway, which could be a promising approach in cellular therapeutics for treating neurodegenerative diseases.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Chemistry, Physical
Simeng Gao, Xinxin Bao, Lintao Yu, Hainan Wang, Junyan Li, Xi Chen
Summary: This study investigates the aggregation behavior and interfacial performance of a series of quasi-gemini surfactants at the oil/water interface using molecular dynamics simulation. The results suggest that subtle structural variations in the surfactants can significantly affect interfacial properties, with 3-C12S(NP) showing the best overall performance in reducing interface tension. These findings are valuable for the design of high-performance surfactants for oil displacement.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Engineering, Biomedical
Antara Banerjee, Praveen Rowlo, Ganesan Jothimani, Asim K. Duttaroy, Surajit Pathak
Summary: By treating mouse mesenchymal stem cells with Wnt inhibitors, the potential of these cells to differentiate into neuronal-like cells was investigated. The results showed promising potential for cell replacement therapies in neurodegenerative diseases. However, further research is needed to understand the mechanism of these small molecules in promoting the differentiation process.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2022)
Article
Cell Biology
Xin-Hong Jiang, Hang-Feng Li, Man-Li Chen, Yi-Xian Zhang, Hong-Bin Chen, Rong-Hua Chen, Ying-Chun Xiao, Nan Liu
Summary: Treadmill exercise and mesenchymal stem cell transplantation have been proven to be practical and effective methods for treating cerebral ischemia. This study investigated the potential synergistic effect between treadmill exercise and mesenchymal stem cell-derived exosomes (MSC-exos) treatment. The results showed that the combination of treadmill exercise and MSC-exos treatment significantly improved neurological function, reduced neuronal apoptosis and cerebral infarct volume, and promoted synaptic formation and axonal regeneration. Mechanistically, it was found that the JNK1/c-Jun signaling pathway played a role in regulating neuronal apoptosis and synaptic-axonal remodeling. These findings provide novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.
NEURAL REGENERATION RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Mohammad Mazloum-Ardakani, Negar Shaker-Ardakani, Azra Ebadi
Summary: In this study, four types of ZIF-8-encapsulated drug composites were developed for sustained release of three drugs without the use of organic solvent. The research aimed to investigate the release kinetics of hydrophilic and hydrophobic drugs using ZIF-8 frameworks. Dual encapsulation of antibiotics was also performed to enhance the synergistic effects against various bacteria. The obtained composites exhibited desirable properties and high toxicity against cancer cells. The drug loading capacity ranged from 7% to 12.61% and the drug release was studied using five kinetic equations.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Cell Biology
Shumin Xia, Ying Bena Lim, Zhen Zhang, Yilin Wang, Shan Zhang, Chwee Teck Lim, Evelyn K. F. Yim, Pakorn Kanchanawong
Review
Biotechnology & Applied Microbiology
Seep Arora, Evelyn K. F. Yim, Yi-Chin Toh
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Grace Pohan, Pascale Chevallier, Deirdre E. J. Anderson, John W. Tse, Yuan Yao, Matthew W. Hagen, Diego Mantovani, Monica T. Hinds, Evelyn K. F. Yim
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2019)
Article
Engineering, Biomedical
Seep Arora, Shiming Lin, Christine Cheung, Evelyn K. F. Yim, Yi-Chin Toh
Review
Cell Biology
Sarah W. Chan, Muhammad Rizwan, Evelyn K. F. Yim
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell & Tissue Engineering
Grace Pohan, Sabrina Mattiassi, Yuan Yao, Aung Moe Zaw, Deirdre E. J. Anderson, Marie F. A. Cutiongco, Monica T. Hinds, Evelyn K. F. Yim
TISSUE ENGINEERING PART A
(2020)
Article
Engineering, Biomedical
Yuan Yao, Aung Moe Zaw, Deirdre E. J. Anderson, Monica T. Hinds, Evelyn K. F. Yim
Article
Engineering, Biomedical
Muhammad Rizwan, Sarah W. Chan, Patricia A. Comeau, Thomas L. Willett, Evelyn K. F. Yim
BIOMEDICAL MATERIALS
(2020)
Article
Engineering, Biomedical
Sharvari R. Sathe, Deepak Jain, Cheng-Gee Koh, Evelyn K. F. Yim
Summary: This study investigates how topographical cues affect cell migration and morphology, especially in the context of POPX2 overexpression. The results show that overexpressing cells are more sensitive to topographical cues and exhibit more direct migration paths, indicating a potential mechanism for directional cell migration combining biochemical and mechanical cues.
BIOMEDICAL MATERIALS
(2021)
Article
Cell & Tissue Engineering
Marek Kukumberg, Aung Moe Zaw, Daniel H. C. Wong, Chin Min Toh, Bernard P. L. Chan, Raymond C. S. Seet, Peter T. H. Wong, Evelyn K. F. Yim
Summary: This study found an increased amount of circulating EPCs in stroke patients, with a rising trend over the 12-month post-stroke period. Isolated CD34(+)KDR(+) cells from stroke patients showed impaired tubular formation capability compared to cells from healthy donors, indicating the impact of stroke on EPC functionality.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Nanoscience & Nanotechnology
John W. Tse, Muhammad Rizwan, Jonathan Rasmussen, Lyndon Jones, Evelyn K. F. Yim
ACS APPLIED BIO MATERIALS
(2020)
Article
Veterinary Sciences
Keping Zuo, Li Buay Koh, Christopher J. Charles, Evelyn K. F. Yim, Jialing Lim, Renee R. Li, Hwa Liang Leo, Fangsen Cui, Pei Ho
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2020)
Review
Materials Science, Biomaterials
YeJin Jeong, Yuan Yao, Evelyn K. F. Yim
BIOMATERIALS SCIENCE
(2020)
Review
Materials Science, Biomaterials
Young Ju Son, John W. Tse, Yiran Zhou, Wei Mao, Evelyn K. F. Yim, Hyuk Sang Yoo
BIOMATERIALS SCIENCE
(2019)
Review
Cell Biology
Deepak Jain, Sabrina Mattiassi, Eyleen L. Goh, Evelyn K. F. Yim
NEURAL REGENERATION RESEARCH
(2020)