Article
Pharmacology & Pharmacy
Allison Cid, Megan E. Smetana, Courtney Hebert, Kelci Coe, Jessica M. Smith
Summary: The aim of this study was to evaluate the effect of concomitant use of fluconazole and direct oral anticoagulants (DOACs) on bleeding risk. The study found that patients receiving a DOAC with fluconazole did not have a significantly increased risk for bleeding at 30 days compared to those receiving a DOAC alone after adjusting for confounding variables.
Review
Obstetrics & Gynecology
Ana Luisa Areia, Anabela Mota-Pinto
Summary: The use of direct oral anticoagulants (DOACs) during pregnancy poses safety concerns despite their practical advantages over low molecular weight heparin. A systematic review of studies on DOACs usage in pregnancy found a higher rate of fetal loss and fetal abnormalities compared to LMWH, although bleeding complications were similar.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Hematology
Myrthe M. A. Toorop, Nienke van Rein, Melchior C. Nierman, Helga W. Vermaas, Menno Huisman, Felix J. M. van der Meer, Suzanne C. Cannegieter, Willem M. Lijfering
Summary: The study found that the inter-individual variability of DOAC concentrations was higher than intra-individual variability, and lower previous VKA dosage and creatinine clearance were associated with higher DOAC trough concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Joseph R. Shaw, Na Li, Joanne Nixon, Karen A. Moffat, Alex C. Spyropoulos, Sam Schulman, James D. Douketis
Summary: Coagulation testing is not a reliable method for predicting DOAC concentrations. There is a weak correlation between coagulation assay results and DOAC levels, except for a moderate correlation between thrombin time and dabigatran concentrations. Prothrombin time and activated partial thromboplastin time have modest sensitivity but poor specificity in predicting DOAC levels.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Styliani Papadaki, Sofia Sidiropoulou, Iraklis C. Moschonas, Alexandros D. Tselepis
Summary: FXa and thrombin can activate OECs and HUVECs through PARs, while rivaroxaban and dabigatran can inhibit this activation, and vorapaxar antagonist can completely block this effect.
Article
Pharmacology & Pharmacy
Chelsea N. Lopez, Luma Succar, Sara Varnado, Kevin R. Donahue
Summary: This study compared the impact on bleeding rates of a delayed, clinically driven strategy versus a standard per-package-insert strategy for transitioning from a direct oral anticoagulant to a parenteral anticoagulant. The primary endpoint showed a higher incidence of major bleeding in the delayed group compared to the standard group. Patients in both groups who experienced bleeding had a higher severity of illness and higher median DOAC anti-factor Xa concentrations.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Hematology
Christian Pfrepper, Lisa-Charlott Behrendt, Hagen Bonigk, Thomas Siegemund, Michael Metze, Dirk Franke, Sirak Petros, Annelie Siegemund
Summary: The study found a moderate predominantly nonlinear correlation between TG parameters and plasma levels of apixaban and rivaroxaban. Rivaroxaban has a stronger effect on TG than apixaban.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Hematology
Philipp Groene, Jennifer Butte, Sarah Thaler, Klaus Goerlinger, Simon T. Schaefer
Summary: This study aimed to evaluate the effectiveness of modified thromboelastometric tests in detecting apixaban and edoxaban. The results showed that the modified tests can effectively detect low concentrations of anticoagulants with high sensitivity and specificity. These findings complement previous research on dabigatran and rivaroxaban.
THROMBOSIS JOURNAL
(2022)
Article
Hematology
Russell Leong, Derek K. Chu, Mark A. Crowther, Siraj Mithoowani
Summary: This review summarizes the evidence on the use of direct oral anticoagulants (DOACs) after bariatric surgery, indicating a substantial risk of DOAC malabsorption that could affect clinical outcomes, although the certainty of evidence is very low.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Zachary R. Caverley, Ross J. Bindler, Pamela Soh, Sherri Mendelson
Summary: This study aimed to assess the effectiveness and safety of direct oral anticoagulants (DOACs) compared to warfarin in patients with atrial fibrillation and class III obesity in a rural population. The results showed that DOACs were non-inferior to warfarin in terms of safety during the first six to 12 months of therapy, but the efficacy analysis was limited by a lack of thrombosis events.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yusuke Ito, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Tetsuo Sasano
Summary: The authors demonstrated a mechanism for attenuating atherosclerosis by administering an oral factor Xa inhibitor, RIV. This attenuation was achieved by suppressing macrophage autophagy and abrogating inflammasome activity.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Biology
Lu Yin, Yuan Qi, Zhiru Ge, Jiajin Li
Summary: This study examined the effects of dabigatran and rivaroxaban on the activities of coagulation factors. The results showed that low doses of dabigatran inhibited activated protein C (APC) activity, while high doses of dabigatran and rivaroxaban inhibited the activities of several coagulation factors, with a more significant effect at higher drug concentrations.
OPEN LIFE SCIENCES
(2022)
Article
Hematology
Simon T. Schaefer, Anne-Christine Otto, Alice-Christin Acevedo, Klaus Goerlinger, Steffen Massberg, Tobias Kammerer, Philipp Groene
Summary: A decision tree-based thromboelastometry algorithm can reliably detect and differentiate direct Xa inhibitors and direct thrombin inhibitors, as well as differentiate them from vitamin K antagonists, dilutional coagulopathy, and healthy controls.
THROMBOSIS JOURNAL
(2021)
Article
Clinical Neurology
Alexandros A. Polymeris, Grzegorz M. Karwacki, Bernhard M. Siepen, Sabine Schaedelin, Dimitrios A. Tsakiris, Christoph Stippich, Raphael Guzman, Christian H. Nickel, Nikola Sprigg, Georg Kaegi, Jochen Vehoff, Filip Barinka, Sebastian Thilemann, Marina Maurer, Benjamin Wagner, Christopher Traenka, Henrik Gensicke, Gian Marco De Marchis, Leo H. Bonati, Urs Fischer, Werner J. Z'Graggen, Krassen Nedeltchev, Susanne Wegener, Philipp Baumgartner, Stefan T. Engelter, David J. Seiffge, Nils Peters, Philippe A. Lyrer
Summary: In a smaller-than-intended patient sample, the study found that tranexamic acid (TXA) did not prevent hematoma expansion in NOAC-ICH but also did not raise major safety concerns. Larger trials targeting an early treatment window are needed for NOAC-ICH.
Article
Cardiac & Cardiovascular Systems
Thomas A. Zelniker, Maddalena Ardissino, Felicita Andreotti, Michelle L. O'Donoghue, Ophelia Yin, Jeong-Gun Park, Sabina A. Murphy, Christian T. Ruff, Hans J. Lanz, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano, Piera Angelica Merlini
Summary: Despite baseline differences and higher endogenous factor Xa levels in women, anticoagulation intensity with edoxaban was similar between sexes. Higher-dose edoxaban regimen showed greater reduction in hemorrhagic stroke and serious bleeding outcomes in women compared to men. Efficacy profile was similar between sexes.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
