Article
Medicine, Research & Experimental
Alec A. Schmaier, Papa F. Anderson, Siyu M. Chen, Emale El-Darzi, Ivan Aivasovsky, Milan P. Kaushik, Kelsey D. Sack, H. Criss Hartzell, Samir M. Parikh, Robert Flaumenhaft, Sol Schulman
Summary: The study found that endothelial cells can switch from an anticoagulant surface to a procoagulant surface under pathogenic stimuli, promoting thrombotic cardiovascular disease. Two TMEM16 family members, TMEM16F and TMEM16E, were identified as crucial for the procoagulant activity of endothelial cells. In addition, the TMEM16 inhibitor benzbromarone was found to prevent endothelial cell procoagulant activity and thrombus formation.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Hiroshi Kobayashi, Sho Matsubara, Chiharu Yoshimoto, Hiroshi Shigetomi, Shogo Imanaka
Summary: This review summarizes the biological functions of TFPI1 and TFPI2 in preeclamptic patients and discusses future directions in preeclampsia research. TFPI1 is an important physiological inhibitor of the TF-initiated extrinsic coagulation pathway, while TFPI2 inhibits fibrinolysis and exerts antifibrinolytic activity. TFPI1 and TFPI2 may play important roles in regulating the coagulation and fibrinolytic system and trophoblast invasion. Concentrations of TF, TFPI1, and TFPI2 are significantly altered in preeclamptic women compared to normal pregnancies. The TFPI protein family may serve as predictive biomarkers for preeclampsia and guide precision therapy.
Article
Medicine, General & Internal
Carolina Balbi, Jacopo Burrello, Sara Bolis, Edoardo Lazzarini, Vanessa Biemmi, Enea Pianezzi, Alessio Burrello, Elena Caporali, Lorenzo Gauthier Grazioli, Gladys Martinetti, Tanja Fusi-Schmidhauser, Giuseppe Vassalli, Giorgia Melli, Lucio Barile
Summary: The study characterized the surface antigen profile of circulating extracellular vesicles (EV) in COVID-19 patients and found a specific surface marker signature that can differentiate COVID-19 patients. CD142 showed the highest discriminating performance and was found to be biologically active on the surface of EV in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Adrienne Wright, Orman (Larry) Snyder, Hong He, Lane K. Christenson, Sherry Fleming, Mark L. Weiss
Summary: Many cell types, including cancer cells, release extracellular vesicles (EVs) that expose tissue factor (TF). It is unclear whether MSC-EVs have a risk of thromboembolism due to TF expression. In this study, the researchers investigated the expression of TF and the procoagulant activity of MSC-EVs. They also examined the impact of different EV isolation methods and cell culture expansion on EV yield, characterization, and potential risk. The results showed that MSC-EVs express TF and have procoagulant activity. Therefore, when using MSC-derived EVs as a therapeutic agent, considerations should be given to TF expression, procoagulant activity, and thromboembolism risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Satoshi Kobayashi, Shiro Koizume, Tomoko Takahashi, Makoto Ueno, Ritsuko Oishi, Shuhei Nagashima, Yusuke Sano, Taito Fukushima, Shun Tezuka, Manabu Morimoto, Sho Nakamura, Hiroto Narimatsu, Wolfram Ruf, Yohei Miyagi
Summary: Tissue factor levels are an independent predictive factor for cancer-associated thromboembolism in patients with pancreatic cancer.
Article
Endocrinology & Metabolism
You Jee Jang, Hee Kyung Kim, Bum Chae Choi, Sang Jin Song, Jae Il Park, Sang Young Chun, Moon Kyoung Cho
Summary: The study found that tissue factor and Tfpi-2 expression are stimulated during ovulation in rats, while tissue factor levels are decreased in OHSS-induced rats. Interestingly, tissue factor concentrations in follicular fluids of women undergoing in vitro fertilization are correlated with pregnancy but not with OHSS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Shona Pedersen, Anne Flou Kristensen, Ursula Falkmer, Gunna Christiansen, Soren Risom Kristensen
Summary: The study found that SCLC patients have significantly increased coagulation activity compared to age-matched healthy controls, but this activity remains relatively stable during treatment and follow-up. Although the EVs from patients showed higher PPL and TF activity, their TG profiles were similar to controls when added to standard plasma. Furthermore, the study did not find differences in coagulation profiles between patients who developed VTE and those who did not, indicating that these tests may not be predictive of VTE in SCLC patients.
Article
Biochemistry & Molecular Biology
Kirill R. Butov, Natalia A. Karetnikova, Dmitry Y. Pershin, Dmitry Y. Trofimov, Mikhail A. Panteleev
Summary: This study showed that the presence of chromosomal mutations in the fetus affects the number and phenotype of extracellular vesicles (EVs) in amniotic fluid (AF) and leads to decreased procoagulant potency. Fetal-derived EVs were found to be the predominant source of procoagulant activity in AF.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Maaike Y. Kapteijn, Shanna Zwaan, Esther ter Linden, El Houari Laghmani, Rob F. P. van den Akker, Araci M. R. Rondon, Sabina Y. van der Zanden, Jacques Neefjes, Henri H. Versteeg, Jeroen T. Buijs
Summary: This study found a promoting role of the commonly used chemotherapeutic agents Temozolomide and Lomustine on tissue factor (TF) procoagulant activity and gene/protein expression in glioblastoma (GBM) cell lines. This may explain the increased risk of thrombosis in GBM patients undergoing chemotherapy. Therefore, GBM patients with high TF levels may benefit from anticoagulant treatment to decrease the risk of chemotherapy-induced thrombosis.
Article
Hematology
Stephanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H. B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Summary: This study suggests that tissue factor pathway inhibitor (TFPI) may play a role in modifying the bleeding risk in individuals with factor XI (FXI) deficiency. In vitro experiments showed that inhibition of TFPI enhanced clot formation and reduced fibrinolysis in FXI-deficient plasma, while increased TFPI had the opposite effects. Higher TFPI concentrations were observed in FXI-deficient individuals with bleeding compared to controls, and total plasma TFPI correlated with clotting and fibrinolysis parameters associated with bleeding risk. These findings indicate that TFPI may be a potential modifier of bleeding risk in FXI-deficient individuals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Food Science & Technology
Theresa Saenger, Florian Hubner, Viktoria Lindemann, Kristina Ganswind, Hans-Ulrich Humpf
Summary: This study aimed to differentiate between low, medium, and high intake of orange juice through urinary biomarkers, with proline betaine identified as the most promising long-term biomarker. Hesperetin and naringenin were also found to be short-term biomarkers, while synephrine sulfate showed fast changes. In contrast, phloretin did not show a clear correlation with orange juice consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Letter
Oncology
Shiro Koizume, Satoshi Kobayashi, Wolfram Ruf, Yohei Miyagi
Summary: Tissue factor-procoagulant activity on cells is regulated by multiple molecular mechanisms. Patients with a high tissue factor antigen level are at a higher risk for cancer-associated thromboembolism. The use of validated ELISA methods, such as the Quantikine assay, can contribute to more precise prediction of this condition.
Article
Pharmacology & Pharmacy
Eriko Nakatani, Yasuo Naito, Kenichi Ishibashi, Naoki Ohkura, Gen-Ichi Atsumi
Summary: Obesity is associated with the risk of venous thromboembolism, and adipocyte-derived extracellular vesicles (ADEVs) can enhance coagulant activity. ADEVs contain tissue factors and phosphatidylserine involved in clot formation, and this effect is further enhanced by proinflammatory cytokines.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Hematology
Yalong Gao, Xiaotian Li, Yafei Qin, Jianlong Men, Jing Ren, Xiaochun Li, Chunlei Xu, Qifeng Li, Ying Li, Weiyun Cui, Shu Zhang, Lei Li, Yaohua Li, Jianning Zhang, Li Liu
Summary: The study found that microparticles (MPs) have a procoagulant effect that contributes to hypercoagulability-induced thrombosis. The MPs-ACT assay was used to determine the procoagulant activity of MPs by measuring changes in plasma viscoelasticity and the time to peak viscoelastic changes. The results showed a linear relationship between MPs-ACT and MPs concentration, and the assay sensitively detected hypercoagulable samples from patients with pre-eclampsia, hip fractures, and lung tumors.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Plant Sciences
Fang Song, Zixuan Li, Ce Wang, Yingchun Jiang, Zhijing Wang, Ligang He, Xiaofang Ma, Yu Zhang, Xin Song, Jihong Liu, Liming Wu
Summary: In this study, researchers identified a transcription factor CsMYB15 from Citrus sinensis that was significantly induced by juice sac granulation and low temperature treatment. CsMYB15 directly bound to the Cs4CL2 promoter and activated its expression, leading to an increase in lignin content in citrus fruits. This study elucidates the biological function of CsMYB15 in regulating lignin biosynthesis and provides novel insights into the transcriptional regulation mechanism underlying juice sac granulation in late-maturing navel oranges.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Nutrition & Dietetics
Simona Esposito, Marialaura Bonaccio, Emilia Ruggiero, Simona Costanzo, Augusto Di Castelnuovo, Alessandro Gialluisi, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: This study explores the relationship between the degree of food processing and the risk of central nervous system (CNS) tumors. It is found that the intake of ultra-processed food (UPF) is associated with an increased risk of CNS tumors, especially malignant tumors, while processed food is inversely related to the risk of this disease.
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Medicine, General & Internal
Christin S. S. Boerschel, Bastiaan Geelhoed, Teemu Niiranen, Stephan Camen, Maria Benedetta Donati, Aki S. S. Havulinna, Francesco Gianfagna, Tarja Palosaari, Pekka Jousilahti, Jukka Kontto, Erkki Vartiainen, Francisco M. M. Ojeda, Hester M. M. den Ruijter, Simona Costanzo, Giovanni de Gaetano, Augusto Di Castelnuovo, Allan Linneberg, Julie K. K. Vishram-Nielsen, Maja-Lisa Lochen, Wolfgang Koenig, Torben Jorgensen, Kari Kuulasmaa, Stefan Blankenberg, Licia Iacoviello, Tanja Zeller, Stefan Soderberg, Veikko Salomaa, Renate B. B. Schnabel
Summary: Atrial fibrillation (AF) is on the rise and traditional cardiovascular risk factors (CVRF) cannot explain all cases. High-sensitivity troponin I (hsTnI) may help bridge this gap as a blood-based biomarker reflecting cardiac injury.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Paola Simeone, Rossella Liani, Romina Tripaldi, Sonia Ciotti, Antonio Recchiuti, Vittorio Abbonante, Benedetta Porro, Piero Del Boccio, Augusto di Castelnuovo, Paola Lanuti, Marina Camera, Damiana Pieragostino, Melissa Lee-Sundlov, Myriam Luongo, Raffaella Auciello, Giuseppina Bologna, Maria Concetta Cufaro, Elena Tremoli, Karin M. Hoffmeister, Francesco Cipollone, Alessandra Balduini, Francesca Santilli
Summary: Prevention of cardiovascular disease with low-dose aspirin may be less effective in patients with faster recovery of platelet cyclooxygenase-1 activity. Patients with accelerated COX-1 recovery exhibit reduced platelet glycoprotein Ib alpha shedding, leading to increased thrombopoietin production and the formation of platelets that are not inhibited by aspirin over 24 hours. Clinical markers including age, non-alcoholic fatty liver disease, visceral obesity, and TPO/GC ratio can accurately predict faster COX-1 recovery and suboptimal aspirin response. The TPO/GC ratio may serve as a simple tool to identify patients who would benefit from more frequent aspirin dosing.
Article
Nutrition & Dietetics
Marialaura Bonaccio, Simona Costanzo, Augusto Di Castelnuovo, Alessandro Gialluisi, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: This study aimed to evaluate the association between long-term changes in adherence to a Mediterranean diet (MD) and concurrent changes in modifiable cardiovascular disease (CVD) risk factors and markers of low-grade inflammation. The results showed that increased adherence to a MD over time was associated with reduced levels of low-grade inflammation, but had little impact on CVD risk scores. These findings suggest the potential of a traditional Mediterranean eating pattern to reduce the long-term risk of inflammation-related chronic diseases in an ageing population.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Oncology
Savino Cilla, Carmela Romano, Gabriella Macchia, Mariangela Boccardi, Donato Pezzulla, Milly Buwenge, Augusto Di Castelnuovo, Francesca Bracone, Amalia De Curtis, Chiara Cerletti, Licia Iacoviello, Maria Benedetta Donati, Francesco Deodato, Alessio Giuseppe Morganti
Summary: This study developed a predictive model for acute radiation toxicity using quantitative spectrophotometric markers in supervised machine learning models. The model showed good classification performance in predicting the severity of skin toxicity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Andrea Amerio, Chiara Stival, Alessandra Lugo, Tiziana Fanucchi, Luca Cavalieri d'ORo, Licia Iacoviello, Anna Odone, David Stuckler, Alberto Zucchi, Gianluca Serafini, Silvano Gallus, LOST Lombardia Study Investigators
Summary: This study examined the prevalence of depressive and anxiety symptoms, hopelessness, and insomnia in older adults before and during the COVID-19 pandemic. The results showed significant increases in depressive symptoms, anxiety symptoms, insufficient sleep, and unsatisfactory sleep during the pandemic. Certain subgroups, such as women, those who decreased physical activity, and those with pre-existing chronic diseases, were at higher risk of experiencing worsening mental health outcomes. The use of psychotropic drugs also increased during the pandemic.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Claudia F. Martinez, Simona Esposito, Augusto Di Castelnuovo, Simona Costanzo, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, James R. Hebert, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi, Marialaura Bonaccio
Summary: Chronological age may not accurately reflect health status, while biological age has been proposed as a relevant indicator of healthy aging. Observational studies have found that decelerated biological aging is associated with a lower risk of disease and mortality. A cross-sectional analysis was performed using data from the Moli-sani Study in Italy, and it was found that a pro-inflammatory diet is associated with accelerated biological aging and an increased risk of inflammation-related diseases and mortality.
Article
Nutrition & Dietetics
Marialaura Bonaccio, Emilia Ruggiero, Augusto Di Castelnuovo, Claudia Francisca Martinez, Simona Esposito, Simona Costanzo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: Late eating is associated with poor metabolic health, potentially due to low diet quality. This study found that meal timing may also be related to food processing, which affects health outcomes. Late eaters consumed less minimally processed food, more ultra-processed food, and had lower adherence to the Mediterranean Diet compared to early eaters. Future research should investigate whether increased consumption of ultra-processed food underlies the association between late eating and adverse metabolic health.
Article
Cardiac & Cardiovascular Systems
Sucharitha Chadalavada, Jaakko Reinikainen, Jonas Andersson, Augusto Di Castelnuovo, Licia Iacoviello, Pekka Jousilahti, Line Lund Karhus, Allan Linneberg, Stefan Soderberg, Hugh Tunstall-Pedoe, Karim Lekadir, Nay Aung, Magnus T. T. Jensen, Kari Kuulasmaa, Teemu J. J. Niiranen, Steffen E. E. Petersen
Summary: This study confirms that women with type 1 diabetes have a higher risk of heart failure compared to men, but there is no significant difference in risk according to sex for type 2 diabetes patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Manufacturing
Sunil Sharma, Prabir Sarkar
Summary: This paper addresses the challenges of capturing and representing biological knowledge in bioinspired design. The authors propose two approaches using the Zachman Framework: one for representing knowledge transfer in a bioinspired design organization, and the other to represent biological entities. The contribution of this paper is to provide a mechanism for holistic bioinspired knowledge activities and guide designers in decision-making for bioinspired design.
INTERNATIONAL JOURNAL OF INTERACTIVE DESIGN AND MANUFACTURING - IJIDEM
(2023)
Meeting Abstract
Hematology
Romy de Laat, Augusto Di Castelnuovo, Lisa van der Vorm, Simona Costanzo, Marisa Ninivaggi, Chiara Cerletti, Dana Huskens, Amalia De Curtis, Alessandro Gialluisi, Cuicui Bai, Giovanni de Gaetano, Dongmei Yin, Maria Benedatta Donati, Bas de Laat, Licia Iacoviello
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Geriatrics & Gerontology
Silvano Gallus, Giansanto Mosconi, Chiara Stival, Andrea Amerio, Guido Bertolini, Cristina Bosetti, Luca Cavalieri d'Oro, Tiziana Fanucchi, Licia Iacoviello, Alessandra Lugo, David Stuckler, Giacomo P. Vigezzi, Alberto Zucchi, Anna Odone, Lost Lombardia Project Investigators
Summary: This study examined the prevalence and determinants of physical and mental superheroes among older adults. The results showed that female sex, higher age, disadvantaged socio-economic status, and physical inactivity were inversely related to being superheroes. Not smoking, alcohol abstention, and absence of feelings of hopelessness were associated with meeting the definition of superheroes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
