Article
Multidisciplinary Sciences
Ahmed M. Shammaa, Thomas G. Powell, Imaan Benmerzouga
Summary: This study used real-world data from the FAERS database to analyze adverse outcomes and events associated with the treatment of Toxoplasma infections. Findings suggest that clindamycin and pyrimethamine may be strongly associated with death, and sulfonamide formulations may have a less favorable safety profile.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Ziyaur Rahman, Tahir Khuroo, Eman M. Mohamed, Sathish Dharani, Canberk Kayalar, Mathew A. Kuttolamadom, Lamba Omar Sangare, Mansoor A. Khan
Summary: The objective of this research is to develop printlet formulations of pyrimethamine (PMT). Printlets formulations were successfully developed by screening design, which varied the laser scanning speed, Kollidon (R) VA 64, polyvinylpyrrolidone, and disintegrant. The laser scanning speed, Kollidon (R) VA, and disintegrant had a significant impact on the hardness, disintegration time, and/or dissolution. The clinical performance of the printlets is expected to be similar to the compressed tablets.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Food Science & Technology
Areej Eskandrani, Keshav Raj Paudel, Bassma H. Elwakil, Basant A. Bakr, Amira Abd-elfattah Darwish, Sara H. Akl, Yahya H. Shahin, Esraa Abdelhamid Moneer, Atef Mohamed Atef
Summary: A broccoli-based diet enhances the effect of pyrimethamine + sulfadiazine against congenital toxoplasmosis and reduces drug adverse effects.
Article
Biochemistry & Molecular Biology
Erica S. Martins-Duarte, Juliana de Araujo Portes, Ramon Borges da Silva, Hugo Silva Pires, Simon J. Garden, Wanderley de Souza
Summary: Toxoplasma gondii is a common parasitic disease worldwide, with limited therapy options. Chemical modification of 1,10-phenanthroline to new derivatives has significantly improved anti-T. gondii activity, potentially serving as lead compounds for the treatment of acute and chronic phases of toxoplasmosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zohreh Khorshidvand, Sadegh Shirian, Hanieh Amiri, Alireza Zamani, Amir Hossein Maghsood
Summary: The study investigated the immunomodulatory effects of propranolol hydrochloride (PRO) in combination with chitosan nanoparticles (CS NPs) as an adjuvant for a vaccine against T. gondii. The results showed that mice immunized with CS-SAG1-PRO NPs had the highest lymphocyte proliferation rate, increased secretion of various cytokines, and elevated levels of protective cytokines. The mice also exhibited a higher level of T. gondii-specific IgG, indicating an immune response biased towards Th1 cells. This approach holds promise for immunostimulation and vaccine delivery against T. gondii infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Damien Dupont, Jian-Sheng Lin, Francois Peyron, Hideo Akaoka, Martine Wallon
Summary: The study demonstrated that Toxoplasma gondii infection can lead to chronic alterations in sleep-wake states in mice, characterized by increased time spent awake, increased cortical EEG theta power density, and decreased slow-wave sleep. These effects can be alleviated by anti-inflammatory treatment with corticosteroid dexamethasone, shedding light on the neurodegenerative and neuropsychiatric disorders reported in infected patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Yanting Lin, Yiming Liu, Zhenhua Gao, Dongquan Jing, Ran Bi, Xinmeng Cui, Qiuhua Cao, Qixiang Zhao, Rui Gao, Yali Su, Siliang Liu, Mingrui Zhao, Yong Yang, Anqi Chen, Beiying Dai, Xinghua Gao
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally, with limited treatment options. In this study, we found that the non-selective 81 and 82 adrenergic receptor blocker propranolol significantly inhibited the development of CRC models. Prop treatment activated immune pathways and improved T cell differentiation, while decreasing the neutrophil to lymphocyte ratio, a biomarker of systemic inflammation, in both CRC models. Prop also regressed the exhaustion of CD4+ and CD8+ T cells in the tumor microenvironment. Our findings suggest that Prop can be repurposed as a promising therapeutic drug for CRC treatment, with T cells as its target.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Microbiology
Linding Xie, Yien Xing, Jun Yang, Min Liu, Yihong Cai
Summary: This study observed the changes in cardiac functions after T. gondii infection and assessed the damage caused by reactivation. The results showed that cardiac functions were impaired in acute and reactivation groups, with myocardial fibrosis and diastolic dysfunction occurring in the chronic stage. Reactivation infection exacerbated cardiac damage and was associated with macrophage activation, myocardial fibrosis, and impaired antioxidant capacity.
Article
Immunology
Hong-chao Sun, Pu-ming Deng, Yuan Fu, Jin-hua Deng, Rong-hui Xie, Jing Huang, Meng Qi, Tuan-yuan Shi
Summary: In this study, PLGA nanoparticles were used as a delivery system for T. gondii GRA12 and GRA7 antigens. Mice immunized with PLGA+GRA12 showed higher levels of IgG antibodies, increased lymphocyte proliferation, and a predominant Th1 immune response. Immunization with PLGA+GRA12 vaccine resulted in significantly reduced parasite loads and longer survival times compared to other vaccinated groups. However, PLGA was ineffective in enhancing the immune response induced by T. gondii GRA7.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
David Susanto, Arthur H. P. Mawuntu, Finny Warouw, Windy M. Wariki
Summary: This study compares the effectiveness and side effects of two treatment regimens for toxoplasma encephalitis and finds no significant difference in treatment effectiveness, but higher side effects in the pyrimethamine-based regimen.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Microbiology
Marjan Enshaeieh, Geita Saadatnia, Jalal Babaie, Majid Golkar, Samira Choopani, Mohammad Sayyah
Summary: The study showed that valproic acid can inhibit chronic Toxoplasma infection and reduce the copy numbers of specific proteins and DNA in the brains of mice, comparable to the common medication TMP-SMZ.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Wael S. Ibrahim, Hoda M. S. Ahmed, Amr A. A. Mahmoud, Mona F. Mahmoud, Islam A. A. E-H Ibrahim
Summary: This study examined the effects of propranolol and L-D-ISOPROT on β-arrestin2 signaling, insulin resistance, and cardiac remodeling in high-fructose, high-fat diet-fed mice. The results showed that these two drugs, like metformin, can reduce insulin resistance and cardiac remodeling. Modulation of β-arrestin2 signaling may be a promising strategy for the treatment of insulin resistance.
Article
Oncology
Katrina Spilsbury, Karen M. M. Tuesley, Sallie-Anne Pearson, Michael D. D. Coory, Peter Donovan, Christopher B. B. Steer, Louise M. M. Stewart, Nirmala Pandeya, Susan J. J. Jordan
Summary: Surgery for epithelial ovarian cancer may activate stress-inflammatory responses that stimulate tumor growth. Observational studies have shown mixed results on the association between beta-blocker use and improved survival. This population-based study found that perioperative supply of nonselective beta-blockers conferred a survival advantage for women age over 50 years with a history of cardiovascular conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Delphine Jublot, Pierre Cavailles, Salima Kamche, Denise Francisco, Diana Fontinha, Miguel Prudencio, Jean-Francois Guichou, Gilles Labesse, Denis Sereno, Corinne Loeuillet
Summary: This study reports on the potential of a histone deacetylase inhibitor called JF363, which has antiviral effects against a range of Toxoplasma strains and Plasmodium parasites. The drug administered in vivo delayed the spread of T. gondii infection and controlled the formation of brain cysts in infected mice. Furthermore, the compound showed promising binding efficiency to the active site of T. gondii HDACs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yang Zou, Jin-Xin Meng, Xin-Yu Wei, Xiao-Yi Gu, Chao Chen, Hong-Li Geng, Li-Hua Yang, Xiao-Xuan Zhang, Hong-Wei Cao
Summary: This study investigated the changes in circRNA and miRNA expression in the livers of mice infected with Toxoplasma gondii. The results showed significant alterations in circRNA and miRNA expression during acute and chronic infection stages. Functional annotation revealed the involvement of immune-related genes and liver disease metabolism pathways in the pathogenesis of hepatic toxoplasmosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Tahereh Mikaeili Galeh, Shahabeddin Sarvi, Seyed Abdollah Hosseini, Ahmad Daryani
Summary: Toxoplasmosis, caused by Toxoplasma gondii, is a common food-borne infection in humans. In rodent populations, atypical genotypes are dominant, while clonal strains circulate with low genetic diversity in this mammal species.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Endocrinology & Metabolism
Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani
Summary: Toxoplasma gondii infection may lead to the development of neuropsychiatric disorders, causing changes in host behavior. These changes are associated with immune responses, parasite manipulation, CNS inflammation, and alterations in hormonal and neuromodulator relationships.
METABOLIC BRAIN DISEASE
(2022)
Review
Multidisciplinary Sciences
Tooran Nayeri, Mahmood Moosazadeh, Shahabeddin Sarvi, Ahmad Daryani
Summary: The global prevalence of N. caninum infection in bovines that had an abortion and aborted fetuses was estimated in this comprehensive study. The results showed a high prevalence of N. caninum infection in bovines with a history of abortion and aborted fetuses.
Article
Public, Environmental & Occupational Health
Hamid Reza Moslemzadeh, Mahmoud Mahami-Oskouei, Ehsan Ahmadpour, Maryam Niyyati, Ali Rostami, Fatemeh Memari, Adel Spotin
Summary: This study investigated the occurrence of granulomatous amoebic encephalitis (GAE) in immunocompromised patients exposed to opportunistic Acanthamoeba infections. Positive Acanthamoeba isolates were detected in nasal mucosa samples, with the circulation of pathogenic strains in HIV/AIDS patients raising concerns about the fatal cases of encephalitis.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Veterinary Sciences
Tooran Nayeri, Shahabeddin Sarvi, Mahmood Moosazadeh, Ahmad Daryani
Summary: This study analyzed the global status of Neospora caninum (N. caninum) infection in sheep and goats, especially in aborted fetuses. The overall prevalence of N. caninum infection in sheep and goat aborted fetuses was found to be relatively high, highlighting the importance of further research for accurate control measures and strategies to reduce the rate of abortion and economic damage in the livestock industry.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Parasitology
Afsaneh Amouei, Shahabeddin Sarvi, Azadeh Mizani, Mohammad Bagher Hashemi-Soteh, Saeid Salehi, Javad Javidnia, Seyed Abdollah Hosseini, Fateme Amuei, Ahad Alizadeh, Shafigheh Shabanzade, Sara Gholami, Ahmad Daryani
Summary: This study investigated the genetic diversity of Toxoplasma gondii in intermediate host animals in Mazandaran Province, Iran. The results revealed the presence of different genotypes and a high prevalence of T. gondii in ruminants and birds, suggesting their potential role in transmitting the parasite to humans through meat consumption. The identification of genotypes also indicates a higher genetic diversity and local environmental contamination. These findings have important implications for public health strategies in preventing and controlling infection.
PARASITES & VECTORS
(2022)
Review
Virology
Saba Ramezanzadeh, Apostolos Beloukas, Abdol Sattar Pagheh, Mohammad Taghi Rahimi, Seyed Abdollah Hosseini, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Ehsan Ahmadpour
Summary: Cyclospora cayetanensis infections are common among people living with HIV and/or AIDS, with a prevalence of 3.89%. The highest prevalence is found in South America (7.87%) and the lowest in Asia (2.77%). CD4 cell count below 200 cells/mL and diarrhea are associated with a higher prevalence of C. cayetanensis in PLWHA.
Article
Parasitology
Mitra Sadeghi, Shahabeddin Sarvi, Saeed Emami, Alireza Khalilian, Seyed Abdollah Hosseini, Mahboobeh Montazeri, Shayesteh Shahdin, Tooran Nayeri, Ahmad Daryani
Summary: Toxoplasmosis is a worldwide prevalent disease caused by Toxoplasma gondii. This study found that new nitrofuran-derived quinolones have anti-parasitic activity against T. gondii and showed a synergistic effect when used in combination with pyrimethamine.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Psychiatry
Tahereh Mikaeili Galeh, Hamed Ghazvini, Shahabeddin Sarvi, Moslem Mohammadi, Hossein Asgarian-Omran, Fatemeh Hajizadeh, Soheil Azizi, Ahmad Daryani
Summary: This study found that chronic infection with the RH strain aggravated anxiety-like behavior and spatial learning impairments in Alzheimer's rats. In contrast, infection with the PRU strain significantly improved spatial learning without affecting memory impairments. The combination of PRU and VEG strains also improved spatial learning and memory impairments. These findings suggest that different strains of Toxoplasma gondii can have varying effects on cognitive deficits in Alzheimer's rats.
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2022)
Review
Chemistry, Analytical
Sonia M. Rodrigues M. Oliveira, Antonio Rebocho, Ehsan Ahmadpour, Veeranoot Nissapatorn, Maria de Lourdes Pereira
Summary: Type 1 diabetes mellitus is a common autoimmune disease in young patients, characterized by the destruction of pancreatic beta-cells and insulin deficiency. Current treatment options, such as islet transplantation and stem cell therapy, show promise but face various challenges.
Article
Veterinary Sciences
Kareem Hatam-Nahavandi, David Carmena, Mostafa Rezaeian, Hamed Mirjalali, Hanieh Mohammad Rahimi, Milad Badri, Aida Vafae Eslahi, Farzaneh Faraji Shahrivar, Sonia Rodrigues M. Oliveira, Maria de Lourdes Pereira, Ehsan Ahmadpour
Summary: This study investigated the prevalence of intestinal parasites in livestock in Iranshahr County, Southeastern Iran. Most animals studied were infected with at least one species of intestinal parasite. It is important to conduct parasitological monitoring in livestock and take preventive measures to prevent the spread of parasites to humans.
VETERINARY SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Tooran Nayeri, Shahabeddin Sarvi, Rohallah Abedian, Shaban Gohardehi, Seyed Abdollah Hosseini, Ahmad Daryani
Summary: The study explores the role of milk as a non-invasive and alternative sample for the diagnosis of animal toxoplasmosis. The results show that milk can be used as a substitute for serum in the diagnosis of toxoplasmosis. However, the high prevalence of Toxoplasma infection in milk poses a potential threat to public health when consuming raw milk from infected animals.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Review
Parasitology
Mitra Sadeghi, Seyed Abdollah Hosseini, Shahabeddin Sarvi, Tooran Nayeri, Mehdi Sharif, Abdol Sattar Pagheh, Afsaneh Amouei, Mahbobeh Montazeri, Ahmad Daryani
IRANIAN JOURNAL OF PARASITOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Mojgan Aryaeipour, Allah Bedasht Mansoorian, Mohammad Bagher Molai Rad, Soheila Rouhani, Majid Pirestani, Ahmad Ali Hanafi-Bojd, Ahmad Daryani, Tina Asadi, Mohammad Bagher Rokni, Shahabeddin Sarvi
Summary: This study investigated the snail fauna in the margin of the Caspian Sea in northern Iran, revealing five different families of freshwater snails. Physidae and Lymnaeidae were the most prevalent snails. Trematode infection was observed in 20% of the studied snails using cercariae release technique, with Echinostomatoidea, Schistosomatoidea, Diplostomoidea, and Plagiorchioidea as the detected parasites. Additionally, other stages of trematodes were found in 60% of the snails.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Sayyed Gholamreza Mortazavi-Moghaddam, Abdol Sattar Pagheh, Ehsan Ahmadpour, Alacsandra Barac, Azadeh Ebrahimzadeh
Summary: The number of extrapulmonary tuberculosis cases has increased in recent years in Iran. This study aimed to determine the epidemiological status, clinical symptoms, diagnostic methods, and treatment strategies of extrapulmonary tuberculosis, specifically focusing on tuberculosis meningitis and miliary tuberculosis. The study found a higher prevalence of tuberculosis meningitis in certain provinces and identified the common symptoms and diagnostic procedures for both tuberculosis meningitis and miliary tuberculosis. The conventional 6-month treatment approach was used for all participants in the investigations.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)