☆ 4.2 Article

The Potential Protective Effect of Low Potassium Dextran against Lipid Peroxidation in a Rat Lung Transplantation Model

THORACIC AND CARDIOVASCULAR SURGEON (2009)

Journal

THORACIC AND CARDIOVASCULAR SURGEON

Volume 57, Issue 5, Pages 309-311

Publisher

GEORG THIEME VERLAG KG

DOI: 10.1055/s-2008-1038634

Keywords

Thoracic surgery; heart and lung transplantation; cardiovascular surgery

Categories

Cardiac & Cardiovascular Systems Respiratory System Surgery

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Abstract

The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation (p < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.

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