Article
Pharmacology & Pharmacy
Ahmed I. Foudah, Mohammed H. Alqarni, Sushma Devi, Akanksha Singh, Aftab Alam, Pravej Alam, Sima Singh
Summary: This study demonstrates that catechin has neuroprotective activity in the chronic constriction injury (CCI) model and can reduce mechanical allodynia and thermal hyperalgesia. Additionally, the analgesic effect of catechin may be related to the expressions of TNF-alpha, IL-6, and IL-beta. Therefore, catechin shows promising potential in the treatment and management of neuropathic pain by decreasing the levels of NF-kappa beta-regulated inflammatory cytokines in the CCI model.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan-juan He, Xiao-mei Wei, Meng-li Wu, Zu-biao Song, Li Jiang, Wei-xi Zhang
Summary: This study aimed to investigate the analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and explore the underlying mechanisms. The results showed that perineural injection of BoNT/A improved the decreased paw mechanical withdrawal threshold (pMWT) and paw thermal withdrawal latency (pTWL) in a CCI rat model. The peripheral analgesic effects were associated with the protection of myelin sheath through inhibiting NLRP3 inflammasome and promoting autophagy flow, while the central analgesic effects were related to inhibiting neuroinflammation and synaptic plasticity in the spinal dorsal horn by inhibiting SNAP-25 and Wnt pathway. This study highlights the potential of perineural injection of BoNT/A as a new treatment for neuropathic pain.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Yatao Liu, Wei Liu, Xiao-Qing Wang, Zhan-Hai Wan, Yong-Qiang Liu, Meng-Jie Zhang
Summary: This study demonstrates that dexmedetomidine alleviates neuropathic pain in chronic constriction injury (CCI) rats by inhibiting the Keap1-Nrf2-HO-1 pathway-related antioxidant response, inflammation, and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Juping Xing, Hongji Wang, Lisha Chen, Hanxi Wang, Huan Huang, Jiabao Huang, Changshui Xu
Summary: This study investigated the role of Cx43 in neuropathic pain mediated by the P2X4 receptor in rats with chronic constriction injury (CCI). The results showed that blocking Cx43 can alleviate neuropathic pain in CCI rats through the P2X4, p38, ERK, and NF-kB signaling pathways. These findings suggest that Cx43 may be a promising therapeutic target for the development of novel pharmacological agents in the management of neuropathic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kuan-Hung Chen, Hung-Sheng Lin, Yi-Chen Li, Pei-Hsun Sung, Yi-Ling Chen, Tsung-Cheng Yin, Hon-Kan Yip
Summary: The study showed that combined probiotic and ADMSC therapy was more effective in alleviating CCI-induced neuropathic pain compared to single therapy, primarily through suppression of inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chunhao Zhu, Miaomiao Tian, Ning Liu, Lin Ma, Xiaobing Lan, Jiamei Yang, Juan Du, Hanxiang Ma, Yuxiang Li, Ping Zheng, Jianqiang Yu, Xiaodong Peng
Summary: Nobiletin, isolated from Citrus reticulata Blanco, possesses analgesic and neuroprotective effects, and can ameliorate neuropathic pain induced by chronic constriction injury (CCI). The study suggests that nobiletin inhibits the IRF5/P2X4R/BDNF signaling pathway in spinal microglia, leading to an analgesic effect. This research provides a potential therapeutic drug for neuropathic pain.
PHYTOTHERAPY RESEARCH
(2022)
Article
Behavioral Sciences
Nisar Ahmad, Fazal Subhan, Nazar Ul Islam, Muhammad Shahid, Naseem Ullah, Rahim Ullah, Shehla Akbar, Muhammad Usman Amin, Muhammad Khurram, Ihsan Ullah, Robert D. E. Sewell
Summary: In comparison to Gabapentin, the synthesized GABA analogue showed higher efficacy in treating neuropathic pain induced by chronic constriction injury without causing adverse motor effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Meng-Yin Yang, Hung-Chuan Pan
Summary: Neuropathic pain is reduced by AhR activation and aggravated by AhR deletion, indicating the neuroprotective effects of AhR. AhR expression is increased after nerve injury, and AhR agonist omeprazole attenuates nerve damage and inflammation. AhR agonists may have potential in neuropathic pain treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Liudai Zhang, Xiu Chen, Lanlan Wu, Yongbiao Li, Liwen Wang, Xiaoqin Zhao, Tingting Zhao, Li Zhang, Zhiyong Yan, Guihua Wei
Summary: This study found that escin has therapeutic effects on neuropathic pain in rats induced by chronic constriction injury, possibly by suppressing pro-inflammatory cytokines, TLR-4/NF-kappa B pathway, and reducing levels of GFAP and NGF.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Runan Yang, Zijing Li, Yuting Zou, Jingjian Yang, Lin Li, Xiumei Xu, Guenther Schmalzing, Hong Nie, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui Xu
Summary: The study reveals that gallic acid alleviates neuropathic pain in CCI rats by inhibiting the activation of the P2X7 receptor and subsequent signaling pathways, showing potential as a therapeutic agent for neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Tufan Mert, Tuba Ozcan Metin, Emel Sahin, Selma Yaman, Mehmet Sahin
Summary: The study aimed to investigate the anti-neuropathic actions of pulsed magnetic field (PMF) treatments in rats with chronic constriction injury (CCI)-induced neuropathy. The results showed that daily PMF treatment improved histopathological consequences of CCI on sciatic nerve, enhanced nerve conduction velocity, suppressed pro-inflammatory molecules and promoted anti-inflammatory cytokines, as well as modulated neuro-angiogenic mediators. These findings suggest that PMF treatment may have neuroprotective and anti-neuropathic pain effects in CCI-induced neuropathy.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Ming-Feng Liao, Shin-Rung Yeh, Kwok-Tung Lu, Jung-Lung Hsu, Po-Kuan Chao, Hui-Ching Hsu, Chi-Hao Peng, Yun-Lin Lee, Yu-Hui Hung, Long-Sun Ro
Summary: G-CSF treatment can attenuate neuropathic pain by modulating autophagic and apoptotic activity in CCI rats. Early upregulation of autophagy and late suppression of apoptosis contribute to the treatment of neuropathic pain.
Article
Neurosciences
Guven Akcay, Dilara Nemutlu Samur, Narin Derin
Summary: tDCS and tsDCS are effective therapies for pain that can alter neuronal activity in the brain and spinal cord. Treatment with tsDCS showed better therapeutic effects on neuropathic pain by regulating oxidant/antioxidant levels and reducing neuroinflammation.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Medicine, General & Internal
Shu-Mei Chen, Mao-Hsien Wang, Hung-Sheng Soung, Hsiang-Chien Tseng, Chih-Hsiang Fang, Yi-Wen Lin, Chih-Chuan Yang, Cheng-Chia Tsai
Summary: In this study, the protective effects of L-theanine on chronic constriction injury (CCI) induced neuropathic pain (NP) and neuronal functional changes were investigated in rats. The results showed that L-theanine alleviated pain symptoms, improved nerve conduction, and reduced oxidative stress, inflammation, and apoptosis in the injured sciatic nerves.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Neurosciences
Yi Wu, Zhiwen Shen, Hui Xu, Kun Zhang, Mingyan Guo, Fei Wang, Junhua Li
Summary: Neuropathic pain, caused by pathological changes in the somatosensory nervous system, remains a global public health issue with limited treatment options. This study shows that BDNF expression in DRG neurons plays a significant role in neuropathic pain, with overexpression exacerbating pain responses and inhibition alleviating sensitivities. Moreover, BDNF may exert its effects by transcriptionally regulating the P2X(7) gene in sensory neurons.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Cheng-Yin Tseng, Mao-Feng Sun, Tzu-Chien Kao, Tsai-Chung Li, Ching -Ting Lin
Summary: The study found that Coptis chinensis and its compounds have potential antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae (CRKP) and can enhance the effectiveness of colistin. They may represent a promising component of combination therapy in clinical settings for CRKP infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Health Care Sciences & Services
Ying-Yi Chen, Tsai-Chung Li, Chia-Ing Li, Shih-Pin Lin, Pin-Kuei Fu
Summary: This study found a correlation between statin prescription and lower mortality rates in older patients diagnosed with chronic obstructive pulmonary disease (COPD). Particularly, statin prescription had a protective effect on long-term survival in patients who experienced acute exacerbation and required hospitalization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chia-Ing Li, Cheng-Chieh Lin, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: This study found a J-shaped association between sleep duration and all-cause and cardiovascular disease mortality in patients with type 2 diabetes. A sleep duration of 5-7 hours was associated with the lowest mortality risk. Sleep duration also showed significant interactions with diabetes duration and age and obesity.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Peripheral Vascular Disease
Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Mu-Cyun Wang, Shing-Yu Yang, Tsai-Chung Li
Summary: This study aimed to evaluate the effects of BP trajectory and variability on chronic kidney disease (CKD) incidence in patients with type 2 diabetes. The study found that there is an association between BP trajectory and variability and CKD risk, with patients in the high-downward-upward DBP trajectory and high variability group facing a higher risk of CKD.
HYPERTENSION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Cheng-Chieh Lin, May Jingchee Niu, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: This study aimed to develop a risk prediction model for chronic kidney disease (CKD) in patients with type 2 diabetes in Taiwan. The model identified age, duration of diabetes, insulin use, estimated glomerular filtration rate, and albumin-to-creatinine ratio as significant risk factors for CKD. The model showed good accuracy in predicting CKD risk for 1 year, 3 years, and 5 years.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Long-Bin Jeng, Tsai-Chung Li, Shih-Chao Hsu, Chiao-Fang Teng
Summary: This study found that higher levels of PD-L1 expression and Tregs infiltration in tumor tissues were associated with an increased risk of HCC recurrence in pre-S2 mutant-positive HCC patients after curative surgical resection.
Article
Medicine, General & Internal
Pei-Chun Lin, Cheng-Chieh Lin, Chia-Ing Li, Tang-Chuan Wang, Yi-Hao Peng, Tung-Ti Chang, Chin-Yi Lin, Tsai-Chung Li, Ching-Liang Hsieh
Summary: Patients with type 2 diabetes have a higher risk of COPD and asthma. Traditional Chinese medicine (TCM) may be beneficial for these patients. A retrospective cohort study found that TCM use was associated with a reduced risk of respiratory hospitalizations, especially in patients with diabetes for <3 years.
Article
Endocrinology & Metabolism
Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Li-Na Liao, Chuan-Wei Yang, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: Through Mendelian randomization (MR) analysis, this study aimed to evaluate the causal relationship between high-sensitivity C-reactive protein (hsCRP) level and diabetic nephropathy (DN). The results showed that hsCRP level was causally related to DN, providing experimental evidence for understanding the mechanism and treatment of DN.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biochemistry & Molecular Biology
Long-Bin Jeng, Tsai-Chung Li, Wen-Ling Chan, Chiao-Fang Teng
Summary: This study aimed to identify independent prognostic biomarkers from 75 HBV-related HCC patients and validate their potential as a combination biomarker for HCC recurrence with pre-S2 gene deletion mutation. The study found that patients with both pre-S2 gene deletion mutation and TNM stage IIIA-IIIC had a higher risk of HCC recurrence. Furthermore, the combination of pre-S2 gene deletion mutation and TNM stage had better performance in predicting HCC recurrence than either factor alone. In conclusion, the study proposed that TNM stage holds significance as a combination biomarker with pre-S2 gene deletion mutation for predicting HCC recurrence after curative surgical resection.
Article
Integrative & Complementary Medicine
Yi-Chun Ma, Jaung-Geng Lin, Cheng-Chieh Lin, Chia-Ing Li, Hui-Man Cheng, Tsai -Chung Li
Summary: This study found that traditional Chinese medicine formulas were significantly associated with a decreased risk of infectious hospitalization among patients with SLE. TCM formulas can be used as a part of SLE treatments to decrease the risk of infectious hospitalization.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Summary: This study investigated the relationship between body shape index (ABSI) and mortality rate in patients with type 2 diabetes. The results showed that ABSI was closely associated with mortality rate, along with other indices such as BMI, WC, WHR, WHtR, and BRI. The combined use of ABSI and BMI provided better explanation of the variation in death risk compared to the independent use of BMI or other indices.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
Li-Na Liao, Tsai-Chung Li, Chih-Ching Yeh, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Ya-Fei Yang, Chih-Hsueh Lin, Fuu-Jen Tsai, Cheng-Chieh Lin
Summary: This study developed and validated a risk prediction model for diabetic nephropathy (DN) in the Han Chinese population by integrating clinical factors and genetic SNPs from multiple CKD-related pathways. This model can be used as a screening tool for early intervention and prevention in clinical risk management practice.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Surgery
Yi-Wen Lin, Tien-Chou Soong, Zhi-Han Sun, Wei-Jei Lee, Chung-Yen Chen, Kong-Han Ser
Article
Medicine, General & Internal
Cheng-Hung Lee, Chia- Tsai, Yi-Chang Su, Shih-Yi Lin, I-Te Lee, Tsai-Chung Li
Summary: This study found that body constitution independently predicts new-onset albuminuria in individuals with type 2 diabetes. Yin deficiency and phlegm stasis are associated with an increased risk of albuminuria, and this relationship is influenced by glucose control status.
Article
Health Care Sciences & Services
Yu-Shan Chang, Yi-Chuan Cheng, Tsai-Chung Li, Li-Chi Huang
Summary: This study explored the perceived level of stress in mothers one month after hospital discharge following the birth of singleton and multiple preterm infants. The findings suggest that social support and sleep deprivation are predictive indicators of maternal stress in preterm infants. It is recommended that the differences in stress and needs of mothers with singleton and multiple births be recognized and addressed in clinics.
