Article
Neurosciences
Bokyung Song, Chong-Hyun Kim
Summary: The PLC81 null mouse model shows enhanced neurogenesis in the DG of the hippocampus, along with increased moving activity and seizures. The results suggest that PLC81 plays a cell-autonomous inhibitory role in the proliferation of adult neural stem/progenitor cells in vivo and the excitability of DG granule cells.
NEUROSCIENCE LETTERS
(2022)
Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Pit Shan Chong, Chi Him Poon, Jaydeep Roy, Ka Chun Tsui, Sze Yuen Lew, Michael Weng Lok Phang, Rachael Julia Yuenyinn Tan, Poh Guat Cheng, Man-Lung Fung, Kah Hui Wong, Lee Wei Lim
Summary: Hericium erinaceus exerts antidepressant effects by promoting neurogenesis and reducing neuroinflammation through enhancing the BDNF-TrkB-CREB signaling pathway. The neurogenesis blocker temozolomide completely eliminates the antidepressant-like effects of HE, and HE induces anti-neuroinflammatory effects by decreasing astrocyte activation in the hippocampus.
Article
Neurosciences
Pierre Lecouflet, Candice M. Roux, Brigitte Potier, Marianne Leger, Elie Brunet, Jean-Marie Billard, Pascale Schumann-Bard, Thomas Freret
Summary: Activation of the 5-HT4R has been shown to impact LTP within the hippocampal CA1 area through modulation of GABAergic neurotransmission. The study also revealed the involvement of GABA(B) receptor in this regulatory process.
Article
Biochemistry & Molecular Biology
Sara Zocher, Rupert W. Overall, Gabriel Berdugo-Vega, Nicole Rund, Anne Karasinsky, Vijay S. Adusumilli, Christina Steinhauer, Sina Scheibenstock, Kristian Handler, Joachim L. Schultze, Federico Calegari, Gerd Kempermann
Summary: Newborn DNA methylation during adult neurogenesis is crucial for the maturation and integration of functional neurons in the hippocampus, facilitating transcriptional up-regulation of neuronal genes and affecting activation patterns in the hippocampal circuitry.
Article
Biochemistry & Molecular Biology
Eri Kitayama, Maki Kimura, Takehito Ouchi, Masahiro Furusawa, Yoshiyuki Shibukawa
Summary: This study investigated the dynamics of intracellular cAMP in cultured human odontoblasts to understand the detailed expression patterns and role of the intracellular cAMP signaling pathway. The results showed the presence of G(alpha)s protein and various receptors (IP, 5-HT4, D-1, A(2A), and VIP) in odontoblasts. Activation of these receptors increased intracellular cAMP levels by activating AC, and this increase was inhibited by an AC inhibitor and receptor antagonists.
Article
Neurosciences
I Olivas-Cano, J. M. Rodriguez-Andreu, J. M. Blasco-Ibanez, C. Crespo, J. Nacher, E. Varea
Summary: Adult neurogenesis remains active during adulthood in certain brain regions, such as the subgranular zone (SGZ) of the hippocampus. Factors and CNS disorders, including major depression, can reduce adult neurogenesis. Antidepressant treatments, like chronic fluoxetine administration, can restore normal levels of adult neurogenesis. This study investigates the relevance of the serotonin receptor 3 (5-HT3) in hippocampal neurogenesis in adult rats, finding that 5-HT3 receptor activation is necessary for the increase in neurogenesis induced by fluoxetine.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuki, Eri Segi-Nishida
Summary: The dentate gyrus of the hippocampus plays a regulatory role in stress-related emotional behaviors and neurogenesis. NT-3 is expressed in the adult dentate gyrus and is enhanced under chronic stress conditions in rodents. However, the functional modulation of the dentate gyrus by NT-3 signaling is still unclear.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Elena Hernandez-Hernandez, M. Julia Garcia-Fuster
Summary: This study aimed to evaluate the antidepressant-like effect of cannabidiol in aged rats. The results showed that cannabidiol exerted a dose-dependent effect and demonstrated a beneficial role for this drug in age-related behavioral deficits. None of the molecular markers analyzed in the hippocampus were altered by cannabidiol's treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Samuel S. Newton, Monica Sathyanesan
Summary: Cognitive deficits are common in psychiatric disorders, such as major depression and schizophrenia, and play a significant role in functional impairment. Targeted treatments for cognitive deficits are limited, with a need for more efficacious treatments. Erythropoietin (Epo) shows promising procognitive effects in psychiatric disorders, supporting a neurotrophic drug development approach.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Elena Carazo-Arias, Phi T. Nguyen, Marley Kass, Hyun Jung Jee, Katherine M. Nautiyal, Valerie Magalong, Lilian Coie, Valentine Andreu, Mark M. Gergues, Huzefa Khalil, Huda Akil, Danusa Mar Arcego, Michael Meaney, Christoph Anacker, Benjamin A. Samuels, John E. Pintar, Irina Morozova, Sergey Kalachikov, Rene Hen
Summary: The opioid system is involved in the antidepressant effects of fluoxetine, potentially mediated through the upregulation of proenkephalin in a specific subgroup of mature granule cells.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Sandra Ledesma-Corvi, M. Julia Garcia-Fuster
Summary: Low dose intensities of ECS exerted antidepressant-like effects in adult female rats. ECS, at the doses tested, did not induce behavioral changes in adolescent female rats. ECS increased neurogenesis independently of the dose and age of treatment.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Neurosciences
Nasrin Hashemi-Firouzi, Siamak Shahidi, Sara Soleimani Asl
Summary: The study demonstrates that activation of the serotonin 5-HT4 receptor modulates A beta-induced cognitive and memory deficits by reducing hippocampal apoptotic neurons and improving synaptic functions.
Article
Pharmacology & Pharmacy
Dae Young Lee, Hee Eun Kang
Summary: This study validated a quantitative assay for DA-6886 in rat plasma and evaluated its pharmacokinetics and tissue distribution in rats. The results showed that DA-6886 distributed extensively in the liver, kidney, lung, and digestive tract, and exhibited nonlinear pharmacokinetics after oral administration.
Review
Neurosciences
Dong Sun, Lin Mei, Wen-Cheng Xiong
Summary: The dentate gyrus, specifically the dorsal dentate granule cells (DGCs), play a crucial role in mood regulation and contribute to the development of psychiatric disorders. While ventral DGCs are known to be important for mood regulation, the functions of dorsal DGCs in this regard are still unclear. Dysfunctional dorsal DGCs have been implicated in various mental disorders such as depression and anxiety disorders. This review focuses on the role of DGCs, particularly dorsal DGCs, in mood regulation, their relationship with DGC development, and their contribution to mental disorders.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Watanabe, Rinka Maekawa, Shimpei Iikuni, Masashi Kakae, Nagisa Matsuo, Hisashi Shirakawa, Shuji Kaneko, Masahiro Ono
Summary: This study characterized four diaryl oxadiazole derivatives as potential myelin-imaging probes for single photon emission computed tomography (SPECT) in multiple sclerosis (MS). The results showed that one of the derivatives, [123I]1,3,4-PODP-DM, could potentially be used as a SPECT probe for imaging myelin in MS.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Toshinori Yoshioka, Daisuke Yamada, Riho Kobayashi, Eri Segi-Nishida, Akiyoshi Saitoh
Summary: Adult hippocampal neurogenesis is closely related to depressive disorders, and psychological stress can decrease cell survival rate in the hippocampus of mice, influencing the validity of emotional stress in animal models of depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Hiroki Nakajima, Sayaka Fujita, Masashi Kakae, Kazuki Nagayasu, Masatsugu Oh-Hora, Hisashi Shirakawa, Shuji Kaneko
Summary: Astrocytes, glial cells in the central nervous system, play homeostatic roles but can also actively participate in CNS inflammation under pathological conditions. This study found that astrocytes upregulate inflammatory factors including PGE(2) when stimulated by TNF alpha and IL1 alpha. Knockdown or knockout of Orai2, a member of the calcium channel family, resulted in increased PGE(2) production and expression of PGE(2) synthase genes, suggesting the modulation of CNS inflammation. These findings contribute to the understanding of astrocyte involvement in inflammatory responses and potential targets for modulation of astrocytic reactivity.
Article
Pharmacology & Pharmacy
Koki Nagaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: In this study, the researchers analyzed databases to find a drug that can be used together with dopamine D2 receptor antagonists to reduce the risk of akathisia. Acetaminophen was found to be the most effective drug in suppressing tardive akathisia. Experimental validation showed that chronic treatment of rats with haloperidol caused akathisia symptoms, while acute treatment with acetaminophen significantly attenuated these symptoms.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Koki Nagaoka, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Repeated administration of dopamine D-2 receptor antagonists for the treatment of psychosis often leads to tardive dyskinesia. This study found that activating adenosine A2A receptors in the striatum can alleviate dyskinetic symptoms caused by TD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Keisuke Nozawa, Takahide Suzuki, Gen Kayanuma, Hiroki Yamamoto, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Recent studies have found that DPP4 inhibitors increase the risk of bullous pemphigoid (BP), a common autoimmune blistering skin disease. The mechanisms behind this association are unclear, and there are currently no identified therapeutic targets for drug-induced BP. However, clinical data mining revealed that concomitant use of lisinopril, an angiotensin-converting enzyme inhibitor, significantly decreased the incidence of BP in patients receiving DPP4 inhibitors. In vitro experiments further showed that DPP4 inhibitors upregulated MMP9 and ACE2 mRNA expression, which play a role in the pathophysiology of BP, and that lisinopril and Mas receptor inhibitors could suppress this upregulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Hiroki Yamamoto, Gen Kayanuma, Takuya Nagashima, Chihiro Toda, Kazuki Nagayasu, Shuji Kaneko
Summary: This study aimed to identify methods for the early detection of a wide range of adverse drug reactions (ADRs). A data-mining approach using large-scale medical records was used, and association rule mining (ARM) was applied to patient symptoms and medications. The results showed that ARM of claims data may be effective in the early detection of a wide range of ADR signals.
Article
Biochemistry & Molecular Biology
Shiori Yamashita, Naoki Dozono, Shota Tobori, Kazuki Nagayasu, Shuji Kaneko, Hisashi Shirakawa, Hiroshi Ueda
Summary: Abnormalities in the peripheral immune system are involved in the pathophysiology of fibromyalgia, and the activation of peripheral beta 2-adrenergic receptors plays an important role in the efferent pathway from the CNS to splenocytes in pain development. The administration of selective beta 2-blockers prevented the development but not the maintenance of pain-like behavior, and beta 2-blockade in donor mice eliminated pain reproduction in recipient mice injected with AcGP splenocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko
Summary: Major depressive disorder (MDD) is a common mental illness, and serotonergic neurons play a crucial role in its pathophysiology and treatment. Recalling positive memories repeatedly is effective for MDD. This study found that activating 5-HT neurons can activate specific neuronal ensembles associated with positive memories, providing insights into the antidepressive effects of serotonin.
Article
Pharmacology & Pharmacy
Zijian Zhou, Takuya Nagashima, Chihiro Toda, Mone Kobayashi, Takahide Suzuki, Kazuki Nagayasu, Hisashi Shirakawa, Satoshi Asai, Shuji Kaneko
Summary: Olanzapine is an atypical antipsychotic drug used for schizophrenia. Vitamin D has been found to reduce the risk of olanzapine-induced dyslipidemia. By analyzing clinical data and conducting experiments, it was discovered that vitamin D improves dyslipidemia by inhibiting cholesterol biosynthesis. This clinical big-data-based drug repurposing approach provides a novel treatment with high clinical predictability and a well-defined molecular mechanism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: The short-term use of dexamethasone prevents fluoroquinolone-induced and age-related tendinopathy by suppressing oxidative stress through upregulation of the antioxidant enzyme glutathione peroxidase 3 (GPX3).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zijian Zhou, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Low concentrations of bortezomib (BTZ) can induce changes in peripheral nervous system cells, including dedifferentiation of Schwann cells, increased GFAP levels in satellite glial cells, and decreased expression levels of sensor and transducer ion channels in dorsal root ganglion neurons. These findings contribute to a better understanding of the mechanisms underlying BTZ-induced peripheral neuropathy.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Respiratory System
Koji Kuronuma, Natsumi Susai, Tomohiro Kuroita, Hiroki Yamamoto, Takeshi Yoshioka, Shuji Kaneko, Hirofumi Chiba
Summary: This study found that PFD may cause pellagra or pellagra-like symptoms such as photosensitivity. Experiments on mice confirmed this hypothesis and suggested that it may be mediated by the actions of NNMT. Urine analysis also supported this hypothesis.
Article
Pharmacology & Pharmacy
Kaito Takayama, Shota Tobori, Chihiro Andoh, Masashi Kakae, Masako Hagiwara, Kazuki Nagayasu, Hisashi Shirakawa, Yukio Ago, Shuji Kaneko
Summary: This study found that prenatal exposure to valproic acid in mice increased empathy-like behaviors, which were associated with hyperactivation of oxytocinergic neurons in the paraventricular nucleus of the hypothalamus (PVN). The results provide clues for further investigation of the oxytocin signaling pathway and the development of novel therapies for ASD.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Multidisciplinary Sciences
Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto
Summary: This study reveals the crucial role of the claustrum in the regulation of stress-induced anxiety-related behaviors. Claustrum activation serves as a reliable marker of acute stress exposure, and its neuronal ensemble activation elicits anxiety-related behaviors while silencing attenuates such behaviors. The claustrum receives strong input from the basolateral amygdala, and selective optogenetic stimulation of the claustrum temporarily induces anxiety-related behaviors. Silencing of the claustrum ensemble increases resistance to chronic stress. The bidirectional control of stress-induced emotional responses by the claustrum suggests its potential as a target for prevention and treatment of stress-related disorders.