Article
Endocrinology & Metabolism
Xiao Song Liu, Xiu Juan Su, Guo Hua Li, Shi Jia Huang, Yang Liu, Han Xiang Sun, Qiao Ling Du
Summary: This study found an association between FT4 and birth weight as well as birth weight discordance in twins, while TSH was not associated with birth weight. These findings have implications for obstetricians in preventing birth weight discordance in twin pregnancies.
Editorial Material
Genetics & Heredity
David M. Evans, Rachel M. Freathy
Summary: This study utilized extensive pedigree data from the Icelandic population to identify genetic effects on birth weight that differ according to parental origin, and to distinguish the contributions from the maternal intrauterine environment and offspring genetics on fetal growth.
Article
Obstetrics & Gynecology
Fiskani J. M. Kondowe, Peter Clayton, Matthew Gittins, Stephen W. D'Souza, Daniel R. Brison, Stephen A. Roberts
Summary: Assessments at 6-8 weeks old and at school entry show that ART twins conceived from frozen embryo transfer (FET) grow faster than both NC twins and ART twins conceived from fresh embryo transfer (ET).
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Wafaa Alrawi, Taisser Atrak, Ashraf Abuobayda, Nabil Elmansoury, Omar Elnakeib, Abhijeet Lonikar
Summary: This article reports the intact survival of extremely preterm twins born at 22 2/7 weeks without significant morbidity. It highlights the importance of perinatal and neonatal management optimization to improve survival rates and clinical outcomes of periviable birth, as well as the need to consider the individuality of each case and the parents' wishes in management decisions.
Article
Pediatrics
Jessica L. Gleason, Edwina H. Yeung, Rajeshwari Sundaram, Diane L. Putnick, Pauline Mendola, Erin M. Bell, Kristen J. Polinski, Sonia L. Robinson, Katherine L. Grantz
Summary: This study investigates the growth patterns of twins and whether they exhibit signs of excess growth similar to singletons born small-for-gestational age (SGA), which may increase future cardiometabolic risk. The results show that although twins have lower height, weight, and BMI z-scores at birth and in early childhood, these differences diminish by 7-9 years of age, with no evidence of pathological growth or increased risk of overweight/obesity in any group of twins.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandra Crivelli-Meyer, Olivier Giannini, Mario Giovanni Bianchetti, Giacomo Domenico Simonetti
Summary: A majority of adults remember their own birth weight, making it reasonable to include this information in risk stratification for cardiovascular and renal diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shan Andrews, Irene J. Yang, Karolin Froehlich, Tomiko Oskotsky, Marina Sirota
Summary: This study presents a mega-analysis of 14 placenta DNA methylation datasets to identify individual CpGs and regions associated with fetal sex. The findings reveal genes and pathways characterizing sex-specific placenta function and health outcomes later in life, providing important evidence for understanding the molecular underpinnings of gender differences in placental structure and function.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Jieman Lin, Jie Ding, Xuemei Di, Wenqin Sun, Huifen Chen, Hai Zhang
Summary: The abuse of antibiotics in animal husbandry and the subsequent passive exposure to residual antibiotics through food consumption has resulted in significant public health concerns. This study aimed to investigate the potential adverse effects of prenatal antibiotics exposure on fetal growth and development. The findings suggest that prenatal exposure to certain antibiotics may negatively impact fetal growth indicators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Genetics & Heredity
Thorhildur Juliusdottir, Valgerdur Steinthorsdottir, Lilja Stefansdottir, Gardar Sveinbjornsson, Erna Ivarsdottir, Rosa B. Thorolfsdottir, Jon K. Sigurdsson, Vinicius Tragante, Kristjan E. Hjorleifsson, Anna Helgadottir, Michael L. Frigge, Gudmundur Thorgeirsson, Rafn Benediktsson, Emil L. Sigurdsson, David O. Arnar, Thora Steingrimsdottir, Ingileif Jonsdottir, Hilma Holm, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson
Summary: The study revealed that maternal and fetal genomes influence fetal birth weight through different mechanisms. Birth weight, as a common measure of fetal growth, is affected by both fetal and maternal genomes.
Article
Microbiology
Christa N. Cheatham, Kevin L. Gustafson, Zachary L. McAdams, Giedre M. Turner, Rebecca A. Dorfmeyer, Aaron C. Ericsson
Summary: Obesity is a major health issue and burden on the healthcare system. The gut microbiome plays a role in body weight regulation and feeding behavior. This research aimed to investigate whether differences in the gut microbiome were associated with differences in intake, fecal energy loss, and fetal growth.
Article
Multidisciplinary Sciences
Emmanuel Yovo, Manfred Accrombessi, Gino Agbota, Alice Hocquette, William Atade, Olaiitan T. Ladikpo, Murielle Mehoba, Auguste Degbe, Ghyslain Mombo-Ngoma, Achille Massougbodji, Nikki Jackson, Nadine Fievet, Barbara Heude, Jennifer Zeitlin, Valerie Briand
Summary: This study evaluated the international fetal growth standards from INTERGROWTH-21st and WHO in a cohort from southern Benin, finding that the centiles in the RECIPAL cohort were higher than INTERGROWTH-21st and closer to WHO. The proportions of fetuses under 10th percentile thresholds were systematically lower when applying INTERGROWTH-21st compared to WHO standards.
Article
Developmental Biology
Nana Matoba, James W. Collins, Maria Dizon
Summary: Despite advancements in perinatal medicine, racial disparities in birth outcomes continue to be a public health concern in the United States. The underlying mechanisms for these disparities, which have persisted for a long time, remain poorly understood. This review examines the transgenerational risk factors for racial disparities in preterm birth, including the impact of interpersonal and structural racism, theoretical models of stress, and biological markers of racial disparities.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Katherine Grantz, Stefanie Hinkle, Dian He, John Owen, Daniel A. Skupski, Cuilin A. Zhang, Anindya A. Roy
Summary: Customized fetal growth charts assume normality and constant coefficient of variation assumptions, but these assumptions have never been formally tested. By analyzing longitudinal sonographic biometric data, we found that the assumptions of proportionality and normal distribution may be questionable. A heteroscedastic model that captures unstable variance in customization characteristics appears to improve the detection of abnormal growth percentiles.
Article
Nutrition & Dietetics
Malgorzata Lewandowska
Summary: The study found that maternal pre-pregnancy obesity is associated with an increased risk of low birth weight, fetal growth restriction, and macrosomia in newborns. Additionally, the risk of macrosomia was three times higher for obese mothers, while the risk of low birth weight was 17 times higher, particularly in the subgroup of normal gestational weight gain. The risk profile showed that higher BMI values were associated with a higher risk of these outcomes, with specific threshold BMI values identified.
Article
Obstetrics & Gynecology
Hong Cui, Ziwei Wang, Jinzhe Yu, Caixia Liu
Summary: This study investigated the birthweight and incidence of birth asphyxia in 5337 pairs of twins, revealing a higher risk of asphyxia in twins with lower birthweight. It was also found that birthweight is an independent predictor of asphyxia.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Immunology
David Horner, Mathis Hjort Hjelmso, Jonathan Thorsen, Morten Rasmussen, Anders Eliasen, Rebecca Kofod Vinding, Ann-Marie Malby Schoos, Nicklas Brustad, Rikke Bjersand Sunde, Klaus Bonnelykke, Bo L. Chawes, Jakob Stokholm, Hans Bisgaard
Summary: This study found that supplementation with fish oil from the 24th week of pregnancy can significantly reduce gastroenteritis symptoms in children's first 3 years of life, including the number of days and episodes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Allergy
Kathleen A. Lee-Sarwar, Yih-Chieh Chen, Yuan Yao Chen, Anita L. Kozyrskyj, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Hans Bisgaard, Jakob Stokholm, Bo Chawes, Soren J. Sorensen, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
Summary: This study found associations between prenatal and early-life fecal microbiomes and childhood asthma phenotypes. Cesarean section was found to increase the risk of early asthma.
Article
Allergy
Casper-Emil Tingskov Pedersen, Anders Ulrik Eliasen, Matthias Ketzel, Jorgen Brandt, Steffen Loft, Lise Marie Frohn, Jibran Khan, Susanne Brix, Morten A. Rasmussen, Jakob Stokholm, Bo Chawes, Andreanne Morin, Carole Ober, Hans Bisgaard, Marie Pedersen, Klaus Bonnelykke
Summary: Prenatal exposure to ambient air pollution is associated with immune perturbations in early life, increasing the risk of allergic rhinitis and asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Nicklas Brustad, Luo Yang, Bo L. Chawes, Jakob Stokholm, Gozde Gurdeniz, Klaus Bonnelykke, Hans Bisgaard
Summary: This study investigated the effects of prenatal micronutrient supplementation on childhood croup and found that intake of 2.4g n-3 long-chained polyunsaturated fatty acid (n-3 LCPUFA) and high-dose vitamin D reduced the risk of croup in early childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Editorial Material
Pediatrics
Ulrikka Nygaard, Nikolai Soren Kirkby, Kia Hee Schultz Dungu, Kim G. Nielsen, Tania Masmas, Klaus Juul, Peter Born, Soren Buus, Lone Graff Stensballe
Article
Biochemical Research Methods
Martin Ostergaard, Soren Jessen, Erik Soren Halvard Hansen, Vibeke Backer, Tina Panchal, Sandra Baldwin, Peter Daley-Yates, Morten Hostrup
Summary: The 2023 Prohibited List permits athletes to use a standard dose of 25 mu g daily of the beta(2)-agonist vilanterol. However, there is limited data on its urine pharmacokinetics, making it challenging to distinguish therapeutic use from supratherapeutic use. A study was conducted on 25 trained individuals to examine the urine concentrations of vilanterol and its metabolites after inhalation of different doses. The findings suggest that current urine concentration thresholds are insufficient, but a higher decision limit of 6 ng center dot ml(-1) is proposed to minimize the risk of false-positive results while still detecting supratherapeutic use.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemical Research Methods
Tina Panchal, Sandra Baldwin, Martin Ostergaard, Erik Soeren Halvard Hansen, Vibeke Backer, Morten Hostrup, Peter Daley-Yates
Summary: This study developed a bioanalytical method to detect the concentration of the ultra-long-acting beta(2)-agonist vilanterol and its metabolites GSK932009 and GW630200 in urine, aiming to potentially monitor its therapeutic and prohibited use in sport.
DRUG TESTING AND ANALYSIS
(2023)
Article
Public, Environmental & Occupational Health
Signe Holst Soegaard, Maria Spanggaard, Klaus Rostgaard, Mads Kamper-Jorgensen, Lone Graff Stensballe, Kjeld Schmiegelow, Henrik Hjalgrim
Summary: Early childcare enrolment is associated with a modest increase in the cumulative number of antimicrobial-treated infections throughout childhood and adolescence, and this increase is not compensated by lower infection risk later in life.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Ophthalmology
Linna Zhu, Inger Christine Munch, Casper Pedersen, Jakob Stokholm, Klaus Bonnelykke, Bo Chawes, Christian Jakob Carlsson, Ann-Marie M. Schoos, Michael Larsen, Hans Bisgaard, Nicklas Brustad
Summary: This study aimed to investigate the effect of multiple pre- and postnatal exposures on optic nerve status in young adults, and found that smoking during pregnancy and higher indoor PM2.5 levels were associated with thinner retinal nerve fibre layer and macular thickness at age 18, while smoking at age 18 showed no significant association with optic nerve status.
ACTA OPHTHALMOLOGICA
(2023)
Article
Clinical Neurology
Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer Madsen, Axel Thielscher, Hartwig Roman Siebner, Messoud Ashina, Anders Hougaard
Summary: In this study, we compared the distances between visual cortical areas and overlying dura mater in female patients with migraine aura without headache and female patients with migraine aura with headache. The results showed no significant differences in distances or volumes between the two groups. Therefore, we conclude that there may not be a direct connection between migraine aura and headache.
Article
Public, Environmental & Occupational Health
Christine Stabell Benn, Nelly Amenyogbe, Anders Bjorkman, Jorge Dominguez-Andres, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby
Summary: The current framework for testing and regulating vaccines needs to be updated to consider the non-specific effects of vaccines, which can affect all-cause mortality and morbidity in ways that are not explained by the prevention of the targeted disease. Immunological studies have provided mechanisms that explain how vaccines might modulate the immune response to unrelated pathogens. Non-specific effects are often greater in female individuals. Currently, these effects are not routinely captured in clinical trials or post-licensure safety surveillance, but a new framework is proposed to address this issue.
Article
Medicine, Research & Experimental
Serena Lillo, Trine Rennebod Larsen, Kirsten Ohm Kyvik, Jens Sondergaard, Steen Antonsen
Summary: GPs in the Region of Southern Denmark were randomly assigned to interventions aimed at maximizing their use of Vitamin D tests. A survey study was conducted to examine GPs' assessment of these interventions. The results showed that guidelines were found helpful by half of the GPs and feedback reports were often read. Pop-up alerts were accepted for frequently used tests, but there were concerns about the interruptive alert appearing every time a Vitamin D test was requested.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Pediatrics
Helene Kildegaard, Lars Christian Lund, Anton Pottegard, Lone Graff Stensballe
Summary: This study assessed the real-world effectiveness of quadrivalent live attenuated influenza vaccines (LAIV-4) in children aged 2-6 years. The results showed that LAIV-4 vaccination was associated with a reduced risk of influenza-related hospital contacts, but did not show significant reductions in other secondary outcomes.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Allergy
Silvia Cabrera Guerrero, Kjell Erik Julius Hakansson, Vibeke Backer, Charlotte Suppli Ulrik, Deepa Rastogi
Summary: This study found that childhood asthma is associated with caregiver depression, which leads to poor asthma control. Sociodemographic risk factors contribute to caregiver depression among children with asthma, even in universal healthcare settings.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Respiratory System
Kjell Erik Julius Hakansson, Silvia Cabrera Guerrero, Vibeke Backer, Charlotte Suppli Ulrik, Deepa Rastogi
Summary: This study investigated the disease and healthcare access of children and adolescents with asthma in Denmark and found that there was a significant unmet need for specialist care, particularly among those with poorly controlled asthma, even in a free healthcare system.
RESPIRATORY RESEARCH
(2023)
