Review
Immunology
Satish Kumar Pandey, Girish C. Mohanta, Vinod Kumar, Kuldeep Gupta
Summary: The article summarizes the severe impact of the COVID-19 pandemic on global human health and the development of diagnostic techniques for the SARS-CoV-2 virus. It discusses rapid and robust diagnostic techniques for respiratory infections, as well as breakthrough developments in diagnostic devices.
Article
Food Science & Technology
Ajda Moskric, Katarina Mole, Janez Presern
Summary: The entomological origin of honey can affect its price, with honey from native or non-domesticated species being more valued. DNA-based techniques are used to determine the source of honey.
Review
Biochemistry & Molecular Biology
C. Lino, S. Barrias, R. Chaves, F. Adega, P. Martins-Lopes, J. R. Fernandes
Summary: Nowadays, the development of new technological solutions in the medical field, especially biosensors, is a priority and a significant investment. Biomarkers combined with biosensors have the potential to revolutionize healthcare management, providing fast, cost-effective, reliable, and highly sensitive clinical diagnosis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Parasitology
Sophie I. Owen, Faria Hossain, Prakash Ghosh, Rajashree Chowdhury, Md. Sakhawat Hossain, Chris Jewell, Isra Cruz, Albert Picado, Dinesh Mondal, Emily R. Adams
Summary: A study conducted in Bangladesh on 720 household and neighboring contacts of 276 VL and PKDL index cases found that 9.6% of the participants had asymptomatic infection detected through various diagnostic tests. The study suggests that Leishmania antigen ELISA on urine may be useful for monitoring transmission and surveillance in an elimination setting.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Corentine Vanlier, Liliane Marot, Eva Laranaga, Philippe D'abadie, Jean-Cyr Yombi, Halil Yildiz, Marie Baeck
Summary: The diagnosis of cutaneous leishmaniasis can be challenging due to its diverse clinical presentations, misleading appearance, and long incubation period. Treatment choice depends on the species of Leishmania, with liposomal amphotericin B showing positive responses in some cases.
Review
Oncology
Diego Barba, Ariana Leon-Sosa, Paulina Lugo, Daniela Suquillo, Fernando Torres, Frederic Surre, Lionel Trojman, Andres Caicedo
Summary: Breast cancer is a common malignancy among women globally, with screening and diagnosis methods improving personalized treatments and outcomes. Collaboration between scientists, healthcare professionals, technical experts, and patients is crucial for developing better detection tools and methods. It is essential to bridge the gaps in interdisciplinary information and understanding to drive innovation in cancer screening and diagnosis.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Medicine, General & Internal
Sachee Bhanu Piyasiri, Rajika Dewasurendra, Nilakshi Samaranayake, Nadira Karunaweera
Summary: Leishmaniasis, a neglected tropical disease, poses a significant risk to over one billion people worldwide. Various clinical phenotypes of the causative parasite and the accuracy of diagnostic tools are important areas of research.
Review
Anesthesiology
Giulia Mesaroli, Amos Hundert, Kathryn A. Birnie, Fiona Campbell, Jennifer Stinson
Summary: CRPS is a severely painful condition with four identified diagnostic tools but none validated for pediatric populations. Future research is recommended to develop diagnostic tools for pediatric CRPS and screening tools for both pediatric and adult populations.
Review
Otorhinolaryngology
Hongyi Lu, Jun Su, Wanlei Chi, Ting Zou, Mingqiang Yu, Kang Wang
Summary: The study integrated TMM and ETDQ-7 to establish T-ETDQ and investigated its diagnostic value for Eustachian tube function. Results showed that T-ETDQ had higher diagnostic value than ETS, making it a suitable diagnostic tool.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Editorial Material
Orthopedics
Eric T. Ricchetti
Summary: The diagnostic performance of serum inflammatory markers following shoulder surgery is worse compared to hip and knee surgeries, likely due to the low virulence of shoulder organisms and less defined normalization of these markers. Understanding the behavior of these markers in the shoulder may enhance their utility in diagnosing and managing infections post elective shoulder surgeries.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Respiratory System
Jean Pastre, Scott D. Barnett, Inga Ksovreli, Nesrin Mogulkoc, Vijaya Ramalingam, Cesar Fukuda, Anusha Yelisetty, Omer Selim Unat, A. Whitney Brown, Oksana A. Shlobin, Kareem Ahmad, Vikramjit Khangoora, Shambhu Aryal, Christopher King, Steven D. Nathan
Summary: A clinical scoring model was established and validated to help stratify the risk of IPF diagnosis in ILD patients, showing high accuracy across multiple cohorts. This tool can increase confidence in diagnosing IPF and potentially reduce the need for lung biopsy in certain cases.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Rheumatology
Ayaka Maeda, Naomi Tsuchida, Yuri Uchiyama, Nobuyuki Horita, Satoshi Kobayashi, Mitsumasa Kishimoto, Daisuke Kobayashi, Haruki Matsumoto, Tomoyuki Asano, Kiyoshi Migita, Ayaka Kato, Ichiro Mori, Hiroyuki Morita, Akihiro Matsubara, Yoshiaki Marumo, Ito Yuji, Tomoaki Machiyama, Tsuyoshi Shirai, Tomonori Ishii, Mari Kishibe, Yusuke Yoshida, Shintaro Hirata, Satoshi Akao, Akitsu Higuchi, Ryo Rokutanda, Ken Nagahata, Hiroki Takahashi, Kosuke Katsuo, Toshio Ohtani, Hiroshi Fujiwara, Hiromichi Nagano, Takashi Hosokawa, Takanori Ito, Yoichiro Haji, Hiroyuki Yamaguchi, Noboru Hagino, Toshimasa Shimizu, Tomohiro Koga, Atsushi Kawakami, Goichi Kageyama, Hiroshi Kobayashi, Akiko Aoki, Akinari Mizokami, Yoichi Takeuchi, Rena Motohashi, Hiroyuki Hagiyama, Masaki Itagane, Hiroyuki Teruya, Tomohiro Kato, Yuji Miyoshi, Takayasu Kise, Naoto Yokogawa, Takako Ishida, Naoki Umeda, Shuntaro Isogai, Taio Naniwa, Toru Yamabe, Kaori Uchino, Jo Kanasugi, Akiyoshi Takami, Yasushi Kondo, Kazunori Furuhashi, Koichi Saito, Shigeru Ohno, Daiga Kishimoto, Mari Yamamoto, Yoshiro Fujita, Yuichiro Fujieda, Sachiko Araki, Hiroshi Tsushima, Kyohei Misawa, Akira Katagiri, Takahiro Kobayashi, Kenichi Hashimoto, Takehiro Sone, Yukiko Hidaka, Hiroaki Ida, Ryuta Nishikomori, Hiroshi Doi, Katsumichi Fujimaki, Keiichi Akasaka, Masako Amano, Hidekazu Matsushima, Kaori Kashino, Hidenori Ohnishi, Yuki Miwa, Noriyuki Takahashi, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Yohei Kirino, Hideaki Nakajima, Naomichi Matsumoto
Summary: The study aims to detect UBA1 variants and establish a clinical scoring system for predicting patients with VEXAS syndrome. Using PCR and sequencing techniques, UBA1 variants were successfully detected, and the clinical scoring system efficiently predicted the presence of variants in patients.
Review
Endocrinology & Metabolism
Pablo Valderrabano, Markus Eszlinger, Paul Stewardson, Ralf Paschke
Summary: Advances in molecular biology of thyroid tumors are being rapidly applied to their clinical management. This review discusses the current use of molecular testing in thyroid tumors, focusing on its diagnostic and prognostic value and considering its limitations.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Immunology
Pushkar Dubey, Aritra Das, Khushbu Priyamvada, Joy Bindroo, Tanmay Mahapatra, Prabhas Kumar Mishra, Ankur Kumar, Ana O. Franco, Basab Rooj, Bikas Sinha, Sreya Pradhan, Indranath Banerjee, Manash Kumar, Nasreen Bano, Chandan Kumar, Chandan Prasad, Parna Chakraborty, Rakesh Kumar, Niraj Kumar, Aditya Kumar, Abhishek Kumar Singh, Kumar Kundan, Sunil Babu, Hemant Shah, Morchan Karthick, Nupur Roy, Naresh Kumar Gill, Shweta Dwivedi, Indrajit Chaudhuri, Allen W. Hightower, Lloyd A. C. Chapman, Chandramani Singh, Madan Prasad Sharma, Neeraj Dhingra, Caryn Bern, Sridhar Srikantiah
Summary: India is making progress towards eliminating visceral leishmaniasis as a public health problem, with timely case detection playing a crucial role in reducing infectivity and controlling outbreaks. Active case detection strategies have been shown to significantly reduce time to diagnosis, lower transmission risk, and ensure higher capture rates of confirmed cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Zhihai Cao, Yuan Xue, Jiaqian Wang
Summary: Osteoporosis is caused by decreased bone formation and increased bone absorption, with ferroptosis playing a key role. Ferroptosis may inhibit bone formation and promote bone absorption through oxidative stress, leading to osteoporosis.
Article
Chemistry, Analytical
Bhagya Deepachandi, Sudath Weerasinghe, Thisira Priyantha Andrahennadi, Nadira D. Karunaweera, Nadeeja Wickramarachchi, Preethi Soysa, Yamuna Siriwardana
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Biotechnology & Applied Microbiology
Yamuna Siriwardana, Bhagya Deepachandi, Sudath Weerasinghe, Nadira Karunaweera, Chandanie Udagedara, Wipula Warnasuriya, Ranthilaka R. Ranawaka, Indira Kahawita
Summary: The study in Sri Lanka explores the clinical diversity of cutaneous leishmaniasis in two independent transmission foci, revealing significant differences in the progression and types of lesions between regions, possibly influenced by parasite strains and host adaptation.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Infectious Diseases
Nadira D. Karunaweera, Sanath Senanayake, Samitha Ginige, Hermali Silva, Nuwani Manamperi, Nilakshi Samaranayake, Rajika Dewasurendra, Panduka Karunanayake, Deepa Gamage, Nissanka de Silva, Upul Senarath, Guofa Zhou
Summary: Leishmaniasis cases in Sri Lanka surged in recent years, due to precipitation, high burden of localized infections, and inter-district dispersal. The study highlighted synchronized transmission dynamics, significant role of neighboring-area dispersal, and importance of climatic variability. The predictive model indicated intensifying transmission and expansion of high-transmission areas, calling for urgent targeted interventions.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Dulani Ruwanika K. Pathirage, Thilini C. Weeraratne, Sanath C. Senanayake, S. H. P. Parakrama Karunaratne, Nadira D. Karunaweera
Summary: This study determined the population genetic structure of sand fly vectors in Sri Lanka, revealing unique genetic sequences and indicating possible gene flow and genetically distinct populations at different study sites.
Article
Mathematical & Computational Biology
Hermali Silva, Kalaivani Chellappan, Nadira Karunaweera
Summary: This study used image processing techniques to extract features from skin lesion images of cutaneous leishmaniasis, captured with a mobile phone camera, in order to assess the clinical status of the lesions. The analysis focused on detecting the extent of inflammatory response and signs of healing in the images, using signal spectrogram technique and principal component analysis for feature extraction. The study aimed to develop a mHealth-based prediction algorithm for remote monitoring of treatment response in cutaneous leishmaniasis.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hermali Silva, Achala Liyanage, Theja Deerasinghe, Vasana Chandrasekara, Kalaivani Chellappan, Nadira D. Karunaweera
Summary: This study is the first detailed investigation of treatment failures in CL in Sri Lanka, revealing a relatively high rate of treatment failure especially in patients over 20 years old. It underscores the importance of further research into the pathogenesis of treatment failures and the need to review existing treatment protocols to introduce more effective strategies.
Article
Biology
Isabelle Louradour, Tiago Rodrigues Ferreira, Emma Duge, Nadira Karunaweera, Andrea Paun, David Sacks
Summary: This study demonstrates that stress-facilitated in vitro hybridization can generate a large number of hybrid genotypes between different Leishmania species and strains. Specific populations associated with Leishmania hybridization and a discernible transcriptomic signature were identified.
Review
Infectious Diseases
Rajamanthrilage Kasun Madusanka, Hermali Silva, Nadira D. Karunaweera
Summary: This translated article introduces the severity of cutaneous leishmaniasis and its impact on many developing countries. The treatment outcomes of the disease are still controversial, and the lack of critical analysis information hinders the overall understanding of the disease. The review discusses the effective doses, drug susceptibilities/resistance, and treatment failures of current and novel therapies for different Leishmania species, providing insights for the treatment and control of leishmaniasis.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Immunology
Sachee Bhanu Piyasiri, Thisum Nilakshi Samaranayake, Hermali Silva, Nuwani Harshamali Manamperi, Nadira Darshani Karunaweera
Summary: This study evaluated the anti-leishmanial IgG antibody response as a biomarker for active leishmaniasis and exposure to Leishmania. The results showed that the serological assay had high performance in diagnosing exposure in endemic individuals. Untreated patients had higher and longer-lasting antibody levels.
PARASITE IMMUNOLOGY
(2022)
Article
Infectious Diseases
Rajika Dewasurendra, Hermali Silva, Nilakshi Samaranayake, Nuwani Manamperi, Nissanka de Silva, Panduka Karunanayake, Upul Senarath, Sanath Senanayake, Guofa Zhou, Nadira Karunaweera
Summary: There are differences in knowledge and perceptions regarding cutaneous leishmaniasis (CL) between patients and communities in Sri Lanka, highlighting the need for health education programs to improve disease awareness and knowledge on vector and its control.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Multidisciplinary Sciences
Hiruni Wijesooriya, Nilakshi Samaranayake, Nadira Karunaweera
Summary: This study investigates the response of key innate immune cells in patients with localized cutaneous leishmaniasis (LCL) and suggests that the clinical phenotype of LCL is the result of a balanced immune response between pro-inflammatory and regulatory mediators.
Article
Parasitology
Hasna Riyal, Tiago R. Ferreira, Andrea Paun, Kashinath Ghosh, Nilakshi Samaranayake, David L. Sacks, Nadira D. Karunaweera
Summary: Leishmaniasis, caused by Leishmania parasites and transmitted by sand flies, has many different species that can cause disease in humans and animals. Recent research has found evidence of genetic exchange and hybridization in L. donovani parasites within the sand fly vector, Phlebotomus argentipes. This discovery provides new insight into the mechanisms for the diversity of clinical manifestations in humans affected by L. donovani.
Review
Immunology
Nimesha Madhushani Edirisinghe, Nuwani Harshamali Manamperi, Vishmi Samudika Wanasinghe, Nadira Karunaweera
Summary: Intracellular pathogens like Leishmania can interact with and hijack the endoplasmic reticulum (ER), triggering ER stress and subsequent ER stress response; this response is a specific response of cells to alterations in the physiological state of the ER, known as the unfolded protein response (UPR) or ER stress response.
PARASITE IMMUNOLOGY
(2023)
Article
Infectious Diseases
Richard Carter, Nadira D. Karunaweera
Article
Immunology
Nadira D. Karunaweera, Samitha Ginige, Sanath Senanayake, Hermali Silva, Nuwani Manamperi, Nilakshi Samaranayake, Yamuna Siriwardana, Deepa Gamage, Upul Senerath, Guofa Zhou
EMERGING INFECTIOUS DISEASES
(2020)