Article
Immunology
Douwe Jan Dijkstra, A. Inkeri Lokki, Lobke Marijn Gierman, Nicole Veronique Borggreven, Carin van der Keur, Michael Eikmans, Kyra Andrea Gelderman, Hannele Laivuori, Ann-Charlotte FINNPEC Core Investigator Grp, Ann-Charlotte Iversen, Marie-Louise P. van der Hoorn, Leendert Adrianus Trouw
Summary: Preeclampsia (PE) may be associated with decreased levels of C1q and FH, which are related to placental dysfunction and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Robert A. J. Byrne, Megan Torvell, Nikoleta Daskoulidou, Dina Fathalla, Eirini Kokkali, Sarah M. Carpanini, B. Paul Morgan
Summary: Recent studies have shown that complement plays important roles in synaptic pruning, with C1q initiating complement activation on synapses and C3 fragments tagging them for removal. The development of sensitive assays for quantification of C1q in rodent models of AD is crucial for further understanding the role of C1q in disease pathogenesis and as a potential biomarker.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Radanova, Vasil Vasilev, Galya Mihaylova, Mariya Kosturkova, Uday Kishore, Lubka Roumenina
Summary: Anti-C1q autoantibodies are important biomarkers in lupus nephritis and are associated with the severity of renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Seline A. Zwarthoff, Kevin Widmer, Annemarie Kuipers, Jurgen Strasser, Maartje Ruyken, Piet C. Aerts, Carla J. C. de Haas, Deniz Ugurlar, Maurits A. den Boer, Gestur Vidarsson, Jos A. G. van Strijp, Piet Gros, Paul W. H. Parren, Kok P. M. van Kessel, Johannes Preiner, Frank J. Beurskens, Janine Schuurman, Daniel Ricklin, Suzan H. M. Rooijakkers
Summary: Complement is a crucial effector mechanism for antibody-mediated clearance of infections and tumor cells. The interaction between C1r2s2 proteases and C1q affects the stability of the complex formed with surface-bound IgG molecules, with potential implications for antibody therapy design. Engineering IgG to enhance hexamer formation improves C1q-IgG stability and enhances complement-dependent phagocytosis, particularly targeting pathogens like Staphylococcus aureus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Margot Revel, Catherine Sautes-Fridman, Wolf-Herman Fridman, Lubka T. Roumenina
Summary: The role of C1q in tumor-associated macrophages is complex and may drive cancer progression, calling for further investigation.
Article
Pediatrics
Huan Li, Juanjuan Chen, Yuanhui Hu, Xin Cai, Pingan Zhang
Summary: The study found that serum C1q levels were significantly elevated in children with sepsis, correlated with disease severity, positively correlated with PCT levels, and negatively correlated with PCIS score. Children infected with different pathogens also showed significantly higher serum C1q levels.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Paula Niewold, Douwe J. Dijkstra, Yi Cai, Delia Goletti, Fabrizio Palmieri, Krista E. van Meijgaarden, Frank A. W. Verreck, Onno W. Akkerman, Regina W. Hofland, Eveline M. Delemarre, Stefan Nierkens, Marije K. Verheul, Andrew J. Pollard, Jaap T. van Dissel, Tom H. M. Ottenhoff, Leendert A. Trouw, Simone A. Joosten
Summary: Tuberculosis (TB) is a common disease with high mortality and morbidity rates. Differentiating TB from other diseases is challenging, especially in clinical settings. The study identified circulating monocytes as the source of complement component C1q, which is a specific biomarker for TB. The expression of C1q was pronounced in classical and intermediate monocytes and varied in non-classical monocytes.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kristina Schulz, Marten Trendelenburg
Summary: This systematic review provides an overview of the role of C1q knockout mice in disease models and potential target diseases for treatment strategies focusing on C1q. The study found that C1q is protective against autoimmune diseases and infections, but may have beneficial effects on diseases such as neurodegenerative disorders. However, depleting and/or inhibiting C1q may also result in some side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Isabel Peterlunger, Livia Simoni, Andrea Balduit, Erica Curtolo, Alessandro Mangogna, Beatrice Belmonte, Davide Vacca, Federico Romano, Tamara Stampalija, Tiziana Salviato, Federica Defendi, Nicoletta Di Simone, Uday Kishore, Giuseppe Ricci, Roberta Bulla
Summary: C1q is essential in pregnancy, and its deficiency can lead to pregnancy failure. Anti-C1q autoantibodies are present in various diseases and in the general population. Recent evidence suggests an increased risk of PE in women undergoing ART. This study found that PE patients have lower levels of anti-C1q, and ART pregnancies showed similar levels of C1q and anti-C1q compared to PE patients. The findings suggest an immunological dysfunction at the fetal-maternal interface in ART pregnancies, with C1q deposition in placentae. Anti-C1q may have a physiological role in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yingbo Ma, Xueqing Ding, Mingxi Shao, Yichao Qiu, Shengjie Li, Wenjun Cao, Gezhi Xu
Summary: This study investigated the association between serum complement components and AMD. The results showed that higher levels of C1q and lower levels of C3 were associated with increased risk of AMD in female patients. This suggests that the complement classical pathway may be involved in the development of AMD, especially in females.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Xiaoxiao Hao, Zhaofei Li, Wei Li, Jannet Katz, Suzanne M. Michalek, Scott R. Barnum, Lucas Pozzo-Miller, Takashi Saito, Takaomi C. Saido, Qin Wang, Erik D. Roberson, Ping Zhang
Summary: Periodontitis may worsen the development and severity of Alzheimer's disease (AD), but the mechanism by which it does so remains unclear. Using a mouse model, this study found that oral infection worsened cognitive impairment and accelerated amyloid beta accumulation in AD mice. The study also revealed that periodontal infection complicates the neuroinflammatory status established by AD and amplifies microglial activation, neuroinflammation, and synaptic tagging through brain overactivation of complement C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Li Tan, Yi Tang, Gaiqin Pei, Zhengxia Zhong, Jiaxing Tan, Ling Zhou, Dongmei Wen, David Sheikh-Hamad, Wei Qin
Summary: The study revealed that mesangial C1q deposition is a predictor of poor renal survival in IgA nephropathy, with C1q-negative patients having significantly higher renal survival rates during the follow-up period compared to C1q-positive patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Christopher T. T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. A. Rubenstein
Summary: This study found that the binding of C1q to gC1qR increases the expression of tissue factor (TF) and may initiate extrinsic coagulation. This result demonstrates the role of C1q in the activation of extrinsic coagulation and suggests that gC1qR may be a link between inflammation and thrombosis.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Neurosciences
Xinmiao Wu, Yuzhu Gao, Cuina Shi, Jianhua Tong, Daqing Ma, Jinchun Shen, Jianjun Yang, Muhuo Ji
Summary: Activated microglia and release of pro-inflammatory cytokines cause neuroinflammation and cognitive impairments, but the underlying molecular mechanisms are unknown.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)