Article
Neurosciences
Bo Cheng, Xiaoliang Hong, Linfang Wang, Yuanyuan Cao, Dengli Qin, Han Zhou, Dianshuai Gao
Summary: Curzerene inhibits the progression of glioma by suppressing the expression of GSTA4 and matrix metalloproteinase 9, and inhibiting the activation of the mTOR pathway. It also induces apoptosis and reduces invasion and migration of glioma cells. In vivo studies have shown that Curzerene significantly inhibits tumor growth and prolongs survival time.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Letter
Respiratory System
Aleksandra Rybka-Fraczek, Marta Dabrowska, Elzbieta M. Grabczak, Katarzyna Bialek-Gosk, Karolina Klimowicz, Olga Truba, Rafal Krenke
Summary: Bronchial hyperresponsiveness may be considered as a predictor of cough variant asthma in non-smoking adults with chronic cough, showing a high positive predictive value in this population. Cough severity and cough related quality of life were not related to the severity of bronchial hyperresponsiveness in CVA patients.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xingang Li, Yuanting Pang, Yiwang Zhong, Zhandong Cai, Qibin Ma, Ke Wen, Hai Nian
Summary: In this study, a tau-like glutathione transferase family gene named GmGSTU23 was identified in soybean, which showed a concentration-time-specific expression pattern in response to salt stress. Transgenic lines with GmGSTU23 displayed enhanced salt tolerance, root length, and fresh weight compared to the wild type. Changes in glutathione pools and associated enzyme activity were observed, indicating that GmGSTU23 enhances the activity of glutathione transferase to scavenge reactive oxygen species and glutathione, thereby conferring enhanced tolerance to salt stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xin Dai, Shyamali C. C. Dharmage, Caroline J. J. Lodge
Summary: Oxidative stress is a major pathophysiological mechanism for chronic respiratory disease. GST genes play important roles in antioxidant defenses and may impact respiratory health. Future research should consider gene-gene interactions, multiple environmental exposures, and gender in these complex associations.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agronomy
Yushi Jiang, Yuzhe Zhang, Ruijie Duan, Jiayi Fan, Peng Jiao, Hongji Sun, Shuyan Guan, Siyan Liu
Summary: ZmGST26 was found to be downregulated in maize under drought stress. Overexpression of ZmGST26 in Arabidopsis resulted in increased sensitivity to drought stress and ABA, as well as inhibited ABA-mediated stomatal closure. ZmGST26 overexpression decreased the resistance of Arabidopsis to drought stress and led to the accumulation of reactive oxygen species.
Editorial Material
Biochemistry & Molecular Biology
Tiffany M. Russell, Des R. Richardson
Summary: GSTs are versatile proteins that play important roles in detoxification and cellular nitric oxide metabolism. They have the ability to convert organic nitrates into nitric oxide, thereby regulating vasodilation. GSTs are also considered suitable targets for pharmaceutical development, particularly in the field of anti-cancer drugs.
Article
Cardiac & Cardiovascular Systems
Hoang Thi Lam, Nguyen Van Tuong, Duong Quy Sy, Bo Lundback, Eva Ronmark
Summary: The study estimated the prevalence and determinants of BHR in Hanoi, Vietnam, and found BHR to be more common in this region compared to other parts of Southeast Asia. PC20 ≤ 2 mg/ml was associated with FEV1 <80% predicted, while PC20 ≤ 2 mg/ml was associated with multi-sensitization to airborne allergens.
RESPIRATORY MEDICINE
(2021)
Article
Microbiology
Alvaro de Obeso Fernandez del Valle, Christian Quintus Scheckhuber, David Armando Chavaro-Perez, Erandi Ortega-Barragan, Sutherland K. Maciver
Summary: Some members of Acanthamoeba are facultative pathogens that can infect the cornea, causing Acanthamoeba keratitis. During encystation, there is an upregulation of glutathione S-transferase (GST) genes, which play a role in maintaining redox balance. Inhibiting GST with ethacrynic acid decreases cell viability by 70%. Targeting GST and associated processes could be a potential treatment strategy to reduce relapses of Acanthamoeba infection.
Article
Medicine, Research & Experimental
Yoshihiko Chiba, Yukika Adachi, Yusuke Ando, Shigeki Fujii, Wataru Suto, Hiroyasu Sakai
Summary: This study aims to investigate the functional role of a long non-coding RNA MALAT1 in the expression and development of bronchial smooth muscle (BSM) hyper-contractility. The findings suggest that MALAT1 positively regulates RhoA protein expression by inhibiting miR-133a-3p in BSM cells, leading to augmented BSM contractility. These findings are of great significance for understanding the pathological mechanisms of airway hyper-responsiveness.
Article
Gastroenterology & Hepatology
Feng Liu, Xiao-Li Xiao, Yu-Jing Liu, Ruo-Hui Xu, Wen-Jun Zhou, Han-Chen Xu, Ai-Guang Zhao, Yang-Xian Xu, Yan-Qi Dang, Guang Ji
Summary: The expression of circ_0084927 is significantly increased in CRC, especially in advanced-stage CRC compared to early-stage CRC. Circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/AKT/mTOR pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Food Science & Technology
Yu Zhang, Ke-Xin Cao, Qin-Jian Niu, Jiang Deng, Ling Zhao, Mahmoud Mohamed Khalil, Niel Alexander Karrow, Kamil Kuca, Lv-Hui Sun
Summary: This study aimed to identify the key glutathione S-transferase (GST) isozymes involved in the detoxification of Aflatoxin B1 (AFB1) in ducks' primary hepatocytes. The researchers isolated and cloned the full-length cDNA encoding 10 GST isozymes from ducks' liver. The results showed that overexpression of GST and GST3 mitigated the toxic effects of AFB1 and increased the detoxified product of AFB1 in ducks' primary hepatocytes.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Aiqin Zhang, Rui Luo, Jiawen Li, Rongqing Miao, Hui An, Xiufeng Yan, Qiuying Pang
Summary: This study provides direct evidence that GSTU20 and GSTF11 are critically involved in aliphatic GSL biosynthesis, revealing their non-redundant but partially overlapping roles in GSL metabolism, with GSTU20 playing a more important role than GSTF11.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lulu Han, Lin Zhou, Hongzhu Zou, Meng Yuan, Yan Wang
Summary: Anthocyanins, the important chromogenic substances responsible for the coloration of flowers, are transported and accumulated predominantly by PsGSTF3 gene. Silencing of PsGSTF3 gene leads to decreased anthocyanin accumulation and affects structural genes in the anthocyanin biosynthesis pathway. Heterologous overexpression of PsGSTF3 enhances anthocyanin accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rehabilitation
Claudia Zanini, Maddalena Fiordelli, Julia Amann, Mirjam Brach, Armin Gemperli, Sara Rubinelli
Summary: This study interviewed family caregivers in Switzerland and identified four main coping strategies used by them, providing the basis for developing tailored support programs.
DISABILITY AND REHABILITATION
(2022)
Article
Biochemical Research Methods
Maximilian Boesch, Martina Sykora, Silvia Gasteiger, Florent Baty, Martin H. Brutsche, Sieghart Sopper
Summary: This optimized multicolor immunofluorescence panel is designed to efficiently identify and quantify various leukocyte populations in human blood with minimal markers. It offers high performance, is suitable for whole blood, and widely applicable for immune cell identification, quantification, and characterization.
Article
Infectious Diseases
Severin Studer, Frank Rassouli, Frederike Waldeck, Martin H. Brutsche, Florent Baty, Werner C. Albrich
Article
Respiratory System
Simona Tabea Huebner, Simona Henny, Stephanie Giezendanner, Thomas Brack, Martin Brutsche, Prashant Chhajed, Christian Clarenbach, Thomas Dieterle, Adrian Egli, Martin Frey, Ingmar Heijnen, Sarosh Irani, Noriane Andrina Sievi, Robert Thurnheer, Marten Trendelenburg, Malcolm Kohler, Anne Barbara Leuppi-Taegtmeyer, Joerg Daniel Leuppi
Summary: This study found that using immunological biomarkers and clinical characteristics can predict the frequency and severity of acute exacerbations in stable COPD patients. However, clinical parameters had better discriminatory power in identifying patients likely to experience frequent AECOPD.
Article
Physiology
Pierre Labeix, Mathieu Berger, Amandine Zellag, Arnauld Garcin, Jean-Claude Barthelemy, Frederic Roche, David Hupin
Summary: This study found that specific inspiratory muscle training (IMT) can significantly reduce the severity of obstructive sleep apnea (OSA) in patients with coronary artery disease (CAD). However, there was no significant improvement in AHI in the IMT group compared to the control group.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Tobias Sinnberg, Christa Lichtensteiger, Omar Hasan Ali, Oltin T. Pop, Ann-Kristin Jochum, Lorenz Risch, Silvio D. Brugger, Ana Velic, David Bomze, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Marie-Therese Abdou, Nina Wyss, Kathrin Hofmeister, Heike Niessner, Carl Zinner, Mara Gilardi, Alexandar Tzankov, Martin Rocken, Alex Dulovic, Srikanth Mairpady Shambat, Natalia Ruetalo, Philipp K. Buehler, Thomas C. Scheier, Wolfram Jochum, Lukas Kern, Samuel Henz, Tino Schneider, Gabriela M. Kuster, Maurin Lampart, Martin Siegemund, Roland Bingisser, Michael Schindler, Nicole Schneiderhan-Marra, Hubert Kalbacher, Kathy D. McCoy, Werner Spengler, Martin H. Brutsche, Boris Macek, Raphael Twerenbold, Josef M. Penninger, Matthias S. Matter, Lukas Flatz
Summary: COVID-19 can cause severe respiratory distress syndrome, and dysregulated immune responses, including autoimmunity, play a key role. This study investigated the presence of IgA autoantibodies targeting lung-specific proteins and their effects on pulmonary surfactant in severe COVID-19 cases.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Clinical Neurology
Carina Faehndrich, Armin Gemperli, Michael Baumberger, Marco Bechtiger, Bianca Roth, Dirk J. Schaefer, Reto Wettstein, Anke Scheel-Sailer
Summary: This scoping review examines surgical multidisciplinary treatment approaches for stage III and IV pressure injuries in individuals with spinal cord injury or disorder. The study identifies 10 different approaches, describes their elements, and evaluates their effectiveness. However, due to variations in the inclusion of certain elements and the absence of some elements in certain approaches, comparability and the effectiveness of these complex approaches remain uncertain.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Review
Geriatrics & Gerontology
Jean-Claude Barthelemy, Vincent Pichot, David Hupin, Mathieu Berger, Sebastien Celle, Lytissia Mouhli, Magnus Back, Jean-Rene Lacour, Frederic Roche
Summary: Stroke prediction is a crucial issue in preventive medicine, and the role of the autonomic nervous system (ANS) is of great importance. Measurement of ANS activity can help prevent stroke by improving its activity level and balance. Long-term studies on decreased parasympathetic activity have shown the benefits of compensatory neurostimulation on endothelial function. Regular evaluation of ANS for the general population, both in a medical setting and remotely through telemedicine digital tools, is necessary to uncover the reasons behind ANS imbalance and decrease the risk of stroke.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Anke Scheel-Sailer, Kamran Koligi, Patricia Lampart, Carina Fahndrich, Hans Peter Gmunder, Stefan Metzger, Dirk Schaefer, Klaus Schmitt, Stefan Stalder, Reto Wettstein, Armin Gemperli
Summary: This study investigated the feasibility of using a computerized decision support system (CDSS) to improve treatment adherence and clinical outcomes for stage III/IV pressure injuries (PIs) in patients with spinal cord injury (SCI). The results showed that the implementation of the CDSS was feasible and helpful for visualizing the treatment process, but technical difficulties need to be addressed for effective integration into the clinical information system.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Respiratory System
Alexandra Lenoir, Andreas Christe, Lukas Ebner, Catherine Beigelman-Aubry, Pierre-Olivier Bridevaux, Martin Brutsche, Christian Clarenbach, Berra Erkosar, Christian Garzoni, Thomas Geiser, Sabina A. Guler, Dik Heg, Frederic Lador, Marco Mancinetti, Sebastian R. Ott, Lise Piquilloud, Maura Prella, Yok-Ai Que, Christophe von Garnier, Manuela Funke-Chambour
Summary: This study aimed to investigate lung function and radiological abnormalities over 12 months in patients after severe and non-severe COVID-19. The study found that patients with severe COVID-19 had lower lung function after one year compared to non-severe patients, although the severe disease group had a greater extent of recovery.
Article
Clinical Neurology
Olena Bychkovska, Piotr Tederko, Vegard Strom, Alvydas Juocevicius, Armin Gemperli
Summary: The study aimed to investigate the association between primary care strength and perceived access to follow-up care services among individuals with chronic spinal cord injury (SCI). The data from the International Spinal Cord Injury (InSCI) cross-sectional survey conducted between 2017 and 2019 were analyzed using logistic regression analysis. The participants included 6658 adults with chronic SCI from eleven European countries.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Medicine, General & Internal
Noriane A. Sievi, Jerome Sepin, Maurice Roeder, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jorg D. Leuppi, Robert Thurnheer, Christian F. Clarenbach, Malcolm Kohler
Summary: This study evaluated whether longitudinal assessment of predictors provides additional information on the mortality risk in COPD compared to cross-sectional analysis. The results showed that predictors of mortality in COPD are not time dependent, and cross-sectional measured predictors still have stable effect estimates over time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Policy & Services
Dima Touhami, Stefan Essig, Isabelle Debecker, Anke Scheel-Sailer, Armin Gemperli
Summary: The objective of this study was to investigate the impact of having a GP as the first point of contact on satisfaction with care services in individuals with SCI. The findings showed that individuals who first contacted a GP and lived within a 10-minute travel distance to the GP practice had lower satisfaction with their GP care. In addition, individuals who were married, employed, had a higher social status, or had tetraplegia were more likely to be satisfied with their GP care.
ZEITSCHRIFT FUR EVIDENZ FORTBILDUNG UND QUALITAET IM GESUNDHEITSWESEN
(2023)
Article
Health Care Sciences & Services
Filipe Barata, David Cleres, Peter Tinschert, Chen-Hsuan Iris Shih, Frank Rassouli, Maximilian Boesch, Martin Brutsche, Elgar Fleisch
Summary: This study validated an automated smartphone-based cough counting system for continuous monitoring of coughs in hospital wards. The system showed high sensitivity and specificity in detecting coughs compared to manual counting. Therefore, it can be used for continuous hourly assessment of cough frequency in the ward.
JMIR FORMATIVE RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Marija Glisic, Peter Francis Raguindin, Armin Gemperli, Petek Eylul Taneri, Dante Salvador, Trudy Voortman, Pedro Marques Vidal, Stefania I. Papatheodorou, Setor K. Kunutsor, Arjola Bano, John P. A. Ioannidis, Taulant Muka
Summary: This article provides a step-by-step, easy-to-understand, practical guide for systematic review and meta-analysis of observational studies. It discusses basic meta-analysis concepts, statistical tools for dealing with heterogeneity, and issues in translating results into clinical and public health recommendations.
PUBLIC HEALTH REVIEWS
(2023)