Article
Cell Biology
Oliver Buchhave Pedersen, Sanne Bojet Larsen, Steen Dalby Kristensen, Anne-Mette Hvas, Erik Lerkevang Grove
Summary: Immature platelet markers cannot predict cardiovascular events in stable CAD patients.
Article
Endocrinology & Metabolism
Ying-Ying Zheng, Ting-Ting Wu, Yi Yang, Xian-Geng Hou, You Chen, Xiang Ma, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie
Summary: The study suggests that personalized antiplatelet therapy based on PLT guidance can reduce ischemic events without increasing bleeding risk in stable CAD patients with or without diabetes undergoing PCI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Hematology
Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti
Summary: This study investigated the effects of PAR4 inhibitory pepducin (RAG8) on coronary artery disease in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet. The results showed that RAG8 reduced coronary artery atherosclerosis and myocardial fibrosis, as well as platelet and leukocyte accumulation in atherosclerotic coronary arteries.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Immunology
Fabrice Cognasse, Anne Claire Duchez, Estelle Audoux, Theo Ebermeyer, Charles Antoine Arthaud, Amelie Prier, Marie Ange Eyraud, Patrick Mismetti, Olivier Garraud, Laurent Bertoletti, Hind Hamzeh-Cognasse
Summary: Platelets are anucleate cytoplasmic fragments derived from medullary megakaryocytes. They form platelet plugs by adhering to damaged endothelium and secrete growth factors that contribute to platelet aggregation and vascular repair. Platelets also play a major role in inflammation and immune defense through receptors and lectins. Additionally, platelet activation leads to the release of inflammatory mediators and direct activation of immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Atsushi Sato, Hideo Kawabata, Hachidai Aizawa, Tetsuhiro Tsujino, Kazushige Isobe, Taisuke Watanabe, Yutaka Kitamura, Richard J. Miron, Tomoyuki Kawase
Summary: Platelet-rich fibrin (PRF) is widely used in regenerative therapy due to its simple preparation. This study examined the distribution of activated platelets in four types of PRF matrices and found that the centrifugal conditions did not significantly affect platelet activation, but H-PRF was distinguishable from other derivatives in terms of activated platelet distribution.
Article
Biochemistry & Molecular Biology
Alvaro Petersen-Uribe, Marcel Kremser, Anne-Katrin Rohlfing, Tatsiana Castor, Kyra Kolb, Valerie Dicenta, Frederic Emschermann, Bo Li, Oliver Borst, Dominik Rath, Karin Anne Lydia Mueller, Meinrad Paul Gawaz
Summary: Platelets play a significant role in atherothrombosis, and this study found that they are a major source of PCSK9 in coronary artery disease (CAD). PCSK9 released by platelets contributes to platelet activation and thrombo-inflammation, with inhibition of PCSK9 showing beneficial effects in reducing these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Dario Bongiovanni, Laura Novelli, Francesco Condello, Kilian Kirmes, Jiaying Han, Bastian Wein, Sebastien Elvinger, Giacomo Viggiani, Moritz von Scheidt, Karl-Ludwig Laugwitz, Philip W. J. Raake, Adnan Kastrati, Mauro Chiarito, Isabell Bernlochner
Summary: This study evaluated the prognostic role of elevated RPs in patients with coronary artery disease. The results showed that elevated RPs are significantly associated with an increased risk of cardiovascular events and cardiovascular death.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Gregory R. Tintinger, Annette J. Theron, Helen C. Steel, Moloko C. Cholo, Jan G. Nel, Charles Feldman, Ronald Anderson
Summary: The study investigated the impact of bedaquiline on platelet activation and found that it exerts anti-platelet effects by inhibiting ADP-activated expression of CD62P, aggregation, and Ca2+ mobilization, possibly through its action on PI3-K. These anti-platelet effects may help mitigate the risk of TB-associated cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Magdy Eldahshan, Marwa A. Byomy, Amira M. Alsadek, Marwa M. Hassan, Heba H. Eltrawy, Marwa K. Abdelwahab, Warda D. K. Ali, Ahmed Eliwa
Summary: The expression of CD62P in COVID-19 patients is associated with clinical severity and outcome. Higher levels of CD62P are found in patients who are more likely to die, and CD62P levels are significantly elevated in severe cases. D-dimer and CD62P levels are significant predictors of mortality risk.
CLINICAL LABORATORY
(2022)
Article
Cell Biology
Chang Chen, Yequn Chen, Jiaxin Xiao, Yanhong Zhang, Zhaorui Yang, Peixuan Yang, Nan Lu, Kaihong Yi, Xiaojun Chen, Shaoxin Chen, Mary Clare O'Gara Msc, Michael O'Meara, Shu Ye, Xuerui Tan
Summary: There is an association between impaired fasting glucose level and a predisposition to severe coronary artery disease indicated by triple vessel disease or myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Franchi, Fabiana Rollini, Latonya Been, Naji Maaliki, Patrick Abou Jaoude, Andrea Rivas, Xuan Zhou, Sida Jia, Maryuri Briceno, Chang Hoon Lee, Andres M. Pineda, Siva Suryadevara, Daniel Soffer, Martin M. Zenni, Theodore A. Bass, Dominick J. Angiolillo
Summary: This study aimed to investigate the impact of different ticagrelor maintenance dose regimens on platelet function and pharmacokinetics in patients with diabetes mellitus (DM) and compare the differences caused by CKD status. The results showed that the 90 mg ticagrelor dose reduced platelet reactivity levels in non-CKD patients with diabetes compared to the 60 mg dose, but there was no significant difference in CKD patients. In addition, pharmacokinetic assessments showed higher plasma concentrations of ticagrelor and its metabolite in CKD patients compared to non-CKD patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Franchi, Luis Ortega-Paz, Fabiana Rollini, Mattia Galli, Latonya Been, Ghussan Ghanem, Awss Shalhoub, Tiffany Ossi, Andrea Rivas, Xuan Zhou Md, Andres M. Pineda, Siva Suryadevara, Daniel Soffer, Martin M. Zenni, Birgit Reiter, Bernd Jilma, Dominick J. Angiolillo
Summary: This study aimed to evaluate the potential drug-drug interaction between cangrelor and ticagrelor in patients who have been pretreated with ticagrelor. The results showed that adding cangrelor to ticagrelor-treated patients significantly reduced platelet reactivity, and there were no differences in platelet inhibition after discontinuation of drug infusion, indicating the absence of a drug-drug interaction.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yoko K. Takada, Michiko Shimoda, Emanual Maverakis, Brunie H. Felding, R. Holland Cheng, Yoshikazu Takada
Summary: CD40L is a member of the TNF superfamily that activates immune cells through integrins alpha v beta 3, alpha 5 beta 1, and also alpha 4 beta 1. The binding to site 2 and activation of integrins may play a role in CD40L signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Hematology
Itshak Amsalem, Elad Asher, Inbar Blaufeld, Rafael Hitter, Nir Levi, Louay Taha, Fauzi Fadi Shaheen, Hani Karameh, Tomer Maller, Nimrod Perel, Yoed Steinmetz, Mohammad Karmi, Kamal Hamayel, Mohammed Manassra, Talya Wolak, Michael Glikson, Arik Wolak
Summary: Coronary calcium score (CCS) is a sensitive marker for coronary artery calcification (CAC) and coronary artery disease (CAD). This study found a strong association between mean platelet volume (MPV) and CAC severity, suggesting that MPV could be an independent predictor for CAD risk. These findings highlight the potential of using MPV as a routine blood test to detect patients at risk for CAD.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Cell Biology
Henry E. Speich, Svetozar Grgurevich, Teddi J. Kueter, Angela D. Earhart, Steven M. Slack, Lisa K. Jennings
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Michael J. Herr, Celia M. Longhurst, Benjamin Baker, Ramin Homayouni, Henry E. Speich, Jayaprakash Kotha, Lisa K. Jennings
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Hematology
H. E. Speich, A. D. Earhart, S. N. Hill, S. Cholera, T. J. Kueter, J. N. Smith, M. M. White, L. K. Jennings
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2009)
Article
Cardiac & Cardiovascular Systems
Henry E. Speich, Ronit R. Furman, Lindsey T. Lands, Geoffrey D. Moodie, Lisa K. Jennings
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2013)
Article
Cardiac & Cardiovascular Systems
Henry E. Speich, Vinay Bhal, Kourtney H. Houser, Alex T. Caughran, Lindsey T. Lands, Aiilyan K. Houng, Jonas Backstrom, Malin Enerback, Guy L. Reed, Lisa K. Jennings
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2014)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)