Journal
THROMBOSIS RESEARCH
Volume 129, Issue -, Pages S62-S64Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2012.02.036
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Manipulations of mouse vessels are difficult due to their small sizes, limiting the possibilities for developing clinically relevant thrombosis models. Currently used models of arterial and venous thrombosis have short-comings not only in terms of clinical relevance but also with respect to collection of data usable and commensurate with thrombodynamic processes. Confocal and multiphoton imaging systems offer continuous evaluation of more direct measures, such as fluorophore-labeled, thrombus-targeting factors, but have been predominantly confined to studies in microvessels (arterioles and venules) with questionable transference of findings to large-vessel thrombotic activities. Going forward, we should select more clinically relevant models, using evaluative measures that yield optimal quantitative data, to refine our understanding of critical aspects of thrombotic processes. (C) 2012 Elsevier Ltd. All rights reserved.
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