Article
Pharmacology & Pharmacy
Suzy Salama, Chin Siang Kue, Haryanti Mohamad, Fatima Omer, Mohamed Yousif Ibrahim, Mahmood Abdulla, Hapipah Ali, Abdalbasit Mariod, Soher Nagi Jayash
Summary: This study evaluated the antioxidant capacity and hepatoprotective potential of the compound quinazoline Q-Br in rats with sub-chronic liver toxicity. The results showed that Q-Br had mild antioxidant capacity, improved liver status, and inhibited oxidative stress. There was also a reduction in the degree of fibrosis. These findings suggest that Q-Br has significant hepatoprotective potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Zeinab A. El-Gendy, Salma A. El-Marasy, Rania F. Ahmed, Seham A. El-Batran, Sahar S. Abd El-Rahman, A. Ramadan, S. A. H. Youssef
Summary: The study demonstrated the significant anti-fibrotic effect of Saccharomyces cervisciae cell wall extract against thioacetamide-induced liver fibrosis in rats by attenuating oxidative stress, inflammation, improving liver function, and reducing fibrotic biomarkers.
Article
Biology
Suhayla H. Shareef, Morteta H. Al-Medhtiy, Ahmed S. Al Rashdi, Peshawa Y. Aziz, Mahmood A. Abdulla
Summary: The study evaluated the effect of pinostrobin on liver cirrhosis induced by TAA in rats. Pinostrobin decreased liver index, hepatocyte propagation, and cell injury. It down-regulated PCNA and alpha-SMA proliferation and increased antioxidant enzyme activities. Pinostrobin also normalized serum biomarkers and modulated inflammatory cytokines. Acute toxicity tests showed no adverse effects. The hepatoprotective effect of pinostrobin was attributed to inhibiting cirrhosis progression, reducing inflammation, and improving liver function.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Suhayla Hamad Shareef, Ameena S. M. Juma, Derin N. F. Agha, Abdullah R. Alzahrani, Ibrahim Abdel Aziz Ibrahim, Mahmood Ameen Abdulla
Summary: The present study investigated the hepatoprotective effects of Alpinetin against TAA-induced liver cirrhosis in rats. The results showed that Alpinetin can alleviate TAA-induced liver injury, reduce liver enzyme activity, increase total protein and albumin levels, enhance SOD and CAT levels, decrease MDA levels, modulate inflammatory cytokines, inhibit cell proliferation, and exhibit a good safety profile. Therefore, Alpinetin could be a potential therapeutic agent for TAA-induced liver damage.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Nayeli Amalinalli Pulido-Hornedo, Javier Ventura-Juarez, Fidel Guevara-Lara, Herson Antonio Gonzalez-Ponce, Esperanza Sanchez-Aleman, Manon Buist-Homan, Han Moshage, Ma Consolacion Martinez-Saldana
Summary: This study evaluated the protective effect of Opuntia robusta fruit on liver fibrosis and found that it has antioxidant capacity. The results demonstrated that Opuntia robusta fruit can reduce fibrotic liver damage.
Article
Biochemistry & Molecular Biology
Mohamed Yousif Ibrahim, Zaenah Zuhair Alamri, Ameena S. M. Juma, Sarah Ashour Hamood, Suhayla Hamad Shareef, Mahmood Ameen Abdulla, Soher Nagi Jayash
Summary: Biochanin A (BCA) has a protective effect on thioacetamide-induced liver cirrhosis by reducing hepatocyte propagation, cell injury, and improving antioxidant enzyme activity and liver function.
Article
Biotechnology & Applied Microbiology
Chittapon Jantararussamee, Siripa Rodniem, Malai Taweechotipatr, Udomsri Showpittapornchai, Wisuit Pradidarcheep
Summary: The study demonstrates that probiotic lactic acid bacteria can attenuate the development of liver fibrosis in rats, reduce liver damage and inflammation, and lower liver enzyme levels.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Food Science & Technology
Ivonne Peugnet-Gonzalez, Sandra Luz Martinez-Hernandez, Manuel Enrique Avila-Blanco, David Alejandro Hernandez-Marin, Jose Roberto Macias-Perez, Liseth Rubi Aldaba-Muruato, Teodulo Quezada-Tristan, Joaquin Sosa-Ramirez, Gloria Stephanie Villa-Jaimes, Javier Ventura-Juarez, Martin Munoz-Ortega, David Ibarra-Martinez
Summary: The study found that watercress extract can prevent liver fibrosis induced by CCl4 through its antioxidant and hepatoprotective effects. Watercress extract can improve steatosis and fibrosis, increase IL-10 expression, and regulate the expression of fibrogenic markers.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Marwan A. ElBaset, Rana S. Salem, Fairouz Ayman, Nadeen Ayman, Nooran Shaban, Sherif M. Afifi, Tuba Esatbeyoglu, Mahmoud Abdelaziz, Zahraa S. Elalfy
Summary: This study discovered that empagliflozin (EMPA) has a hepatoprotective effect in TAA-induced hepatotoxicity by targeting AMPK/SIRT-1 activity and inhibiting HIF-1 alpha. It also found that EMPA can mitigate liver fibrosis and protect the liver from injury.
Article
Toxicology
Ahmed A. Elnfarawy, Asmaa E. Nashy, Alaa M. Abozaid, Ibrahim F. Komber, Rawan H. Elweshahy, Rehab S. Abdelrahman
Summary: Vinpo has shown anti-fibrotic effects against TAA-induced liver fibrosis in rats by alleviating oxidative stress and inflammation, and modulating angiogenesis and proliferation. These findings suggest the potential of Vinpo as a therapeutic agent for liver fibrosis.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biology
Suhayla Hamad Shareef, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Morteta H. Al-Medhtiy, Mahmood Ameen Abdulla
Summary: This study evaluated the hepatoprotective effects and mechanism of green tea extract in rats with liver fibrosis induced by TAA. Green tea showed potential in inhibiting liver cirrhosis progression, reducing cellular inflammation, and restoring antioxidant enzyme levels.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Nada F. Abo El-Magd, Dalia H. El-Kashef, Mohamed El-Sherbiny, Salma M. Eraky
Summary: Hesperidin exhibits hepatoprotective effects and ameliorates hepatic encephalopathy through modulation of NLRP3/Sirt1/FOXO signaling pathway. It reduces liver enzymes, bile and ammonia levels, restores oxidant/antioxidant balance, improves motor and cognitive abilities, and enhances tissue architecture. Hesperidin also decreases IL-113 and caspase-1 expression.
Article
Biochemistry & Molecular Biology
Amr M. Abdelhamid, Ayman Selim, Mai A. Zaafan
Summary: Liver fibrosis is characterized by the activation of hepatic stellate cells into myofibroblasts, which is triggered by specific signaling pathways. Piperine has shown promising potential as an anti-fibrotic agent through modulation of TGF-beta 1/Smad pathway. The study evaluated the beneficial effects of piperine in liver fibrosis through modulation of miRNA-17 and TGF-beta/smads pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Medicinal
Qian Zhang, Meng-Meng Shang, Qu-Fei Ling, Xiao-Ping Wu, Chun-Yu Liu
Summary: MLP showed hepatoprotective effects on DMN-induced liver fibrosis in rats by reducing ALT, AST, Hyp, HA, LN, PC-III, C-IV, MMP-2, TIMP-1, alpha-SMA, and TGF-beta(1) levels, while increasing Alb and MMP-9 levels. The mechanism may involve modulation of ECM synthesis and degradation, inhibition of HSCs activation, and TGF-beta(1) expression.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ahmed A. J. Jabbar, Zaenah Zuhair Alamri, Mahmood Ameen Abdulla, Ahmed S. AlRashdi, Soran Kayfi Najmaldin, Mustafa AbdulMonam Zainel
Summary: Sinapic acid (SA) has protective effects against thioacetamide (TAA) induced fibrosis in rats by reducing hepatocyte injuries, inhibiting fibrosis, promoting heat shock protein (HSP) up-regulation, down-regulating alpha-smooth muscle actin (a-SMA) expression, and improving liver index and antioxidant enzymes levels.
Article
Materials Science, Textiles
Mohamad Nurul Azman Mohammad Taib, Wageeh Abdulhadi Yehye, Nurhidayatullaili Muhd Julkapli, Sharifah Bee O. A. Abdul Hamid
FIBERS AND POLYMERS
(2018)
Article
Pharmacology & Pharmacy
Elham Amini, Mojtaba Golpich, Abdoreza S. Farjam, Behnam Kamalidehghan, Zahurin Mohamed, Norlinah M. Ibrahim, Abolhassan Ahmadiani, Azman A. Raymond
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Omid Akbarzadeh, Noor Asmawati Mohd Zabidi, Nor Aliya Hamizi, Yasmin Abdul Wahab, Zulkifli Merican Aljunid Merican, Wageeh A. Yehya, Shamima Akhter, Md Shalauddin, Elisa Rasouli, Mohd Rafie Johan
Review
Health Care Sciences & Services
Farkhondeh Pouresmaeili, Behnam Kamalidehghan, Maryam Kamarehei, Yong Meng Goh
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2018)
Correction
Medicine, Research & Experimental
Ali Kadivar, Mohamed Ibrahim Noordin, Arya Aditya, Behnam Kamalidehghan, Ehsan Taghizadeh Davoudi, Reihaneh Sedghi, Hamid Akbari Javar
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Multidisciplinary Sciences
Lina A. Al-Ani, Wageeh A. Yehyei, Farkaad A. Kadir, Najihah M. Hashim, Mohammed A. AlSaadi, Nurhidayatullaili M. Julkapli, Vincent K. S. Hsiao
Article
Chemistry, Multidisciplinary
Ibrahim Khalil, Chia-Man Chou, Kun-Lin Tsai, Steven Hsu, Wageeh A. Yehye, Vincent K. S. Hsiao
APPLIED SCIENCES-BASEL
(2019)
Review
Biochemistry & Molecular Biology
Ibrahim Khalil, Wageeh A. Yehye, Alaitz Etxabide Etxeberria, Abeer A. Alhadi, Seyedehsara Masoomi Dezfooli, Nurhidayatullaili Binti Muhd Julkapli, Wan Jefrey Basirun, Ali Seyfoddin
Article
Endocrinology & Metabolism
Kazem Vatankhah Yazdi, Seyed Mehdi Kalantar, Massoud Houshmand, Masoud Rahmanian, Masoud Reza Manaviat, Mohammad Reza Jahani, Behnam Kamalidehghan, Amir Almasi-Hashiani
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Chemistry, Multidisciplinary
Hayman Sardar Abdulrahman, Mohamed Hassan Mohammed, Lina A. Al-Ani, Mohd Hafiz Ahmad, Najihah M. Hashim, Wageeh A. Yehye
JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Li-Hsiou Chen, Huan-Ting Shen, Wen-Hsin Chang, Ibrahim Khalil, Su-Yu Liao, Wageeh A. Yehye, Shih-Chuan Liu, Chih-Chien Chu, Vincent K. S. Hsiao
Review
Chemistry, Multidisciplinary
Maryam Sadat Alehashem, Azhar Bin Ariffin, Paul B. Savage, Wageeh Abdulhadi Yehya Dabdawb, Noel Francis Thomas
Article
Chemistry, Analytical
Ibrahim Khalil, Wageeh A. A. Yehye, Nurhidayatullaili Muhd Julkapli, Abu Ali Ibn Sina, Shahrooz Rahmati, Wan Jefrey Basirun, Ali Seyfoddin
Review
Genetics & Heredity
Behnam Kamalidehghan, Mohsen Habibi, Sara S. Afjeh, Maryam Shoai, Saeideh Alidoost, Rouzbeh Almasi Ghale, Nahal Eshghifar, Farkhondeh Pouresmaeili
APPLICATION OF CLINICAL GENETICS
(2020)
Review
Food Science & Technology
Md. Eaqub Ali, Sharmin Sultana, Sharifah Bee Abd Hamid, M. A. Motalib Hossain, Wageeh A. Yehya, Md. Abdul Kader, Suresh K. Bhargava
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2018)