Thrombin-induced platelet activation via PAR4: pivotal role for exosite II

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner

(2012) D. Jonnalagadda et al.   BLOOD

PKC inhibition markedly enhances Ca2+ signaling and phosphatidylserine exposure downstream of protease-activated receptor-1 but not protease-activated receptor-4 in human platelets

(2011) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin Inhibition by Serpins Disrupts Exosite II

(2010) Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

(2010) Prafull S. Gandhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined blockade of thrombin anion binding exosite-1 and PAR4 produces synergistic antiplatelet effect in human platelets

(2010) C.-C. Wu et al.   THROMBOSIS AND HAEMOSTASIS

Suboptimal Activation of Protease-activated Receptors Enhances α2β1Integrin-mediated Platelet Adhesion to Collagen

(2009) Robin J. Marjoram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyphosphate binds with high affinity to exosite II of thrombin

(2009) N. J. MUTCH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin

(2009) S. M. Nimjee et al.   RNA

Fibrinogen-elongated γ Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors

(2008) Stefano Lancellotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase

(2008) J. MÜLLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS