Article
Neurosciences
Jie Pan, Ying-lei Jin, Ying Gu, Ya-jun Duan, Han Yan
Summary: The study found that plasma PZ/ZPI levels were closely related to inflammatory response, coagulation process, and platelet activation, and may be involved in the development of acute ischemic stroke. Plasma PZ level was identified as one of the independent risk factors for acute ischemic stroke, and plasma ZPI was closely related to coagulation and platelet parameters.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Subash Chellam Gayathri, Suchetana Gupta, Aravind Suresh, Sanjib Senapati, Tanusree Sengupta
Summary: The study on ZPI revealed the impact of E371 and S359 variants on the dynamics of its Reactive Centre Loop (RCL). It was found that the RCL of E371 variants was stable, while the S359 variants resulted in increased flexibility of RCL.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Obstetrics & Gynecology
Ci Pan, Yulian Huang, Xiaopei Guo, Cunhua Gu, Jing Guo, Xiaohua Luo
Summary: Plasma levels of PZ and ZPI are significantly decreased in pregnant women with FGR, and their combination shows better diagnostic value for FGR than other indicators, with an AUC of 0.92, sensitivity of 0.82, and specificity of 0.88.
GINEKOLOGIA POLSKA
(2022)
Article
Biochemistry & Molecular Biology
Gabor Balogh, Zsuzsanna Bereczky
Summary: This study investigated the interaction between coagulation factors Xa and IXa and their inhibitor, antithrombin (AT), using X-ray diffraction studies. A model was proposed based on docking and molecular dynamics simulations to understand the conformational behavior of the systems when AT is not binding a pentasaccharide. The simulations revealed variability in conformation for both factors and provided insights into the effects of conformational activation on the complexes. The atomistic models from these simulations help to better understand the conformational activation mechanism of AT against its target factors.
Article
Biochemistry & Molecular Biology
Qingyu Cheng, Yupeng Wu, Honghai Xia, Xiaoyuan Song
Summary: Colon cancer exhibits clinical differences among patients of different ages, with age-dependent transcription factors and genes identified in this study potentially linking aging and colon cancer progression. These findings provide insights for mechanism research, diagnosis, and therapies, especially in young patients.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Iga Kwiatkowska, Ewa Zekanowska, Simona Lattanzi, Andrea M. Alexandre, Agata Kister-Kowalska, Artur Slomka
Summary: Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago, and its biological properties and role in hemostasis have been extensively studied. The structure of FSAP and its interactions with other proteins and compounds that modulate its activity have been elucidated. This review summarizes the current knowledge on FSAP, including its structure, the processes regulating its activity, and its role in hemostasis and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilaria De Simone, Constance C. F. M. J. Baaten, Martine Jandrot-Perrus, Jonathan M. Gibbins, Hugo ten Cate, Johan W. M. Heemskerk, Chris Jones, Paola E. J. van der Meijden
Summary: Platelet and coagulation activation are reciprocal processes, and factors other than thrombin or fibrin can induce platelet activation via GPVI and PAR receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Bjorn Dahlback, Sinh Tran
Summary: This study aimed to identify the specific part of preAR2 required for the synergistic TFPI alpha-cofactor activity between FV-short and protein S. Results showed that FV709-1476, FV712-1478, and FV712-1481 exhibited full synergistic activity with protein S, while FV712-1484 showed intermediate activity and FV712-1487 and FV712-1490 were inactive.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Bjorn Dahlback, Sinh Tran
Summary: The research elucidated the mechanisms behind the synergistic activity between FV756-1458 and protein S as TFPI alpha cofactors, showing that the presence of the preAR2 region is crucial for this synergism.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Peng Zhang, Yu-Chen Li, Lei Li, Yong Lu
Summary: This study found significantly lower levels of ZPI antigen in PE patients compared to controls, but there was no convincing correlation between exon-3 mutations and PE. However, a close relationship was observed between the genotypes of the exon 3 polymorphisms 181 A > G and 481 A > T in the ZPI gene.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shan Li, Feng Wang, Gang Zhang, Tsui-Fen Chou
Summary: CB-5339, an ATP-competitive p97 inhibitor, shows potential as an anti-cancer therapy. Through chemical proteomics and drug-induced thermal proteome changes, the researchers identified drug targets of CB-5339, and discovered its impact on glycometabolism. Further investigations revealed that NMS-873, a non-p97 dependent inhibitor, also influences glycometabolism and identified NDUFAF5 as a potential target.
Article
Plant Sciences
Tenghua Wang, Wenxiu Ye, Yin Wang, Maoxing Zhang, Yusuke Aihara, Toshinori Kinoshita
Summary: The study identified 17 protease inhibitors that can inhibit light-induced stomatal opening, with the top three (PI1, PI2, PI3) acting by suppressing the activity of H+-ATPase. These inhibitors were predicted to target factors involved in the process of light-induced stomatal opening through bioinformatics analysis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Oncology
Daisuke Yamamoto, Hiroko Oshima, Dong Wang, Haruna Takeda, Kenji Kita, Xuelian Lei, Mizuho Nakayama, Kazuhiro Murakami, Takashi Ohama, Hirofumi Takemura, Mutsumi Toyota, Hiromu Suzuki, Noriyuki Inaki, Masanobu Oshima
Summary: Loss-of-function mutations in RNF43 stabilize the Frizzled receptor and activate Wnt signaling, playing a crucial role in colorectal cancer development. This study reveals the mechanism of how RNF43 mutations promote tumorigenesis through the serrated pathway. Additionally, it highlights the significant role of stromal cells in promoting the malignant phenotype of RNF43-mutant CRC cells and explores potential therapeutic targets for RNF43-mutant CRC.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ksenia N. Chukhontseva, Igor M. Berdyshev, Dina R. Safina, Maria A. Karaseva, Timur N. Bozin, Vadim V. Salnikov, Petr Konarev, Vladimir V. Volkov, Alexander Grishin, Viacheslav Kozlovskiy, Sergey Kostrov, Ilya Demidyuk
Summary: Protealysin is a metalloproteinase of the M4 peptidase family in Serratia proteamaculans, serving as the prototype of a large group of similar proteases. PLPs are likely to play a role in bacterial interaction with plants and animals as well as in bacterial pathogenesis. The study indicates that PLP genes in bacteria co-localize with the genes of putative conserved proteins, forming a bicistronic operon in S. proteamaculans.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Yilin Deng, Jinjin Gao, Guangying Xu, Yuan Yao, Yan Sun, Yehui Shi, Xishan Hao, Liling Niu, Hui Li
Summary: This study found that HDAC6 is highly expressed in metastatic colon cancer tissues and inhibiting or silencing HDAC6 can suppress colon cancer metastasis. The study also revealed the interaction between HDAC6 and AKAP12, and the deacetylation and ubiquitination processes that lead to the degradation of AKAP12.
Article
Oncology
Natalia Samolyk-Kogaczewska, Ewa Sierko, Dorota Dziemianczyk-Pakiela, Klaudia Beata Nowaszewska, Malgorzata Lukasik, Joanna Reszec
Review
Oncology
Ewa Zabrocka, Ewa Sierko
Review
Oncology
Marek Z. Wojtukiewicz, Piotr Skalij, Piotr Tokajuk, Barbara Politynska, Anna M. Wojtukiewicz, Stephanie C. Tucker, Kenneth V. Honn
Article
Oncology
Marek Z. Wojtukiewicz, Marta Mysliwiec, Ewa Sierko, Monika Sobierska, Joanna Kruszewska, Alina Lipska, Piotr Radziwon, Stephanie C. Tucker, Kenneth Honn
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Medicine, General & Internal
Piotr Szumowski, Artur Szklarzewski, Lukasz Zukowski, Saeid Abdelrazek, Malgorzata Mojsak, Katarzyna Porebska, Ewa Sierko, Janusz Mysliwiec
Summary: This paper introduces a pre-processing method for enhancing the specificity of PET imaging of hypermetabolic pulmonary nodules. The PCUL-FDG method demonstrated improved diagnostic accuracy in distinguishing between benign and malignant nodules, with 73.9% definitively diagnosed and 26.1% remaining uncertain. The findings suggest that images obtained using the PCUL-FDG method could be used for automatic analysis of PET data with convolutional neural networks.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Marek Z. Wojtukiewicz, Magdalena M. Rek, Kamil Karpowicz, Maria Gorska, Barbara Politynska, Anna M. Wojtukiewicz, Marcin Moniuszko, Piotr Radziwon, Stephanie C. Tucker, Kenneth V. Honn
Summary: Immune checkpoint inhibitors (ICI) have made a significant breakthrough in cancer treatment, improving outcomes and prognosis for patients with different types of malignancy. However, the expansion of their use presents new challenges, highlighting the need for multidisciplinary teamwork to address adverse reactions.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Tomasz Kowalczyk, Joanna Kisluk, Karolina Pietrowska, Joanna Godzien, Miroslaw Kozlowski, Joanna Reszec, Ewa Sierko, Wojciech Naumnik, Robert Mroz, Marcin Moniuszko, Adam Kretowski, Jacek Niklinski, Michal Ciborowski
Summary: The study focused on metabolomics analysis of early-stage NSCLC to differentiate subtypes SCC and ADC, revealing potentially significant changes in biochemical pathways involving N-acylethanolamine biosynthesis. Analysis of COPD and NSCLC plasma excluded inflammatory-related metabolites and identified cancer-specific compounds. This research may lead to new diagnostic and therapeutic approaches in NSCLC.
Review
Oncology
Patryk Gugnacki, Ewa Sierko
Summary: Human microbiome research is rapidly expanding in various medical and public health disciplines, showing potential in oncology for investigating the impact of oral microbiome on oncogenesis and treatment side effects. Studies indicate that the human microbiome can have oncogenic effects through various mechanisms, and that the oral microbiome plays a role in the development of head and neck cancer and radiation-induced oral mucositis. Further research is needed to better understand the structure and dynamics of the oral microbiome to develop personalized preventive measures and treatments.
Article
Biochemistry & Molecular Biology
Barbara Boczkowska-Radziwon, Piotr Jozef Olbromski, Anna Rogowska, Magdalena Bujno, Marta Mysliwiec, Agnieszka Zebrowska, Dariusz Sredzinski, Barbara Politynska, Marek Z. Wojtukiewicz, Piotr Radziwon
Summary: This study demonstrates that ozone treatment significantly increases the release of microparticles derived from blood and endothelial cells. Although there were statistically significant changes in some coagulation factors, they were mild and did not exceed normal levels.
Review
Oncology
Monika Konopka-Filippow, Dominika Hempel, Ewa Sierko
Summary: Breast cancer is a leading cause of brain metastases among solid malignancies, accounting for 10-16% of all brain metastases in oncological patients. Brain metastases significantly affect the quality of life, particularly in terms of neurocognitive functions. This review explores the current knowledge on breast cancer brain metastases and provides insight into the indications for specific types of treatment, with a focus on the protective role of hippocampus sparing in preserving neurocognitive functions during radiation therapy.
Editorial Material
Oncology
Marek Z. Wojtukiewicz, Magda Pogorzelska, Barbara Politynska
CANCER AND METASTASIS REVIEWS
(2022)
Article
Oncology
Monika Konopka-Filippow, Ewa Sierko, Dominika Hempel, Rafal Maksim, Natalia Samolyk-Kogaczewska, Tomasz Filipowski, Ewa Rozkowska, Stefan Jelski, Beata Kasprowicz, Eryka Karbowska, Krzysztof Szymanski, Kamil Szczecina
Summary: Hippocampal-sparing brain radiotherapy (HS-BRT) in cancer patients preserves neurocognitive function and improves quality of life. The study found discrepancies in spatial localization, shape, and volume of the hippocampus during treatment planning. The most challenging area for hippocampus delineation was the posterior horn of the lateral ventricle. Training in accurate hippocampus contouring is necessary for optimal outcomes.
Article
Oncology
Marek Z. Wojtukiewicz, Marta Mysliwiec, Elwira Matuszewska, Stanislaw Sulkowski, Lech Zimnoch, Barbara Politynska, Anna M. Wojtukiewicz, Stephanie C. Tucker, Kenneth V. Honn
Summary: Brain gliomas exhibit intense invasive growth and new blood vessel formation, with higher-grade malignancy showing stronger expression of proangiogenic and procoagulant factors.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Oncology
Piotr Radziwon, Maciej Krzakowski, Ewa Kalinka, Renata Zaucha, Piotr Wysocki, Dariusz Kowalski, Jerzy Gryglewicz, Marek Z. Wojtukiewicz
ONCOLOGY IN CLINICAL PRACTICE
(2020)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
