Article
Medicine, General & Internal
Paula Savola, Marja Lemponen, Lotta Joutsi-Korhonen, Tuukka A. Helin
Summary: The study found that commercial DOAC removal methods can effectively decrease DOAC concentrations and false positive results in LAC testing. DOAC removal reduces the need for confirmation or mixing tests, thus reducing unnecessary repeated LAC testing.
Article
Pathology
Brenda J. Nelson Strande, Meera Sridharan, Rachel R. Leger, Melissa S. Stuart, Julie Tange, Serena D. Navitska, Nahla Heikal, Aneel A. Ashrani, Dong Chen, Jansen N. Seheult, Rajiv K. Pruthi
Summary: This study investigated the impact of residual platelets in frozen-thawed plasma on the dilute Russell's viper venom time (DRVVT) assay. The results showed that residual platelets in plasma samples resulted in a shortening of DRVVT assay results after one freeze-thaw cycle, which may lead to false-negative LAC test results.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Hematology
Bob Smit, Francisca Hudig, Jan-Hendrik Venhuizen, Saskia Haitjema, Maarten Limper, Rolf Urbanus, Albert Huisman
Summary: Although routine screening of the general hospital population is discouraged, a lupus sensitive activated partial thromboplastin time test (aPTT) can be used by medical laboratories to screen for lupus anticoagulant (LA). LA testing is laborious and time-consuming, while aPTT is fully automated and easily interpreted. Therefore, a normal LA sensitive aPTT result can be used to reduce the need for costly LA testing in the absence of strong clinical suspicion.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Hematology
Gary W. Moore
Summary: Lupus anticoagulant (LA) is an important criterion for the classification and diagnosis of antiphospholipid syndrome. The detection of LA is based on the functional behavior of antibodies in coagulation assays. However, no single screening test is sensitive to all LA, and no test is specific for LA. Various screening tests are available, but the combination of dilute Russell's viper venom time and LA-sensitive activated partial thromboplastin time is widely used. Other assays, such as dilute prothrombin time and Taipan snake venom time with ecarin time confirmatory test, can also improve diagnostic performance.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Emmanuel J. Favaloro, Elysse Dean, Sandya Arunachalam
Summary: Lupus anticoagulant (LA) is one of the laboratory criteria for diagnosing antiphospholipid syndrome (APS). Guidelines recommend using different clot-based tests to assess the presence of LA. Variability in test reagents and processes can affect the results.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Sport Sciences
Ana L. Bertolaccini, Aline Alves da Silva, Emerson L. Teixeira, Brad J. Schoenfeld, Vitor de Salles Painelli
Summary: This study investigated whether the expectancy of subjects on static stretching effects could influence strength-endurance performance. The manipulation of subjects' expectancy showed that positive information about static stretching improved performance in the last set of exercise, while negative information did not have a significant impact. Expectancy may play a partial role in influencing strength-endurance performance.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Hematology
Gary W. Moore, Eleanor Foxton, Sean Platton, Nada Yartey, Danielle White, Stephen G. MacDonald
Summary: This study investigated the frequency of single LA assay positivity in triple-positive patients and found that a significant proportion of patients may be positive in one of the assays, posing a significant risk for misdiagnosis and inappropriate management through single LA assay repertoires.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Veterinary Sciences
Natalia Camila Minucci Bonatto, Lais Sodre Santana Alves, Luara Evangelista Silva, Carolina Aparecida Milhorine, Luiz Daniel de Barros, Julian Andrade Santos, Breno Fernando Martins de Almeida, Karina Keller Marques da Costa Flaiban
Summary: This study evaluated the interference of postprandial lipemia on blood gas parameters and acid-base status. The results showed that postprandial lipemia does not interfere with blood gas analysis but can affect variables used to assess acid-base status.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Hematology
Naruto Shimonishi, Kenichi Ogiwara, Yukio Oda, Toshiki Kawabe, Mari Emmi, Midori Shima, Keiji Nogami
Summary: The study demonstrated that the mixing test based on CWA can effectively differentiate between HA, HA-inh, and LA by using different mix ratios and incubation periods. Specifically, plasma samples in a 1:1 mix ratio showed significant differences between HA-inh and LA, while samples in 9:1 and 1:9 mix ratios could fully distinguish HA-inh from LA. The inhibitor index values obtained from the mixing tests were highly correlated with inhibitor titers below 40 BU/mL, potentially allowing for estimation of FVIII inhibitor titers.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pharmacology & Pharmacy
L. Puccetti, V Sammartano, P. Calzoni, F. Bacchiarri, A. Santoni, D. Fineschi, M. Bocchia
Summary: During the COVID-19 pandemic, switching to edoxaban may be a safe and effective option for patients with previous unprovoked VTE/PE who are no longer eligible for VKA treatment due to the difficulty of performing INR tests.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yi-Min Kuo, Hsien-Yung Lai, Elise Chia-Hui Tan, Yi-Shiuan Li, Ting-Yun Chiang, Shiang-Suo Huang, Wen-Cheng Huang, Ya-Chun Chu
Summary: GlideScope achieved equivalent performance in nasotracheal intubation (NTI) with or without cervical immobilization. The upper lip bite test class was predictive of intubation time, the necessity of auxiliary manipulations, and a nasoIDS >= 4.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Roncati, Lorenzo Corsi, Giuseppe Barbolini
Summary: The study presented a catastrophic case of COVID-19 in a 44-year-old male patient from the Philippines, showing similarities to Asherson's syndrome. Both diseases share common features including hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation, and high mortality rates, suggesting a potential genetic predisposition for these conditions.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Biochemistry & Molecular Biology
Soumya Sengupta, Gargee Bhattacharya, Subhasmita Mohanty, Shubham K. K. Shaw, Gajendra M. M. Jogdand, Rohila Jha, Prakash K. K. Barik, Jyoti R. R. Parida, Satish Devadas
Summary: Systemic lupus erythematous (SLE) is a chronic autoimmune disorder characterized by systemic inflammation and diverse clinical manifestations. SLE patients have higher levels of activated, inflamed, and hyper-polarized CD8(+) T cells, dysregulated CD8(+) T cell differentiation, elevated inflammatory cytokines, and increased accumulation of cellular ROS compared to healthy controls. The differential phenotype and redox response of SLE CD8(+) T cells and Tc1 cells may be attributed to their cytokine environments during their differentiation and activation. The inflammatory cytokine environment in SLE may drive the extreme aberrancy in SLE CD8(+) T cells.
Article
Hematology
Suhyeon Woo, Bohyun Kim, Nam Hun Heo, Min-Sun Kim, Young Ahn Yoon, Young-Jin Choi
Summary: This study investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. The results showed that LA positivity could be an indicator of more severe infection, but it was not associated with thrombotic complications or mortality.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Review
Hematology
Emmanuel J. Favaloro, Leonardo Pasalic
Summary: This review discusses the interference of anticoagulants on LA testing and presents strategies to mitigate such interference.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Letter
Hematology
Li Li, Dana Huskens, Lisa Florin, Bas de Laat, Mark Roest, Katrien M. J. Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The study evaluated the traditional 40/80-unit thresholds used for categorization of antiphospholipid antibodies in different analytical systems, and found that alternative thresholds can improve consistency in interpretation. By using different thresholds, the positivity levels of antiphospholipid antibodies can be more accurately assessed.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Pauline Vermeiren, Arne Vandevelde, Harlinde Peperstraete, Katrien M. J. Devreese
Summary: This study compared the effectiveness of global coagulation assays, including thrombin generation assay (TGA), with the anti-Xa assay for monitoring heparin therapy. The results showed that the TGA may not be sensitive enough for low concentrations of low molecular weight heparin (LMWH), but it could be a useful additional tool for monitoring heparin therapy in heparin-resistant patients.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Review
Medicine, General & Internal
Arne Vandevelde, Katrien M. J. Devreese
Summary: The diagnosis and risk stratification of antiphospholipid syndrome (APS) are complex and require various laboratory tests. Efforts to standardize and optimize these tests are ongoing to improve diagnostic accuracy and repeatability. There are challenges in laboratory testing, such as interference by anticoagulation therapy for LAC detection and high variability due to different reagents and detection techniques.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Thomas Foret, Virginie Dufrost, Marie Heymonet, Jessie Risse, Gilbert C. Faure, Huguette Louis, Jeremy Lagrange, Patrick Lacolley, Katrien Devreese, Sebastien Gibot, Veronique Regnault, Stephane Zuily, Denis Wahl
Summary: This study demonstrated that the levels of circulating endothelial cells (CECs) were associated with thromboembolic events in patients with antiphospholipid antibody (aPL) and/or autoimmune diseases.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Veterinary Sciences
Despoina Georgaki, Femke Vandael, Helena Cardoso de Carvalho Ferreira, Maria Eleni Filippitzi, Patrick De Backer, Mathias Devreese, Jeroen Dewulf, Siska Croubels
Summary: This study conducted a qualitative risk assessment to estimate the risks associated with reduced homogeneity and stability, as well as increased residual concentrations of antimicrobial drugs in medicated feed and drinking water on pig farms. Factors such as human error during the preparation of medicated feed and dosing pump type for medicated drinking water were found to pose moderate to high risks. It is crucial to identify and understand these factors in order to ensure the effectiveness and safety of antimicrobial drug treatment.
BMC VETERINARY RESEARCH
(2023)
Letter
Anesthesiology
Michael Vandenheuvel, Korneel Vandewiele, Carla Van Gompel, Pieter M. De Kesel, Piet Wyffels, Filip De Somer, Katrien M. J. Devreese, Patrick F. Wouters
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Rachel Gehlen, Arne Vandevelde, Bas de Laat, Katrien M. J. Devreese
Summary: This systematic review examined if the thrombin generation (TG) assay could be useful for the diagnosis and risk assessment of antiphospholipid syndrome (APS). The findings suggest that APS patients have increased aPC resistance compared to healthy and thrombotic controls, but its diagnostic and prognostic value compared to current strategies is unclear. More research is needed to determine the potential added value of other TG parameters in APS diagnosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Meeting Abstract
Hematology
Katrien Devreese
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Arne Vandevelde, Luna Crevits, Katrien M. J. Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Pauline Vermeiren, Arne Vandevelde, Katrien M. J. Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Delphine De Smet, Dimitri Hemelsoet, Katrien Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Hematology
Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: Currently, the added value of antiphosphatidylserine/prothrombin antibodies testing in the diagnosis of obstetric antiphospholipid syndrome seems limited compared with other antibodies. However, it may be useful in specific subsets of patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Eleni A. Linskens, Pieter De Kesel, Katrien M. J. Devreese
Summary: This study evaluated the effectiveness of DOAC Filter (DF) in removing DOAC interference in LAC testing. DF was found to effectively eliminate DOAC interference in LAC testing and had an impact on the LAC assay results. Therefore, DF should be used for filtration when performing DOAC measurements.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
