Article
Behavioral Sciences
Fan Cheng, Xiao-Min Si, Gong-Li Yang, Lan Zhou
Summary: This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.
BRAIN AND BEHAVIOR
(2021)
Review
Cardiac & Cardiovascular Systems
Xiaoxian Gong, Luowei Chen, Bo Song, Xiang Han, Weihai Xu, Bo Wu, Feng Sheng, Min Lou
Summary: The study found that an increase in total cholesterol and triglycerides is associated with an increased risk of ischemic stroke and a reduced risk of hemorrhagic stroke, while an increase in high-density lipoprotein cholesterol is associated with a reduced risk of ischemic stroke. It is recommended to control total cholesterol and low-density lipoprotein cholesterol levels within certain ranges.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Clinical Neurology
Jie Chai, Xian-Ling Cao, Feng Lu
Summary: This meta-analysis found no significant association between IL-6 -174G/C(rs1800795) polymorphism and ischemic stroke (IS), but subgroup analysis showed that the relationship varied significantly according to ethnicity and geography.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Yunnan Jing, Siya Hu, Jing Song, Xu Dong, Ying Zhang, Xiaowei Sun, Dongyan Wang
Summary: This Meta-analysis found that four miRNA polymorphisms were associated with the risk of ischemic stroke, although the overall and subgroup analyses were not entirely consistent.
Article
Clinical Neurology
Benjamin Beland, Fouzi Bala, Aravind Ganesh
Summary: A systematic review and meta-analysis found that patients with prestroke disability who received IVT treatment had better odds of returning to baseline function compared to those who did not receive treatment. There were no significant differences in mortality and sICH rates between treated and untreated patients with disability. Further high-quality data comparing treated and untreated patients with prestroke disability are needed to clarify the issue.
Article
Biochemistry & Molecular Biology
Kunhui He, Zhengping Zhu, Yongheng Chen
Summary: The meta-analysis suggests that LPL HindIII and S447X polymorphisms may be protective factors for myocardial infarction, while PvuII is not associated. There are ethnic differences in the response to these polymorphisms, indicating the need for larger case-control studies to confirm the results.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Multidisciplinary Sciences
Pradeep Kumar, Priyanka Swarnkar, Shubham Misra, Manabesh Nath
Summary: The meta-analysis found a significant association between increased levels of Lp(a) and the risk of ischemic stroke (IS) as well as its subtypes, including large artery atherosclerosis (LAA) and intracerebral hemorrhage (ICH). Elevated Lp(a) levels could serve as a predictive marker for identifying individuals at risk of developing IS, LAA, and ICH.
SCIENTIFIC REPORTS
(2021)
Review
Genetics & Heredity
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Hong Fan, Qian Hao, Dingli Song, Jialiang Lu, Ziwei Lu, Yating Jian, Heying Wang, Xiaoya Wang, Yulun Wu, Guilian Zhang
Summary: This study found a significant association between the MTHFR rs1801133 (677C > T) gene mutation and an increased risk of ischemic stroke, particularly in the Asian, Hispanic, or Latin population and middle-aged and elderly individuals.
FRONTIERS IN GENETICS
(2023)
Review
Medicine, General & Internal
Yumeng Song, Xiaohong Zhang, Chaoxiu Li, Shuang Xu, Baosen Zhou, Xiaomei Wu
Summary: There is no consensus on the role of bilirubin in acute ischemic stroke. Higher levels of serum bilirubin may indicate greater oxidative stress and severity of stroke. A study found that both total bilirubin and direct bilirubin levels are positively associated with the severity of ischemic stroke, with a linear correlation observed for direct bilirubin.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Luis F. Rendon, Stephanie Malta, Jacob Leung, Rafael Badenes, Ala Nozari, Federico Bilotta
Summary: Cocaine consumption has increased, and it can lead to serious neurovascular complications. This systematic review and meta-analysis aimed to describe the clinical features and outcomes of strokes associated with cocaine use. The findings show that cocaine use increases the risk of strokes and leads to worse outcomes such as mortality, vasospasm, and seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Limin Yan, Dedong Xu, Ying Xiao, Mingming Dai, Ting Wang, Xinhong Zhuang, Kunliang Wu
Summary: This study investigated the relationship between NQO1 gene polymorphism and ischemic stroke susceptibility in Chinese Han nationality. The results showed that the C allele of NQO1 rs1800566 may be associated with ischemic stroke susceptibility, and polymorphism of the rsl800566 locus in the NQO1 gene may have a protective effect against ischemic stroke risk.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Review
Geriatrics & Gerontology
Ranran Duan, Na Wang, Yanan Shang, Hengfen Li, Qian Liu, Li Li, Xiaofeng Zhao
Summary: This study found a correlation between TNF-alpha rs1800629 polymorphism, increased levels of TNF-alpha, and decreased levels of IGF-1 with the etiology of ischemic stroke (IS).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Hematology
Xiao-Qin Peng, Fan Cheng, Lan Zhou
Summary: A meta-analysis of 19 case-control studies found no significant association between TGF-beta 1 gene polymorphisms and ischemic stroke risk.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Review
Clinical Neurology
Qi Li, Mohamad Abdalkader, James E. Siegler, Shadi Yaghi, Amrou Sarraj, Bruce C. V. Campbell, Albert J. Yoo, Osama O. Zaidat, Johannes Kaesmacher, Deep Pujara, Raul G. Nogueira, Jeffrey L. Saver, Lei Li, Qin Han, Yi Dai, Hongfei Sang, Qingwu Yang, Thanh N. Nguyen, Zhongming Qiu
Summary: This study compared the efficacy and safety of endovascular thrombectomy (EVT) versus medical management (MM) in patients with large vessel occlusion (LVO) and found that EVT improved functional outcomes without increasing the risk of symptomatic intracranial hemorrhage.
Review
Behavioral Sciences
Wei Chen, Xiaomin Zhu, Yueqiang Hu, Huangzhong Hong, Longjiao Kuang, Ni Liang, Jianmin Zhu, Lingfei Jiang, Lin Wu
Summary: A meta-analysis was conducted to investigate the association between CRP gene polymorphisms and the risk of ischemic stroke (IS). The study included 12 case-control studies with a total of 3880 IS cases and 5233 controls. The findings showed no significant association between CRP gene variants rs1800947, rs1130864, rs3093059, rs2794521, and rs1205 and the risk of IS. Further research is needed for the rs1800947 polymorphism in a specific population.
BRAIN AND BEHAVIOR
(2023)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)