Article
Oncology
Huang Chen, Aiping Song, Ye Wang, Yifan He, Jie Tong, Jinxi Di, Chun Li, Zhongren Zhou, Xiaopin Cai, Dingrong Zhong, Jiping Da
Summary: The study demonstrated that combining fine-needle aspiration cytology with BRAF(V600E) mutation testing can improve the accuracy of papillary thyroid cancer diagnosis, especially for thyroid nodules with indeterminate or nondiagnostic cytology.
Article
Endocrinology & Metabolism
Zhijie Yang, Xin Gao, Lu Yang
Summary: The study aimed to identify predictors and establish a prediction model for positive fine needle aspiration biopsy (FNAB) in C-TIRADS 4 thyroid nodules. The nomogram can assist clinicians in evaluating the risk of positive FNAB and determining the need for FNAB.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Michael Osseis, Georges Jammal, Daniel Kazan, Roger Noun
Summary: This study compared the diagnostic accuracy of fine needle aspiration cytology (FNAC) and ultrasound in thyroid nodule diagnosis. The results showed that FNAC had a higher sensitivity than ultrasound, while ultrasound had a higher specificity than FNAC. Combining these two methods can improve diagnostic accuracy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dianna L. Ng, Annemieke van Zante, Ann Griffin, Nancy K. Hills, Britt-Marie Ljung
Summary: This study retrospectively reviewed the UCSF pathology database for thyroid FNABs, analyzing a large cohort of patients with long-term follow-up to determine the risk of thyroid malignancy for different diagnostic categories. The results showed that patients with initial benign or unsatisfactory biopsy results are unlikely to develop thyroid malignancy or die of thyroid cancer, highlighting the high accuracy of FNAB in detecting malignancy.
Article
Otorhinolaryngology
Tobias Todsen, Finn Noe Bennedbaek, Katalin Kiss, Laszlo Hegedus
Summary: Fine needle aspiration biopsy (FNAB) is crucial for evaluating thyroid nodules with suspicious features, and the use of US-guidance is important for real-time visualization of the needle. Collaboration among different specialties is essential for a standardized and meticulous technique to reduce nondiagnostic specimens and false-negative results.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Lei Gong, Yan Liu, Xinghong Guo, Chuan Wang, Fei Yan, Jinbo Liu, Xinguo Hou, Li Chen, Kai Liang
Summary: This study evaluated the impact of ultrasound-guided fine-needle aspiration biopsy (UG-FNAB) and BRAF p.V600E genetic testing on the malignancy rate in thyroid surgery. The results showed that the successful implementation of these two tests improved the malignancy rate in thyroid surgery and reduced unnecessary diagnostic surgery.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Chen, Jia-jia Wang, Dong-ming Guo, Yu-xia Zhai, Zhuo-zhi Dai, Hong-hui Su
Summary: This study aimed to evaluate the diagnostic value of combined fine-needle aspiration (FNA) and core needle biopsy (CNB). The results showed that regardless of nodule size, combined FNA/CNB tended to yield lower proportions of inconclusive results than CNB or FNA alone and exhibited higher performance in diagnosing malignancy. The combined FNA/CNB technique may be a more valuable diagnostic method for nodules ???1.5 cm and nodules with a risk of malignancy than CNB and FNA alone.
Article
Otorhinolaryngology
Seon Min Jung, Hye Ryoung Koo, Ki Seok Jang, Min Sung Chung, Chang Myeon Song, Yong Bae Ji, Jeong Seon Park, Kyung Tae
Summary: Ultrasound-guided CNB is more effective than rFNA for repeat biopsy of thyroid nodules with inconclusive initial FNA results, especially for patients with categories I and III, but showed no significant differences for category IV nodules.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Pathology
Michael Rechter, Sivan Saraph, Hector Cohen, Ohad Ronen
Summary: This study compared the effects of different needle sizes (23-, 25-, and 27-gauge) on the non-diagnostic (ND) rates of thyroid fine-needle aspiration biopsy (FNAB). The results showed that the 25-gauge needle had a significantly lower ND rate compared to the 27-gauge needle, and increased nodule size was associated with a reduced ND rate.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leehi Joo, Dong Gyu Na, Ji-Hoon Kim, Hyobin Seo
Summary: This study compared core needle biopsy (CNB) and repeat fine-needle aspiration (rFNA) in reducing the rates of potential diagnostic surgery and unnecessary surgery for nodules initially diagnosed as atypia/follicular lesions of undetermined significance (AUS/FLUS). CNB was found to be superior to rFNA in reducing the rates of diagnostic surgery and unnecessary surgery.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ye Wang, Zhenhe Chen, Lin Zhang, Dingrong Zhong, Jinxi Di, Xiaodong Li, Yajuan Lei, Jie Li, Yao Liu, Ruiying Jiang, Lei Cao
Summary: A rapid classification method for malignant and benign thyroid nodules was developed using machine learning with ultrasound guided-fine needle aspiration biopsy (FNAB) samples. The new features generated from pairwise coupling of ions showed better performance than the traditional features, resulting in high accuracy for undetermined patients and especially for those with suspicious for papillary carcinoma diagnosis.
APPLIED SCIENCES-BASEL
(2022)
Article
Endocrinology & Metabolism
Xiao-qin Qian, Enock Adjei Agyekum, Ling-ling Zhao, Run-liu Yu, Xiu-ying Li, De-jian Gu, Na Yan, Ming Xu, Yuan Yuan, Yu-guo Wang, Xin-ping Wu, Fei-ju Xu
Summary: This study compared the performance of DP-TOF and NGS methods in detecting multiple-gene mutations in thyroid nodule fine-needle aspiration fluid. The MS method demonstrated higher sensitivity and specificity in detecting BRAF(V600E) gene mutation compared to NGS. The MS method can be considered as an inexpensive, accurate, and dependable initial screening method to detect gene mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Tao Liu, Manisha Tilak, Sara Awad, Joshua Lakoff
Summary: Pain levels during thyroid nodule FNAB are influenced by various factors, including patient-related and procedure-related factors. Nodule calcification, the number of needle passes, the aspiration technique, perpendicular needle placement, and not using safety devices are associated with increased pain. Needle size, biopsy type, operator expertise, and patient education do not appear to be correlated with pain. Subcutaneous lidocaine may provide better pain relief than a topical analgesic.
ENDOCRINE PRACTICE
(2022)
Article
Multidisciplinary Sciences
Saif Bunni, Heikki J. Nieminen
Summary: This study investigates the impact of needle bevel geometry and length on resonance characteristics and deflection magnitude, finding differences in deflection-to-power ratio among needles with different bevel geometries in air and water. The study emphasizes the importance of the relationship between bevel geometry flexural stiffness and insertion media, providing insights for controlling post-puncture cutting action.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Giulia Capitoli, Isabella Piga, Vincenzo L'Imperio, Francesca Clerici, Davide Leni, Mattia Garancini, Gabriele Casati, Stefania Galimberti, Fulvio Magni, Fabio Pagni
Summary: Fine-needle aspiration biopsies (FNA) are commonly used to exclude the malignant nature of thyroid nodules, but a significant proportion of cases are indeterminate. A study found that matrix-assisted laser-desorption ionization mass spectrometry imaging (MALDI-MSI) can improve the diagnostic performance of FNA by separating benign and malignant cell areas. However, the performance of the model is affected by poor spectra and noise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)