Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Mohamed Zoughaib, Kenana Dayob, Svetlana Avdokushina, Marat I. Kamalov, Diana V. Salakhieva, Irina N. Savina, Igor A. Lavrov, Timur I. Abdullin
Summary: Synthetic hydrogels, specifically oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels, have been developed as a potential biodegradable scaffold for spinal cord repair with improved control over properties. The combination of different components in the cryogels allows for optimization of cell-supporting characteristics. The results show that OPF-based cryogels can be a tunable synthetic scaffold for neural tissue repair with advantages over hydrogel counterparts.
Article
Chemistry, Physical
Jinlong Cao, Xiaowen Zhao, Lin Ye
Summary: In this work, a self-healing PVA-based hydrogel was fabricated by grafting benzaldehyde groups onto a PVA molecular chain and forming reversible imine bonds with amine groups on a quaternized chitosan chain. The hydrogel showed high healing efficiency, rapid recovery, and dynamic features. It has great potential application in biomedical fields such as smart infill biomaterials and tissue engineering scaffolds.
Article
Cell & Tissue Engineering
Matthew N. Rush, Kent E. Coombs, Christian T. Denny, David Santistevan, Quan M. Huynh, Kirsten N. Cicotte, Elizabeth L. Hedberg-Dirk
Summary: OPF, a macromolecule with promising properties, can be used to create suitable three-dimensional hydrogel environments for studying cell behavior and delivering therapeutics. An alternative one-pot synthesis approach using inert gas sparging has overcome issues of traditional synthesis techniques, resulting in a longer chain and cleaner polymer product with greater tunability in hydrogel properties.
TISSUE ENGINEERING PART C-METHODS
(2021)
Article
Engineering, Biomedical
Alessondra T. Speidel, Phillip R. A. Chivers, Christopher S. Wood, Derrick A. Roberts, Ines P. Correia, April S. Caravaca, Yu Kiu Victor Chan, Catherine S. Hansel, Johannes Heimgaertner, Eliane Mueller, Jill Ziesmer, Georgios A. Sotiriou, Peder S. Olofsson, Molly M. Stevens
Summary: Polyurethane-based hydrogels with tunable mechanical properties and nonfouling characteristics have been synthesized and tested for various applications. The gels show excellent biocompatibility and reduced cellular adhesion compared to a mechanically matched formula. Preliminary implant studies indicate a mild foreign body response. This method offers a simplified platform for fabricating soft PU-based biomaterials.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Polymer Science
Bipin Gaihre, Xifeng Liu, A. Lee Miller, Michael Yaszemski, Lichun Lu
Summary: Fumarate-based polymers like PCLF and OPF have gained significant interest in biomedical applications for their tunable mechanical properties and biodegradability. PCLF is used for scaffolds while OPF is mostly explored as a hydrogel system, showing important applications in nerve, cartilage, and bone tissue engineering as well as drug delivery. Innovations in synthesis methods and the development of nano- and micro-composites using these polymers are key areas of research in enhancing cartilage and bone tissue regeneration.
Article
Cell Biology
Ezequiel Monferrer, Oana Dobre, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Alexandre Trubert-Paneli, Delia Acevedo-Leon, Rosa Noguera, Manuel Salmeron-Sanchez
Summary: The tumor microenvironment plays a crucial role in cancer development, and the use of decoupled elements in 3D in vitro systems is important for studying cancer progression. In this study, hydrogels incorporating VN into PEG networks were developed to mimic the native NB microenvironment. Results showed that VN-cell interaction plays a key role in NB aggressiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Polymer Science
Chen Zhang, Zhanping Zhang, Yuhong Qi
Summary: Introducing polystyrene microspheres into hydrogels can significantly improve the compressive strength and swelling degree, while gradually reducing the surface energy of the hydrogels.
Article
Engineering, Biomedical
Xifeng Liu, Bipin Gaihre, Matthew N. George, A. Lee Miller, Haocheng Xu, Brian E. Waletzki, Lichun Lu
Summary: This study presents a new bioink made of OPF and gelatin for 3D bioprinting, showing excellent performance in terms of cell viability, spreading, and proliferation. The results indicate that OPF bioink holds great potential in future 3D bioprinting applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Materials Science, Multidisciplinary
Shahryar Hosseini, Niloofar Eslahi, Reza Jahanmardi
Summary: The aim of this research was to prepare self-healing injectable nanocomposite hydrogels based on benzaldehyde-modified polyethylene glycol and chitosan, reinforced with graphene oxide (GO), for the delivery of pomegranate extract (PG) in hard tissue engineering. The incorporation of GO into the hydrogels improved the pore structure, elastic properties, compressive strength, and antibacterial properties. The designed system shows promising potential as a delivery platform for pharmaceuticals in hard tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Tomoya Hayashi, Fumika Nakagawa, Yoshitaka Ohno, Yusuke Suzuki, Honatsu Ishiki, Risako Onodera, Taishi Higashi, Yoshihisa Shimamura, Hiroshi Itou, Yoichiro Iwase, Hidetoshi Arima, Keiichi Motoyama
Summary: The study demonstrates that alpha- and gamma-CyD PPRX hydrogels can serve as novel vaccine formulations, significantly enhancing the immunogenicity and stability of the antigen protein while reducing local irritation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biophysics
Marco Laurati, Gavino Bassu, Emiliano Fratini
Summary: We investigated the effects of confinement imposed by poly(ethylene glycol) (PEG) hydrogel matrices on the dynamics of soft microgels through characterization of the internal structure. The microgel dynamics slowed down and changed from diffusive to sub-diffusive due to increasing confinement. The decrease in diffusivity can be attributed to hydrodynamic and steric effects in addition to the geometrical constriction of cylindrical pores. The dependence of the effective diffusion coefficient on the pore volume fraction suggests the presence of microgel-hydrogel interactions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Alexandra-Diana Diaconu, Corina-Lenuta Logigan, Catalina Anisoara Peptu, Constanta Ibanescu, Valeria Harabagiu, Cristian Peptu
Summary: Polymer networks based on cyclodextrin and polyethylene glycol were prepared and characterized. The hydrophilic and encapsulation properties were confirmed, and the influence of crosslinking reaction feed was investigated. The thermal water swelling and hydrolytic degradation were studied, and the drug loading and release capacity were evaluated.
Article
Chemistry, Multidisciplinary
Flavia Zisi Tegou, Diana Velluto, Aaron A. Stock, Samantha N. Fitzgerald, Samuel Stealey, Silviya P. Zustiak, Allison L. Bayer, Alice A. Tomei
Summary: This study developed a polyethylene glycol hydrogel platform for sustained release of beta cell antigens and CCL21 immunomodulatory molecule, enabling the development of antigen-specific tolerance therapies for Type-I Diabetes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Yuwan Huang, Pavithra B. Jayathilaka, Md Shariful Islam, Carina B. Tanaka, Meredith N. Silberstein, Kristopher A. Kilian, Jamie J. Kruzic
Summary: This study evaluated the mechanical and biological properties of hybrid double network (DN) hydrogels and found that the monomer molecular weight and structure of polyethylene glycol (PEG) affected the mechanical properties. The alginate network played an important role in the DN hydrogel, and showed potential in guiding musculoskeletal differentiation. These findings are significant for the design of hydrogels with controllable properties.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Catalina Vallejo-Giraldo, Katarzyna Krukiewicz, Ivo Calaresu, Jingyuan Zhu, Matteo Palma, Marc Fernandez-Yague, Benjamin W. McDowell, Nathalia Peixoto, Nazar Farid, Gerard O'Connor, Laura Ballerini, Abhay Pandit, Manus Jonathan Paul Biggs
Article
Multidisciplinary Sciences
Seungmae Seo, Angela Mathison, Adrienne Grzenda, Jewel Pod Ratz, Ezequiel Calvo, Stephen Brimijoin, Anthony Windebank, Juan Lovanna, Gwen Lomberk, Raul Urrutia
SCIENTIFIC REPORTS
(2018)
Article
Electrochemistry
Katarzyna Krukiewicz, Dawid Janas, Catalina Vallejo-Giraldo, Manus J. P. Biggs
ELECTROCHIMICA ACTA
(2019)
Article
Cell Biology
Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O'Brien, Seungmae Seo, Joo-Heon Shin, Brian G. Rash, Shaojie Ma, Yanhong Wang, Nicolas A. Olivares, Jon Arellano, Kristen R. Maynard, Elana J. Fertig, Alan J. Cross, Roland W. Burli, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald D. McKay
Article
Materials Science, Biomaterials
Ghazal Tadayyon, Katarzyna Krukiewicz, James Britton, Aitor Larranaga, Catalina Vallejo-Giraldo, Marc Fernandez-Yague, Yina Guo, Gemma Orpella-Aceret, Lu Li, Anup Poudel, Manus J. P. Biggs
Summary: This study evaluated the physicomechanical, electrochemical, and active pressure sensing behavior of an electrically conductive and biodegradable PGSU composite reinforced with PEDOT:PSS functionalized CNTs. The incorporation of functionalized CNTs into the biodegradable elastomer resulted in enhanced mechanical strength, conductivity, and tailored matrix biodegradation. PGSU-CNT composites showed optimal sensitivity to applied 1% uniaxial tensile strains, with low cytotoxicity and supporting neuron adhesion, viability, and proliferation in vitro.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Immunology
Everardo Hegewisch-Solloa, Seungmae Seo, Bethany L. Mundy-Bosse, Anjali Mishra, Erik H. Waldman, Sarah Maurrasse, Eli Grunstein, Thomas J. Connors, Aharon G. Freud, Emily M. Mace
Summary: This study investigates the expression profile of integrin adhesome in NK cells from various human sources, revealing differences in gene and protein expression associated with cell isolation site and developmental stage. Furthermore, differences in cortical actin content linked to varying expression of actin regulating proteins were identified, suggesting an association between adhesome expression and cortical actin homeostasis in NK cells.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Seungmae Seo, Emily M. Mace
Summary: This study provides a comprehensive understanding of the diversity of human NK cells, using next generation sequencing and single-cell transcriptomic studies. It offers new insights into the developmental trajectories and mature subsets of NK cells, and highlights critical outstanding questions in the field.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Catalina Vallejo-Giraldo, Katarzyna Krukiewicz, Manus Jonathan Paul Biggs
Summary: Current research on neural implants focuses on solving challenges with foreign body reactions and promoting long-term device performance in vivo. Understanding the molecular processes of gliosis and scar formation is crucial for developing stable and specific neural recording/stimulation devices.
ADVANCED NANOBIOMED RESEARCH
(2022)
Proceedings Paper
Engineering, Biomedical
Estelle A. Cuttaz, Christopher A. R. Chapman, Josef A. Goding, Catalina Vallejo-Giraldo, Omaer Syed, Rylie A. Green
Summary: Soft, flexible polymer-based bioelectronics show potential in minimizing chronic inflammatory reactions associated with metallic devices. Conductive elastomers (CEs) made of chemically synthesized PEDOT nanowires embedded in a polyurethane matrix demonstrate improved electrochemical properties and performance compared to platinum electrodes. The CEs also show promise as an alternative to metals in fabricating soft bioelectronics.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Article
Biotechnology & Applied Microbiology
Catalina Vallejo-Giraldo, Martina Genta, Olivia Cauvi, Josef Goding, Rylie Green
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Hematology
Samantha L. Smith, Philippa R. Kennedy, Kevin B. Stacey, Jonathan D. Worboys, Annie Yarwood, Seungmae Seo, Everardo Hegewisch Solloa, Brandon Mistretta, Sujash S. Chatterjee, Preethi Gunaratne, Kimaada Allette, Ying-Chih Wang, Melissa Laird Smith, Robert Sebra, Emily M. Mace, Amir Horowitz, Wendy Thomson, Paul Martin, Steve Eyre, Daniel M. Davis
Article
Materials Science, Biomaterials
Estelle Cuttaz, Josef Goding, Catalina Vallejo-Giraldo, Ulises Aregueta-Robles, Nigel Lovell, Diego Ghezzi, Rylie A. Green
BIOMATERIALS SCIENCE
(2019)
Review
Materials Science, Biomaterials
Josef Goding, Catalina Vallejo-Giraldo, Omaer Syed, Rylie Green
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Engineering, Biomedical
Katarzyna Krukiewicz, Magdalena Chudy, Catalina Vallejo-Giraldo, Malgorzata Skorupa, Daria Wieclawska, Roman Turczyn, Manus Biggs
BIOMEDICAL MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Catalina Vallejo-Giraldo, Niccolo Paolo Pampaloni, Anuradha R. Pallipurath, Parvaneh Mokarian-Tabari, John O'Connell, Justin D. Holmes, Alexandre Trotier, Katarzyna Krukiewicz, Gemma Orpella-Aceret, Eugenia Pugliese, Laura Ballerini, Michelle Kilcoyne, Eilis Dowd, Leo R. Quinlan, Abhay Pandit, Paul Kavanagh, Manus Jonathan Paul Biggs
ADVANCED FUNCTIONAL MATERIALS
(2018)