Review
Biochemistry & Molecular Biology
Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G. de Groot, Mark Roest, Johan W. M. Heemskerk
Summary: This paper reviews the functional reversibility of integrin alpha IIb beta 3 activation and transient aggregation and discusses the signaling pathways involved. The study finds that ADP P2Y(1) and P2Y(12) receptor signaling via phosphoinositide 3-kinases and Akt are the principal pathways linked to reversible integrin activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Marc Laine, Vassili Panagides, Corinne Frere, Thomas Cuisset, Caroline Gouarne, Bernard Jouve, Gilles Lemesle, Franck Paganelli, Marie-Christine Alessi, Julien Mancini, Laurent Bonello
Summary: This study aimed to investigate the association between ticagrelor platelet reactivity (PR) and clinical outcomes in ACS patients undergoing PCI. The results showed that PR measured by the VASP was not associated with bleeding or thrombotic events in this clinical setting. Therefore, PR measured by the VASP should not be used as a surrogate endpoint in studies on ticagrelor.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Vasiliki Mougiou, Theodora Boutsikou, Rozeta Sokou, Maria Kollia, Serena Valsami, Abraham Pouliakis, Maria Boutsikou, Marianna Politou, Nicoletta Iacovidou, Zoe Iliodromiti
Summary: This study aimed to evaluate the platelet function of neonates born to mothers with gestational diabetes mellitus (GDM). The results showed that neonates from the GDM group demonstrated a more hyporesponsive phenotype of their platelets.
Article
Hematology
Sourav K. Kundu, Eric J. Heilmann, Reynaldo Sio, Carmen Garcia, Rosa M. Davidson, Roy A. Ostgaard
Summary: This manuscript introduces a new in vitro system, PFA-100(R), for detecting platelet dysfunction. The system provides a quantitative measure of platelet function by generating platelet plugs on a membrane. The test is sensitive to platelet adherence and aggregation abnormalities, and offers the advantages of accuracy, ease of operation, and rapid results.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Eberhard F. Mammen, Philip C. Comp, Robert Gosselin, Charles Greenberg, W. Keith Hoots, Craig M. Kessler, Edward C. Larkin, Darla Liles, Diane J. Nugent
Summary: The study introduces the PFA-100 system, a platelet function analyzer designed to measure primary hemostasis. The system is able to detect various platelet defects and shows high accuracy in discriminating normal and abnormal platelet function. It is a useful tool for screening patients with platelet-related hemostasis defects.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Smaragdi Antonopoulou, Filio Petsini, Maria Detopoulou, Theoharis C. Theoharides, Constantinos A. Demopoulos
Summary: This study found that mRNA vaccination for COVID-19 affects human platelet aggregation response and the Spike protein modulates PAF production and activity. This finding may provide new directions for treating patients infected with SARS-CoV-2.
Article
Hematology
Dolors Llobet, Cristina Vallve, Isabel Tirado, Noelia Vilalta, Marina Carrasco, Artur Oliver, Jose Mateo, Jordi Fontcuberta, Juan Carlos Souto
Summary: The study aimed to investigate the correlation between platelet hyperaggregability, closure times, and venous thrombosis risk in a Spanish population. While initial analysis showed associations between ADP and EPI aggregation and venous thrombosis risk, these associations were no longer significant after adjustments for age, indicating that platelet hyperaggregability may not be a risk factor for developing venous thrombosis.
BLOOD COAGULATION & FIBRINOLYSIS
(2021)
Article
Endocrinology & Metabolism
Ahmet Bolat, Cengiz Zeybek, Orhan Gursel, Onur Akin, Mehmet Emre Tascilar
Summary: This study evaluated the effects of premature adrenarche (PA) on platelet (PLT) aggregation in female patients. Results showed that collagen-induced PLT aggregation was significantly higher in PA patients compared to the control group. Given the association between PA and a higher risk of cardiovascular events, close follow-up of PA in this aspect may be beneficial.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2023)
Article
Pathology
Joseph H. Cho, Geoffrey D. Wool, Melissa Y. Tjota, Jocelyn Gutierrez, Krzysztof Mikrut, Jonathan L. Miller
Summary: This study explored the feasibility of assessing platelet dense granule release in response to platelet stimuli using less than 1 mL of whole blood. The optimization of the luciferin-luciferase assay for ATP release in diluted whole blood resulted in similar levels of granule secretion compared to platelet-rich plasma. Classic platelet stimuli like TRAP, ADP, and collagen all stimulated ATP release under the optimized conditions of this study.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Hematology
Vaishali B. Nagose, Purnima M. Kodate, Dinkar T. Kumbhalkar, Shivanand S. Rathod, Suprita P. Nayak
Summary: This study aimed to determine whether there is a higher degree of platelet and coagulation activation in sickle cell anemia patients and its relationship with clinical risk factors. The results showed that platelet aggregation can be used to monitor and manage patients with sickle cell disease.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Hematology
Severien Meyers, Marleen Lox, Sirima Kraisin, Laurens Liesenborghs, Caroline P. Martens, Liesbeth Frederix, Stijn Van Bruggen, Marilena Crescente, Dominique Missiakas, Pieter Baatsen, Thomas Vanassche, Peter Verhamme, Kimberly Martinod
Summary: Neutrophil extracellular traps (NETs) released by neutrophils play a protective role in infective endocarditis (IE), but do not affect the occurrence of IE. Staphylococcus aureus coagulases inhibit the formation of NETs and reduce the severity of infection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Simona Esposito, Marialaura Bonaccio, Emilia Ruggiero, Simona Costanzo, Augusto Di Castelnuovo, Alessandro Gialluisi, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: This study explores the relationship between the degree of food processing and the risk of central nervous system (CNS) tumors. It is found that the intake of ultra-processed food (UPF) is associated with an increased risk of CNS tumors, especially malignant tumors, while processed food is inversely related to the risk of this disease.
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Nutrition & Dietetics
Marialaura Bonaccio, Simona Costanzo, Augusto Di Castelnuovo, Alessandro Gialluisi, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: This study aimed to evaluate the association between long-term changes in adherence to a Mediterranean diet (MD) and concurrent changes in modifiable cardiovascular disease (CVD) risk factors and markers of low-grade inflammation. The results showed that increased adherence to a MD over time was associated with reduced levels of low-grade inflammation, but had little impact on CVD risk scores. These findings suggest the potential of a traditional Mediterranean eating pattern to reduce the long-term risk of inflammation-related chronic diseases in an ageing population.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Ambra Cappelletto, Harriet E. Allan, Marilena Crescente, Edoardo Schneider, Rossana Bussani, Hashim Ali, Ilaria Secco, Simone Vodret, Roberto Simeone, Luca Mascaretti, Serena Zacchigna, Timothy D. Warner, Mauro Giacca
Summary: Thrombosis of the lung microvasculature is a key characteristic of severe COVID-19 infection, and is triggered by the Spike protein of SARS-CoV-2. The Spike protein enhances platelet activation and procoagulant activity, leading to clot formation. Niclosamide and Clofazimine effectively inhibit this Spike-induced procoagulant response and may be repurposed for COVID-19 therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Claudia F. Martinez, Simona Esposito, Augusto Di Castelnuovo, Simona Costanzo, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, James R. Hebert, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi, Marialaura Bonaccio
Summary: Chronological age may not accurately reflect health status, while biological age has been proposed as a relevant indicator of healthy aging. Observational studies have found that decelerated biological aging is associated with a lower risk of disease and mortality. A cross-sectional analysis was performed using data from the Moli-sani Study in Italy, and it was found that a pro-inflammatory diet is associated with accelerated biological aging and an increased risk of inflammation-related diseases and mortality.
Article
Nutrition & Dietetics
Marialaura Bonaccio, Emilia Ruggiero, Augusto Di Castelnuovo, Claudia Francisca Martinez, Simona Esposito, Simona Costanzo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Summary: Late eating is associated with poor metabolic health, potentially due to low diet quality. This study found that meal timing may also be related to food processing, which affects health outcomes. Late eaters consumed less minimally processed food, more ultra-processed food, and had lower adherence to the Mediterranean Diet compared to early eaters. Future research should investigate whether increased consumption of ultra-processed food underlies the association between late eating and adverse metabolic health.
Article
Urology & Nephrology
Plinio Ferreira, Ricky Vaja, Maria Lopes-Pires, Marilena Crescente, He Yu, Rolf Nuesing, Bin Liu, Yingbi Zhou, Magdi Yaqoob, Anran Zhang, Matthew Rickman, Hilary Longhurst, William E. White, Rebecca B. Knowles, Melissa Chan, Timothy D. Warner, Elizabeth Want, Nicholas S. Kirkby, Jane A. Mitchell
Summary: By producing prostacyclin, COX-2 protects the cardiorenal system. ADMA, a biomarker of cardiovascular and renal disease, is found to be related to COX-2/prostacyclin and renal function in both mouse and human models.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Nutrition & Dietetics
Claudia Francisca Martinez, Augusto Di Castelnuovo, Simona Costanzo, Teresa Panzera, Simona Esposito, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Marialaura Bonaccio
Summary: A study on Mediterranean populations found that a general pro-vegetarian food pattern was associated with a lower rate of overall cancer incidence. Additionally, a healthful pro-vegetarian pattern was linked to a lower risk of digestive cancer, while an unhealthful pro-vegetarian pattern was associated with a higher risk of respiratory cancer.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
