Article
Biotechnology & Applied Microbiology
Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Yla-Herttuala
Summary: VEGF-B186R127S induces vascular growth in mouse heart by recruiting EPCs. It is a novel therapeutic agent for cardiac therapeutic angiogenesis to rescue myocardial tissue after an ischemic insult.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pakiza Ruknudin, Ali Riza Nazari, Maelle Wirth, Isabelle Lahaie, Emmanuel Bajon, Alain Rivard, Sylvain Chemtob, Michel Desjarlais
Summary: Endothelial Progenitor Cells (EPCs) play an active role in revascularization in oxygen-induced retinopathy (OIR). The study found that Nogo-A affects the function of EPCs in OIR, and the inhibition of Nogo-A in EPCs can restore the neovascular functions of EPCs. In addition, the inhibition of Nogo-A enhances the expression of key angiogenic factors in the retina and promotes vascularization in an OIR model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Giulia Mallucci, Fausta Beneventi, Roberto Bergamaschi, Cristina Bizzotto, Chiara Cavagnoli, Irene De Maggio, Camilla Bellingeri, Cristina Monti, Gianluca Viarengo, Arsenio Spinillo
Summary: This study found that pregnant patients with MS had higher levels of circulating EPCs compared to healthy controls, but the trend was similar. A correlation was also observed in MS patients between cord blood EPCs and circulating EPCs at delivery.
NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hayan Kwon, Yun Ji Jung, Yeji Lee, Ga-Hyun Son, Hyun Ok Kim, Yong-Sun Maeng, Ja-Young Kwon
Summary: Maternal hyperglycemia induced by GDM has detrimental effects on fetal vascular development, increasing the risk of cardiovascular diseases in offspring. Altered gene expression and epigenetic changes in fetal EPCs contribute to the impaired angiogenic function. Increased PCDH10 expression and hypomethylation of the PCDH10 promoter are associated with this dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Doralisa Morrone, Maria Elena Lucia Picoi, Francesca Felice, Andrea De Martino, Cristian Scatena, Paolo Spontoni, Antonio Giuseppe Naccarato, Rossella Di Stefano, Uberto Bortolotti, Massimo Dal Monte, Stefano Pini, Marianna Abelli, Alberto Balbarini
Summary: The review focuses on the potential opportunities that EPCs could offer in regenerative medicine, given their known mobilization from bone marrow into circulation in various clinical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Ruiying Liu, Ying Zheng, Tao Han, Jie Lan, Laixi He, Jianyou Shi
Summary: This study indicates that PF, an active compound from Traditional Chinese Medicine, has angiogenic effects by promoting proliferation, migration, and tube formation in BM-EPCs, and reducing cerebral infarction while increasing pro-angiogenic factors and vascular density in an ischemic stroke rat model. Up-regulation of VEGF/VEGF-R-2 may be the underlying mechanism of PF's angiogenic action.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haijun Zhao, Yanhui He
Summary: Increasing evidence suggests that lysophosphatidylcholine (LPC) is closely related to endothelial dysfunction. This study aimed to investigate the mechanism of LPC in inhibiting pro-angiogenesis and vascular inflammation in human endothelial progenitor cells (EPCs) derived from CD34(+) hematopoietic stem cells. LPC was found to suppress the expression of certain inflammatory cytokines and genes associated with angiogenesis in EPCs, while promoting the activation of the PKC signaling pathway. Additionally, LPC treatment inhibited the angiogenesis-promoting effect of EPCs on human umbilical vein endothelial cells (HUVECs).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Sport Sciences
William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
Summary: This article discusses the benefits of exercise training on cardiovascular health and the role of circulating angiogenic cells in these changes. It emphasizes the essential function of secreted factors from these cells in maintaining cardiovascular health and summarizes the findings of studies on the effects of exercise training on these factors.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jack D. Hywood, Sara Sadeghipour, Zoe E. Clayton, Jun Yuan, Colleen Stubbs, Jack W. T. Wong, John P. Cooke, Sanjay Patel
Summary: This study investigated the generation of induced endothelial cells (iECs) from fibroblasts collected from PAD patients, and their pro-angiogenic properties. The results showed that patient-derived iECs can be successfully generated and have potential therapeutic effects in a murine model of peripheral arterial disease.
Article
Cardiac & Cardiovascular Systems
Wenhui Yang, Haizhen Wang, Qiuzhe Guo, Xiaocui Xu, Tao Guo, Lin Sun
Summary: By enhancing the activity of CACs, TRPV4 can regulate angiogenesis and improve therapeutic outcomes in the area of myocardial infarction.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Osnat Itzhaki Ben Zadok, Dorit Leshem-Lev, Tuvia Ben-Gal, Ashraf Hamdan, Nili Schamroth Pravda, Tali Steinmetz, Irit Kandinov, Ilit Ovadia, Ran Kornowski, Alon Eisen
Summary: The study found that tafamidis has a protective effect on cEPCs in ATTR-CA patients, promoting endothelial repair by increasing levels of CD34((+))/VEGFR-2((+)) and CD133((+))/VEGFR-2((+)), as well as enhancing EPC-CFUs numbers and viability, and increasing VEGF levels.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Martyna Schonborn, Iwona Gregorczyk-Maga, Krzysztof Batko, Katarzyna Bogucka, Mikolaj Maga, Anna Plotek, Patrycja Pasieka, Krystyna Slowinska-Solnica, Pawel Maga
Summary: Despite inconsistent changes in angiogenic factor levels, this study found a significant correlation between plasma FGF-2 levels and penetrating ulcers in patients with ischemic diabetic foot syndrome (DFS). Plasma FGF-2 may serve as a potential biomarker for predicting DFU advancement and progression.
Article
Immunology
Massimo R. R. Mannarino, Vanessa Bianconi, Giulia Scalisi, Luca Franceschini, Giorgia Manni, Alessia Cucci, Francesco Bagaglia, Giulia Mencarelli, Francesco Giglioni, Doriana Ricciuti, Filippo Figorilli, Benedetta Pieroni, Elena Cosentini, Eleonora Padiglioni, Cecilia Colangelo, Dietmar Fuchs, Paolo Puccetti, Antonia Follenzi, Matteo Pirro, Marco Gargaro, Francesca Fallarino
Summary: Chronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1) activity has a specific relationship with circulating EPC numbers. Low doses of lipopolysaccharide (LPS) decreased circulating EPCs in mice, while l-kynurenine (l-kyn) supplementation increased EPC numbers. In patients with low-grade inflammation, there was an association between IDO1 activity and high-sensitivity C-reactive protein (hs-CRP) in predicting circulating EPCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Dan Li, Jiaping Tang, Ruifang Gao, Jinxin Lan, Wenzhi Shen, Yanhua Liu, Yanan Chen, Hongwei Sun, Jie Yan, Yongwei Nie, Na Luo
Summary: Breast cancer is a major global health concern, and the process of angiogenesis and metastasis plays a crucial role in its progression. This study investigates the role of PFKFB4 in breast cancer angiogenesis and provides evidence that PFKFB4 regulates IL-6 expression and lactate secretion to promote angiogenesis. Furthermore, a specific PFKFB4 inhibitor, 5-MPN, is found to suppress angiogenesis, suggesting its potential as a therapeutic strategy for breast cancer patients.
Article
Cardiac & Cardiovascular Systems
Francisco Rodriguez-Esparragon, Laura B. Torres-Mata, Juan Carlos Lopez-Fernandez, Laura Cappiello, Jesus M. Gonzalez-Martin, Bernardino Clavo, Jaime A. Serna-Gomez, Lidia Estupinan-Quintana, Cristina Torres-Ascension, Jesus Villar
Summary: This single-center observational study explores the functional characteristics of endothelial progenitor cells (EPCs) in ischemic stroke (IS) patients. The study found that the count of circulating angiogenic cells (CACs) was positively correlated with colony-forming units (CFU-ECs). Thrombolytic treatment and the number of risk factors were identified as the main determinants of the variation in CACs and CFU-ECs.
BMC CARDIOVASCULAR DISORDERS
(2022)
