Article
Cell Biology
Andrew S. Huhn, Patrick H. Finan, Charlene E. Gamaldo, Alexis S. Hammond, Annie Umbricht, Cecilia L. Bergeria, Eric C. Strain, Kelly E. Dunn
Summary: This study examined the use of a dual-orexin receptor antagonist in opioid withdrawal and found that it may have potential benefits for improving sleep and withdrawal outcomes.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hale Guler Kara, Mehmet Emin Erdal, Senay Gorucu Yilmaz, Cem Sengul, Ceyhan Balci Sengul, Kamuran Karakulah
Summary: Although the study did not find a significant association between NRG3 and ERBB4 gene polymorphisms and nicotine dependence in the Turkish population, as well as no correlation with dependence levels, it is the first study to investigate these SNPs for the first time in ND and to find some genotypes in the Turkish population when compared to other populations. Furthermore, the findings are important in terms of their contribution to the literature and forensic genetics.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Thomas Greither, Hermann M. Behre, Holger Herlyn
Summary: Deciphering the functional relationships between genes associated with phenotypic variations can be challenging. In this study, a genome-wide association study (GWAS) linked twelve non-synonymous single-nucleotide polymorphisms (SNPs) to fertility variation in men. These SNPs were located in nine genes that have been previously implicated in male fertility. The study also identified potential biomarkers for the diagnosis of male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Tabea Schoeler, Jessie Baldwin, Andrea Allegrini, Wikus Barkhuizen, Andrew McQuillin, Nicola Pirastu, Zoltan Kutalik, Jean-Baptiste Pingault
Summary: A common genetic liability was found to contribute to the co-occurrence of nicotine, alcohol, and cannabis consumption. Genetic correlations among 6 measures of substance dependence and frequency of use were analyzed, leading to the identification of 42 genetic variants related to substance involvement. These findings provide insights into the genetic architecture underlying the use of common psychoactive substances.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Nicola Forte, Alba Clara Fernandez-Rilo, Letizia Palomba, Brenda Marfella, Fabiana Piscitelli, Paolo De Girolamo, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristino
Summary: A regular sleep-wake cycle has a positive effect on preserving synaptic plasticity and brain activity from neuropathological injuries. This study found that the neuropeptide orexin-A (OX-A), which is central in sleep-wake regulation, is over-expressed in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients with sleep disturbances. OX-A promotes the biosynthesis of 2-arachidonoylglycerol (2-AG), which can be phosphorylated to 2-arachidonoyl lysophosphatidic acid (2-AGP). The study also revealed a positive correlation between OX-A and 2-AGP concentrations in the plasma, and an increase of 2-AGP levels in the CSF of AD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Qixin Guo, Lan Huang, Yong Jiang, Zhixiu Wang, Yulin Bi, Guohong Chen, Hao Bai, Guobin Chang
Summary: Good feed efficiency is crucial for the economic output of the livestock and poultry industries. This study conducted a genome-wide association study to identify potential variants and genes associated with seven feed efficiency measures in ducks. The findings provide insights into the genetic mechanisms and genes involved in feed efficiency-related traits in ducks. Further investigations are warranted to validate these findings.
Article
Biochemistry & Molecular Biology
Bryce Rowland, Sanan Venkatesh, Manuel Tardaguila, Jia Wen, Jonathan D. Rosen, Amanda L. Tapia, Quan Sun, Mariaelisa Graff, Dragana Vuckovic, Guillaume Lettre, Vijay G. Sankaran, Georgios Voloudakis, Panos Roussos, Jennifer E. Huffman, Alexander P. Reiner, Nicole Soranzo, Laura M. Raffield, Yun Li
Summary: Using transcriptome-wide association study, this research identified numerous gene-trait associations related to hematological traits and assigned these variants to putative target genes.
HUMAN MOLECULAR GENETICS
(2022)
Article
Veterinary Sciences
Keon Kim, Jung Eun Song, Jae Beom Joo, Hyeon A. Park, Chang Hyeon Choi, Chang Yun Je, Ock Kyu Kim, Sin Wook Park, Yoon Jung Do, Tai-Young Hur, Sang-Ik Park, Chang-Min Lee
Summary: This study conducted a GWAS analysis to investigate the genetic predisposition to mammary gland tumors (MGT) in Maltese dogs. Several significant SNPs associated with MGT phenotype were identified, providing a basis for further research on the genetic predisposition to MGTs in Maltese dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Plant Sciences
Huilong Hong, Mei Li, Yijie Chen, Haorang Wang, Jun Wang, Bingfu Guo, Huawei Gao, Honglei Ren, Ming Yuan, Yingpeng Han, Lijuan Qiu
Summary: This study analyzed the phenotypic diversity and genetic basis of epicotyl length (EL) in soybean using 951 cultivars and landraces from different regions. The study identified 180 QTNs and QEIs associated with EL, and predicted 10 candidate genes that may be involved in seed germination and seedling development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
Peiqi Wang, Xinghan Sun, Qiang Miao, Hao Mi, Minyuan Cao, Shan Zhao, Yiyi Wang, Yang Shu, Wei Li, Heng Xu, Ding Bai, Yan Zhang
Summary: This study investigated the genetic predispositions of aesthetic facial traits in the Chinese population. Several novel genetic associations were identified, and functional annotation and polygenic scores were used to understand the genetic basis of these traits.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Bowen Gu, Ruifan Sun, Xingqiang Fang, Jipan Zhang, Zhongquan Zhao, Deli Huang, Yuanping Zhao, Yongju Zhao
Summary: This study conducted a genome-wide association study on a Chinese indigenous goat breed, Dazu black goats, to identify the genetic variants associated with body conformation traits. A total of 53 significant single nucleotide polymorphisms and 42 candidate genes were detected. These findings have practical applications for genetic improvement and economic benefits in the goat meat industry.
Article
Psychiatry
Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J. Edenberg, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer
Summary: The study found stimulant dependence to be heritable, with potential genetic factors and genes underlying the trait identified through a genome-wide association study. Four suggestive loci were identified, with genes related to other substance use disorders also being highlighted.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Fisheries
W. K. M. Omeka, D. S. Liyanage, Sukkyoung Lee, Chaehyeon Lim, Hyerim Yang, W. M. Gayashani Sandamalika, H. M. V. Udayantha, Gaeun Kim, Subothini Ganeshalingam, Taehyug Jeong, Seong-Rip Oh, Seung-Hwan Won, Hyoung-Bum Koh, Mun-Kwan Kim, David B. Jones, Cecile Massault, Dean R. Jerry, Jehee Lee
Summary: Traits linked to growth performance in farmed fish are important for profitability in aquaculture. A genome-wide association study (GWAS) on olive flounder identified several single nucleotide polymorphisms (SNPs) associated with growth traits. These findings contribute to understanding the molecular basis of growth regulation and promote the use of SNP-based genomic selection in flounder culture.
Article
Immunology
Shou-En Wu, Wei Liang Chen
Summary: The study investigated sarcopenia-related SNPs in Asian older adults and created a genotype score to test the combined effect of these SNPs on sarcopenia risk. Results revealed significant associations between SNPs and sarcopenic indices, with higher genotype scores linked to increased sarcopenia risk.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Letter
Clinical Neurology
Tzuyao Lo, Itaru Kushima, Branko Aleksic, Akira Yoshimi, Toshiyuki Someya, Yuichiro Watanabe, Norio Ozaki
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study investigated the association between light exposure in daily life and circadian activity rhythms in patients with bipolar disorder. The results showed that daytime light exposure was positively associated with circadian activity rhythms, while nighttime light exposure was negatively associated.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Pathology
Keisuke Nonaka, Morito Kurata, Moriaki Tachibana, Akiko Komatsu, Yuuki Shichi, Fujiya Gomi, Toshiyuki Ishiwata, Kou Miyamoto, Tomio Arai
PATHOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Toshio Fujisawa, Takayoshi Tsuchiya, Motohiko Kato, Masafumi Mizuide, Kazuki Takakura, Makoto Nishimura, Hiromu Kutsumi, Yoko Matsuda, Tomio Arai, Shomei Ryozawa, Takao Itoi, Hiroyuki Isayama, Hideyuki Saya, Naohisa Yahagi
Summary: This study aimed to evaluate the safety and efficacy of STNM01 in combination with S-1 as second-line therapy for unresectable pancreatic ductal adenocarcinoma. The results showed that the combination therapy of STNM01 and S-1 prolonged overall survival and increased T cell infiltration in the tumor microenvironment.
Article
Gastroenterology & Hepatology
Hiroyuki Kimura, Shinichi Kishi, Hisashi Narita, Teruaki Tanaka, Tsuyoshi Okada, Daisuke Fujisawa, Naoko Sugita, Shun'ichi Noma, Yosuke Matsumoto, Ayako Ohashi, Hiroshi Mitsuyasu, Keizo Yoshida, Hiroaki Kawasaki, Katsuji Nishimura, Yasuhiro Ogura, Norio Ozaki
Summary: This study examined the impact of comorbid psychiatric disorders on the survival rate of liver transplant recipients. The results indicated that overall comorbid psychiatric disorders did not significantly affect the survival rate of these recipients.
BMC GASTROENTEROLOGY
(2023)
Article
Psychiatry
Shuhei Wada, Kunihiro Iwamoto, Hiroki Okumura, Hirotake Hida, Shuichi Hiraoka, Aya Kamei, Daisuke Mori, Kiyofumi Yamada, Norio Ozaki
Summary: This study aims to evaluate the effect of D-sorbitol on the bitter taste of asenapine in patients with schizophrenia. Participants will rinse their mouths with different liquids and complete questionnaires to assess taste changes and willingness to continue asenapine. The findings will provide evidence on the efficacy of D-sorbitol in improving adherence to asenapine.
Article
Biochemistry & Molecular Biology
Naoko Honma, Tomio Arai, Yoko Matsuda, Yosuke Fukunaga, Masaaki Muramatsu, Shinobu Ikeda, Yuri Akishima-Fukasawa, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Kengo Takeuchi, Tetuo Mikami
Summary: The role of estrogen in colorectal cancer is controversial. The microsatellite ESR2-CA, which represents ESR2 polymorphism, is associated with colon cancer risk in women. The study found that the shorter allele of ESR2-CA increased the risk of colon cancer in older women, but decreased it in younger postmenopausal women. The study also examined the expression of ESR2-CA and ER-beta in cancerous and non-cancerous tissue, and found that their expression levels were affected by age, tissue type, and mismatch repair protein status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Biochemistry & Molecular Biology
Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Yuki Matsuda, Shinsuke Kito, Nakao Iwata
MOLECULAR PSYCHIATRY
(2023)
Article
Pathology
Tomio Arai, Akiko Komatsu, Nobuo Kanazawa, Keisuke Nonaka, Toshiyuki Ishiwata
Summary: This study aimed to clarify the clinicopathological features, molecular classification, and PD-L1 expression characteristics of papillary adenocarcinoma, especially tumors with microsatellite instability. The results showed a female predominance and frequent microsatellite instability in papillary adenocarcinoma compared to tubular adenocarcinoma. Microsatellite instability was significantly correlated with older age, tumor-infiltrating lymphocytes, and Crohn's-like lymphoid reactions. Molecular classification revealed that the genomically stable type was the most common, followed by the microsatellite-unstable type. Among the cases with PD-L1 expression in tumor cells, a significant portion involved carcinomas with microsatellite instability.
PATHOLOGY INTERNATIONAL
(2023)
Article
Clinical Neurology
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study examined the association between sleep disturbance and mood episode relapses in patients with bipolar disorder. The results revealed a significant correlation between variability in sleep time and the recurrence of mood episodes, indicating that inconsistent sleep time is associated with shorter duration between mood episode relapses. The findings suggest that maintaining consistency in sleep time may help prevent the relapse of mood episodes in bipolar disorder.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hidenori Tabata, Daisuke Mori, Tohru Matsuki, Kaichi Yoshizaki, Masato Asai, Atsuo Nakayama, Norio Ozaki, Koh-ichi Nagata
Summary: 22q11.2 deletion syndrome (22q11.2DS) is associated with a high risk of psychiatric and developmental disorders. A mouse model of this disease, Del(3.0Mb)/+, was generated and its behavior was extensively studied. The histological features of the brains of Del(3.0Mb)/+ mice were investigated and changes were observed in the morphology of individual neurons in specific brain regions. These changes in the dopamine system may explain the abnormal behaviors of the mice and the psychiatric symptoms of 22q11.2DS.
Article
Clinical Neurology
Masaya Ogasawara, Masahiro Takeshima, Shumpei Kosaka, Aya Imanishi, Yu Itoh, Dai Fujiwara, Kazuhisa Yoshizawa, Norio Ozaki, Kazuyuki Nakagome, Kazuo Mishima
Summary: This study tested the performance of three sleep-tracking devices against polysomnography (PSG) in patients with psychiatric disorders. The results showed that the portable EEG device (Sleepgraph) had the best sleep stage-tracking performance, while the consumer sleep device (Fitbit Sense) exhibited poor sleep stage-tracking performance in patients with psychiatric disorders.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Neurosciences
Hiroki Kimura, Itaru Kushima, Masahiro Banno, Toshiya Inada, Akira Yoshimi, Branko Aleksic, Norio Ozaki
Summary: This article reports detailed clinical cases of four patients with schizophrenia and 16p13.11 duplication, with one patient having treatment-resistant schizophrenia and an additional pathogenic rare CNV. Two of the four patients had potential environmental risk factors. The results suggest that a genetic cohort study would be useful in understanding the variable expressivity of 16p13.11 duplication and elucidating the pathophysiology of schizophrenia.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Psychiatry
Kazuyuki Nakagome, Manabu Makinodan, Mitsuhiro Uratani, Masaki Kato, Norio Ozaki, Seiko Miyata, Kunihiro Iwamoto, Naoki Hashimoto, Atsuhito Toyomaki, Kazuo Mishima, Masaya Ogasawara, Masahiro Takeshima, Kazumichi Minato, Toshikazu Fukami, Mari Oba, Kazuyoshi Takeda, Hideki Oi
Summary: This study investigated the feasibility of estimating mental health status using a wrist-worn wearable device that measures movement and optical pulse photoplethysmography (PPG). The results showed significant correlations between heart rate variability (HRV) and heart rate (HR) with mental health status in the wake after sleep onset stage within 3 days of assessment. The conclusion was that using a wearable device to measure HR and HRV can serve as an objective assessment of mental health status.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Neurosciences
Yoshitaka Kawashima, Misa Yamada, Hiroki Furuie, Hiroshi Kuniishi, Kie Akagi, Tomoko Kawashima, Takamasa Noda, Mitsuhiko Yamada
Summary: This study aimed to evaluate the efficacy and tolerability of riluzole for patients with psychiatric disorders characterized by anxiety or fear. The findings indicate insufficient evidence to confirm the effects of riluzole for these patients.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)