Review
Pharmacology & Pharmacy
Jiahui Ma, Pengyu Lei, Haojie Chen, Lei Wang, Yimeng Fang, Xiaoqing Yan, Qinsi Yang, Bo Peng, Libo Jin, Da Sun
Summary: The use of lncRNAs from stem cell exosomes shows promise in treating cardiovascular diseases, as they can directly target specific signaling pathways. This mini review summarizes the key regulatory actions of lncRNAs from different stem cells on various cardiovascular diseases, such as myocardial aging and apoptosis, ischemia-reperfusion injury, retinopathy, atherosclerosis, and hypertension. The challenges and future prospects of using lncRNAs for the treatment of cardiovascular diseases are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Shuang He, Rongrong Chen, Li Peng, Zhenzuo Jiang, Haixin Liu, Zihao Chen, Tiechan Zhao, John Owoicho Orgah, Jie Ren, Peng Zhang, Yuefei Wang, Xiumei Gao, Yan Zhu
Summary: This study investigates the chemical basis and mechanism of angiogenesis regulation by a multicomponent Chinese medicine called Danhong injection (DHI). The researchers identified two distinct chemical components in DHI, one promoting angiogenesis and the other inhibiting angiogenesis. The pro-angiogenesis activity of DHI enhances the repair of ischemic vascular injury, while the anti-angiogenesis activity inhibits tumor growth. The active pro- and anti-angiogenesis activities are composed of unique chemical combinations that differentially regulate angiogenesis-related gene networks.
Review
Biochemistry & Molecular Biology
Amanda Louise White, Gregory Jaye Bix
Summary: Therapeutic angiogenesis, using VEGFA, has shown promising results in animal models for vasculature disruptions, such as cerebral vasculature diseases. However, clinical trials using VEGFA have not been successful in replicating these results in humans, potentially due to administration methods and VEGFA's ability to increase vascular permeability. Alternative splicing of VEGFA isoforms may offer a solution to mitigate side effects and provide a potential therapeutic approach for cerebrovascular diseases.
Review
Cell Biology
Huihua Huang, Xuejun Du, Zhiguo He, Zifeng Yan, Wei Han
Summary: Mesenchymal stem cells (MSCs) show potential in treating cardiovascular diseases, but face challenges such as low survival rate post-transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Helene E. K. Sundelin, Anna Walas, Jonas Soderling, Peter Bang, Jonas F. Ludvigsson
Summary: Ischemic stroke is a common cause of death in adults, but the mortality after pediatric ischemic stroke has not been well researched. This study investigated the long-term and cause-specific mortality in children with ischemic stroke and their first-degree relatives. The study found that the mortality rate was significantly higher in children with ischemic stroke compared to controls, and the risk of death remained elevated even 20 years later.
Review
Chemistry, Multidisciplinary
Zaiyong Zheng, Shuang Zhu, Mingming Lv, Zhanjun Gu, Houxiang Hu
Summary: Cardiovascular diseases remain a significant health concern globally, and nanotechnology presents novel solutions for their diagnosis and therapy. This comprehensive review utilizes bibliometric analysis to identify and analyze publication trends, countries/institutes, referenced sources, and research hotspots of nanotechnology in the cardiovascular field. The review provides a comprehensive overview of the major biomedical applications of nanotechnology in cardiovascular diseases, including diagnosis (biosensor and imaging) and therapy (drug delivery and tissue engineering). The review also discusses the limitations and future prospects of nanoparticles in cardiovascular diseases.
Review
Chemistry, Multidisciplinary
Xi Li, Yabing Zhang, Xiangyi Ren, Yan Wang, Dongxu Chen, Qian Li, Minfeng Huo, Jianlin Shi
Summary: Advancements in nanoscience and nanotechnology offer a new opportunity for delivering drugs for treating ischemia-related diseases effectively, while intelligent biomaterials have been developed to enhance the therapeutic benefits of drugs for treating myocardial ischemia.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yan Wu, Dongxu Jia, Kunyan Lu, Haixin Zhang, Chunxia Liu, Yuancheng Lin, Jingjing Cheng, Yi Zou, Hu Xu, Hong Chen, Yanxia Zhang, Qian Yu
Summary: A multifunctional dressing based on bacterial cellulose (BC) deposited with a tannic acid/Cu2 + ion/Mg2 + ion (TCM) complex film is developed in this study. The TCM complex exhibits robust interfacial adhesion and good photothermal properties to effectively eradicate bacteria in the wound area under near-infrared (NIR) irradiation. The released Cu2 + and Mg2 + ions from the TCM complex are favorable for endothelial cell proliferation, migration, and tube formation in vitro, promoting angiogenesis and collagen deposition in bacteria-infected wounds.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fangyu Yang, Jianjiang Xue, Guixue Wang, Qizhi Diao
Summary: Cardiovascular disease is a common health problem worldwide, and current pharmaceutical treatment is suboptimal. Nanoparticle-based drug delivery systems have shown significant therapeutic effects and offer a safer and more effective strategy for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Carl Randall Harrell, Biljana Popovska Jovicic, Valentin Djonov, Vladislav Volarevic
Summary: Mesenchymal stem cells play a crucial role in combating viral infections by modulating the activity of immune cells, producing cytokines, and promoting tissue repair. Their therapeutic potential in treating viral diseases is significant.
Article
Cell Biology
Stephane Oudard, Nadine Benhamouda, Bernard Escudier, Patrice Ravel, Thi Tran, Emeline Levionnois, Sylvie Negrier, Philippe Barthelemy, Jean Francois Berdah, Marine Gross-Goupil, Cora N. Sternberg, Petri Bono, Camillo Porta, Ugo De Giorgi, Omi Parikh, Robert Hawkins, Martin Highley, Jochen Wilke, Thomas Decker, Corinne Tanchot, Alain Gey, Magali Terme, Eric Tartour
Summary: This study found that a decrease in pro-angiogenic monocyte subpopulations is associated with clinical response in mRCC patients receiving anti-angiogenic drugs. Specifically, a decrease in VEGFR-1(+)CD14 cells was correlated with longer progression-free survival and overall survival, while a decrease in Tie2(+)CD14 cells was associated with improved overall survival.
Review
Biochemistry & Molecular Biology
Xuefang Hao, Qian Li
Summary: Cell-based nanotherapy has immense potential in transforming the diagnosis and treatment of cardiovascular diseases (CVDs). Coating nanoparticles with cell membranes is an effective approach to enhance their biocompatibility, immune evasion, and specificity. Furthermore, extracellular vesicles (EVs) have emerged as promising tools for the diagnosis and therapy of CVDs due to their ability to transfer cargos to distant tissues. This review summarizes recent progress in cell-based nanotherapy for CVDs, highlighting different sources of EVs and biomimetic nanoplatforms derived from natural cells. It also discusses their potential applications in the diagnosis and targeted treatment of various CVDs, while addressing the challenges and future prospects.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Cell Biology
Jiaqi Yang, Qianyun Guo, Xunxun Feng, Yang Liu, Yujie Zhou
Summary: Cardiovascular diseases (CVDs) are a major public health concern, with mitochondrial dysfunction playing a significant role in their development. Excessive reactive oxygen species (ROS) can cause mitochondrial dysfunction and cell death, but mitochondria can protect against these damages by regulating homeostasis. Mitochondria-targeted therapy for CVDs has gained attention, with clinical drugs showing mitochondrial protective functions. Experimental and clinical studies have identified various cardiac mitochondrial targets that have cardioprotective effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Thi Van Anh Bui, Jin-Ju Kim, Xin Huang, Aoyang Pu, Xin Li, Seok Beom Hong, Yeon-Jik Choi, Hae-Won Kim, Xi Yao, Hun-Jun Park, Kiwon Ban
Summary: The patch-based delivery system shows promise for treating vascular diseases, but conventional methods have limitations. In this study, we propose a novel core-shell-shaped droplet patch system called an angiogenic patch (AP) that overcomes these limitations. The AP offers advantages such as rapid and straightforward fabrication, minimal toxicity, excellent physical integrity, and customizable dimensions. It enables the loading and controlled release of angiogenic cytokines, which have significant effects on endothelial cell functions and survival. In vivo experiments using a mouse model of hindlimb ischemia also demonstrate the effectiveness of the AP in restoring blood flow and promoting muscle regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Thomas Spater, Marisa Assuncao, Kwok Keung Lit, Guidong Gong, Xiaoling Wang, Yi-Yun Chen, Ying Rao, Yucong Li, Chi Him Kendrick Yiu, Matthias W. Laschke, Michael D. Menger, Dan Wang, Rocky S. Tuan, Kay-Hooi Khoo, Michael Raghunath, Junling Guo, Anna Blocki
Summary: This study proposes an approach to capture and concentrate the pro-angiogenic activities of mesenchymal stem cells (MSCs) by engineering a functional biomaterial. By interacting with MSC-derived extracellular matrix (ECM) components, a dextran sulfate-ECM hybrid material is generated and processed into microparticles of solidified secretome (MIPSOS), which protect protein components from degradation and facilitate their sustained release. The proteomic analysis shows that MIPSOS are highly enriched in pro-angiogenic factors, resulting in an accelerated revascularization and healing of skin wounds.
BIOACTIVE MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Bruna Lima Correa, Nadia El Harane, Ingrid Gomez, Hocine Rachid Hocine, Jose Vilar, Manon Desgres, Valerie Bellamy, Kamaleswaran Keirththana, Chloe Guillas, Maria Perotto, Laetitia Pidial, Paul Alayrac, Thi Tran, Sisareuth Tan, Thomas Hamada, Dominique Charron, Alain Brisson, Nisa K. Renault, Reem Al-Daccak, Philippe Menasche, Jean-Sebastien Silvestre
Summary: EV-CPC do not elicit an immune response in in vitro human allogeneic models or in immunocompetent animal models. They have the capacity to direct the response of monocyte/macrophages towards resolving inflammation, which enhances their clinical attractiveness as an acellular therapy for cardiac repair.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Immunology
Chao Zhang, Fu-Sheng Wang, Jean-Sebastien Silvestre, Fernando Arenzana-Seisdedos, Hong Tang
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Yuehua Fang, Yanyi Sun, Chen Luo, Jianing Gu, Zhongwei Shi, Guoping Lu, Jean-Sebastien Silvestre, Zhenyue Chen
Article
Multidisciplinary Sciences
Marion Bouvet, Olivier Claude, Maguelonne Roux, Dan Skelly, Nihar Masurkar, Nathalie Mougenot, Sophie Nadaud, Catherine Blanc, Clement Delacroix, Solenne Chardonnet, Cedric Pionneau, Claire Perret, Elisa Yaniz-Galende, Nadia Rosenthal, David-Alexandre Tregouet, Giovanna Marazzi, Jean-Sebastien Silvestre, David Sassoon, Jean-Sebastien Hulot
SCIENTIFIC REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Article
Medicine, Research & Experimental
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sebastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Summary: The study demonstrated that TREM-1 plays a crucial role in the pathophysiology of AAA and could be a potential therapeutic target for the disease in humans.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Xian Yu, Stephen A. Newland, Tian X. Zhao, Yuning Lu, Andrew S. Sage, Yanyi Sun, Rouchelle S. Sriranjan, Marcella K. L. Ma, Brian Y. H. Lam, Meritxell Nus, James E. Harrison, Simon J. Bond, Xiang Cheng, Jean-Sebastien Silvestre, James H. F. Rudd, Joseph Cheriyan, Ziad Mallat
Summary: ILC2s play a critical role in cardiac healing and improvement of heart function after myocardial infarction. Activation of ILC2 using low-dose IL-2 could be a novel therapeutic strategy to promote a reparative response after MI.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yanyi Sun, Cristina Pinto, Stephane Camus, Vincent Duval, Paul Alayrac, Ivana Zlatanova, Xavier Loyer, Jose Vilar, Mathilde Lemitre, Angelique Levoye, Meritxell Nus, Hafid Ait-Oufella, Ziad Mallat, Jean-Sebastien Silvestre
Summary: This study reveals the important role of follicular B cells and marginal zone B cells in the recovery of cardiac function after acute myocardial infarction (MI). The miR21/HIF-alpha pathway plays a critical role in B-cell functions. Activation of the miR21/HIF-1 alpha pathway in marginal zone B cells is associated with the recruitment of inflammatory monocytes and adverse cardiac remodeling.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Giuseppe Rizzo, Julius Gropper, Marie Piollet, Ehsan Vafadarnejad, Anna Rizakou, Sourish Reddy Bandi, Panagiota Arampatzi, Tobias Krammer, Nina DiFabion, Oliver Dietrich, Anahi Paula Arias-Loza, Marco Prinz, Matthias Mack, Kai Schlepckow, Christian Haass, Jean Sebastien Silvestre, Alma Zernecke, Antoine Emmanuel Saliba, Clement Cochain
Summary: The study utilized single-cell immune profiling to map the transition of monocyte/macrophage populations in the infarcted heart, revealing the origin and dynamic changes of cardiac macrophages. In summary, the research provides valuable insights into how these cells can be potentially modulated to enhance post-ischaemic heart repair.
CARDIOVASCULAR RESEARCH
(2023)
Review
Endocrinology & Metabolism
Vincent Duval, Paul Alayrac, Jean-Sebastien Silvestre, Angelique Levoye
Summary: Chemokines and their receptors play a crucial role in cardiovascular diseases. ACKR3, as an atypical chemokine receptor, has an exclusive role in CVD. Better understanding of ACKR3's precise functions may lead to the development of novel therapeutic strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ingrid Gomez, Virginie Robert, Paul Alayrac, Adele Arlat, Vincent Duval, Marie-Laure Renoud, Jose Vilar, Mathilde Lemitre, Jean-Sebastien Silvestre, Beatrice Cousin
Summary: Medullary and extra-medullary hematopoiesis play a significant role in regulating inflammatory cell infiltration and cardiac remodeling after acute myocardial infarction. Adipose tissue can serve as an alternative source of immune cell production and affect cardiac homeostasis. However, in the presence of diabetes, the function of immune cells derived from adipose tissue is compromised.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jean-Sebastien Silvestre
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, Research & Experimental
Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloe Guillas, Laetitia Pidial, Valerie Bellamy, Emilie Baron, Gwennhael Autret, Keirththana Kamaleswaran, Chloe Pezzana, Marie-Cecile Perier, Jose Vilar, Antonio Alberdi, Alain Brisson, Nisa Renault, Massimiliano Gnecchi, Jean-Sebastien Silvestre, Philippe Menasche
Summary: The study suggests that extracellular vesicles do not trigger cardiomyocyte proliferation but still improve cardiac function through other mechanisms, potentially including the regulation of fibrosis.
Article
Endocrinology & Metabolism
Haleh Soleimanzad, Mireia Montaner, Gaetan Ternier, Mathilde Lemitre, Jean-Sebastien Silvestre, Nadim Kassis, Paolo Giacobini, Christophe Magnan, Frederic Pain, Hirac Gurden
Summary: Obese mice exhibited glucose intolerance and compromised odor-evoked CBF in the younger group. Prolonged HFD feeding led to insulin resistance and stronger impairment in activity-dependent CBF. Aging specifically negatively impacted resting CBF. Decreased olfactory sensitivity was observed only in older, middle-aged obese mice.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)