Article
Engineering, Biomedical
Kenneth J. Furdella, Shinichi Higuchi, Ali Behrangzade, Kang Kim, William R. Wagner, Jonathan P. Vande Geest
Summary: The study demonstrates the importance of compliance matching in tissue engineered vascular grafts (TEVGs) for improved acute remodeling. Compliance matched grafts showed better performance in vivo compared to hypocompliant grafts, resulting in reduced inflammation and improved cellular infiltration. The use of computational optimization approaches in designing TEVGs enhances their mechanical properties and overall success in coronary artery bypass surgery.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Fengjie Guo, Zhipeng Ren, Dongxu Liu, Linghui Wang, Xiaobin Hou, Wen Chen
Summary: Regulatory T cells (Treg cells) inhibit intimal hyperplasia of tissue-engineered blood vessels (TEBVs) in diabetic pigs by promoting endothelial progenitor cells (EPCs) mobilization, anti-inflammatory action, and cellular protection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shira Landau, Abigail Newman, Shlomit Edri, Inbal Michael, Shahar Ben-Shaul, Yulia Shandalov, Tom Ben-Arye, Pritinder Kaur, Ming H. Zheng, Shulamit Levenberg
Summary: Lymphatic system plays a critical role in various biological processes, yet lymphangiogenesis is less studied compared to angiogenesis. By culturing human lymphatic endothelial cells on thick collagen sheets with supporting cells and blood endothelial cells, a functional lymphatic vessel network was successfully developed in a short period of time. The model provides a potential platform for investigating lymphangiogenesis and lymphatic disease mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Mathias Lemarchand, Kiefer Thouin, Thiery De Serres-Berard, Sabrina Bellenfant, Sebastien Cadau, Francois Berthod
Summary: Diabetic foot ulcers, a major complication of diabetes, result from minor trauma and are induced by hyperglycemia and the accumulation of advanced glycation end-products (AGEs). AGEs negatively impact wound healing, causing chronic ulcers and increasing the risk of amputation. A tissue-engineered wound healing model was developed using collagen sponge biomaterial and human keratinocytes, fibroblasts, and endothelial cells. Treating the model with glyoxal induced AGEs formation, carboxymethyl-lysine accumulation, and delayed wound closure, mimicking the effects of diabetic ulcers. This model can be used to screen new compounds for the treatment of diabetic ulcers by preventing glycation.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Engineering, Biomedical
Marcus Ground, Steve Waqanivavalagi, Robert Walker, Paget Milsom, Jillian Cornish
Summary: Tissue engineered heart valves offer a potential alternative to traditional valve prostheses, but predicting their in vivo performance is challenging. Understanding the short and long term immune reactions is crucial for bringing these prostheses to market, and researchers need to utilize a variety of models to fully elucidate the host's impact on the graft.
ACTA BIOMATERIALIA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng Xu, Chengcheng Wang, Qing Tao, Jian Zhang, Mingming Zhao, Shiwei Shi, Mengmeng Zhu, Chunxiang Tang, Longjiang Zhang, Changsheng Zhou, Chunhong Hu
Summary: The non-invasive stent-specific perivascular fat attenuation index (FAI) was found to be associated with target vessel revascularization (TVR) in patients with stent implantation, making it a promising imaging marker for functional assessment.
EUROPEAN RADIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Chris Munley, Wenchao Ma, Johannes E. Froch, Quentin A. A. Tanguy, Elyas Bayati, Karl F. Bohringer, Zin Lin, Raphael Pestourie, Steven G. Johnson, Arka Majumdar
Summary: Meta-optics is a rapidly growing research field within optics and photonics, which focuses on controlling optical wavefronts through interaction with sub-wavelength scatterers. In this study, an inverse design approach is used to create single-layer meta-optics that can focus light and shape its spectra without the need for filters. The experimental demonstrations of these devices match the theoretical predictions and provide insight into their focusing mechanism.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Hui Yan, Yumei Qin, Yanyan Li, Yongqi An, Haoshuang Wu, Chong Chen, Li Yang, Fanjun Zhang, Rifang Luo, Qing Jiang, Yunbing Wang
Summary: This study proposes a relatively bio-inert anti-fouling coating that can achieve anti-coagulation and anti-inflammation at the early stage of implantation and promote cardiovascular tissue healing.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Xiling Zhang, Thomas Puehler, Jette Seiler, Stanislav N. Gorb, Janarthanan Sathananthan, Stephanie Sellers, Assad Haneya, Jan-Hinnerk Hansen, Anselm Uebing, Oliver J. Mueller, Derk Frank, Georg Lutter
Summary: Although transcatheter pulmonary valve replacement has shown favorable results as an alternative treatment for pulmonary valve disease, many patients are still not suitable candidates for this procedure. One of the significant future challenges is to expand the use of transcatheter pulmonary valve replacement to a broader patient population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ariel A. Szklanny, Majd Machour, Idan Redenski, Vaclav Chochola, Idit Goldfracht, Ben Kaplan, Mark Epshtein, Haneen Simaan Yameen, Uri Merdler, Adam Feinberg, Dror Seliktar, Netanel Korin, Josef Jaros, Shulamit Levenberg
Summary: Creating engineered hierarchical vasculatures is crucial for implantable functional thick tissues. This study introduces a combined approach using millimetric vessel-like scaffolds and 3D bioprinted vascularized tissues to achieve fully engineered hierarchical vascular constructs for implantation. The use of sacrificial molds, endothelial cells, and vascularizing hydrogels enables the formation of functional vessels within the engineered tissue, promoting tissue perfusion and host vasculature ingrowth.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Lior Debbi, Barak Zohar, Margarita Shuhmaher, Yulia Shandalov, Idit Goldfracht, Shulamit Levenberg
Summary: By combining living cells, biological hydrogel, and biodegradable synthetic polymer, a multi-scale vascular network within thick, implantable engineered tissues was successfully fabricated in this study. The functionality and patency of the multi-scale vascular network were demonstrated by dextran passage and physiological flow conditions, leading to significant improvements in blood perfusion compared to control micro-scale-vascularized grafts. This innovative approach of designing and fabricating multi-scale vascular architectures within 3D engineered tissues shows promise for both in vitro models and therapeutic translation research.
Review
Biotechnology & Applied Microbiology
Chloe D. Devillard, Christophe A. Marquette
Summary: The field of biofabrication has seen significant advancements in recent years, particularly in 3D bioprinting technologies. By combining improvements in fabrication methods, cell source availability, biomaterial formulation, and vascular tissue development, new strategies for creating blood vessels that meet clinical needs are being developed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Hironobu Takahashi, Haruno Wakayama, Kenichi Nagase, Tatsuya Shimizu
Summary: This study presents a multilayering approach to produce engineered human muscle tissue with sufficient contractile force. The tissue shows unidirectional contraction and can quantitatively measure drug effects.
Article
Chemistry, Multidisciplinary
Michele Carrabba, Marco Fagnano, Mohamed T. Ghorbel, Filippo Rapetto, Bo Su, Carmelo De Maria, Giovanni Vozzi, Giovanni Biglino, Adam W. Perriman, Massimo Caputo, Paolo Madeddu
Summary: This study reports a novel hybrid tissue-engineered vascular graft that mimics the natural structure of small arteries. The graft is constructed using co-electrospinning and bioprinting techniques, and shows good biocompatibility and blood flow properties after cellularization. It demonstrates the ability to be successfully implanted and remain patent in a swine model.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell & Tissue Engineering
Giulio Ciucci, Karim Rahhali, Giovanni Cimmino, Francesco Natale, Paolo Golino, Gianfranco Sinagra, Chiara Collesi, Francesco S. Loffredo
Summary: The cellular and molecular mechanisms responsible for the poor regenerative capacity of the adult heart after myocardial infarction (MI) are still unknown. In this study, cryoinjury on rat Engineered Heart Tissues (rEHTs) was used as a model to investigate cardiac regeneration. The results suggest that the extent of cardiomyocyte maturation plays a crucial role in their response to injury.
JOURNAL OF TISSUE ENGINEERING
(2023)