Article
Immunology
Derek R. MacFadden, Colleen Maxwell, Dawn Bowdish, Susan Bronskill, James Brooks, Kevin Brown, Lori L. Burrows, Anna Clarke, Bradley Langford, Elizabeth Leung, Valerie Leung, Doug Manuel, Allison McGeer, Sharmistha Mishra, Andrew M. Morris, Caroline Nott, Sumit Raybardhan, Mia Sapin, Kevin L. Schwartz, Miranda So, Jean-Paul R. Soucy, Nick Daneman
Summary: Antibiotic use is common among patients diagnosed with SARS-CoV-2. However, those who have completed the primary COVID-19 vaccination series have significantly reduced antibiotic use.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Yen-Chang Chen, Ming-Chang Li, Ying-Hui Yu, Chih-Ming Lin, Szu-Yuan Wu
Summary: This study reveals that COPD and AECOPD severity are important factors affecting the survival outcomes of patients with colon adenocarcinoma receiving standard treatments. Patients with COPD have poorer survival outcomes, especially those who have been hospitalized for AECOPD before colon adenocarcinoma treatment. This highlights the need for effective COPD management and prevention of AECOPD exacerbations to improve survival outcomes in these patients.
Article
Cardiac & Cardiovascular Systems
Tanveer Mir, Mohammed Uddin, Amir Khalil, Prateek Lohia, Lekiesha Porter, Neelambuj Regmi, Jarrett Weinberger, Parvaiz A. Koul, Ayman O. Soubani
Summary: This study revealed a strong association between aspergillosis infection and high mortality among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Malignancy and organ transplant status were identified as predominant predictors of aspergillosis development in AECOPD patients. The study also found a decrease in the yearly rate of aspergillosis, while the mortality trend remained steady.
RESPIRATORY MEDICINE
(2022)
Article
Health Care Sciences & Services
Marcella J. Jewell, JoAnna Leyenaar, Meng-Shiou Shieh, Penelope S. Pekow, Mihaela Stefan, Peter K. Lindenauer
Summary: This study identified unnecessary antibiotic use in hospitalized children with asthma and found that children with complex chronic conditions, admitted to the ICU, and hospitalized in general hospitals lacking pediatric specialty support were more likely to receive antibiotic treatment.
BMJ QUALITY & SAFETY
(2021)
Article
Multidisciplinary Sciences
Akihiro Shiroshita, Keisuke Anan, Masafumi Takeshita, Yuki Kataoka
Summary: This study evaluated the impact of systemic steroid therapy on 30-day mortality in patients with pneumonic chronic obstructive pulmonary disease (COPD) exacerbation. The results showed that systemic steroid therapy initiated within two days of admission was associated with higher 30-day mortality rates.
Article
Multidisciplinary Sciences
Ryo Yamazaki, Osamu Nishiyama, Sho Saeki, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda
Summary: This study aimed to identify risk factors for recurrent acute exacerbations (AEs) of idiopathic pulmonary fibrosis (IPF) by analyzing the total doses of corticosteroids administered over the first 30 days after the AE. Results showed that a higher total dose of corticosteroids during this period was associated with a decreased risk of subsequent recurrence of AEs within 1 year after the first AE. No significant differences were observed in the total doses of corticosteroids administered over longer periods or in the rates of immunosuppressive and antifibrotic treatments between patients with and without recurrent AEs.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Chao-Hsin Huang, Jiun-Hung Geng, Da-Wei Wu, Szu-Chia Chen, Chih-Hsing Hung, Chao-Hung Kuo
Summary: The study examined the relationship between betel nut chewing and lung function in Taiwan, finding a significant association between betel nut chewing and obstructive lung disease. Long-term chewing, more frequent use, higher daily amount, and high cumulative dose of betel nut were all linked to obstructive lung disease.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Jing-Yang Huang, Chuck Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin
Summary: Despite the decreasing rate of smoking, there has been an increase in the incidence of lung cancer. The ratio of adenocarcinoma to squamous cell carcinoma and the ratio of women to men in lung cancer cases are still increasing. Human papillomavirus (HPV) has been found in lung cancer tissues and blood specimens, especially in Eastern countries, but its association with lung adenocarcinoma remains unclear.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Lowie E. G. W. Vanfleteren, Anne Lindberg, Caddie Zhou, Fredrik Nyberg, Caroline Stridsman
Summary: Stratifying patients with chronic obstructive pulmonary disease (COPD) based on severity is clinically important. This study examined the association between different GOLD groups (A0, A1, B0, B1, and E) and future exacerbations, hospitalizations, and mortality. The results showed that GOLD group B1 had a significantly higher risk for future exacerbation, hospitalization, and mortality compared to group B0.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Microbiology
Xinzhu Yi, Yanjun Li, Haiyue Liu, Xiaomin Liu, Junhao Yang, Jingyuan Gao, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, David C. L. Lam, Martin R. Stampfli, Paul W. Jones, Rongchang Chen, Zhang Wang
Summary: The airway resistome in COPD patients is associated with the inflammatory endotype, and there are distinct resistome profiles based on neutrophilic or eosinophilic inflammation. Different bacterial species, host pathways, and inflammatory markers are associated with these resistome profiles.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
So Yeon Lee, Hyunjae Yu, Dong-Kyu Kim
Summary: This study aimed to investigate the association between glaucoma and obstructive sleep apnea (OSA). The results showed a significant association between primary angle-closure glaucoma (PACG) and increased incidence of OSA, while no significant association was found between primary open-angle glaucoma (POAG) and OSA.
Article
Immunology
Trenten J. Theis, Trevor A. Daubert, Kennedy E. Kluthe, Kenan L. Brodd, Austin S. Nuxoll
Summary: Staphylococcus aureus biofilm infections are mainly caused by persister cells, which exhibit tolerance to antibiotics. This may explain why biofilm infections are often chronic or relapsing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Yufei Xie, Jiajun Xie, Annemarie H. Meijer, Marcel J. M. Schaaf
Summary: The study found that synthetic glucocorticoid beclomethasone could potentially increase bacterial burden and decrease the phagocytic activity of macrophages, leading to a greater severity of bacterial infections, such as tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Fabrizio Luppi, Marco Sebastiani, Carlo Salvarani, Elisabeth Bendstrup, Andreina Manfredi
Summary: This review summarizes the clinical features, diagnosis, management, and prognosis of acute exacerbation of interstitial lung disease in patients with rheumatic diseases. It highlights the lack of specific definition and evidence-based therapeutic strategies for this condition, underscoring the need for further research and development in this area.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Allergy
Yunus Colak, Truls S. Ingebrigtsen, Barge G. Nordestgaard, Jacob L. Marott, Peter Lange, Jargen Vestbo, Shoaib Afzal
Summary: High plasma IgE is associated with an increased risk of severe exacerbation and all-cause mortality in individuals with COPD in the general population.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Education & Educational Research
Josepha Kuhn, Silvia Mamede, Pieter van den Berg, Laura Zwaan, Petra van Peet, Patrick Bindels, Tamara van Gog
Summary: This study investigated whether general practice residents would learn the deliberate reflection procedure through 'learning-by-teaching' and apply it to diagnose new cases. The results showed no significant differences between the conditions in the test phase, indicating that teaching deliberate reflection to a fictitious peer did not increase the residents' reflective reasoning when diagnosing future cases.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Edith M. Heintjes, Anastassia Anastassopoulou, Josephina Kuiper, Aikaterini Bilitou, Fernie J. A. Penning-van Beest, Ron M. C. Herings, Maarten J. Postma, J. Wouter Jukema
Summary: This study aimed to investigate the treatment patterns, LDL-C levels and healthcare resource utilization of patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular risk in the Netherlands in 2018. The findings revealed suboptimal treatment with the majority of patients receiving statin monotherapy and only a small percentage receiving combination therapy. Alternative treatment strategies are required to further lower cardiovascular risk.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Education & Educational Research
Charlotte G. M. van Sassen, Pieter J. van den Berg, Silvia Mamede, Lilian Knol, Manon P. Eikens-Jansen, Walter W. van den Broek, Patrick J. E. Bindels, Laura Zwaan
Summary: The study aimed to identify and prioritize educational content from a malpractice claims database to enhance clinical reasoning education in General Practitioners' training. The prioritized conditions included complex common, complex rare, and more straightforward common conditions, often exhibiting atypical presentations or complex contextual factors.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Primary Health Care
Eline Houben, Karin M. A. Swart, Eric AP Steegers, Petra J. M. Elders, Ron MC Herings
Summary: This study examined GPs' awareness of pregnancy and its association with prescribing medication with potential safety risks to women. Results indicated that although GPs' awareness of pregnancy improved over time, inadequate use of available information systems for appropriate drug surveillance still exists.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Linda C. C. Hendriksen, Paul D. D. van Der Linden, Ron M. C. Herings, Bruno H. H. Stricker, Loes E. E. Visser
Summary: Recent studies indicate that women using diuretics have a higher risk of hospital admission due to diuretic-induced hyponatremia compared to men. This study aimed to determine whether these sex differences persist after adjusting for confounding variables.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Rheumatology
S. E. (Sabine) Kloprogge, N. (Nienke) Katier, A. K. E. (Adinda) Mailuhu, J. (Jeanette) van Vooren, J. M. (John) van Ochten, P. J. E. (Patrick) Bindels, S. M. A. (Sita) Bierma-Zeinstra, M. (Marienke) van Middelkoop
Summary: This study aimed to determine the prevalence of radiographic ankle osteoarthritis (OA) in a population referred for ankle radiography, and to identify differences in prevalence between specific subgroups of patients. The results showed that the prevalence of radiographic ankle OA was 9.2%, 0.4%, and 7.0% for the talocrural, subtalar, and talonavicular joints, respectively. Obesity and male sex were associated with higher prevalence of ankle OA.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Public, Environmental & Occupational Health
Jetty A. Overbeek, Karin M. A. Swart, Eline Houben, Fernie J. A. Penning-van Beest, Ron M. C. Herings
Summary: This study aimed to assess the completeness and representativeness of the PHARMO GP data for the Dutch population. The findings showed that the PHARMO GP data were representative of the Dutch population in terms of demographic characteristics and diagnoses, but differences were observed in non-urbanized areas and medication use. Therefore, caution should be exercised when using this data for research purposes.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Annemarie Voss, Elisabeth Smits, Karin M. A. Swart, Yanina Balabanova, Gunnar Brobert, Kiliana Suzart-Woischnik, Ron M. C. Herings, Tania Schink, Ulrike Haug
Summary: Since its market approval in 2011, the use of rivaroxaban, a direct oral anticoagulant, has significantly increased in Europe. The baseline characteristics of new rivaroxaban users with non-valvular atrial fibrillation in Germany and the Netherlands have changed over time, with an increasing proportion of patients in Germany not using oral anticoagulants prior to starting rivaroxaban and an increasing proportion of patients in the Netherlands having heart failure at baseline.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Primary Health Care
Karin M. A. Swart, Amber A. W. A. van der Heijden, Marieke T. Blom, Jetty A. Overbeek, Giel Nijpels, Hein P. J. van Hout, Petra J. M. Elders, Ron M. C. Herings
Summary: This study aimed to estimate the ability of using electronic medical record data to identify frailty in older patients. The Charlson Comorbidity Index (CCI) was found to be the only measure with acceptable performance, while the other measures showed poorer performance in older age groups.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Luis Alberto Garcia Rodriguez, Ana Ruigomez, Tania Schink, Annemarie Voss, Elisabeth Smits, Karin M. A. Swart, Yanina Balabanova, Kiliana Suzart-Woischnik, Gunnar Brobert, Ron M. C. Herings
Summary: This study evaluated the safety and effectiveness of rivaroxaban versus vitamin K antagonists in stroke prevention for patients with nonvalvular atrial fibrillation in Europe. The results showed that the incidence of intracranial bleeding was generally lower with rivaroxaban, while gastrointestinal and urogenital bleeding were higher.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Genetics & Heredity
Denise van der Drift, Mirjam Simoons, Birgit C. P. Koch, Gemma Brufau, Patrick Bindels, Maja Matic, Ron H. N. van Schaik
Summary: This study investigated the use of pharmacogenetics (PGx) in primary care in the Netherlands, finding that side effects were the main reason for testing and antidepressants were the most commonly tested drugs. The survey revealed a lack of knowledge among general practitioners (GPs) on when and how to use PGx, suggesting a need for more education on the topic.
Article
Tropical Medicine
Duc Hong Du, Nguyen Quan Nhu Hao, Nguyen Van Hao, Tran Tan Thanh, Huynh Thi Loan, Lam Minh Yen, Tran Thi Diem Thuy, Duong Bich Thuy, Nguyen Thanh Nguyen, Nguyen Thi Phuong Dung, Evelyne Kestelyn, Ha Thi Hai Duong, Nguyen Thanh Phong, Pham Thi Tuyen, Nguyen Hoan Phu, Ho Dang Trung Nghia, Bui Thi Bich Hanh, Pham Kieu Nguyet Oanh, Phan Vinh Tho, Phung Tran Huy Nhat, Phan Nguyen Quoc Khanh, Duncan Wyncoll, Nicholas P. J. Day, Nguyen Van Vinh Chau, H. Rogier van Doorn, Le Van Tan, Ronald B. Geskus, C. Louise Thwaites
Summary: Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm involves inhibition of central inhibitory synapses by tetanus toxin, while that of cardiovascular disturbance is believed to relate to disinhibition of the autonomic nervous system. In this study, the relationship between catecholamines, cardiovascular parameters, and clinical outcomes in adults with tetanus was investigated, and it was found that adrenaline and noradrenaline were associated with subsequent development of autonomic nervous system dysfunction and length of ICU stay.
TROPICAL MEDICINE AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kerstin D. Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra, Varun Kumar, Lucy Chai See Lum, Jameela Sathar, Ernesto Pleite's Sandoval, Gabriela M. Maron, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Ridwanur Rahman, Andrea Caprara, Bruno Souza Benevides, Ernesto T. A. Marques, Tereza Magalhaes, Patricia Brasil, Guilherme Amaral Calvet, Adriana Tami, Sarah E. Bethencourt, Tam Dong Thi Hoai, Kieu Nguyen Tan Thanh, Ngoc Tran Van, Nam Nguyen Tran, Viet Do Chau, Sophie Yacoub, Kinh Nguyen Van, Maria G. Guzman, Pedro A. Martinez, Quyen Nguyen Than Ha, Cameron P. Simmons, Bridget A. Wills, Ronald B. Geskus, Thomas Jaenisch
Summary: This study aimed to improve the early diagnosis of dengue, especially in resource-limited settings where distinguishing dengue from other febrile illnesses is crucial. The study found that platelet count and white blood cell count were strongly associated with dengue, and the importance of serial measurements over time was highlighted.
LANCET GLOBAL HEALTH
(2023)
Article
Primary Health Care
Hevy Hassan, Selinde Snoeck Henkemans, Jolande van Teeffelen, Kees Kornelisse, Patrick J. E. Bindels, Bart W. Koes, Marienke van Middelkoop
Summary: Children from socially deprived areas have a higher risk of dropping out and a lower compliance rate in weight-loss programmes. Parental weight is an important predictor for children's dropout from the programme.
