Journal
THROMBOSIS AND HAEMOSTASIS
Volume 101, Issue 4, Pages 613-618Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH08-11-0726
Keywords
Chemokines; collagens; wound healing
Categories
Funding
- NHLBI NIH HHS [R01 HL073848, R01 HL073848-10, R01 HL098329, R01 HL098329-01A1] Funding Source: Medline
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Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express markers of leukocytes, haematopoietic progenitor cells, and fibroblasts. They play a pivotal role in tissue remodelling and fibrosis in both physiologic and pathologic settings. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature.
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