Article
Immunology
Jiri Fronek, Libor Janousek, Jakub Kristek, Jaroslav Chlupac, Marek Pluta, Robert Novotny, Jana Maluskova, Michael Olausson
Summary: This study reported the first live birth after a deceased donor uterus transplant in Europe, demonstrating that nulliparous uteri may be a suitable source of uterine grafts for transplantation. Stenting appears to be a feasible treatment for vaginal anastomotic stenosis.
Article
Psychology, Multidisciplinary
Yvette M. G. A. Hendrix, Melanie A. M. Baas, Joost W. Vanhommerig, Ad de Jongh, Maria G. Van Pampus
Summary: This study investigated the prevalence and course of fear of childbirth (FoC) in different trimesters, revealing that while FoC is common in each trimester, the prevalence decreases over the course of pregnancy. Pregnant women with FoC are more likely to actively seek for help.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Obstetrics & Gynecology
Wenjing Ding, So Ling Lau, Chi Chiu Wang, Tao Zhang, Olena Getsko, Nikki May Wing Lee, Stephen Siu Chung Chim, Chun Kwok Wong, Tak Yeung Leung
Summary: This study found that immunomodulation occurs during human parturition, and there are differences in immune responses during labor between nulliparous and multiparous women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Reproductive Biology
J. S. Vicente, F. Marco-Jimenez, M. Perez-Garcia, C. Naturil-Alfonso, D. S. Penaranda, M. P. Viudes-de-Castro
Summary: Superovulation treatments aim to stimulate multifollicular recruitment, maximizing the number of oocytes or transferable embryos produced. Factors associated with the superovulation protocol, female characteristics and many other factors are determinants in the number and quality of oocytes obtained. Genetic expression provides a more accurate way to assess oocyte quality than morphological appearance. This study compares the response of nulliparous and multiparous females to superovulatory stimulation and investigates its effects on gene expression, embryonic development, and viability rate at birth.
Article
Obstetrics & Gynecology
Karen R. Husby, Kim O. Gradel, Niels Klarskov
Summary: Hysterectomy increases the risk of pelvic organ prolapse surgery for nulliparous women by 60%. This historical matched cohort study found an increased risk of pelvic organ prolapse surgery after hysterectomy in comparison to women who did not undergo hysterectomy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Reproductive Biology
Acacia Eduarda de Jesus Nascimento, Luciano Cardoso Santos, Bianca Reis Santos, Emilly Oliveira Santos, Maria Clara da Silva Gairao Cunha, Paola Pereira das Neves Snoeck, Mario Sergio Lima de Lavor, Juneo Freitas Silva
Summary: Sex steroids and antioxidant enzymes play important roles in female sexual development and reproductive functions. This study investigated the expression profile of sex steroid receptors and antioxidant enzymes in the uterus of domestic cats during the estrous cycle. The results showed differential expression of estrogen alpha and progesterone receptors, as well as antioxidant enzymes, in different phases of the cycle. These findings contribute to a better understanding of the mechanism of action of sex steroids and antioxidant enzymes in the uterus of domestic cats.
Article
Agriculture, Dairy & Animal Science
Gabriele Marino, Alessandra Sfacteria, Giuseppe Catone, Antonina Zanghi, Fabiana Pecchia, Angela Difrancesco, Marco Russo
Summary: Canine pseudo-placentational endometrial hyperplasia is a rare lesion characterized by tissue organization resembling the layers of the maternal placenta. It may be induced by foreign body insertion and provides insight into canine placentation. Well-organized forms of the lesion can be detected by gross examination or ultrasound imaging. It helps understand the cystic endometrial hyperplasia/pyometra complex in dogs.
Article
Agriculture, Dairy & Animal Science
Giorgia Tura, Giulia Ballotta, Marco Cunto, Massimo Orioles, Giuseppe Sarli, Daniele Zambelli
Summary: This study investigates three cases of uterus masculinus in dogs. A specialized diagnostic approach integrating diagnostic imaging, surgery, and histopathology analysis is required for the definitive diagnosis of this condition. Inflammation of the uterus masculinus in dogs should be considered as a potential cause of abdominal pain.
Article
Veterinary Sciences
Miguel Tavares Pereira, Renata Nowaczyk, Rita Payan-Carreira, Sonia Miranda, Selim Aslan, Duygu Kaya, Mariusz P. Kowalewski
Summary: The study found that the expression of certain immune factors in canine pregnancy is influenced by the presence of embryos, with varying levels of immune regulation and anti-inflammatory conditions at different stages of pregnancy.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Jessica de Souza Andrade, Elizangela Mirian Moreira, Vanessa Lemos de Souza, Ingrid Pedraca Barbosa, George Moreira Silva, Leonardo Silva Gomes, Samira Alves de Souza Silva, Gabrielly Cristina Santos Noleto, Renata Reis da Silva, Uriel Secco Londero, Marcio Nunes Correa, Luiz Francisco Machado Pfeifer
Summary: This study compared the postpartum uterine dynamics of primiparous precocious (PP), primiparous conventional (PC), and multiparous conventional (MC) Bos indicus beef cows. The study found that primiparous precocious cows had more pronounced uterine inflammation and may require a longer recovery time for uterine health after calving.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Medicine, General & Internal
Kymberleigh A. Pagel, Hoyin Chu, Rashika Ramola, Rafael F. Guerrero, Judith H. Chung, Samuel Parry, Uma M. Reddy, Robert M. Silver, Jonathan G. Steller, Lynn M. Yee, Ronald J. Wapner, Matthew W. Hahn, Sriraam Natarajan, David M. Haas, Predrag Radivojac
Summary: This cohort study found that the addition of polygenic risk scores (PRS) was associated with the stratified risk of gestational diabetes (GD) diagnosis among high-risk patient subgroups, suggesting the benefits of targeted PRS ascertainment to encourage early intervention.
Article
Veterinary Sciences
Veronica Mollica Govoni, Claudio Pigoli, Eleonora Brambilla, Felipe Augusto Ruiz Sueiro, Rafael Torres Neto, Renee Laufer-Amorim, Juliany Gomes Quitzan, Valeria Grieco, Carlos Eduardo Fonseca-Alves
Summary: This study evaluated Caveolin-1, GATA-3, and Ki67 immunostaining in canine bladder urothelial carcinoma (UC) samples and found that Caveolin-1 and GATA-3 expression could be promising markers for bladder UC aggressiveness.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
David B. Chapel, Livia Maccio, Emma Bragantini, Gian F. Zannoni, Bradley J. Quade, Carlos Parra-Herran, Marisa R. Nucci
Summary: This study aimed to characterize dedifferentiated uterine leiomyosarcoma (LMS) morphologically and immunophenotypically. The results showed that the differentiated component of uterine LMS was mainly leiomyosarcoma, and the dedifferentiated component exhibited noncohesive polygonal cells and atypical features. Dedifferentiated uterine LMS had significantly shorter disease-specific and disease-free survival compared to non-dedifferentiated uterine LMS.
Article
Agriculture, Dairy & Animal Science
Isabel Oliveira Cosentino, Felipe Zandonadi Brandao, Pedro Henrique Nicolau Pinto, Raquel Perez Clariget, Rodolfo Ungerfeld
Summary: The study aimed to investigate the effects of resynchronization protocol in multiparous and nulliparous ewes, showing a higher pregnancy rate in multiparous ewes at the first artificial insemination. Resynchronized multiparous ewes had better reproductive performance compared to postpartum lactating ewes, and resynchronization treatments were found to have positive effects on nulliparous ewes' reproductive programs.
Article
Obstetrics & Gynecology
Afsoon Ghafari-Saravi, Sarina R. Chaiken, Claire H. Packer, Caroline C. Davitt, Bharti Garg, Aaron B. Caughey
Summary: This study investigated the association of hospital characteristics with cesarean delivery rates in California. Low-volume hospitals had higher rates of cesarean delivery, while medium-high-volume hospitals had lower rates. Cesarean delivery rates were also higher in rural and non-teaching hospitals, with variations observed among nulliparous women and multiparous women with and without prior cesarean deliveries in different types of hospitals.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Reproductive Biology
Haolin Li, Xiaomeng Pei, Hao Yu, Wei Wang, Dagan Mao
Summary: This study investigated the effects of APN/AdipoRon on autophagy and apoptosis in goat luteal cells, and found that autophagy and apoptosis play important roles in the structural regression of goat corpus luteum.
Article
Reproductive Biology
Yan-Qiu Wang, He-Xuan Qu, Yan-Wei Dong, Jia-Jia Qi, Hua-Kai Wei, Hao Sun, Hao Jiang, Jia-Bao Zhang, Bo-Xing Sun, Shuang Liang
Summary: This research reveals the crucial role of Ferroptosis Suppressor Protein 1 (FSP1) in regulating the development and quality of porcine early embryos. Inhibition of FSP1 impairs blastocyst formation, induces glutathione-independent ferroptosis, and leads to oxidative stress due to mitochondrial dysfunction.
Article
Reproductive Biology
Xiong Lai, Ruizhuo Liu, Mengyu Li, Yaochun Fan, Hongxia Li, Guotao Han, Ruijie Guo, Hairui Ma, Huimin Su, Wanjin Xing
Summary: This study identifies WDR54 as a protein involved in sperm-oocyte fertilization and shows that it interacts with IZUMO1 and JUNO. The formation of the JWIJ complex on the oocyte surface suggests its importance in sperm-oocyte adhesion and fusion. This discovery provides new insights into the mechanisms of mammalian sperm-oocyte adhesion and fusion.
Article
Reproductive Biology
S. Nandi, B. Sampath Kumar, P. S. P. Gupta, S. Mondal, V. Girish Kumar
Summary: This study examined the effects of plant bioactive compounds on the survival and growth parameters of ovine preantral follicles granulosa cells (GCs) and the expression of key developmental genes. The results showed that KAE, MYR and QUE had dose-dependent responses on the morphological and functional parameters of the cells, with KAE being the most potent in augmenting ovarian functions.
Article
Reproductive Biology
Francisco E. Martin-Cano, Gemma Gaitskell-Phillips, Laura Becerro-Rey, Eva da Silva, Javier Masot, Eloy Redondo, Antonio Silva-Rodriguez, Cristina Ortega-Ferrusola, Maria Cruz Gil, Fernando J. Pena
Summary: The presence of a more efficient glycolysis mechanism depending on pyruvate in stallion spermatozoa can counteract the detrimental effects of higher glucose concentrations. Incubating spermatozoa with 10 mM pyruvate in a modified Tyrode's media with 67 mM glucose showed increased motility and maintained viability. This improvement is attributed to the conversion of lactate to pyruvate and increased NAD(+) enhancing glycolysis efficiency.
Article
Reproductive Biology
Thanida Sananmuang, Denis Puthier, Catherine Nguyen, Kaj Chokeshaiusaha
Summary: Ongoing progress in mRNA-Sequencing technologies has contributed to the refinement of assisted reproductive technologies. This study utilized mRNA-Seq datasets of various mammalian species to analyze differential transcript usage (DTU) and identified ten cross-species DTU genes. Gene Ontology (GO) term enrichment analysis revealed the involvement of these genes in RNA and cell-cycle control mechanisms, suggesting their importance during oocyte maturation. Further exploration of these genes' transcript isoforms may lead to the discovery of novel markers for reproductive technologies.
Article
Reproductive Biology
Chenglei Song, Zhe Zhang, Yilin Wei, Yaqing Dou, Kunlong Qi, Xiuling Li, Feng Yang, Xinjian Li, Kejun Wang, Ruimin Qiao, Xuelei Han
Summary: In this study, the changes in protein levels in boar sperm with different liquid preservation abilities were analyzed. Key proteins related to sperm liquid preservation ability were identified. The findings provide new insights into the molecular mechanisms of boar sperm liquid preservation ability.
Article
Reproductive Biology
Genevieve M. VanWye, Emily G. Smith, Christine Spinka, Michael F. Smith, Matthew C. Lucy, Jordan M. Thomas
Summary: A series of experiments evaluated treatment schedules for controlling the estrous cycle in beef heifers. The results showed that the duration of progestin treatment and the timing of prostaglandin administration had an impact on estrus expression and pregnancy rates.
Article
Reproductive Biology
Hongwei Duan, Shuai Yang, Longfei Xiao, Shanshan Yang, Zhenxing Yan, Fang Wang, Xiaofei Ma, Lihong Zhang, Yong Zhang, Junjie Hu, Xingxu Zhao
Summary: This study first elucidated the mechanism by which melatonin regulates progesterone secretion in the corpus luteum of sheep, namely by promoting progesterone secretion through the regulation of autophagy. This has important implications for further exploring the role of melatonin in regulating sheep ovarian function.
Article
Reproductive Biology
Zhijie Zheng, Yingfang Guo, Yonghui Zheng, Haichong Wu
Summary: This study demonstrates that miR-92b plays a protective role in LTA-induced endometritis by targeting FZD10 and reducing the production of pro-inflammatory cytokines, thus alleviating uterine injury.
Article
Reproductive Biology
Areeg Almubarak, Sanghoon Lee, Il-Jeoung Yu, Yubyeol Jeon
Summary: This study found that Nobiletin (NOB) can promote the cryosurvival and embryo development of porcine sperm after in vitro fertilization (IVF). The addition of NOB improves sperm motility, acrosome integrity, viability, and mitochondrial membrane potential, reduces lipid peroxidation, and increases cleavage and blastocyst formation rates. Furthermore, NOB treatment upregulates the expression of genes related to pluripotency and cell differentiation in the resulting embryos.
Article
Reproductive Biology
Yuan Li, Lishu Li, Wenjie Xiong, Xing Duan, Huaming Xi
Summary: This study investigated the cytotoxicity and toxicological mechanisms of fluorochloridone (FLC) on cultured goat Sertoli cells. The results showed that FLC exposure induced oxidative stress, promoted apoptosis and autophagy, inhibited lysosomal biogenesis, and blocked autophagic flux in goat Sertoli cells. FLC also caused mitochondrial dysfunction and disturbed mitophagy, leading to cell apoptosis. The antioxidant N-acetyl-L-cysteine (NAC) reduced FLC-induced ROS accumulation and reversed the disorder of autophagy levels.
Article
Reproductive Biology
Gabriela Ramos Leal, Thais de Almeida Oliveira, Mariana Pedrosa de Paula Guimaraes, Lucas Francisco Leodido Correia, Erlandia Marcia Vasconcelos, Joanna Maria Goncalves Souza-Fabjan
Summary: This study investigated the time course of lipid accumulation during IVM and the effects of lipid modulators on cat oocytes. The results showed that adding lipid modulators can reduce lipid content and improve viability after cryopreservation.
Article
Reproductive Biology
Isabella Rio Feltrin, Amanda Guimaraes da Silva, Cecilia Constantino Rocha, Priscila Assis Ferraz, Paola Maria da Silva Rosa, Thiago Martins, Juliano Coelho da Silveira, Milena Lopes Oliveira, Mario Binelli, Guilherme Pugliesi, Claudia Maria Bertan Membrive
Summary: The study evaluated the effects of E2 treatment on Nelore heifers on day 15 of the estrous cycle, finding that E2 promoted an increase in PGFM concentrations and accelerated functional and structural luteolysis by upregulating the expression of PGR and OXTR. This suggests that within 3 hours after E2 stimulus, the expression of these receptors is associated with triggering luteolysis in cattle.
Article
Reproductive Biology
Aline Matos Arrais, Angelo Jose Burla Dias, Claudio Luiz Melo de Souza, Alinne Gloria Curcio, Marco Roberto Bourg de Mello
Summary: This study evaluated the effect of phospholipase C (PLC) on the capacitation of cryopreserved ovine semen. The results showed that the inhibitor U73122 can prevent premature capacitation and acrosome reaction induced by the freezing procedure, without affecting the kinetics and integrity of the sperm membranes.