Review
Clinical Neurology
N. L. P. Starmans, M. R. van Dijk, L. J. Kappelle, C. J. M. Frijns
Summary: This study retrospectively reviewed patients diagnosed with Sneddon syndrome (SS) between 1996 and 2017, and found that SS predominantly affects young women with a relatively large number of cardiovascular risk factors. The study results showed that there were few statistically significant differences between APL-positive and APL-negative patients in terms of vascular events before diagnosis.
JOURNAL OF NEUROLOGY
(2021)
Review
Rheumatology
Pierre Loiseau, Thomas Foret, Ersilia M. DeFilippis, Jessie Risse, Anais D. Etienne, Virginie Dufrost, Thomas Moulinet, Doruk Erkan, Herve Devilliers, Denis Wahl, Stephane Zuily
Summary: This meta-analysis demonstrates an increased risk of livedo in aPL-positive SLE patients compared to aPL-negative patients. For daily clinical practice, livedo associated with aPL in patients with SLE may represent a specific group with small vessel disease.
Article
Medicine, General & Internal
Maria Rosa Burg, Carolin Mitschang, Tobias Goerge, Stefan Werner Schneider
Summary: Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. Diagnosis is made through a synopsis of history, clinical, and histopathological findings. Early and adequate therapy is crucial for maintaining the quality of life for patients.
FRONTIERS IN MEDICINE
(2022)
Letter
Ophthalmology
Juan Martin Sanchez, Mauricio Davila, Radgonde Amer
Summary: This article reports a case of a patient with probable catastrophic antiphospholipid syndrome (CAPS) involving the eyes, brain, and skin. The patient was treated with immunomodulatory therapy, Enoxaparin, and retinal laser photocoagulation, leading to significant improvement in symptoms.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Rheumatology
Ecem Sevim, Salma Siddique, Madhavi Latha S. Chalasani, Susan Chyou, William D. Shipman, Orla O'Shea, Joanna Harp, Oral Alpan, Stephane Zuily, Theresa T. Lu, Doruk Erkan
Summary: This study investigated the activation of the mammalian target of rapamycin (mTOR) in the skin of patients with livedo and antiphospholipid antibodies (aPL). The results showed increased mTOR activity in the skin of aPL-positive patients, which may have implications for further research on the mTOR pathway in these patients.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Hematology
Claudia Schoenichen, Samantha J. Montague, Sanne L. N. Brouns, James J. Burston, Judith M. E. M. Cosemans, Kerstin Jurk, Beate E. Kehrel, Rory R. Koenen, Fionnuala Ni Ainle, Valerie B. O'Donnell, Oliver Soehnlein, Steve P. Watson, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Magdolna Nagy
Summary: This study reveals the key interaction mechanisms between platelets and neutrophils in arterial thrombus formation. Activated platelet integrin αIIbβ3 plays a role in preventing leukocyte adhesion, while platelet-released substances promote neutrophil activation. These findings provide insights for potential pharmacological intervention.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Rheumatology
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H. Belmont, Maria Laura Bertolaccini, D. Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M. Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K. Leaf, Nina Kello, Jason S. Knight, Carl Laskin, Alfred I. Lee, Kimberly Legault, Steve R. Levine, Roger A. Levy, Maarten Limper, Michael D. Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L. Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A. Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V. Seshan, Savino Sciascia, Maria G. Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
Summary: This study developed new APS classification criteria with high specificity, including clinical and laboratory domains, and improved classification accuracy through weighting and stratification.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Immunology
Antonella Capozzi, Gloria Riitano, Serena Recalchi, Valeria Manganelli, Agostina Longo, Anne Falcou, Manuela De Michele, Tina Garofalo, Fabio M. Pulcinelli, Maurizio Sorice, Roberta Misasi
Summary: This study analyzed the occurrence of aPL IgG in patients with acute ischemic stroke (AIS) during COVID-19 and evaluated the effect of Ig fractions from these patients on platelet signaling and functional activation. The results demonstrated the presence of aPLs IgG in AIS patients during COVID-19, suggesting a role in the mechanisms contributing to their hypercoagulable state.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alex A. Gandhi, Shanea K. Estes, Christine E. Rysenga, Jason S. Knight
Summary: Antiphospholipid syndrome (APS) is a leading cause of thrombosis, with pathogenic antibodies circulating at stable levels in blood, but thrombotic events often requiring a second hit. Investigators have turned to animal models to explore APS mechanisms, with each model having potential advantages and disadvantages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Walid Chayoua, Phillip L. R. Nicolson, Joost C. M. Meijers, Caroline Kardeby, Lourdes Garcia-Quintanilla, Katrien M. J. Devreese, Bas de Laat, Stephen P. Watson, Philip G. de Groot
Summary: This study investigated whether antiprothrombin antibodies induce platelet aggregation and identified the platelet receptors involved. It also found that reduced prothrombin levels resulted in less antiprothrombin antibody-mediated platelet aggregation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Gil-Etayo, Sara Garcinuno, Antonio Lalueza, Raquel Diaz-Simon, Ana Garcia-Reyne, Daniel Enrique Pleguezuelo, Oscar Cabrera-Marante, Edgard Alfonso Rodriguez-Frias, Alfredo Perez-Rivilla, Manuel Serrano, Antonio Serrano
Summary: The presence of aPL in COVID-19 patients is significantly associated with thrombosis, with potential mechanisms including early immune dysregulation and delayed aPL-mediated thrombosis. Additionally, aPL found in COVID-19 patients may preexist before the infection.
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Chun Li, Yu Zuo, Song Zhang, Una E. Makris, David R. Karp, Zhanguo Li
Summary: This study aimed to identify additional clinical and epidemiological risks of arterial thrombosis, venous thrombosis, and pregnancy morbidities in individuals with persistent antiphospholipid antibodies (aPLs)-positive carriers. The study analyzed a large cohort of patients and found that smoking, hypertension, and the presence of underlying autoimmune diseases were additional risk factors for arterial thrombosis. Smoking and the presence of underlying autoimmune diseases were additional risk factors for venous thrombosis, and the presence of underlying autoimmune diseases was significantly associated with pregnancy morbidities. Furthermore, higher levels of cell-free DNA and citrullinated histone H3 were observed in APS patients and aPL patients with autoimmune diseases.
CHINESE MEDICAL JOURNAL
(2022)
Article
Immunology
Simona Truglia, Antonella Capozzi, Silvia Mancuso, Valeria Manganelli, Luca Rapino, Gloria Riitano, Serena Recalchi, Serena Colafrancesco, Fulvia Ceccarelli, Tina Garofalo, Cristiano Alessandri, Agostina Longo, Roberta Misasi, Fabrizio Conti, Maurizio Sorice
Summary: Antiphospholipid syndrome (APS) is more common in women than in men, with male patients often exhibiting high levels of IgM anti-cardiolipin antibodies and a higher incidence of arterial thrombosis and myocardial infarction. Gender appears to influence the serological and clinical profiles of APS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Irena Smaga, Karolina Wydra, Kacper Witek, Paulina Surpwla, Agata Suder, Renata Pieniazek, Lucia Caffino, Fabio Fumagalli, Marek Sanak, Malgorzata Filip
Summary: This study demonstrated that Tat-NR2B9c attenuated cocaine seeking behavior and cue-induced reinstatement in rats, while also reducing levels of GluN2B/PSD95 complexes in the ventral hippocampus. These findings suggest that disrupting GluN2B/PSD95 complexes during cocaine abstinence and extinction training may be a helpful strategy in reducing reinstatement of cocaine-seeking behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Marcin Surmiak, Katarzyna Wawrzycka-Adamczyk, Joanna Kosalka-Wegiel, Stanisnaw Polanski, Marek Sanak
Summary: This study characterized the profile of microRNAs trafficked by extracellular vesicles (EVs) in patients with granulomatosis with polyangiitis (GPA). Four differentially expressed microRNAs were identified in EVs from GPA patients, with miR-223-3p being the best discriminator between GPA patients and healthy controls. MiR-664a-3p was able to discriminate between active and remission phases of GPA. The correct classification rate based on multivariate discriminant analysis was 92% for acute phase and 85% for all study participants. Pathway analysis revealed potential target genes of these microRNAs, involved in focal adhesion, mTOR signaling, and neutrophil extracellular traps formation. Two microRNAs positively correlated with disease activity were found to be involved in neutrophil extracellular traps formation and apoptosis inhibition.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Daniel P. Potaczek, Gabriela Trad, Marek Sanak, Holger Garn, Lucyna Mastalerz
Summary: The study found a negative correlation between sensitization to aeroallergens and the production of pro-inflammatory eicosanoids in AERD patients, suggesting a possible protective effect of atopic sensitization against inflammatory activity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Wojciech J. Szlachcic, Agnieszka Dabrowska, Aleksandra Milewska, Natalia Ziojla, Katarzyna Blaszczyk, Emilia Barreto-Duran, Marek Sanak, Marcin Surmiak, Katarzyna Owczarek, Dariusz Grzanka, Julia Durzynska, Krzysztof Pyrc, Malgorzata Borowiak
Summary: Recent studies have found that SARS-CoV-2 can infect the adult human pancreas and cause damage. In this study, it was discovered that the receptors ACE2, TMPRSS2, and NRP1, which are necessary for SARS-CoV-2 infection, are expressed in the precursor cells of insulin-producing pancreatic beta-cells. The study also revealed that SARS-CoV-2 can efficiently enter and replicate in human multipotent pancreatic and endocrine progenitors. Interestingly, the mechanism of viral entry in pancreatic cells involves cathepsin-dependent endocytosis, which differs from the entry route in the respiratory tract. These findings have implications for studying potential drugs to inhibit viral entry and understanding the impact of SARS-CoV-2 infection on pancreas development.
Letter
Allergy
Lucyna Mastalerz, Radoslaw Kacorzyk, Bogdan Jakiela, Adam Cmiel, Marek Sanak
Article
Immunology
Jakub Swadzba, Tomasz Anyszek, Andrzej Panek, Agnieszka Chojeta, Anna Piotrowska-Mietelska, Emilia Martin
Summary: This study investigated the humoral response of 100 vaccinees to Pfizer/BioNTech COVID-19 vaccine over a year, with a focus on the effect of a booster shot administered around 10 months after the primary immunization. The researchers found that while the anti-spike IgG level gradually declined between 30 and 240 days after the first dose, there was an increase between days 240 and 360, especially in the boosted individuals. The booster immunization is the most effective way of stimulating the production of anti-spike antibodies, and individuals with a low level of antibodies may benefit the most from the booster dose administration.
Article
Biochemistry & Molecular Biology
Pawel M. Potocki, Piotr Wojcik, Lukasz Chmura, Bartlomiej Goc, Marcin Fedewicz, Zofia Bielanska, Jakub Swadzba, Kamil Konopka, Lukasz Kwinta, Piotr J. Wysocki
Summary: BRAF V600E and KRAS mutations in colorectal cancer are associated with poor prognosis. Targeted therapies for BRAF V600E and KRAS G12C are being developed. A retrospective database was created to analyze the clinical characteristics of patients with metastatic CRC and these mutations. BRAF V600E was more prevalent in tumors with neuroendocrine features, while KRAS G12C was associated with left-sided primary tumors and brain metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Lucyna Mastalerz, Natalia Celejewska-Wojcik, Adam Cmiel, Krzysztof Wojcik, Joanna Szaleniec, Karolina Hydzik-Sobocinska, Jerzy Tomik, Marek Sanak
Summary: This study examined the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). Four NEA subtypes were identified based on clinical and laboratory data, with distinct inflammatory signatures and asthma severity. Sputum prostaglandin D-2 levels were found to be a distinguishing factor among these subtypes.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Immunology
Monika Bociaga-Jasik, Martyna Lara, Aleksandra Raczynska, Barbara Wizner, Stanislaw Polanski, Ewa Mlicka-Kowalczyk, Aleksander Garlicki, Marek Sanak
Summary: This study evaluated the immune response of 121 PLWH after receiving COVID-19 vaccines. The majority of patients who received mRNA vaccines developed an immune response, while a small number of patients did not. The mRNA-1273 vaccine showed the best immune response in this population.
Article
Allergy
Jerzy Soja, Karolina Gorka, Iwona Gross-Sondej, Bogdan Jakieta, Stawomir Mikrut, Krzysztof Okon, Adam Cmiel, Piotr Sadowski, Wojciech Szczeklik, Anna Andrychiewicz, Tomasz Stachura, Grazyna Bochenek, Stanistawa Bazan-Socha, Krzysztof Stadek
Summary: The aim of this study was to validate the use of endobronchial ultrasound (EBUS) in assessing the effectiveness of bronchial thermoplasty (BT) treatment for severe asthma. BT was found to significantly decrease the thickness of bronchial wall layers and reduce the mass of airway smooth muscle. However, EBUS was not able to predict the clinical response to BT therapy.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Biochemistry & Molecular Biology
Sabina Licholai, Dorota Studzinska, Hanna Plutecka, Tomasz Gubala, Marek Sanak
Summary: Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been extensively studied for their ability to regulate cellular processes. However, the interactions between these molecules and the biogenesis of circular RNAs remain unclear. In this study, we analyzed the circular RNAs in endothelial cells and identified their expression across the genome. We also proposed computational strategies to identify potentially functional molecules and demonstrated the altered expression levels of circRNAs mediated by microRNAs using an in vitro model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jakub Swadzba, Maciej Bednarczyk, Tomasz Anyszek, Emilia Martin
Summary: This study evaluated the clinical utility of commercial anti-SARS-CoV-2 assays and found a high overall concordance between the comparative CLIA method and ELISA and different LFIAs.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Materials Science, Biomaterials
Aldona Mzyk, Gabriela Imbir, Yuri Noguchi, Marek Sanak, Roman Major, Justyna Wiecek, Przemyslaw Kurtyka, Hanna Plutecka, Klaudia Trembecka-Wojciga, Yasuhiko Iwasaki, Masato Ueda, Sachiro Kakinoki
Summary: The blood compatibility of self-assembled monolayers (SAMs) of oligoproline was studied and found to strongly suppress the adsorption of blood components and the adhesion of blood cells, especially the activation of platelets.
BIOMATERIALS SCIENCE
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)