Article
Cardiac & Cardiovascular Systems
Abdulaziz Al-Khaldi, Atif Alsahari, Abdulmajeed Alotay, Tarek Momenah, Juan J. Alfonso
Summary: This study retrospectively reviewed 22 patients with single-ventricle physiology who underwent surgical reconstruction for peripheral pulmonary artery stenosis (PPAS). The surgical approach was either single stage or two stage depending on the presence or absence of PA hypoplasia distal to the PPAS.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Sherry Liang, Md Abdullah Shamim, Ayaz Shahid, Mengbing Chen, Kristan H. Cleveland, Cyrus Parsa, Robert Orlando, Bradley T. Andresen, Ying Huang
Summary: This study demonstrates that R-carvedilol, a non-beta-blocking enantiomer of the racemic beta-blocker carvedilol, has promising preventive effects against skin cancer. It effectively prevents EGF-induced neoplastic transformation and UV-induced oxidative stress in skin cells, as well as delays and reduces the development of skin squamous cell carcinoma in mouse models. This suggests that R-carvedilol may be a safer and more effective option for skin cancer prevention without the common cardiovascular side effects associated with beta-blockers.
CANCER PREVENTION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Rui Xiao, Shengquan Luo, Ting Zhang, Yankai Lv, Tao Wang, Jiwei Zhang, Yuan Su, Matthieu Ruiz, Jocelyn Dupuis, Liping Zhu, Qinghua Hu
Summary: The activation of CaSR has been identified as a critical mediator of hypoxia-induced pulmonary hypertension. By blocking CaSR polymerization, researchers were able to reduce hypoxia-induced activation and downstream events leading to pulmonary hypertension, both in vitro and in vivo. This method represents an attractive inhaled preventive alternative worth further development.
Article
Multidisciplinary Sciences
Qian Lei, Zhimin Yu, Hang Li, Jun Cheng, Yanggan Wang
Summary: This study reveals the significant role of fatty acid-binding protein 5 (FABP5) in pulmonary hypertension secondary to left heart disease (PH-LHD). Through experiments and in vitro studies, it was demonstrated that inhibiting FABP5 can improve pulmonary vascular remodeling and cardiac function. FABP5 may serve as a potential therapeutic target for PH-LHD.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Peripheral Vascular Disease
Seng Chan You, Harlan M. Krumholz, Marc A. Suchard, Martijn J. Schuemie, George Hripcsak, RuiJun Chen, Steven Shea, Jon Duke, Nicole Pratt, Christian G. Reich, David Madigan, Patrick B. Ryan, Rae Woong Park, Sungha Park
Summary: The study found no significant differences in the effectiveness and safety when comparing the third-generation beta-blockers with atenolol as first-line treatment for hypertension, but patients on third-generation beta-blockers had a higher risk of stroke compared to those on ACE inhibitors and thiazide diuretics.
Article
Pharmacology & Pharmacy
Hardjit Kharagjitsing, Rike van Eekeren, Eugene P. van Puijenbroek, Teun van Gelder, Eric F. H. van Bommel
Summary: Disproportionality analysis of cases in VigiBase showed a potential safety signal for RPF associated with BBAs, but clinical evidence did not support a cause-and-effect relationship. Most cases did not show consistent dechallenge results after discontinuation of BBAs, indicating the need for further research and validation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chen Wang, Yuanming Xing, Jiao Zhang, Ming He, Jianjie Dong, Shanshan Chen, Haoyu Wu, Hsi-Yuan Huang, Chih-Hung Chou, Liang Bai, Fangzhou He, Jianqing She, Ailing Su, Youhua Wang, Patricia A. Thistlethwaite, Hsien-Da Huang, Jason X-J Yuan, Zu-Yi Yuan, John Y-J Shyy
Summary: The dysregulated BMP/TGF-beta signaling pathways play a crucial role in pulmonary arterial hypertension (PAH) and pulmonary hypertension (PH). MED1 and KLF4 collaboratively regulate BMPR2, ERG, and TGFBR2, highlighting the importance of their synergistic effect in maintaining pulmonary endothelial function. Dysregulation of MED1 contributes to impaired BMP/TGF-beta signaling and disease progression in PAH and PH.
CIRCULATION RESEARCH
(2022)
Article
Respiratory System
Sneha Samant, Hai Tran, Robert B. Uddo, Bennett P. DeBoisblanc, Lesley Ann Saketkoo, Shigeki Saito, Fred R. Helmcke, Matthew R. Lammi
Summary: This study investigated whether a handheld ultrasound estimate of right atrial pressure correlates with B-type natriuretic peptide (BNP) and clinical outcome in outpatients with pulmonary hypertension. The results showed that the handheld ultrasound estimate of right atrial pressure is associated with BNP at baseline and serially over time, and it is also independently associated with clinical worsening. Therefore, the use of handheld ultrasound to estimate right atrial pressure should be considered in pulmonary hypertension clinics.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, Research & Experimental
Fangyun Zhao, Chunhong Pan, Yue Zhang, Jiao Yang, Xiqian Xing
Summary: The study reveals that PP7 modulates beta-catenin protein levels by promoting miR-205-5p expression, thereby alleviating PH symptoms and vascular remodeling. Furthermore, the overexpression of miR-205-5p can attenuate hypoxia-induced proliferation and apoptosis in pulmonary arterial smooth muscle cells (PASMCs), while the overexpression of beta-catenin exacerbates these effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan Pan, Aidong Chen, Xingxing Wang, Changlei Bao, Shuxin Liang, Haiyang Tang, Ying Han
Summary: This study investigated the effects of salusin-beta on endothelium-dependent vascular relaxation and the progression of PAH. The results showed that elevated salusin-beta levels in PAH rats led to reduced endothelium-dependent vasodilatation and participated in PAH progression by stimulating NAD(P)H oxidase-ROS production and inhibiting eNOS-NO release.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Guizhu Liu, Naifu Wan, Qian Liu, Yuqin Chen, Hui Cui, Yuanyang Wang, Jiaoqi Ren, Xia Shen, Wenju Lu, Ying Yu, Yujun Shen, Jian Wang
Summary: The study found that RvE1 alleviated pulmonary hypertension by inhibiting PASMC proliferation in experimental animal models, and its mechanism involved the RvE1/ChemR23 axis modulating the wingless-type MMTV integration site family member 7a/beta-catenin signaling pathway in PASMCs.
Article
Cardiac & Cardiovascular Systems
Pooya Torkian, Stephanie Wallace, Nicholas Lim, Siobhan Flanagan, Jafar Golzarian, Shamar J. Young
Summary: The purpose of this study was to evaluate the impact of pre-TIPS hepatic encephalopathy (HE) on developing post-TIPS HE. The results showed that pre-TIPS HE did not predict the development of HE within 3 months of TIPS. There were no significant differences in hospital admission and survival rates between patients with and without pre-TIPS HE.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Respiratory System
Thomas Lacoste Palasset, Marie-Camille Chaumais, Jason Weatherald, Laurent Savale, Xavier Jais, Laura C. Price, Charles Khouri, Sophie Bulifon, Andrei Seferian, Mitja Jevnikar, Athenais Boucly, Gregoire Manaud, Stefana Pancic, Celine Chabanne, Kais Ahmad, Mathilde Volpato, Nicolas Favrolt, Anne Guillaumot, Delphine Horeau-Langlard, Gregoire Prevot, Pierre Fesler, Laurent Bertoletti, Martine Reynaud-Gaubert, Nicolas Lamblin, David Launay, Gerald Simonneau, Olivier Sitbon, Frederic Perros, Marc Humbert, David Montani
Summary: The study found an association between leflunomide and pulmonary hypertension, which is rare and usually associated with other risk factors. Pharmacovigilance analysis and experimental data further support this association.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Takashi Kunihara, Heinrike Wilkens, Michael Halank, Matthias Held, Ryota Nomura, Takashi Igarashi, Fumihiro Sata, Hans-Joachim Schaefers
Summary: Preoperative treatment with bosentan for CTEPH patients undergoing PEA surgery can improve postoperative PVR without adverse clinical events. Patients with higher preoperative PVR may benefit more from bosentan treatment before surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)