Review
Biochemistry & Molecular Biology
Dalila Di Francesco, Alexa Pigliafreddo, Simona Casarella, Luca Di Nunno, Diego Mantovani, Francesca Boccafoschi
Summary: The clinical demand for tissue-engineered vascular grafts is increasing, and there are many challenges to obtain functional small-diameter grafts. Advances in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to promising solutions for vascular graft production. The use of natural materials as scaffolds for vascular tissue engineering has gained attention and new strategies have been developed to overcome the drawbacks.
Review
Biochemistry & Molecular Biology
Xiling Zhang, Thomas Puehler, Jette Seiler, Stanislav N. Gorb, Janarthanan Sathananthan, Stephanie Sellers, Assad Haneya, Jan-Hinnerk Hansen, Anselm Uebing, Oliver J. Mueller, Derk Frank, Georg Lutter
Summary: Although transcatheter pulmonary valve replacement has shown favorable results as an alternative treatment for pulmonary valve disease, many patients are still not suitable candidates for this procedure. One of the significant future challenges is to expand the use of transcatheter pulmonary valve replacement to a broader patient population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Takashi Nagase, Masaaki Yamagishi, Yoshinobu Maeda, Satoshi Asada, Hisayuki Hongu, Eijiro Yamashita, Rie Nakai, Hitoshi Yaku
Summary: In pediatric cardiovascular surgery, autologous pericardium is commonly used for pulmonary artery augmentation, but there are cases where it is not available. Since 2014, tissue-engineered vascular grafts (TEVGs) have been developed as an alternative and have shown good results. We present a successful case of multiple pulmonary artery plasty using TEVGs in a patient with pulmonary atresia/ventricular septal defect with major aortopulmonary collateral arteries.
ANNALS OF THORACIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Ilya Klabukov, Dmitri Atiakshin, Evgenia Kogan, Michael Ignatyuk, Mikhail Krasheninnikov, Nickolay Zharkov, Anna Yakimova, Vyacheslav Grinevich, Pavel Pryanikov, Vladimir Parshin, Dmitry Sosin, Andrey A. Kostin, Peter Shegay, Andrey D. Kaprin, Denis Baranovskii
Summary: There is a lack of comprehensive research on immune responses to xenogeneic tissue-engineered grafts. This study aims to investigate the immunological features of tracheal repair using human xenogeneic scaffolds modified by laser radiation in rabbits. The study found that seeding xenogeneic cartilage with chondrocytes resulted in changes in immune reactions and plasma cell infiltration during implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Larisa Antonova, Anton Kutikhin, Viktoriia Sevostianova, Arseniy Lobov, Egor Repkin, Evgenia Krivkina, Elena Velikanova, Andrey Mironov, Rinat Mukhamadiyarov, Evgenia Senokosova, Mariam Khanova, Daria Shishkova, Victoria Markova, Leonid Barbarash
Summary: This study successfully prevented complications such as thrombosis and infection in tissue-engineered vascular grafts (TEVGs) by conjugating drugs and antimicrobial substances to the surface of the grafts. The TEVGs were implanted into the carotid artery of sheep and showed complete replacement with vascular tissue, no complications, and good blood circulation. However, proteomic analysis revealed some protein expression defects in the TEVGs, suggesting further optimization is needed.
Article
Engineering, Biomedical
Tonghe Zhu, Hongbing Gu, Hongmei Zhang, Hongsheng Wang, Huitang Xia, Xiumei Mo, Jinglei Wu
Summary: The study synthesized PEUU@PEG-Hep vascular graft with good biocompatibility and blood compatibility, and the covalent grafting of PEG and heparin significantly enhanced endothelial cell adhesion, spreading, and proliferation, as well as improved the grafts' ability to prevent platelet deposition.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Larisa V. Antonova, Evgenia O. Krivkina, Viktoriia V. Sevostianova, Andrey V. Mironov, Maria A. Rezvova, Amin R. Shabaev, Vadim O. Tkachenko, Sergey S. Krutitskiy, Mariam Yu. Khanova, Tatiana Yu. Sergeeva, Vera G. Matveeva, Tatiana V. Glushkova, Anton G. Kutikhin, Rinat A. Mukhamadiyarov, Nadezhda S. Deeva, Tatiana N. Akentieva, Maxim Yu. Sinitsky, Elena A. Velikanova, Leonid S. Barbarash
Summary: The biodegradable PHBV/PCL[VEGF-bFGF-SDF](Hep/Ilo) grafts showed better short- and long-term results compared to the bio-stable ePTFE analogues, although reinforcement is needed for efficient prevention of aneurysms. The regenerated arteries displayed a hierarchical three-layer structure similar to native blood vessels, being fully endothelialized, highly vascularized, and populated by vascular smooth muscle cells and macrophages. While most of the regenerated arteries were free of calcifications, they suffered from aneurysmatic dilation.
Article
Cardiac & Cardiovascular Systems
Christopher G. A. Mcgregor, Guerard W. Byrne, Zhiqiang Fan, Christopher J. Davies, Irina A. Polejaeva
Summary: This study developed genetically engineered sheep that can produce anti-Gal antibodies, which mirror the immunologic incompatibility currently seen in clinical heart valve implantation. The genetically engineered sheep provide a new advanced standard for preclinical testing of heart valves, taking into account the human immune responses to residual Gal antigen.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cell & Tissue Engineering
Sumati Sundaram, Todd Jensen, Tina Roffidal, Karissa Paquin, Heather Wanczyk, Michael D. Cockman, Shawyon Shadman, Christine Finck, William Fodor
Summary: Diseases and injuries of the esophagus can be treated with surgical intervention, but tissue engineered esophageal implants provide an organ sparing alternative. Research showed that the implants promoted tissue regeneration and remodeling over a one-year period, resulting in the development of a functional esophagus and long-term survival.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Health Care Sciences & Services
Aneta Klotzka, Patrycja Wozniak, Marcin Misterski, Michal Rodzki, Mateusz Puslecki, Marek Jemielity, Marek Grygier, Aleksander Araszkiewicz, Sylwia Iwanczyk, Piotr Buczkowski
Summary: Transcatheter aortic valve implantation (TAVI) is the preferred method in high-risk patients with severe aortic valve stenosis, but it can lead to post-TAVI complications. These complications often stem from concomitant aortic stenosis with significant aortic insufficiency, paravalvular leak, and atrioventricular block. Thorough imaging assessments, such as echocardiography and angio-CT, are crucial in the TAVI qualification process to ensure accurate valve measurements and optimal valve selection. Introducing new interventional treatment approaches and improved imaging tools have reduced the occurrence of significant paravalvular leaks and improved prognosis for TAVI patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Surgery
Martina S. Draxler, Ziad Al-Adas, Daniyal Abbas, Yasaman Kavousi, Loay S. Kabbani, Judith C. Lin, Mitchell R. Weaver, Alexander D. Shepard, Timothy J. Nypaver
Summary: The study aimed to compare the outcomes of patients undergoing SFA stent implantation with and without ADSI surveillance. Results showed that patients with ADSI surveillance had advantages in assisted primary patency, secondary patency, and were more likely to undergo endovascular re-intervention.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Dermatology
Mingmei Li, Zhenxing Yu, Qiong Chen, Qian Zhao, Xiang Chen, Changjiang Lei, Xiaohui Wang, Rui Yang
Summary: The meta-analysis compares sternal wound infections in patients who underwent coronary bypass surgery using bilateral internal mammary artery grafts versus single internal mammary artery grafts. The analysis includes studies from multiple languages and found that bilateral internal mammary artery grafting is associated with significantly higher rates of sternal wound infection, particularly in diabetic individuals, the elderly, and those who underwent pedicled or skeletonized preparation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Sonia Selbonne, Celina Madjene, Benjamin Salmon, Yacine Boulaftali, Marie-Christine Bouton, Veronique Arocas
Summary: In this study, we found that in ischemic conditions, PN-1(-/-) mice showed increased capillary density, leukocyte recruitment, and elevated levels of IL-6 and MCP-1, promoting neoangiogenesis. This suggests that PN-1 limits neovascularization in pathological conditions.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Mathias Kaspar, Alexander Bott, Aljoscha Rastan, Joern Fredrik Dopheide, Heinz Drexel, Marc Schindewolf
Summary: This study aims to analyze the risk factors and phenotypes associated with CD-TLR in patients with peripheral arterial occlusive disease (PAOD) after endovascular treatment of the superficial femoral artery (SFA). The study found that younger women, patients with dyslipidemia, or those with renal insufficiency are more likely to experience recurrent midterm CD-TLR after treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Nicolette D. Jackson, Abraham Nyska, Ezequiel Palmanovich, Meir Nyska
Summary: Biointegrative, mineral fiber-reinforced bone fixation implants have expanded treatment options for fractures and bone deformities. A double-arm study evaluated the safety and biocompatibility of fiber-reinforced plates implanted on sheep. The implants demonstrated bone remodeling and complete biointegration, with no adverse tissue response.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)