Article
Cardiac & Cardiovascular Systems
Jenifer M. Brown, Wunan Zhou, Brittany Weber, Sanjay Divakaran, Leanne Barrett, Courtney F. Bibbo, Jon Hainer, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Summary: Insufficient myocardial perfusion to match global metabolic demand may be a risk marker for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Review
Multidisciplinary Sciences
Jaber S. Alqahtani, Tope Oyelade, Abdulelah M. Aldhahir, Renata Goncalves Mendes, Saeed M. Alghamdi, Marc Miravitlles, Swapna Mandal, John R. Hurst
Summary: Studies have shown a 50% reduction in hospital admissions for COPD exacerbations during the COVID-19 pandemic, likely due to a decrease in respiratory viral infections. However, the rate of community-treated exacerbations remains inconclusive, and there is not a significant relationship between exacerbation reduction and the COVID-19 Containment and Health Index. Future guidelines should include recommendations on respiratory virus infection control measures to reduce the burden of COPD exacerbations beyond the pandemic period.
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Editorial Material
Cardiac & Cardiovascular Systems
Lucia La Sala, Antonio E. Pontiroli
Summary: The study reveals a clear association between diabetes and heart diseases, but fails to mention the role of body mass index and hypertension. Future research should focus on assessing the impact of obesity and hypertension on heart disease incidence.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yoshiaki Kubota, Wan Ting Tay, Tiew-Hwa Katherine Teng, Kuniya Asai, Takashi Noda, Kengo Kusano, Atsushi Suzuki, Nobuhisa Hagiwara, Shinji Hisatake, Takanori Ikeda, Ryobun Yasuoka, Takashi Kurita, Wataru Shimizu
Summary: This study investigated the impact of cardio-selective and non-cardio-selective beta-blockers on the long-term outcomes of patients with HF and COPD. The results showed a significant decrease in cardiovascular mortality in the non-cardio-selective beta-blocker group, while no significant decrease was observed in the cardio-selective beta-blocker group.
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Cardiac & Cardiovascular Systems
Davood Javidgonbadi, Maria Schaufelberger, Ingegerd Ostman-Smith
Summary: Several studies have reported higher disease-related mortality in females with obstructive hypertrophic cardiomyopathy (oHCM) compared to males. This study aimed to compare risk factors for disease-related death between sexes in a geographical cohort of oHCM patients. The results showed that females had a higher disease-related mortality rate and more advanced septal hypertrophy at diagnosis. Calcium-blocker therapy was a risk factor that was used more frequently in females. However, a higher dose of beta-blocker therapy reduced the risk of disease-related death in both males and females. This study highlights the importance of addressing sex disparities in the diagnosis and pharmacological therapy for oHCM patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Respiratory System
Paul Leong, Martin I. MacDonald, Paul T. King, Christian R. Osadnik, Brian S. Ko, Shane A. Landry, Kais Hamza, Ahilan Kugenasan, John M. Troupis, Philip G. Bardin
Summary: Dynamic CT can detect clinically silent CAD and HFrEF during hospitalised AECOPD, offering opportunities to improve outcomes through established cardiac treatments. The prevalence of severe CAD was 35%, left ventricular systolic dysfunction was found in 8% of cases, and right ventricular systolic dysfunction was present in 12% of cases among patients with hospitalised AECOPD.
Article
Cell Biology
Rashmi Rana, Vivek Ranjan, Naveen Kumar, Parul Chugh, Kamini Khillan, Atul Gogia, Devinder Singh Rana, Nirmal Kumar Ganguly
Summary: This study examines the impact of diabetes, hypertension, and chronic kidney disease on the prognosis and mortality of COVID-19 infection. The results show that all comorbidities are significantly associated with ICU admission and mortality. CKD has the highest relative risk of severity and mortality, followed by hypertension and diabetes. The risk of ICU admission and mortality increases with the number of underlying comorbidities. Younger patients with underlying comorbidities are at higher risk of severity and mortality compared to elderly patients with similar conditions. Females also have a higher risk of mortality compared to males with the same comorbid conditions, except for hypertensive patients. Diabetes, hypertension, and CKD are all associated with the progression and higher mortality risk of COVID-19.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Didier Collard, Nick S. Nurmohamed, Yannick Kaiser, Laurens F. Reeskamp, Tom Dormans, Hazra Moeniralam, Suat Simsek, Renee Douma, Annet Eerens, Auke C. Reidinga, Paul W. G. Elbers, Martijn Beudel, Liffert Vogt, Erik S. G. Stroes, Bert-Jan H. van den Born
Summary: Recent studies have shown a correlation between hypertension, dyslipidaemia, and diabetes in COVID-19 patients, leading to an increased risk of short-term mortality independent of age and sex. Further research is needed to understand how these risk factors impact COVID-19 patients differently.
Article
Cardiac & Cardiovascular Systems
Jakub Lagan Lekarz, Erik B. Schelbert, Josephine H. Naish, Jorgen Vestbo, Christien Fortune, Joshua Bradley, John Belcher, Edward Hearne, Foluwakemi Ogunyemi, Richard Timoney, Daniel Prescott, Hamish D. C. Bain, Tasneem Bangi, Mahvash Zaman, Christopher Wong, Anthony Ashworth, Helen Thorpe, Robin Egdell, Jerome McIntosh, Bruce R. Irwin, David Clark, Graham Devereux, Jennifer K. Quint, Richard Barraclough, Matthias Schmitt, Christopher A. Miller
Summary: This study identified an association between COPD and heart failure, with myocardial fibrosis potentially serving as a pathophysiological link between the two conditions. Myocardial fibrosis was independently associated with hospitalization for heart failure and all-cause mortality.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Respiratory System
Leila Karimi, Lies Lahousse, Phebe De Nocker, Bruno H. Stricker, Guy G. Brusselle, Katia M. C. Verhamme
Summary: Observational studies have shown a reduction in COPD exacerbations in patients treated with beta-blockers, but the BLOCK COPD trial found an increase in exacerbations in COPD patients without cardiovascular conditions. The study found that current use of cardioselective beta-blockers was associated with a reduced risk of exacerbations in COPD patients with cardiovascular disease, while there was no significant association in those without cardiovascular conditions. This suggests that the potential benefits of beta-blockers may be limited to COPD patients with cardiovascular disease.
Review
Environmental Sciences
Liliane R. Teixeira, Frank Pega, Angel M. Dzhambov, Alicja Bortkiewicz, Denise T. Correa da Silva, Carlos A. F. de Andrade, Elzbieta Gadzicka, Kishor Hadkhale, Sergio Iavicoli, Martha S. Martinez-Silveira, Malgorzata Pawlaczyk-Luszczynska, Bruna M. Rondinone, Jadwiga Siedlecka, Antonio Valenti, Diana Gagliardi
Summary: This study systematically reviewed and meta-analyzed the effects of occupational noise exposure on cardiovascular disease. The evidence quality was deemed low, with uncertainty surrounding the relationship between occupational noise exposure and cardiovascular disease due to limitations and low certainty.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Clinical Neurology
Anqi Duan, Zhihua Huang, Meixi Hu, Zhihui Zhao, Qing Zhao, Qi Jin, Lu Yan, Yi Zhang, Xin Li, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study retrospectively analyzed data from 450 patients with pre-capillary pulmonary hypertension and found that the presence and severity of obstructive sleep apnea (OSA) were closely associated with left ventricular function, comorbidity burden, and disease phenotype. OSA was relatively common in pre-capillary pulmonary hypertension patients and was independently associated with various comorbidities and the atypical phenotype, highlighting the importance of OSA as a modifiable factor for optimal treatment in pre-capillary pulmonary hypertension with comorbidities.
Article
Cardiac & Cardiovascular Systems
Gerhard-Paul Diller, Dominic Enders, Astrid E. Lammers, Stefan Orwat, Renate Schmidt, Robert M. Radke, Joachim Gerss, Fernando De Torres Alba, Gerrit Kaleschke, Ulrike M. Bauer, Ursula Marschall, Helmut Baumgartner
Summary: This study analyzed data on the morbidity and mortality of severe viral pneumonia requiring hospital admission in patients with congenital heart disease (CHD) from 2005-2018. The study found that patients with CHD had higher mortality rates compared to those without CHD, with younger CHD patients having mortality rates equivalent to older non-CHD individuals. Risk factors for adverse outcomes included age, CHD complexity, chromosomal anomalies, cardiac medication, use of immunosuppressants, and lack of influenza vaccination.
Letter
Critical Care Medicine
Mihaela S. Stefan, Brian H. Nathanson, Peter K. Lindenauer
CRITICAL CARE MEDICINE
(2015)
Article
Critical Care Medicine
Mihaela S. Stefan, Brian H. Nathanson, Aruna Priya, Penelope S. Pekow, Tara Lagu, Jay S. Steingrub, Nicholas S. Hill, Robert J. Goldberg, David M. Kent, Peter K. Lindenauer
Article
Immunology
Raquel K. Belforti, Tara Lagu, Sarah Haessler, Peter K. Lindenauer, Penelope S. Pekow, Aruna Priya, Marya D. Zilberberg, Daniel Skiest, Thomas L. Higgins, Mihaela S. Stefan, Michael B. Rothberg
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Medicine, General & Internal
Mihaela S. Stefan, Aruna Priya, Benjamin Martin, Penelope S. Pekow, Michael B. Rothberg, Robert J. Goldberg, Ernest DiNino, Peter K. Lindenauer
JOURNAL OF HOSPITAL MEDICINE
(2016)
Article
Health Care Sciences & Services
Ernest DiNino, Mihaela S. Stefan, Aruna Priya, Benjamin Martin, Penelope S. Pekow, Peter K. Lindenauer
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2016)
Article
Critical Care Medicine
Brian H. Nathanson, Thomas L. Higgins, Mihaela Stefan, Tara Lagu, Peter K. Lindenauer, Jay S. Steingrub
JOURNAL OF CRITICAL CARE
(2019)
Article
Cardiac & Cardiovascular Systems
Mihaela Tiru, Anis John Kadado, Vida Rastegar, Kanval Shah, Kirti K. Joshi, Peter Lindenauer, Tara Lagu, Mihaela S. Stefan
Article
Health Care Sciences & Services
Mihaela S. Stefan, Doug Salvador, Tara K. Lagu
AMERICAN JOURNAL OF MEDICAL QUALITY
(2021)
Article
Critical Care Medicine
Mihaela S. Stefan, Penelope S. Pekow, Aruna Priya, Richard ZuWallack, Kerry A. Spitzer, Tara C. Lagu, Quinn R. Pack, Victor M. Pinto-Plata, Kathleen M. Mazor, Peter K. Lindenauer
Summary: Initiating pulmonary rehabilitation within 90 days of discharge can reduce the risk of rehospitalization for COPD patients among Medicare beneficiaries. These findings support results from randomized controlled clinical trials and emphasize the importance of identifying effective strategies to increase participation in pulmonary rehabilitation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Mihaela S. Stefan, Penelope S. Pekow, Christopher M. Shea, Ashley M. Hughes, Nicholas S. Hill, Jay S. Steingrub, Mary Jo S. Farmer, Dean R. Hess, Karen L. Riska, Taylar A. Clark, Peter K. Lindenauer
Summary: There is significant variation in NIV use across hospitals, impacting morbidity and mortality rates. Researchers aimed to improve NIV uptake in COPD patients by studying the effectiveness of online education versus interprofessional education strategies, making adjustments to their study design due to the COVID-19 pandemic.
Article
Medicine, General & Internal
Mihaela S. Stefan, Ahmed Eltanbedawi, Neil C. Devoe, Sabiha Khan, Ya Zhou, Taroob Latef, Anthony Esposito, Anum Fatima, Alexander B. Knee, Tara C. Lagu
Summary: This study found that slightly less than half (40%) of patients who died of complications of COVID-19 had unexpected deaths. For the 60% of patients for whom death was not a surprise, the findings suggest opportunities to improve end-of-life discussions and implement shared decision-making in high-risk patients early on or prior to hospitalization.
JOURNAL OF HOSPITAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Mihaela S. Stefan, Alexander B. Knee, Audrey Ready, Vida Rastegar, Jennifer Burgher Seaman, Bridget Gunn, Ehryn Shaw, Raveendhara R. Bannuru
Summary: This meta-analysis examined the effectiveness of non-physician provider-led palliative care interventions on patient-reported outcomes and advance care planning. The results showed no significant improvement in quality of life, anxiety, or depression, but a positive impact on advance care planning discussions and documentation.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Respiratory System
Laura C. Maclagan, Fangyun Wu, Ning Liu, Peter Tanuseputro, Therese A. Stukel, Jun Guan, Tetyana Kendzerska, Mihaela S. Stefan, Peter K. Lindenauer, Andrea S. Gershon
Summary: This study examined the association between palliative care and rates of days at home, locations of death, and acute healthcare use in patients with COPD. The results showed that receiving palliative care did not reduce days at home or healthcare use, but was associated with a slight increase in the proportion of patients who died at home.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Rebecca S. Starr, Mihaela S. Stefan
HOSPITAL MEDICINE CLINICS
(2016)
Article
Respiratory System
Mihaela S. Stefan, Brian H. Nathanson, Tara Lagu, Aruna Priya, Penelope S. Pekow, Jay S. Steingrub, Nicholas S. Hill, Robert J. Goldberg, David M. Kent, Peter K. Lindenauer
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2016)