Journal
THIN SOLID FILMS
Volume 519, Issue 6, Pages 2003-2010Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.tsf.2010.10.054
Keywords
Hydrogen silsesquioxane; Mesenchymal stem cells; Electron-beam curing; Atomic force microscopy; Plasma polymerization
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Funding
- BBSRC
- Rutherford Appleton Laboratories
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Hydrogen silsesquioxane (HSQ) is a material with the potential for studying the effect of surface stiffness on stem cell differentiation. Here, the effects of electron beam dose on the topography and the mechanical properties of HSQ obtained with or without trimethylamine (TMA) development are characterised by atomic force microscopy imaging and indentation. A correlation between the surface stiffness (uniform across the sample) and electron beam exposure is observed. Surface roughness of HSQ samples developed in TMA decreases exponentially with increasing electron beam exposure. Surface coating with plasma polymerised allylamine (ppAAm) leads to an overall decrease in stiffness values. However, the increase in surface stiffness with increasing electron beam exposure is still evident. The ppAAm coating is shown to facilitate human mesenchymal stem cell adhesion. (C) 2010 Elsevier B.V. All rights reserved.
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