Article
Cardiac & Cardiovascular Systems
Roemer J. Vos, Bart P. van Putte, Bas A. J. M. de Mol, Marieke Hoogewerf, Tim J. Mandigers, Geoffrey T. L. Kloppenburg
Summary: The study aimed to investigate whether the addition of local gentamicin in DSWI patients could shorten the hospital stay. The results showed that adding local gentamicin did not lead to a shorter hospital stay in the treatment group. Further research is needed to explore the effects of different treatment strategies on DSWI.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Dermatology
Yanbing Zhang, Pengyu Zhang, Han Li, Haitao Chi, Nan Zheng, Xu Pan, Chuzhong Tang
Summary: We conducted a meta-analysis to evaluate the impact of topical vancomycin (TV) application on reducing sternal wound infections (SWIs) following cardiac surgery (CS). The analysis included 23,745 participants who underwent CS, with 8,730 using TV and 15,015 as controls. The results showed that TV significantly reduced the occurrence of SWIs and deep SWIs post-CS compared to the control group.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Shenyu Zhu, Jianfeng Gao, Wenbo Yu, Jianxian Xiong
Summary: A meta-analysis was conducted to evaluate the effect of platelet-rich plasma (PRP) on sternal wound healing (SWH) in cardiac surgery (CS) patients. A total of 1098 relevant studies were reviewed, and 11 studies were included in the analysis, involving 8961 CS patients. The results showed that PRP significantly reduced the incidence of sternal wound infection (SWI), including deep and superficial SWI, compared to the control group. However, caution is needed due to the low sample size of some studies included in the meta-analysis.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Materials Science, Ceramics
Aathira Pradeep, Praveen Kerala Varma, Thennavan Arumugam, Anjaly Maravattikal Vijayan, Anil Kumar Vasudevan, Jayakumar Rangasamy
Summary: Deep sternal wound infection (mediastinitis) after cardiac surgery can be caused by both Gram-positive and Gram-negative bacteria. The incidence of sternal infection is increasing in current practice and is associated with longer hospital stay, higher medical costs, and increased mortality. A new antibacterial bone adhesive cement called TPAV, composed of tetracalcium phosphate, phosphoserine, amikacin, and vancomycin, has been developed and characterized. TPAV exhibits effective antibacterial properties against various bacteria, inhibiting their growth and biofilm formation. In in vivo studies using a rat sternotomy model infected with Staphylococcus aureus and Escherichia coli, TPAV demonstrated significant inhibitory activity. This study highlights the potential of TPAV as a preventive treatment for mediastinitis in clinical settings.
CERAMICS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Ihor Krasivskyi, Borko Ivanov, Kaveh Eghbalzadeh, Frederike Fehlau, Stephen Gerfer, Clara Grossmann, Ahmed Elderia, Anton Sabashnikov, Parwis Baradaran Rahmanian, Navid Mader, Ilija Djordjevic, Thorsten Wahlers
Summary: Sex is not associated with the prevalence of deep sternal wound infection after cardiac surgery. The incidence of acute renal failure was significantly higher in males compared to females, but there were no significant differences in dialysis rate and in-hospital mortality rate between sexes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Xiaotong Qiu, Xingwang Sun, Guobao Huang
Summary: Deep sternal wound infection is a severe complication after cardiac surgery. This meta-analysis evaluated the impact of immediate flap and NPWT on mortality and length of hospital stay. Immediate flap was associated with lower in-hospital mortality and length of stay, while no significant difference was found in late mortality and ICU stay time between the two groups. Immediate flap could reduce in-hospital mortality and length of stay for patients with deep sternal wound infection.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Emil Kaspersen, Susanne J. Nielsen, Andri Wilberg Orrason, Astridur Petursdottir, Martin Ingi Sigurdsson, Anders Jeppsson, Tomas Gudbjartsson
Summary: The study found that DSWI patients have higher short- and long-term mortality risks compared to non-DSWI patients. This highlights the importance of preventing these infections and carefully monitoring DSWI patients postoperatively.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Polymer Science
Karina Mitchell, Sreejith S. Panicker, Calista L. Adler, George A. O'Toole, Katherine R. Hixon
Summary: Honey has been used for centuries to reduce bacterial infection, and Manuka honey with Unique Manuka Factor (UMF) possesses additional antibacterial properties. This study investigated the incorporation of Manuka honey into chitosan-gelatin cryogels and hydrogels, finding that lower concentrations showed improved bacterial clearance while higher concentrations resulted in cell death.
Article
Respiratory System
Yoon Ki Cha, Min Suk Choi, So Hyeon Bak, Jeung Sook Kim, Chu Hyun Kim, Myung Jin Chung
Summary: A retrospective study on 3,410 patients who underwent cardiothoracic surgery via median sternotomy found a sternal osteomyelitis incidence rate of 0.47%, with no correlation between known risk factors of deep sternal wound infections and sternal OM.
JOURNAL OF THORACIC DISEASE
(2022)
Review
Chemistry, Medicinal
Aathira Pradeep, Jayakumar Rangasamy, Praveen Kerala Varma
Summary: Sternal wound infections, classified as superficial or deep, are common complications of cardiac surgery, mostly caused by staphylococcal organisms. Diagnosis involves characteristic symptoms and observation of infection during operation.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Dermatology
Yaoyao Song, Wanli Chu, Ming Zhang, Zhaoxing Liu, Dawei Li, Fan Zhao, Bohan Zhang, Mengmeng Gao, Huageng Yuan, Chuanan Shen
Summary: This study aims to explore and analyze the risk factors for primary healing failure in DSWI patients treated with PRP and NPWT. The results showed that sinus, osteomyelitis, albumin, and platelet were the risk factors affecting primary healing outcomes.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Microbiology
Mei Li, Hong Xiao, Yongmei Su, Danlin Cheng, Yan Jia, Yingli Li, Qi Yin, Jieying Gao, Yong Tang, Qunhua Bai
Summary: Prevention and control of infections have become a formidable challenge due to the increasing resistance of pathogens to antibiotics. Probiotics have been discovered to have positive effects on the host, and it is well-known that some Lactobacilli are effective in treating and preventing inflammatory and infectious diseases. The study developed an antibacterial formulation consisting of honey and Lactobacillus plantarum. The formulation showed antimicrobial effects and mechanisms in vitro, as well as a healing effect on skin infections in rats.
Article
Surgery
Andrew D. Hawkins, Erik J. Scott, Jeison De Guzman, Sarah J. Ratcliffe, J. Hunter Mehaffey, Robert B. Hawkins, Raymond J. Strobel, Alan Speir, Mark Joseph, Leora T. Yarboro, Nicholas R. Teman
Summary: Deep sternal wound infection (DSWI) is a rare but highly fatal complication. Previous studies have shown seasonal variability in surgical site infections, but this pattern has not been observed in DSWI. The study aimed to assess temporal clustering of DSWIs and found no significant seasonal pattern.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
G. Zhong, C. Tong, X. Liu, J. Fan, X. Xiong, P. Chen, A. Zhu, R. Yu, B. Liu
Summary: In this study, new nanocomplexes of Chi@HMPB@CBD were designed to eradicate MRSA. The results showed that the nanocomplexes effectively killed MRSA in vitro by inducing bacterial surface perforation, content leakage, ROS production, and ATP reduction. In vivo experiments demonstrated that the nanocomplexes, when combined with laser irradiation, effectively removed bacteria and accelerated wound healing in MRSA-infected mice. The nanocomplexes also exhibited excellent biocompatibility and ultra-low toxicity, and delayed the time for multidrug-resistance induction compared to silver nanoparticles. Green therapeutics against MRSA have great potential in clinical application.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Surgery
Olimpiu Bota, Jessica Pablik, Feras Taqatqeh, Maxime Muelhausen, Klaus Matschke, Adrian Dragu, Stefan Rasche, Kevin Bienger
Summary: This study investigated the histopathological manifestation of sternal osteomyelitis. The results showed that infection could cause ubiquitous inflammation of the sternal bone, and the harvest of arteries may worsen the extent of infection.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
