Article
Critical Care Medicine
Daniel J. Tan, Caroline J. Lodge, E. Haydn Walters, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, Jonathan Pham, Bircan Erbas, Jennie Hui, Garun S. Hamilton, Paul S. Thomas, Mark Hew, George Washko, Richard Wood-Baker, Michael J. Abramson, Jennifer L. Perret, Shyamali C. Dharmage
Summary: This study aimed to characterize the longitudinal phenotypes of asthma and identified five distinct longitudinal asthma phenotypes. The results showed differential effects of these phenotypes on the risk of chronic obstructive pulmonary disease and nonrespiratory comorbidities at age 53 years.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Ya-Bin Hu, Yi-Ting Chen, Shi-Jian Liu, Fan Jiang, Mei-Qin Wu, Chong-Huai Yan, Jian-Guo Tan, Guang-Jun Yu, Yi Hu, Yong Yin, Jia-Jie Qu, Sheng-Hui Li, Shi-Lu Tong
Summary: The prevalence of childhood asthma in Shanghai has dramatically increased over the past three decades. Potential risk factors include male gender, younger age, preterm delivery, season of birth, elective cesarean section, allergy history, and exposure to passive smoking, latex paint, and dust. Potential protective factors include spending more time outdoors, having indoor plants, and cleaning rooms more frequently.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Allergy
Ji Soo Park, Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu Jung, Minkyu Han, Eunjin Eom, Jinho Yu, Woo Kyung Kim, Dae Hyun Lim, Jin Tack Kim
Summary: This study aimed to predict exacerbation-prone asthma (EPA) in children. The findings suggest that in addition to asthma control level, baseline lung function and white blood cell count are important factors for predicting EPA.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Michael Marget, Yamini V. Virkud, Wayne G. Shreffler, Victoria M. Martin, Qian Yuan
Summary: This study evaluated the timing of allergen introduction in the U.S. and found that updated guidelines, race, and birth order all influenced earlier introduction of peanut. Further research is needed to evaluate current practices and potential disparities in allergen introduction.
FRONTIERS IN PEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Zhen Li, Lianmeng Cao, Ziyu Zhou, Maozhi Han, Chang Fu
Summary: This study aimed to investigate the proportion and influencing factors of prehypertension progressing to hypertension among Chinese middle-aged and elderly populations over a 2-year period. The study found that 28.5% of individuals with prehypertension progressed to hypertension, with higher rates in men. Risk factors for progression differed by sex, including age, obesity, and number of chronic diseases for men, and age, marriage/cohabitation, obesity, and longer naps for women.
Article
Psychology, Educational
Christopher Osterhaus, Susanne Koerber
Summary: This 5-year longitudinal study investigated the development of advanced theory-of-mind (AToM) in German children aged 5 to 10. The study found that core aspects of AToM developed nonlinearly, reaching a milestone around age 7. Different mechanisms may underlie diverse aspects of social cognition in middle childhood.
Article
Pediatrics
Anna Delahunt, Marie C. Conway, Eileen C. O'Brien, Aisling A. Geraghty, Linda M. O'Keeffe, Sharleen L. O'Reilly, Ciara M. McDonnell, Patricia M. Kearney, John Mehegan, Fionnuala M. McAuliffe
Summary: This study found that maternal socio-economic status, children's screen time, and childcare arrangements are associated with eating behaviours in 5-year-old children. Specifically, mothers with lower socio-economic status and children with higher screen time tend to have a greater desire to drink, while childcare exposure is associated with higher scores for the desire to drink.
Article
Public, Environmental & Occupational Health
Young-Ran Lee, Sun-Nam Park, Mi-Ran Lee, Eunjeong Nam
Summary: This study explores how early childhood teachers (ECTs) can improve their personal resilience to adapt to and overcome disasters in the context of early childhood education and care (ECEC). The study found that self-efficacy, resilience, disaster awareness, COVID-19 stress, and work-related stress have effects on the disaster preparedness of ECTs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Respiratory System
Mohammad Talaei, Pauline M. Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergstrom, Seif O. Shaheen
Summary: A study found that different dietary patterns in childhood are associated with lung function and incident asthma in adolescence. A 'health-conscious' diet was positively associated with lung function, while a diet high in processed food was negatively associated with lung function. However, there was no significant association between a 'traditional' diet and lung function or incident asthma.
RESPIRATORY RESEARCH
(2023)
Article
Allergy
Julie Nyholm Kyvsgaard, Bo Lund Chawes, David Lyle George Horner, Laura Marie Hesselberg, Mathias Elsner Melgaard, Signe Kjeldgaard Jensen, Ann-Marie M. Schoos, Jonathan Thorsen, Casper-Emil Tingskov Pedersen, Nicklas Brustad, Klaus Bonnelykke, Hans Bisgaard, Jakob Stokholm
Summary: Asthma-like symptoms in young children are common, and this study investigated the risk factors and their age-related impact on the symptom burden. The results showed that male sex, maternal asthma, low birth weight, maternal antibiotic use, high asthma exacerbation polygenic risk score, and high airway immune score were associated with a higher number of episodes. The impact of certain risk factors increased with age, while others remained stable.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Aya Isumi, Satomi Doi, Manami Ochi, Tsuguhiko Kato, Takeo Fujiwara
Summary: Child maltreatment may hinder the development of resilience and prosocial behavior, leading to behavior problems in early elementary school children.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Pediatrics
Arndis Ros Stefansdottir, Bjorn Runar Ludviksson, Bjorn Ardal, Asgeir Haraldsson
Summary: The study aimed to describe the prevalence of allergic diseases and changes in clinical expression in a birth cohort followed for three decades. Results showed that 46% of Icelandic adults diagnosed with allergic diseases during childhood still had symptoms at the age of 29, usually mild, developing from eczema in infancy to asthma and allergic rhinitis in adulthood.
Article
Public, Environmental & Occupational Health
Teresa Shamah-Levy, Lucia Cuevas-Nasu, Elsa B. Gaona-Pineda, Danae G. Valenzuela-Bravo, Ignacio Mendez Gomez-Humaran, Marco A. Avila-Arcos
Summary: The prevalence of overweight and obesity in school-age children in Mexico is on the rise, with serious repercussions for future health. Increasing consumption of fruits and vegetables can help reduce the prevalence of these conditions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Parasitology
Bo Bodker Jensen, Mie Topholm Bruun, Per Moestrup Jensen, Andreas Kristian Pedersen, Pierre-Edouard Fournier, Sigurdur Skarphedinsson, Ming Chen
Summary: The study in Denmark investigated seroprevalence and seroconversion of Borrelia burgdorferi and Rickettsia spp. among blood donors, finding low rates of borrelia infection and a limited concern for rickettsiosis in the country. Tick bites and seroconversion were not significantly associated with reported symptoms, but the study population commonly experienced unspecific symptoms. Weather conditions and season did not have a significant impact on tick bites or seroconversion.
PARASITES & VECTORS
(2021)
Editorial Material
Medicine, General & Internal
Louis J. Muglia, Katrien Benhalima, Stephen Tong, Susan Ozanne
Summary: This article explores the importance of improving pregnancy health for the lifelong well-being of the mother and offspring. It highlights the immediate and long-term impacts of maternal environmental factors on fetal development and maternal cardiometabolic health. Using 'omics technologies across different platforms, research on preterm birth, metabolic influences, maternal disorders, and their effects on pregnancy outcomes and child health is expected to provide new insights and preventative strategies.
Article
Nutrition & Dietetics
Raul Zamora-Ros, Valerie Cayssials, Ramon Cleries, Maria Torrents, Graham Byrnes, Elisabete Weiderpass, Maria Sandstrom, Martin Almquist, Marie-Christine Boutron-Ruault, Anne Tjonneland, Cecilie Kyro, Verena A. Katzke, Charlotte Le Cornet, Giovanna Masala, Vittorio Krogh, Gabriella Iannuzzo, Rosario Tumino, Lorenzo Milani, Guri Skeie, Esther Ubago-Guisado, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Suzanne Janzi, Linda Eriksson, Heinz Freisling, Alicia K. Heath, Sabina Rinaldi, Antonio Agudo
Summary: This study found that consumption of sweetened beverages was associated with an increased risk of differentiated thyroid cancer, while a dietary pattern characterized by alcohol consumption was associated with a decreased risk of thyroid cancer.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Substance Abuse
Rukshar K. Gobarani, Gregory R. Weeks, Michael J. Abramson, Billie Bonevski, Shin J. Liau, Johnson George
Summary: This qualitative study explored the experiences of participants in a randomized controlled trial of varenicline treatment for smoking cessation. The study found that a forced abstinence environment played a key role in motivating quit attempts. The main barriers to adherence to varenicline treatment were medication side effects, relapse to smoking, and a lack of belief in the medication's effectiveness. Participants who adhered to treatment adopted a reduce-to-quit approach and noticed a gradual reduction in cigarette cravings. They expressed the need for proactive follow-up by health professionals and more active behavioral support.
JOURNAL OF ADDICTIVE DISEASES
(2023)
Article
Respiratory System
Melvin Tandra, E. Haydn Walters, Jennifer Perret, Adrian J. Lowe, Caroline J. Lodge, David P. Johns, Paul S. Thomas, Gayan Bowatte, Peter G. Davis, Michael J. Abramson, Shyamali C. Dharmage, Dinh S. Bui
Summary: The association between birth weight relative to gestational age and adult lung function was investigated in this study. It was found that infants born small for gestational age had reduced lung function in middle age, while higher birth weight was associated with better lung function. Adult height played a significant mediating role in these associations.
Article
Public, Environmental & Occupational Health
Rukshar K. Gobarani, Gregory R. Weeks, Michael J. Abramson, Billie Bonevski, Eldho Paul, Ashley Webb, Sue Kirsa, Brian J. Smith, Dennis Thomas, Sharmilla Perinpanathan, Jacqueline Parkinson, Darshana Meanger, Lisa Coward, Olivia Rofe, Paula Lee, Johnson George
Summary: This study aimed to describe smoking-related behaviors, past-quit attempts, and self-reported difficulties experienced in quitting among hospital patients who enrolled in a smoking cessation trial of varenicline. The study found that those who had a prior hospitalization and were unemployed had significantly greater odds of reporting past quit attempts. Further research is needed to investigate the degree of adherence among inpatient smokers with the smoke-free hospital policies and the frequency of NRT provision and uptake on admission.
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2023)
Article
Critical Care Medicine
Alan L. James, Graham M. Donovan, Francis H. Y. Green, Thais Mauad, Michael J. Abramson, Alvenia Cairncross, Peter B. Noble, John G. Elliot
Summary: The distribution of airway smooth muscle (ASM) remodeling in asthma varies widely within and between individuals, and is related to asthma severity. Despite the heterogeneous distribution, ASM remodeling is present in the majority of asthma cases, both in large and small airways. These findings emphasize the importance of patient-specific targeting of ASM remodeling in asthma treatment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Minhee L. Sung, Adam Viera, Denise Esserman, Guangyu Tong, Daniel Davidson, Sherry Aiudi, Genie L. Bailey, Ashley L. Buchanan, Marianne Buchelli, Mark Jenkins, Betsey John, Jennifer Kolakowski, Albana Lame, Sean M. Murphy, Elizabeth Porter, Laura Simone, Manuel Paris, Carla J. Rash, E. Jennifer Edelman
Summary: This study introduces a new research called CoMPASS, which aims to promote HIV risk reduction among persons who inject drugs (PWID). It is a hybrid type 1 effectiveness-implementation trial that utilizes rewards and ongoing support to encourage PWID to use HIV preexposure prophylaxis (PrEP). Trained PrEP navigators deliver interventions, including PrEP and other relevant treatments. The primary outcome is sustained PrEP adherence at 24 weeks. The results of this study will provide insights into the feasibility and impact of implementing CoMPASS in community-based organizations.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Environmental Sciences
Yao Wu, Rongbin Xu, Shanshan Li, Ee Ming Wong, Melissa C. Southey, John L. Hopper, Michael J. Abramson, Shuai Li, Yuming Guo
Summary: A study found that short-term temperature fluctuations can affect DNA methylation levels and are associated with various diseases such as cancer and mental disorders, providing evidence for exploring the biological mechanisms underlying the health impact of temperature fluctuations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Yijun Zhou, Maria R. Ampon, Michael J. Abramson, Alan L. James, Graeme P. Maguire, Richard Wood-Baker, David P. Johns, Guy B. Marks, Helen K. Reddel, Brett G. Toelle
Summary: This study found that adults with a dual diagnosis of asthma and COPD experience more severe symptoms and disease burden compared to those with asthma or COPD alone. It highlights the importance of regular comprehensive evaluations for patients with both diagnoses.
Article
Public, Environmental & Occupational Health
Caroline X. Gao, Jana Menssink, Timothy C. H. Campbell, Catherine L. Smith, Jillian F. Ikin, Tyler Lane, Michael J. Abramson, Matthew Carroll
Summary: This study investigated the interaction between physical and mental symptoms following wildfire smoke exposure in a community exposed to multiple events. The results showed that general psychological distress and posttraumatic stress were independently associated with various somatic symptoms. These findings emphasize the importance of considering the interconnectedness of these conditions when supporting communities affected by climate-related disasters.
Article
Allergy
Yulia Olsen, Elias Arildskov, Stefan Nygaard Hansen, Marianne Pedersen, Shyamali C. Dharmage, Mathilde Kloster, Torben Sigsgaard
Summary: The study found that an increase in concentrations of Alternaria and Cladosporium is associated with an increased risk of acute asthma hospitalizations. Males are more susceptible to both genera, while males and females under the age of 40 are more susceptible to Alternaria.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Respiratory System
Chamara V. Senaratna, Adrian Lowe, E. Haydn Walters, Michael J. Abramson, Dinh Bui, Caroline Lodge, Bircan Erbas, John Burgess, Jennifer L. Perret, Garun S. Hamilton, Shyamali C. Dharmage
Summary: This study provides the first known evidence for individual and profiled early-life and childhood risk factors for OSA in adults.
Article
Oncology
Sabrina Wang, Farhana Sultana, Anne Kavanagh, Carolyn Nickson, Amalia Karahalios, Lyle C. Gurrin, Dallas R. English
Summary: This study aimed to quantify the impact of mammographic screening on breast cancer mortality and overdiagnosis. The results showed that women who participate in Australia's national screening program have lower breast cancer mortality, but some screen-detected cancers may be overdiagnosed.
Article
Respiratory System
Nawar Alotaibi, Brigitte M. Borg, Michael J. Abramson, Eldho Paul, Nicholas Zwar, Grant Russell, Sally Wilson, Anne E. Holland, Billie Bonevski, Ajay Mahal, Johnson George
Summary: Case finding using validated questionnaires and handheld devices can improve the diagnosis of COPD in primary care. Handheld spirometry devices can facilitate case finding of COPD in smokers and ex-smokers attending general practice.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)