Review
Polymer Science
Abdalla Abdal-hay, Faheem A. Sheikh, N. Gomez-Cerezo, Abdulrahman Alneairi, Monis Luqman, Hem Raj Pant, Saso Ivanovski
Summary: PCL scaffolds have great potential in tissue engineering, but their biological activity and surface wettability are limited. Scaffold manipulations can enhance protein adsorption and achieve optimized biocompatibility.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biophysics
Peng Liu, Tiecheng Qiu, Jiabing Liu, Xiaoxi Long, Xianwei Wang, Hemin Nie, Mengqiang Yu, Chao Ma, Nan Lin, Swee Hin Teoh, Zuyong Wang
Summary: Researchers have developed a biomimetic film with the potential to be used as a synthetic periosteum. This film, made of a blend of poly(epsilon-caprolactone) and microtantalum particles, shows enhanced surface wettability and mechanical strength. It also promotes cell proliferation, alignment, and osteogenic enhancement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Raquel Sanchez Diaz, Jong-Ryul Park, Leona L. Rodrigues, Paul D. Dalton, Elena M. De-Juan-Pardo, Tim R. Dargaville
Summary: This study introduces a rapid and efficient system to adapt commercially available polymers for melt electrowriting (MEW) for the fabrication of micro-fibrous scaffolds. By pre-treating PLCL at 150 degrees C for 24-48 h, it can be printed into scaffolds at 110 degrees C with fiber diameters of 14-40 μm, becoming the first low-temperature MEW scaffolds of its kind. This approach requires no modification of the MEW machine and can be readily adopted by any MEW user with minimal polymer manipulation.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Pinxue Li, Liwei Fu, Zhiyao Liao, Yu Peng, Chao Ning, Cangjian Gao, Daxu Zhang, Xiang Sui, Yunfeng Lin, Shuyun Liu, Chunxiang Hao, Quanyi Guo
Summary: This study developed a promising cartilage regenerative system using a chitosan/3D-printed PCL hybrid scaffold containing SMSCs and recruiting TFNA, which greatly improved cartilage defect repair through enhanced cell proliferation and chondrogenesis.
Article
Biochemistry & Molecular Biology
Georg Lutter, Thomas Puehler, Lukas Cyganek, Jette Seiler, Anita Rogler, Tanja Herberth, Philipp Knueppel, Stanislav N. Gorb, Janarthanan Sathananthan, Stephanie Sellers, Oliver J. Mueller, Derk Frank, Irma Haben
Summary: In this study, biodegradable PCL nanofiber scaffolds were used as a matrix for the generation of tissue-engineered heart valves with human ECFCs and iMSCs. Results showed good cell adhesion and distribution on PCL fibers, with coated fibers increasing cell numbers only at early stages. Mechanical properties of seeded PCL scaffolds were comparable to native heart valves, indicating successful tissue engineering of heart valves with human cells on a biodegradable scaffold.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Anna A. Dokuchaeva, Tatyana P. Timchenko, Elena V. Karpova, Sergei V. Vladimirov, Ilya A. Soynov, Irina Y. Zhuravleva
Summary: This study aims to investigate the effects of electrospinning technique alterations on the structural and mechanical properties of PCL scaffolds, and compare them with fresh rat aorta samples. The results suggest that fiber diameter is a crucial factor affecting the mechanical properties of the scaffold.
Article
Polymer Science
Oskar Alvarez-Ortega, Luis Roberto Ruiz-Ramirez, Jesus Alberto Garibay-Alvarado, Alejandro Donohue-Cornejo, Leon Francisco Espinosa-Cristobal, Juan Carlos Cuevas-Gonzalez, Simon Yobanny Reyes-Lopez
Summary: Poly-epsilon-caprolactone nanofibers embedded with silver nanoparticles were manufactured using the electrospinning technique and tested for biocompatibility in Wistar rats as oral dressings. Despite showing good healing in rats, the nanofibers elicited a foreign body reaction after six weeks of implantation.
Article
Polymer Science
Tainara de Paula de Lima Lima, Caio Augusto de Almeida Canelas, Joyce da Cruz Ferraz Dutra, Ana Paula Drummond Rodrigues, Rebecca Thereza Silva Santa Brigida, Viktor Oswaldo Cardenas Concha, Fernando Augusto Miranda da Costa, Marcele Fonseca Passos
Summary: This study prepared multizonal scaffolds with bilayer architecture using the rotary jet spinning technique. The presence of pracaxi vegetable oil and alginate hydrogel were found to decrease the crystallinity of the scaffolds and create varying wettability gradients. Molecular interactions within the scaffold formulation affected the maximum degradation temperature, and reduced cell viability was observed in the presence of alginate hydrogel and pracaxi vegetable oil in in vitro tests.
Article
Chemistry, Multidisciplinary
Alena Opalkova Siskova, Maria Buckova, Zuzana Kronekova, Angela Kleinova, Stefan Nagy, Joanna Rydz, Andrej Opalek, Monika Slavikova, Anita Eckstein Andicsova
Summary: Nanofiber mats loaded with Diclofenac sodium salt on the base of poly(epsilon-caprolactone) were studied for their biocompatibility and ability to inhibit bacterial infections. The mats demonstrated good viability with human cells culture and showed significant activity against cancer cells. A minimal concentration of 12.5% was found to effectively eradicate both Gram-negative and Gram-positive bacteria.
Article
Materials Science, Multidisciplinary
Mahboobeh Mahmoodi, Vida Haghighi, Marjan Mirhaj, Maryam Tavafoghi, Fatemeh Shams, Ali Darabi
Summary: The addition of CNTs-COOH to PCL/Kr scaffold significantly improved its mechanical properties and osteogenic characteristics, resulting in reduced fiber diameter, increased specific surface area, and enhanced osteoconductivity. The PCL/Kr/CNT scaffold showed excellent osteogenic differentiation in simulated body fluid and promoted mineral formation on the scaffold's surface for mesenchymal stem cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Polymer Science
Sara Biscaia, Joao C. Silva, Carla Moura, Tania Viana, Ana Tojeira, Geoffrey R. Mitchell, Paula Pascoal-Faria, Frederico Castelo Ferreira, Nuno Alves
Summary: Understanding the coupling mechanisms between mechanics and biology in biomaterials is crucial for tissue engineering. This study investigates the effects of adding graphene nanoparticles on the mechanical and biological properties of a poly(epsilon-caprolactone) scaffold. The results show that adding 0.5% graphene nanoparticles significantly improves the compressive modulus of the scaffold and supports cell adhesion, proliferation, and migration.
Article
Chemistry, Multidisciplinary
Jeong Hun Park, Hyun-Ji Park, Sarah Jo Tucker, Sarah R. Rutledge, Lizhen Wang, Michael E. Davis, Scott J. Hollister
Summary: A successful 3D printing of a novel 3D architected auxetic for large-volume soft tissue engineering is reported. The 3D auxetic design is analyzed through finite element (FE) simulation and created by selective laser sintering (SLS) of Poly-epsilon-caprolactone (PCL) for further mechanical and biological analysis. The 3D auxetic exhibits high flexibility and nonlinear stress-strain response, which is achieved despite the relatively stiff and linear properties of PCL. The excellent mechanical and biological performance of the 3D auxetic is attributed to the synergistic effect of its novel design and the printing characteristic of SLS.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Seyed Nasir Hosseini Karimi, Rouhollah Mehdinavaz Aghdam, S. A. Seyyed Ebrahimi, Yalda Chehrehsaz
Summary: This study fabricated novel tri-layered electrospun alginate-graphene oxide (GO)/poly(epsilon-caprolactone) (PCL) conductive scaffolds using sequential electrospinning method. The scaffold consists of a middle PCL layer for mechanical support, and top/bottom alginate-GO nanofibrous layers for cell viability, attachment, and electroconductivity. The nanofibrous scaffold aims to simulate cardiac extracellular matrix and showed enhanced cell viability, adhesion, and proliferation. The tri-layered electroconductive alginate-PCL nanofibrous scaffolds could be potential candidates for cardiac tissue regeneration.
POLYMER INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Quinten Thijssen, Astrid Quaak, Joseph Toombs, Elly De Vlieghere, Laurens Parmentier, Hayden Taylor, Sandra Van Vlierberghe
Summary: Current biodegradable and cross-linkable polymers mainly rely on acrylate crosslinking, but their brittleness limits their applicability. In this study, photo-cross-linkable poly(e-caprolactone) networks through orthogonal thiol-ene chemistry are introduced, which show improved mechanical properties compared to acrylate cross-linked materials. The tunability of the materials is evaluated by altering the molar mass between cross-links, and their biocompatibility and volumetric printability are demonstrated. This research opens up new possibilities for bedside manufacturing of biodegradable patient-specific implants.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Luis Roberto Ruiz-Ramirez, Oskar Alvarez-Ortega, Alejandro Donohue-Cornejo, Leon Francisco Espinosa-Cristobal, Jose Rurik Farias-Mancilla, Carlos A. Martinez-Perez, Simon Yobanny Reyes-Lopez
Summary: Biodegradable polymers of natural origin are preferred in tissue engineering due to their immunogenic potential and interaction with living tissues. However, synthetic polymers such as Poly-epsilon-caprolactone have also been developed for tissue engineering. Nanofibers with unique properties can be produced using nanotechnology and electrospinning. This study tested the biocompatibility of Poly-epsilon-caprolactone nanofibers embedded with hydroxyapatite and alumina nanoparticles in rats.
Article
Engineering, Chemical
Otavio A. Silva, Michelly G. Pella, Ketul C. Popat, Matt J. Kipper, Adley F. Rubira, Alessandro F. Martins, Heveline D. M. Follmann, Rafael Silva
Summary: This study presents a simple and effective method to prepare cell-compatible drug nanocarriers using human hair as a sustainable keratin source. The extracted rod-shaped keratin nanoparticles (KNPs) demonstrated improved properties compared to KNPs prepared using alkaline methods. They exhibited cytocompatibility towards adipose mesenchymal stem cells and healthy cells, and were found to be a suitable carrier for the anticancer drug berberine. The photothermal properties of the KNPs enhanced the drug release and cytotoxicity against colon adenocarcinoma cells.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Vignesh K. Manivasagam, Gopinath Perumal, Harpreet Singh Arora, Ketul C. Popat
Summary: Micro/nano scale surface modifications of titanium based orthopedic and cardiovascular implants have been shown to improve biocompatibility. However, bacterial infection remains a major concern for implant failure. Recent studies have found that superhydrophobic surfaces can prevent protein and bacterial cell adhesion. This study used a thermochemical treatment to modify the properties of the titanium surface and achieved superhydrophilic and superhydrophobic surfaces by modifying with polyethylene glycol and silane, respectively. The modified surfaces significantly reduced bacterial cell adhesion and prevented biofilm formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Engineering, Manufacturing
Rahul Davis, Abhishek Singh, Kishore Debnath, Roberta Maia Sabino, Ketul Popat, Paulo Soares, Anup Kumar Keshri, Bhaskar Borgohain
Summary: In the field of high-precision miniaturized medical implants, the biomedical Ti-6Al-4V alloy meets the requirements for longevity, biocompatibility, and sterilizability. By adding different concentrations of bioactive zinc powder particles, the researchers were able to reduce machining time and dimensional deviation in micro-electric discharge machining. The combination of a copper micro-tool electrode and a 6 g/l zinc powder concentration showed the best results, with lower machining time, dimensional deviation, and recast layer thickness. The modified alloy surface also showed potential for dental applications and potential antiviral activity against COVID-19.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Engineering, Chemical
Debora P. Facchi, Suelen P. Facchi, Paulo R. Souza, Elton G. Bonafe, Ketul C. Popat, Matt J. Kipper, Alessandro F. Martins
Summary: Ecovio (R) is a hydrophobic and biodegradable synthetic polymer blend that can be electrospun with the addition of Tween 20 and a chloroform/formic acid mixture. The resulting fibers have thin diameters and improved electrical conductivity and viscosity. The addition of Tween 20 also makes the fibers wettable and capable of adsorbing silver ions, enhancing their antimicrobial properties. The biodegradable composite filter made from Ecovio (R)/Tween 20 fibers can effectively remove bacteria from water.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Evandro Bonifacio, Debora P. Facchi, Paulo R. Souza, Johny P. Monteiro, Ketul C. Popat, Matt J. Kipper, Alessandro F. Martins
Summary: This study presents an innovative adsorbent material obtained through dialysis and freezing-thawing cycles, resulting in a solid adsorbent with water insolubility and stability. The adsorbent showed high efficiency in removing dyes from water and exhibited favorable kinetic and equilibrium properties. The adsorption process was spontaneous, endothermic, and governed by hydrophobic interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Siqi Niu, Wenbin Yang, Heng Wei, Michail Danilov, Ihor Rusetskyi, Ketul C. Popat, Yao Wang, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang
Summary: A new photovoltaic device using Ti foil/TiO2 nanotubes and MWCNTs as the photoanode and photosensitizer, respectively, was prepared. The TiO2-NTs and cut-MWCNTs were combined by electrophoresis to form a heterostructure, showing enhanced photocurrent response and efficiency in the photovoltaic device.
Article
Nanoscience & Nanotechnology
Arpit Thomas, Ambrish Kumar, Gopinath Perumal, Ram Kumar Sharma, Vignesh Manivasagam, Ketul Popat, Aditya Ayyagari, Anqi Yu, Shalini Tripathi, Edgar Buck, Bharat Gwalani, Meha Bhogra, Harpreet Singh Arora
Summary: This report presents a new approach to overcome the low energy density of supercapacitors by using physical deformation, chemical dealloying, and microstructure engineering to create high-capacity, energy-dense NiMn alloy electrodes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Joao Pedro Aquiles Carobolante, Adelvam Pereira Junior, Celso Bortolini Junior, Kerolene Barboza da Silva, Roberta Maia Sabino, Ketul C. Popat, Ana Paula Rosifini Alves Claro
Summary: The study focuses on the development and characterization of a new Ti10Mo8Nb6Zr beta alloy for bone tissue repair. The alloy processing involved melting, heat treatment, and forging. The results showed that the alloy exhibited good biocompatibility, superior cell viability, and low Young's modulus, making it a promising candidate for biomedical applications.
Article
Chemistry, Multidisciplinary
Daniel J. Sutherland, Adil M. Rather, Roberta M. Sabino, Sravanthi Vallabhuneni, Wei Wang, Ketul C. Popat, Arun K. Kota
Summary: With the legalization of hemp production, we have developed sustainable and robust slippery surfaces using hemp paper coated with beeswax and infused with hemp oil. These surfaces allow liquids to slide easily without leaving a trace. We have also created hemp-based slippery metal surfaces that display icephobic and antithrombotic properties. These hemp-based surfaces have the potential to be used in various applications such as food packaging, anti-icing coatings, and medical devices.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Vignesh K. Manivasagam, Ketul C. Popat
Summary: The aim is to develop a superhydrophobic implant surface with a novel micro-nano topography using a facile thermochemical process. The blood compatibility on different surfaces is assessed by evaluating hemolysis, fibrinogen adsorption, cell adhesion and identification, thrombin generation, complement activation, and whole blood clotting kinetics. The results indicate that the super-hemo/hydrophobic micro-nano titanium surface improves hemocompatibility, making it highly potential as an implant.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Physical
Kerolene Barboza da Silva, Joao Pedro Aquiles Carobolante, S. Sudhagara Rajan, Celso Bortolini Junior, Roberta Maia Sabino, Mauricio Rangel Seixas, Roberto Zenhei Nakazato, Ketul C. Popat, Ana Paula Rosifini Alves Claro
Summary: This study characterizes a new Ti-25Ta-25Nb-5Sn alloy for biomedical application. The microstructure, phase formation, mechanical and corrosion properties, as well as the cell culture study, were investigated. The alloy showed increased microhardness and decreased Young's modulus compared to CP Ti, and its corrosion resistance was similar to CP Ti. In vitro experiments demonstrated favorable interactions between the alloy surface and cells. This alloy presents potential for biomedical applications with required properties.
Article
Materials Science, Multidisciplinary
Justin Gangwish, Abhishek Bhattacharjee, Roberta M. Sabino, Vignesh K. Manivasagam, Yan Vivian Li, Ketul C. Popat, Melissa Reynolds, Susan James
Summary: The COVID-19 pandemic has caused millions of deaths, making wearing masks an important strategy to reduce disease spread. Improving the adsorption capacity of masks can effectively reduce the transmission of the virus.
MATERIALS ADVANCES
(2022)
Meeting Abstract
Cell & Tissue Engineering
V. Kannigaipair Manivasagam, K. Popat
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Multidisciplinary
Lerato N. Madike, M. Pillay, Ketul C. Popat
Summary: Tulbaghia violacea plant extracts may have potential antiplatelet and anticoagulant effects, making them a potential therapeutic agent to inhibit platelet adhesion and reduce the incidence of cardiovascular events.
Article
Chemistry, Physical
Roberta M. Sabino, Julietta V. Rau, Angela De Bonis, Adriana De Stefanis, Mariangela Curcio, Roberto Teghil, Ketul C. Popat
Summary: Titanium and its alloys are commonly used biomaterials for orthopedic and dental applications, but up to 10% of medical devices may still fail. A novel surface modification method using manganese-containing bioactive glass has been shown to enhance osteogenic activity on titanium, reducing the risk of device failure.
APPLIED SURFACE SCIENCE
(2021)