Editorial Material
Cell Biology
Prabin Kumar, Sandip Shah, Akshay Chaudhary, Nirali C. Thakker, Harishankar Kumar
Summary: The full-length sequence of the HLA-A*11:01:54 allele has been identified.
Article
Immunology
Jielin Wang, Xuan You, Yanmin He, Xiaozhen Hong, Ji He, Sudan Tao, Faming Zhu
Summary: In this study, a high-throughput method was developed for simultaneous genotyping of HLA-A and HLA-B loci, as well as HPA genotyping. The method was found to be accurate and successfully genotyped 204 blood specimens for all 34 HPA systems as well as HLA-A and HLA-B loci. This method provides important genetic information for the treatment of alloimmunization platelet transfusion refractoriness.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Namsoo Kim, Sinyoung Kim, Jong Rak Choi, Younhee Park
Summary: This study shared the experience of HLA typing using next-generation sequencing (NGS) in patients with hematologic malignancies and evaluated its association with hematologic diseases. The data from 211 Korean patients with a hematologic disease were reviewed, and NGS was performed for 11 HLA loci. The study found that NGS-based HLA typing enables detailed analysis of the HLA system and identified a specific HLA gene associated with myelodysplastic syndrome.
Article
Immunology
Lisa E. Creary, Sridevi Gangavarapu, Stacy J. Caillier, Paola Cavalcante, Rita Frangiamore, Benedicte A. Lie, Mats Bengtsson, Hanne Flinstad Harbo, Susanna Brauner, Jill A. Hollenbach, Jorge R. Oksenberg, Pia Bernasconi, Angelina Hatlo Maniaol, Lennart Hammarstrom, Renato Mantegazza, Marcelo A. Fernandez-Vina
Summary: This study reveals the associations of specific HLA alleles and haplotypes with genetic susceptibility to myasthenia gravis in different populations. Different immunogenetic predisposition profiles for early-onset and late-onset MG were identified, indicating distinct genetic factors involved. The findings also suggest a potential role for non-coding HLA genetic variants in the pathogenesis of MG.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Jessica Ward, Pamela Guthrie, Leigh Keen, Anthony Poles, Elizabeth Wroe
Summary: HLA-DRB1*15:184 differs from HLA-DRB1*15:01:01 by a single base substitution in exon 3 at codon 134.
Article
Immunology
Ping Liu, Minya Yao, Yu Gong, Yunjie Song, Yanan Chen, Yizhou Ye, Xiao Liu, Fugen Li, Hua Dong, Rui Meng, Hao Chen, Aiwen Zheng
Summary: With advancements in NGS technology, HLA typing accuracy has increased while costs have decreased. Comparing three HLA assays and seven NGS-based HLA algorithms, HISAT-genotype and HLA-HD showed the highest accuracy, making them recommended choices for HLA genotyping. Capture-based NGS HLA typing may be more suitable than whole exome sequencing in clinical practice due to lower costs and higher sequencing depth.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Charlene Bouthemy, Mamy Ralazamahaleo, Jonathan Visentin, Marylise Fort, Nicolas Congy-Jolivet
Summary: The difference between HLA-DQB1*05:275 and DQB1*05:01 lies in one nucleotide substitution in codon 224 in exon 4.
Editorial Material
Cell Biology
Charlene Bouthemy, Marine Cargou, Gwendaline Guidicelli, Marylise Fort, Nicolas Congy-Jolivet
Summary: HLA-DPA1*01:49 differs from DPA1*01:03:01:04 by a single nucleotide substitution at codon 119 in exon 3.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Emeric Texeraud, Gerald Bertrand, Virginie Renac
Summary: B*51:296 differs from B*51:01:01:01 by a single nucleotide substitution at position 1030 in exon 6.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Carl Nivet, Mathilde Cherel, Virginie Renac
Summary: HLA-C*14:114 differs from C*14:02:01:01:01 by a nucleotide substitution at position 1077 in exon 7.
Editorial Material
Cell Biology
Steve Genebrier, Paul Rouzaire, Emeric Texeraud, Gerald Bertrand, Virginie Renac
Summary: DQA1*01:39 differs from DQA1*01:02:01:01 by a single nucleotide substitution at position 49 in exon 1.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Emeric Texeraud, Gerald Bertrand, Virginie Renac
Summary: B*40:450 differs from B*40:01:02:01:01 by a single nucleotide substitution at position 5 in exon 1.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Carl Nivet, Mathilde Cherel, Virginie Renac
Summary: B*18:181 differs from B*18:01:01:02 by a single nucleotide substitution at position 1043 in exon 6.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Emeric Texeraud, Gerald Bertrand, Virginie Renac
Summary: DRB1*01:107 differs from DRB1*01:01:01:01 by a single nucleotide substitution at position 484 in exon 3.
Editorial Material
Cell Biology
Steve Genebrier, Vincent Elsermans, Emeric Texeraud, Gerald Bertrand, Virginie Renac
Summary: The two genotypes differ by one nucleotide substitution at position 179 in exon 2.
Article
Immunology
F. Yamamoto, B. Hoeglund, M. Fernandez-Vina, D. Tyan, M. Rastrou, T. Williams, P. Moonsamy, D. Goodridge, M. Anderson, H. A. Erlich, C. L. Holcomb
Article
Cell Biology
P. V. Moonsamy, T. Williams, P. Bonella, C. L. Holcomb, B. N. Hoeglund, G. Hillman, D. Goodridge, G. S. Turenchalk, L. A. Blake, D. A. Daigle, B. B. Simen, A. Hamilton, A. P. May, H. A. Erlich