Article
Hematology
Myrthe M. A. Toorop, Nienke van Rein, Melchior C. Nierman, Helga W. Vermaas, Menno Huisman, Felix J. M. van der Meer, Suzanne C. Cannegieter, Willem M. Lijfering
Summary: The study found that the inter-individual variability of DOAC concentrations was higher than intra-individual variability, and lower previous VKA dosage and creatinine clearance were associated with higher DOAC trough concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Ryohei Ono, Kazutaka Nishimura, Hidehisa Takahashi, Yasuhiko Hori, Kenichi Fukushima, Yoshio Kobayashi
Summary: This study measured the levels of anti-factor Xa activity (AXA), prothrombin time (PT), and activated partial thromboplastin time (APTT) in patients with venous thromboembolism (VTE) or non-valvular atrial fibrillation (NVAF) who were administered apixaban, edoxaban, and rivaroxaban. Each FXa inhibitor showed different ranges of AXA values, and higher AXA values were observed with twice-daily use compared to once-daily use. Different dosages of the inhibitors also resulted in variations in AXA values.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Hematology
Bjorn Dahlback, Sinh Tran
Summary: This study aimed to identify the specific part of preAR2 required for the synergistic TFPI alpha-cofactor activity between FV-short and protein S. Results showed that FV709-1476, FV712-1478, and FV712-1481 exhibited full synergistic activity with protein S, while FV712-1484 showed intermediate activity and FV712-1487 and FV712-1490 were inactive.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Bjorn Dahlback, Sinh Tran
Summary: The research elucidated the mechanisms behind the synergistic activity between FV756-1458 and protein S as TFPI alpha cofactors, showing that the presence of the preAR2 region is crucial for this synergism.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Jahanzeb Malik, Nismat Javed, Matiullah Kamin
Summary: Heparin-induced thrombocytopenia (HIT) is an immune-mediated condition that causes thrombocytopenia and paradoxical thrombosis after exposure to heparin or low-molecular-weight heparin. Fondaparinux, an artificial pentasaccharide similar to heparin, has been rarely reported to cause HIT. This manuscript presents a case of HIT associated with fondaparinux use.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Pancras C. Wong, Earl Crain
Summary: This study calibrated the rabbit model against apixaban and correlated its effects with in vivo therapeutic drug exposure levels in AF patients. The study found that achieving human-equally-effective plasma concentrations to the rabbit ECAT may result in clinical efficacy in patient populations like AF.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Hematology
Pancras C. Wong, Earl J. Crain, Jeffrey M. Bozarth, Yiming Wu, Andrew K. Dilger, Ruth R. Wexler, William R. Ewing, David Gordon, Joseph M. Luettgen
Summary: Milvexian is an effective antithrombotic agent with limited impact on hemostasis, even when combined with aspirin. The study results suggest that Milvexian has a wide therapeutic window for antithrombotic therapy.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas A. Zelniker, Maddalena Ardissino, Felicita Andreotti, Michelle L. O'Donoghue, Ophelia Yin, Jeong-Gun Park, Sabina A. Murphy, Christian T. Ruff, Hans J. Lanz, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano, Piera Angelica Merlini
Summary: Despite baseline differences and higher endogenous factor Xa levels in women, anticoagulation intensity with edoxaban was similar between sexes. Higher-dose edoxaban regimen showed greater reduction in hemorrhagic stroke and serious bleeding outcomes in women compared to men. Efficacy profile was similar between sexes.
Article
Cardiac & Cardiovascular Systems
Meina Lv, Tingting Wu, Shaojun Jiang, Wenjun Chen, Jinhua Zhang
Summary: Patients with atrial fibrillation who take DOACs have a lower risk of intracranial hemorrhage compared to VKAs, with dabigatran 110 mg being the safest choice. Rivaroxaban 20 mg presents a relatively higher risk of ICH in this population.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Hematology
Amanda M. Marshall, Taylor M. Trussell, Addison M. Yee, Mathew P. Malone
Summary: The study revealed that over 20% of pediatric patients in intensive care units receiving enoxaparin for VTE prophylaxis had serum anti-Xa levels consistent with therapeutic anticoagulation, with 5% achieving supratherapeutic anticoagulation levels. There was no correlation between serum anti-Xa levels and dosing frequency, body mass index, or creatinine levels, but blood urea nitrogen levels were found to have a positive association with anti-Xa levels above 0.5 units/mL. Routine monitoring of anti-Xa levels during VTE prophylaxis may be warranted to prevent unintended therapeutic anticoagulation.
THROMBOSIS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Shin-Yi Lin, Ching-Hua Kuo, Li-Ting Ho, Yen-Bin Liu, Chih-Fen Huang, Sung-Chun Tang, Jiann-Shing Jeng
Summary: The study identified factors associated with increased or decreased edoxaban exposure. Higher trough concentrations were associated with higher creatinine clearance and the use of the 30 mg regimen, while higher peak concentrations were associated with an off-label overdosing regimen.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martina Havrdova, Teijo I. Saari, Jouko Jalonen, Marko Peltoniemi, Mika Kurkela, Tero Vahlberg, Anri Tienhaara, Janne T. Backman, Klaus T. Olkkola, Alexey Schramko
Summary: The study evaluated the relationship between edoxaban plasma concentrations and viscoelastic measurement parameters, showing a significant correlation between ROTEM CT and edoxaban plasma concentrations. This suggests that ROTEM CT can be used to estimate the effect of edoxaban on anticoagulation activity.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Hematology
Floris T. M. Bosch, Frits Mulder, Menno Huisman, Jeffrey Zwicker, Marcello Di Nisio, Marc Carrier, Annelise Segers, Peter Verhamme, Saskia Middeldorp, Jeffrey Weitz, Michael A. Grosso, Anil Duggal, Harry R. Buller, Tzu-Fei Wang, David Garcia, Pieter Willem Kamphuisen, Gary E. Raskob, Nick van Es
Summary: In gastrointestinal cancer patients receiving edoxaban, advanced cancer and low hemoglobin levels were significantly associated with an increased risk of gastrointestinal bleeding. However, further research is needed to identify other risk factors.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Caitlyn Whitaker, Amanda McKinney, Reagan Bollig, Nathan Hieb, R. Frank Roberts, A. Shaun Rowe
Summary: This study found no significant difference in rates of thrombosis or bleeding events between obese and non-obese patients who received aPCC for reversal of apixaban and rivaroxaban.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Hematology
Giuseppe Boriani, Christian T. Ruff, Julia F. Kuder, Minggao Shi, Hans J. Lanz, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano
Summary: This study analyzed the pharmacokinetics/pharmacodynamics and clinical outcomes of patients receiving different anticoagulant treatments at extremes of body weight. Edoxaban showed similar efficacy compared with warfarin, with the most favorable outcomes in terms of non-major bleeding and net clinical results in LBW patients.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Rehabilitation
Richard Crevenna, Franz Kainberger, Christoph Wiltschke, Christine Marosi, Michael Wolzt, Fadime Cenik, Mohammad Keilani
DISABILITY AND REHABILITATION
(2020)
Article
Pharmacology & Pharmacy
Ludwig Traby, Marietta Kollars, Alexandra Kaider, Jolanta M. Siller-Matula, Martin F. Wolkersdorfer, Michael Wolzt, Paul A. Kyrle, Sabine Eichinger
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Cardiac & Cardiovascular Systems
Guenter Stix, Michael Wolzt, Hans Domanovits, Pavla Kadlecova, Bernhard Husch, Michaela Trebs, Juri Hodisch, Martin Unger, Guenther Krumpl
CIRCULATION JOURNAL
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabian Niess, Albrecht Ingo Schmid, Wolfgang Bogner, Michael Wolzt, Pierre Carlier, Siegfried Trattnig, Ewald Moser, Martin Meyerspeer
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Medicine, General & Internal
Stefan Traussnigg, Emina Halilbasic, Harald Hofer, Petra Munda, Tatjana Stojakovic, Guenter Fauler, Karl Kashofer, Martin Krssak, Michael Wolzt, Michael Trauner
Summary: In non-diabetic NAFLD patients, the non-steroidal FXR agonist PX-104 improved insulin sensitivity and liver enzymes after 4 weeks of treatment. While hepatic steatosis and other measures did not change, alterations in fecal BAs and gut microbiota warrant further investigation.
WIENER KLINISCHE WOCHENSCHRIFT
(2021)
Article
Pharmacology & Pharmacy
Ludwig Traby, Marietta Kollars, Alexandra Kaider, Jolanta Maria Siller-Matula, Oskar Steinbrecher, Michael Wolzt, Paul Alexander Kyrle, Sabine Eichinger
Summary: Both DAPT and SAPT have similar effects on platelet and coagulation activation in venous blood.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Applied
Astrid Pany, Marie Wohlgenannt, Safoura Klopprogge, Michael Wolzt, Thomas Heuser, Harald Kotisch, Claudia Valenta, Victoria Klang
Summary: The study evaluated the effect of HP-beta-CD in cosmetic submicron emulsions and emulsion gels on physiological skin parameters during regular application. The results showed that both submicron emulsions and gels had satisfactory storage stability and good skin tolerability, without significant effects on skin barrier function.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2021)
Article
Medicine, General & Internal
Rainer Oberbauer, Matthias Edinger, Gabriela Berlakovich, Peter Kalhs, Nina Worel, Georg Heinze, Michael Wolzt, Thomas Lion, Thomas Wekerle
Summary: This study aims to investigate whether treatment with recipient Tregs and donor BM can lead to transient chimerism in kidney transplant recipients, potentially offering a new therapeutic option for immunomodulation in organ transplantation.
FRONTIERS IN MEDICINE
(2021)
Article
Geriatrics & Gerontology
Safoura Sheikh Rezaei, Hana Sinkovec, Alexander Schoeberl, Christoph Rinner, Georg Heinze, Michael Wolzt, Walter Gall
Summary: This study aimed to estimate the utilization of PIM and incidence of ADE in older adults with CKD. The research found that despite the high utilization of PIM, only a small number of these drugs eventually led to hospitalization due to ADE, suggesting an assessment of potential ADE severity to a PIM list is prudent.
Article
Multidisciplinary Sciences
Stefan Wampl, Tito Koerner, Ladislav Valkovic, Siegfried Trattnig, Michael Wolzt, Martin Meyerspeer, Albrecht Ingo Schmid
Summary: The study investigated the impact of heart geometry and metabolic activity variations over the cardiac cycle on P-31 MRS data quality and metabolite ratios. By triggering acquisitions to end-systole, improved signal amplitudes and fit quality were observed. The study concluded that triggering to end-systole is superior to triggering to diastasis.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Claudia Vater, Alexandra Apanovic, Christoph Riethmuller, Brigitte Litschauer, Michael Wolzt, Claudia Valenta, Victoria Klang
Summary: The study evaluated the effects of pure lecithins compared to conventional surfactants on skin, with results indicating better skin tolerability with lecithin-based surfactants and encouraging further investigation.
Article
Medicine, General & Internal
Thomas Perkmann, Nicole Perkmann-Nagele, Thomas Koller, Patrick Mucher, Astrid Radakovics, Michael Wolzt, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: Individuals with previous SARS-CoV-2 infection showed significantly higher antibody response after receiving the first dose of the Pfizer vaccine compared to those who were naive to the virus. This suggests the need for further research on whether individuals with prior infection would benefit from a two-dose vaccination schedule or if the second doses could be saved for others in need.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Public, Environmental & Occupational Health
Jasmina Preinreich, Safoura Sheikh Rezaei, Martina Mittlboeck, Stefan Greisenegger, Berthold Reichardt, Michael Wolzt
Summary: In Austria, NOAC treatment is associated with a lower risk of stroke recurrence compared to VKA, but with increased mortality. The study found that diabetes, cardiovascular disease, and age are significant factors influencing stroke recurrence or death.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Article
Multidisciplinary Sciences
Karolina Samekova, Christa Firbas, Johanna Irrgeher, Christine Opper, Thomas Prohaska, Anika Retzmann, Cornelius Tschegg, Claudia Meisslitzer, Anastassiya Tchaikovsky, Ghazaleh Gouya, Michael Freissmuth, Michael Wolzt
Summary: Oral intake of purified clinoptilolite tuff can reduce enteral uptake of Pb-204 in healthy humans by approximately 90%, leading to a decrease in lead toxicity.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Janine Kutzsche, Dagmar Jurgens, Antje Willuweit, Knut Adermann, Carola Fuchs, Stefanie Simons, Manfred Windisch, Michael Humpel, Wolfgang Rossberg, Michael Wolzt, Dieter Willbold
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2020)