Article
Geriatrics & Gerontology
Qing-Tian Luo, Yuan-Chun Ye, Wei-Ming Guo, Qing Zhu, Sa-Shuang Wang, Nan Li, Wang Lei, Chun-Sheng Cheng, Gang Fan
Summary: This study investigates the use of the D+Q combination to treat the intestinal tract of elderly mice and found that it can enhance intestinal functionality and reduce the expression of aging-related genes.
Article
Biochemistry & Molecular Biology
Yuxuan Zhao, Mengyao Kong, Jiaxue Yang, Xiaoxian Zhao, Yiran Shi, Yimeng Zhai, Jun Qiu, Chengkun Zheng
Summary: Although cobalt is essential for life, excess accumulation of cobalt is toxic to cells. The DmeRF system in Vibrio parahaemolyticus is involved in cobalt resistance and maintaining cobalt homeostasis. DmeR functions as a repressor of the dmeRF operon and the DmeRF system is not required for V. parahaemolyticus virulence in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Jun Ishikawa, Makoto Takeo, Ayako Iwadate, Junko Koya, Miho Kihira, Masamitsu Oshima, Yuki Suzuki, Kazushi Taniguchi, Ayaka Kobayashi, Takashi Tsuji
Summary: Liver maintains whole-body homeostasis through its three-dimensional arrangement and high regenerative capacity. Regeneration occurs as hypertrophy, controlling size and structure strictly. Mechanical homeostasis plays critical roles in initiation and termination of liver regeneration, coordinating with cytokine networks.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Kelvin W. Pond, Julia M. Morris, Olga Alkhimenok, Reeba P. Varghese, Carly R. Cabel, Nathan A. Ellis, Jayati Chakrabarti, Yana Zavros, Juanita L. Merchant, Curtis A. Thorne, Andrew L. Paek
Summary: The establishment and maintenance of different cellular compartments in tissues is crucial for all metazoans, especially in the human colon. This study reveals the critical role of wave-like ERK signaling induced by apoptotic cells in maintaining tissue patterning and homeostasis.
Article
Biochemistry & Molecular Biology
Shan-Yan Gao, Yong-Ping Liu, Ri Wen, Xin-Mei Huang, Ping Li, Yu-Hang Yang, Ni Yang, Tie-Ning Zhang
Summary: Uncontrolled diabetes leads to complications in multiple organs, including impaired skeletal muscle and mobility. The expression of Kcnma1 gene, which is involved in myogenesis, decreases in the skeletal muscle of diabetic mice. Knockdown of Kcnma1 in muscle-specific mice results in muscle atrophy and impaired myogenesis, which is more severe in diabetic mice. Further studies reveal that loss of Kcnma1 affects mitochondrial dynamics and biogenesis. In conclusion, Kcnma1 plays a crucial role in maintaining mitochondrial homeostasis and its loss contributes to muscle loss in diabetes.
Review
Immunology
Hongxiang Sun, Jianmei Tan, Hongqian Chen, Ningbo Wu, Bing Su
Summary: The mammalian intestine is a complex organ that plays a crucial role in maintaining immune homeostasis and facilitating nutrient absorption. The interactions between intestinal epithelial cells, mesenchymal stromal cells, and immune cells are essential for the proper functioning of the intestine. Recent advances in single-cell and spatial transcriptomics have revealed the heterogeneity and spatial distribution of intestinal mesenchymal stromal cells, which play key roles in mediating immune regulation and niche formation in different regions of the intestine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
A. A. Almet, H. M. Byrne, P. K. Maini, D. E. Moulton
Summary: The study introduces a mechanical model specialized to the intestinal crypt for tissue homeostasis, using morphoelastic rod theory to model growth and deformation of the crypt. By analyzing mechanochemical growth mechanisms and identifying necessary conditions for homeostasis, essential features of crypt homeostasis are extracted, alongside deriving closed-form solutions for growth and sloughing dynamics in homeostasis. The importance of crypt morphology on homeostatic growth, migration, and sloughing is demonstrated through numerical solutions, highlighting the value of this framework for studying the role of mechanics in homeostasis.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Plant Sciences
Wei-Yu Hsieh, Hsin-Mei Wang, Yi-Hsin Chung, Kim-Teng Lee, Hong-Sheng Liao, Ming-Hsiun Hsieh
Summary: This study reveals the involvement of TH2-GFP in the biosynthetic pathway of vitamin B1 in Arabidopsis. The TMP/TDP phosphatase activity of TH2 plays a crucial role in the synthesis and homeostasis of vitamin B1.
Article
Plant Sciences
Yun Li, Jingjun Li, Yihong Yu, Xia Dai, Changyi Gong, Dongfang Gu, Ending Xu, Yiheng Liu, Yu Zou, Peijiang Zhang, Xi Chen, Wei Zhang
Summary: OsNRAMP2 is an important transporter for iron translocation between the cytosol and vacuole in rice, playing a crucial role in seed germination and plant growth and development.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Wanhong Liu, Chunsong Huo, Linshen He, Xue Ji, Ting Yu, Jinwei Yuan, Ziyi Zhou, Lingrong Song, Qin Yu, Ji Chen, Nan Chen
Summary: Plant natural resistance-associated macrophage protein (NRAMP) plays an important role in maintaining intracellular metal homeostasis and coping with environmental heavy metal stress. In this study, NtNRAMP1 was cloned from tobacco cultivar TN90 and was found to be highly expressed in the roots, especially under iron deficiency. Overexpression of NtNRAMP1 in tobacco enhanced the uptake of Cd and the transport of Fe from roots to shoots. However, it also disrupted Fe homeostasis in the leaves, leading to increased levels of MDA and H2O2.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Aimin Xu, In-Kyu Lee, Jae-Han Jeon, Ghader Bashiri, Alok Mitra, Yu Wang
Summary: This study found that adipose SIRT1 plays an important role in the interaction between mitochondria and endoplasmic reticulum, and can prevent metabolic abnormalities caused by high-fat diet by triggering endoplasmic reticulum stress and initiating mitochondrial hormesis.
Article
Food Science & Technology
Zhen Yang, Xinyuan Shi, Jiale Ren, Hongqing Yin, Dongna Li, Lili Song, Yanjun Zhang
Summary: ZSWF improves cognitive ability and reduces pathological damage and neuronal apoptosis in Alzheimer's disease by regulating neuronal mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Agriculture, Dairy & Animal Science
Lijun Zou, Yirui Shao, Yinfeng Xu, Yuliang Wu, Jian Zhou, Xia Xiong, Yulong Yin
Summary: This study investigates the genetic reprogramming of intestinal epithelial cells (IECs) maturation along the crypt-villus axis. The analysis reveals differentially expressed genes between upper villus epithelial cells (F1) and crypt epithelial cells (F3) of suckling piglets. These genes are closely related to the differentiation, proliferation, maturation, and apoptosis of IECs. The findings provide important insights into the regulatory mechanisms underlying intestinal epithelial cell renewal and repair.
Article
Agriculture, Dairy & Animal Science
Jakub Novotny, Lucie Horakova, Michal Rihacek, Dana Zalesakova, Ondrej Stastnik, Eva Mrkvicova, Vojtech Kumbar, Leos Pavlata
Summary: This article focuses on the effects of different feed particle sizes on the morphology of the gastrointestinal tract, digesta viscosity, and blood biochemical parameters. It is found that coarse feed particles have a positive impact on the health of the gizzard and small intestine, while finer particles may have adverse effects on the liver.
Article
Agriculture, Dairy & Animal Science
Maddison L. Wiersema, Lucas R. Koester, Stephan Schmitz-Esser, Dawn A. Koltes
Summary: The study discovered that different housing systems, cage versus cage-free, have an impact on the gastrointestinal health of commercial hens. Hens in cage-free systems showed advantages in intestinal morphology, microbial diversity, while hens in cage systems also showed some benefits in intestinal health.
Article
Cell Biology
Maria D. Vazquez-Carretero, Pablo Garcia-Miranda, Maria S. Balda, Karl Matter, Anunciacion A. Ilundain, Maria J. Peral
Summary: The study shows that Dab2 is crucial for maintaining adherens junctions in the intestine, and its absence may contribute to the development of colon inflammation and cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ana M. Espinosa-Oliva, Pablo Garcia-Miranda, Isabel Maria Alonso-Bellido, Ana E. Carvajal, Melania Gonzalez-Rodriguez, Alejandro Carrillo-Jimenez, Arturo J. Temblador, Manuel Felices-Navarro, Irene Garcia-Dominguez, Maria Angustias Roca-Ceballos, Maria D. Vazquez-Carretero, Juan Garcia-Revilla, Marti Santiago, Maria J. Peral, Jose Luis Venero, Rocio M. de Pablos
Summary: Peripheral inflammation, particularly originating in the colon, is emerging as a significant predisposing factor for Parkinson's disease. Deletion of galectin-3 effectively reduces neuroinflammation in acute peripheral inflammation models, indicating a central regulatory role of galectin-3 in microglial activation induced by peripheral inflammation. Modulation of galectin-3 function could be a promising strategy to minimize undesirable microglia polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Bayleigh E. Benner, James W. Bruce, Jacob R. Kentala, Magdalena Murray, Jordan T. Becker, Pablo Garcia-Miranda, Paul Ahlquist, Samuel E. Butcher, Nathan M. Sherer
Summary: This study reveals the mechanisms of Gag-Pol protein incorporation into HIV-1 virions. The study found that GP is enriched in virions about 3-fold compared to cells, and viral infectivity is better maintained at subphysiological levels of GP. It was also discovered that GP is more efficiently incorporated into virions when synthesized from the same mRNA as Gag. Furthermore, virions exhibit a strong upper limit to trans-delivered GP incorporation. These results provide new insights into the importance and regulation of GP in HIV-1 virion assembly.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to investigate the potential of AQP1 and AQP4 proteins in CSF as biomarkers for iNPH, but ELISA analysis showed insufficient sensitivity to detect their presence. The study also revealed differences in vascular risk factors between patients with iNPH and AD.
Article
Biochemistry & Molecular Biology
Livia Carrascal, Maria D. Vazquez-Carretero, Pablo Garcia-Miranda, Angela Fontan-Lozano, Maria L. Calonge, Anunciacion A. Ilundain, Carmen Castro, Pedro Nunez-Abades, Maria J. Peral
Summary: This study demonstrates that acute colon inflammation activates neuroinflammation and disrupts neuronal electrical properties, leading to impaired motor coordination. These findings resemble early features of amyotrophic lateral sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jose M. Serrano-Morales, Maria D. Vazquez-Carretero, Pablo Garcia-Miranda, Ana E. Carvajal, Maria L. Calonge, Anunciacion A. Ilundain, Maria J. Peral
Summary: Colon cancer is a complex disease with various genetic, environmental, and lifestyle risk factors. This study investigated the role of the protein reelin in the initiation and progression of colon cancer using both mouse models and human samples. The results suggest that reelin may serve as a potential biomarker for predicting the progression of colon pathology, and its dysregulation may contribute to the development of colon cancer. These findings provide valuable insights into the molecular mechanisms of colon cancer and could have implications for its diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Cristina Ubeda, Maria D. Vazquez-Carretero, Andrea Luque-Tirado, Rocio Rios-Reina, Ricardo Rubio-Sanchez, Emilio Franco-Macias, Pablo Garcia-Miranda, Maria L. Calonge, Maria J. Peral
Summary: Metabolites produced by an altered gut microbiota, including fecal volatile organic compounds (VOCs), are potential biomarkers in Alzheimer's disease (AD) development. The study found differences in VOCs and bacterial taxa between healthy subjects and AD patients at different stages. Specific VOCs and bacteria were associated with different stages of AD, suggesting a crosstalk between VOCs and microbiota in AD. Some identified VOCs could be potential biomarkers for AD initiation and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Neurosciences
R. M. de Pablos, A. M. Espinosa-Oliva, P. Garcia-Miranda, A. E. Carvajal-Vazquez, M. A. Roca-Ceballos, M. D. Vazquez-Carretero, M. Santiago, M. J. Peral, J. L. Venero
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to analyze the presence of AQP1 and AQP4 in the CSF of iNPH and AD patients as potential biomarkers. However, ELISA analysis showed insufficient sensitivity to detect these proteins, ruling out their use as biomarkers for diagnosing iNPH.