Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Article
Multidisciplinary Sciences
Andrea T. Obi, Sriganesh B. Sharma, Megan A. Elfline, Catherine E. Luke, Abigail R. Dowling, Qing Cai, Andrew S. Kimball, Mike Hollinstat, Livia Stanger, Bethany B. Moore, Farouc A. Jaffer, Peter K. Henke
Summary: Deep venous thrombosis and residual thrombus burden are associated with circulating IL-6 levels in humans. By investigating the cellular source and role of IL-6 in thrombus resolution, the study found that IL-6 deficiency impairs thrombus recanalization and resolution. Restoring or augmenting IL-6 signaling in monocytes may improve thrombus resolution.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Nehal Farouk, Walaa Mohamed Omar Ashry, Hanan A. El-Hagrasy, Eman F. Mohamed, Heba H. Eltrawy, Asmaa M. El-Nasser, Walaa Shipl, Shahinaz El Attar, Lobna Kh Sakr, Maisa A. Abdel Wahab, Eman M. Abdelsalam, Fawzia A. Sharaf, Inass Hassan Ahmad
Summary: The present study identified a potential correlation between elevated levels of P-selectin and IL-6 and the development of DVT in hospitalized Covid-19 patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Maya R. Chilbert, Dylan VanDuyn, Sara Salah, Collin M. Clark, Qing Ma
Summary: Cardiovascular disease is a leading cause of death worldwide. Managing cholesterol, particularly low-density lipoprotein, is an important method for preventing complications. Combination therapy with high-intensity rosuvastatin and ezetimibe has shown potential benefits in reducing cholesterol levels and preventing atherosclerosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Luke J. Laffin, Dennis Bruemmer, Michelle Garcia, Danielle M. Brennan, Ellen McErlean, Douglas S. Jacoby, Erin D. Michos, Paul M. Ridker, Tracy Y. Wang, Karol E. Watson, Howard G. Hutchinson, Steven E. Nissen
Summary: This study compared the efficacy of a low-dose statin with placebo and 6 common supplements in impacting lipid and inflammatory biomarkers. The results showed that rosuvastatin significantly lowered LDL-C compared to placebo and each supplement. None of the dietary supplements demonstrated a significant decrease in LDL-C compared to placebo.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nicola Potere, Antonio Abbate, Yogendra Kanthi, Marc Carrier, Stefano Toldo, Ettore Porreca, Marcello Di Nisio
Summary: Venous thromboembolism (VTE) is a significant health burden, and the activation of the inflammasome pathway is related to its pathogenesis. Blocking inflammasome signaling may be a potential therapeutic approach to reduce venous thrombosis and vascular injury, protecting against VTE occurrence and subsequent complications.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cell Biology
Saeideh Saadat, Mohammad Hossein Boskabady
Summary: The study reveals that rosuvastatin treatment can reduce inflammation response and oxidative stress levels in asthma patients, effectively improving asthma symptoms.
Review
Medicine, General & Internal
Allan H. Ropper, Joshua P. Klein
Summary: Cerebral venous thrombosis is a rare complication characterized by infarction, focal neurologic deficits, increased intracranial pressure, and often accompanied by disseminated intravascular coagulation and hemorrhage, particularly observed in some Covid-19 vaccines.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aurelien Philippe, Mathilde Puel, Celine Narjoz, Nicolas Gendron, Marie Agnes Durey-Dragon, Benoit Vedie, Malika Balduyck, Richard Chocron, Caroline Hauw-Berlemont, Olivier Sanchez, Tristan Mirault, Jean-Luc Diehl, David M. Smadja, Marie Anne Loriot
Summary: This study examines the ability of alpha-1-antitrypsin (AAT) to predict thrombosis and in-hospital mortality during COVID-19. The results show that patients with higher levels of AAT are more prone to thrombosis and have a higher survival rate. There is no significant correlation between abnormal AAT variants and thrombosis.
Article
Chemistry, Medicinal
Qing Sun, Li Li, Quan Zhou
Summary: This study investigated the effects of Wuzhi capsule on the pharmacokinetics of rosuvastatin in rats. The results showed that acute or long-term intake of Wuzhi capsule did not have a significant impact on the pharmacokinetics of rosuvastatin. Therefore, rosuvastatin could be considered as an alternative to atorvastatin and simvastatin when co-administered with Wuzhi capsule.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Medicine, General & Internal
Sara Malik, Philip R. Cohen
Summary: Drug-associated adverse events, such as dizziness and pruritus, can have varying symptoms. This case report discusses a 48-year-old woman who experienced dizziness and pruritus after initiating rosuvastatin treatment, with symptoms diminishing and eventually resolving completely after discontinuation of the medication.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ibrahim Ashraf, Pierre A. Hanna, Shadeed Gad, Fathy I. Abd-Allah, Khalid M. El-Say
Summary: This study developed a fast-dissolving film (FDF) formulation of rosuvastatin (RSV) and compared it with a conventional tablet. The optimized RSV-FDF showed a faster onset of action and improved lipid-lowering effects, highlighting its potential for enhancing the bioavailability and therapeutic efficacy of rosuvastatin in treating dyslipidemia.
Article
Chemistry, Medicinal
Kwang Je Lee, Jae-Kean Ryu, Yun-Hyeong Cho, Won Yong Shin, Jeong Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok-Min Kang
Summary: This study aimed to assess the effectiveness and safety of a fixed-dose combination of rosuvastatin and valsartan (Rovatitan (R)) in Korean patients with concomitant hypertension and hyperlipidemia. The study drug was found to be effective and well tolerated, making it a good alternative for patients taking multiple medications.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Immunology
Christina Maeder, Thimoteus Speer, Angela Wirth, Jes-Niels Boeckel, Sameen Fatima, Khurrum Shahzad, Marc Freichel, Ulrich Laufs, Susanne Gaul
Summary: The presence of IL-1α on the cell surface of circulating leukocytes is crucial for the development of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Insik Song, Minjin Kim, Hangseok Choi, Jeong Hwan Kim, Kang Hyeon Lim, Hee Soo Yoon, Yoon Chan Rah, Euyhyun Park, Gi Jung Im, Jae-Jun Song, Sung-Won Chae, June Choi
Summary: This study compared the effects of hydrophilic and lipophilic statin on hearing loss using a common database model. The results showed that hydrophilic statin users had a significantly lower risk of hearing loss compared to lipophilic statin users in patients with hyperlipidemia.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Sergio Gianesini, Giovanni Mosti, Maria Grazia Sibilla, Elisa Maietti, Jose Antonio Diaz, Joseph D. Raffetto, Paolo Zamboni, Erica Menegatti
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2019)
Article
Hematology
Adam Miszta, Anna K. Kopec, Asmita Pant, Lori A. Holle, James R. Byrnes, Daniel A. Lawrence, Kirk C. Hansen, Matthew J. Flick, James P. Luyendyk, Bas de laat, Alisa S. Wolberg
Article
Biochemistry & Molecular Biology
Mary Migliorini, Shih-Hon Li, Anqi Zhou, Cory D. Emal, Daniel A. Lawrence, Dudley K. Strickland
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Surgery
Jose Antonio Diaz
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2020)
Article
Hematology
Hekmat B. Khoukaz, Yan Ji, Drew J. Braet, Manisha Vadali, Ahmed A. Abdelhamid, Cory D. Emal, Daniel A. Lawrence, William P. Fay
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Mary Cushman, Geoffrey D. Barnes, Mark A. Creager, Jose A. Diaz, Peter K. Henke, Kellie R. Machlus, Marvin T. Nieman, Alisa S. Wolberg
Article
Surgery
Maxim E. Shaydakov, Jose A. Diaz, Anthony J. Comerota, Fedor Lurie
Summary: Significant upregulation of antithrombotic, prothrombotic, and proinflammatory genes was found in the valve cusp compared with the vein wall. PROCR and THBD demonstrated the highest level of upregulation in the valve cusp. At the protein level, PROCR, SERPINE1, and SELP were upregulated in the valve cusp.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Editorial Material
Surgery
Jose Antonio Diaz
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Editorial Material
Hematology
Jose Antonio Diaz
Summary: The study investigated the role of Slc44a2 in thrombosis, highlighting the importance of HNA-3a expression for neutrophil adhesion to VWF mediated by Slc44a2. Specific flow conditions induced the formation of neutrophil extracellular traps, demonstrating the complex mechanisms involved in neutrophil recruitment and activation during thrombosis.
Review
Surgery
Maxim E. Shaydakov, Windsor Ting, Mikel Sadek, Faisal Aziz, Jose A. Diaz, Joseph D. Raffetto, William A. Marston, Brajesh K. Lal, Harold J. Welch
Summary: Despite major progress, the understanding of VLU pathogenesis and wound healing biology is still limited. The data on topical treatment of venous ulcers are insufficient and weak, with significant methodological flaws. There is a need for updating clinical practice guidelines and further research directions.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Editorial Material
Surgery
Maxim E. Shaydakov, Jose A. Diaz
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Monica E. Polcz, Molly A. Olson, Joel Bradley, Joseph Broucek, Meredith C. Duke, Ajita Prabhu, Samantha Rosen, Art Sedrakyan, Benjamin K. Poulose, Richard A. Pierce
Summary: Gender differences exist in operative approach, mesh use, and mesh position in ventral hernia repair, but it remains unknown whether these differences result in differing clinical outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Hematology
Jose Antonio Diaz
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Neurosciences
Federico Martin Riolo, Derwin Plazas Alvarez, Miguel Osvaldo Villegas, Jose Antonio Diaz
Article
Hematology
Mary Cushman, Geoffrey D. Barnes, Mark A. Creager, Jose A. Diaz, Peter K. Henke, Kellie R. Machlus, Marvin T. Nieman, Alisa S. Wolberg
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
