Article
Medical Laboratory Technology
Michael Vogeser
Summary: Therapeutic drug monitoring plays a crucial role in medicine, yet it is often overlooked in laboratory medicine. A goal for laboratory medicine in the 21st century should be enabling clinicians to verify the presence of the right drug in the right patient with appropriate blood concentrations for each compound.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Bin Lin, Yangmin Hu, Ping Xu, Tao Xu, Chunyan Chen, Le He, Mi Zhou, Zhangzhang Chen, Chunhong Zhang, Xuben Yu, Luo Fang, Junfeng Zhu, Yanlan Ji, Qun Lin, Hengbin Cao, Youqin Dai, Xiaoyan Lu, Changcheng Shi, Li Li, Changjiang Wang, Xumei Li, Qiongyan Fang, Jing Miao, Zhengyi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Yalan Zhu, Xinjun Cai, Yin Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yubin Xu, Pea Federico, Saiping Jiang, Haibin Dai
Summary: Through in-depth research on Linezolid, a team of experts from various disciplines has formed a consensus on the therapeutic drug monitoring and safe use of Linezolid.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Sergey Zyryanov, Irina Bondareva, Olga Butranova, Alexandra Kazanova
Summary: This study aimed to determine the population pharmacokinetic parameters of meropenem in preterm infants and evaluate the pharmacodynamic indices and covariates affecting pharmacokinetics. Analysis of demographic, clinical, and therapeutic drug monitoring data from 66 preterm newborns revealed that the median values for elimination rate and volume of distribution of meropenem were 0.31 1/h and 1.2 L respectively, and the median values for total clearance and elimination half-life were 0.22 L/h/kg and 2.33 h. Individualized Bayesian posterior models improved prediction quality compared to the population model.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Obesity is associated with increased risks of comorbidities, postoperative infections, and nosocomial infections. The pharmacokinetics and pharmacodynamics of antibiotics are affected by obesity, leading to increased risks of antibiotic therapy failure and toxicity. Precision dosing of antibiotics using therapeutic drug monitoring may improve the management of critically ill obese patients with infections.
Review
Immunology
Rekha Pai Mangalore, Aadith Ashok, Sue J. Lee, Lorena Romero, Trisha N. Peel, Andrew A. Udy, Anton Y. Peleg
Summary: TDM-guided dosing of beta-lactam antibiotics improved clinical and microbiological cure in critically ill patients, with no significant impact on mortality and length of stay.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Rekha Pai Mangalore, Aadith Ashok, Sue J. Lee, Lorena Romero, Trisha N. Peel, Andrew A. Udy, Anton Y. Peleg
Summary: This article conducted a systematic review and meta-analysis on the relationship between TDM-guided dosing and clinical outcomes in critically ill patients. The results showed that TDM-guided dosing improved clinical cure, microbiological cure, and treatment response. However, the impact on mortality and length of stay remains unclear and further research is needed.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Anne-Grete Martson, Gena Burch, Samiksha Ghimire, Jan-Willem C. Alffenaar, Charles A. Peloquin
Summary: Therapeutic drug monitoring (TDM) is recommended for tuberculosis (TB) treatment optimization but is currently only used in a few countries. This review provides an update on drugs used in TB, treatment strategies, and TDM. Individualizing treatment using TDM may help reduce adverse effects and poor treatment outcomes. Funding, training, and randomized controlled trials are necessary to advance TDM for TB patients.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eduard Schmulenson, Nigina Zimmermann, Gerd Mikus, Markus Joerger, Ulrich Jaehde
Summary: New data on 5FU-TDM strengthen its advantages over BSA-guided dosing, as it can reduce pharmacokinetic variability to improve treatment efficacy and safety. Interprofessional collaboration can help overcome barriers for implementation. Pharmacogenetic testing followed by 5FU-TDM can enhance 5FU exposure for many patients, with a model framework integrating pharmacokinetics and pharmacodynamics being crucial for precision medicine advancement.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei Lu, Meng Pan, Hongqin Ke, Jun Liang, Wenbin Liang, Ping Yu, Penghua Zhang, Qibin Wang
Summary: Antimicrobial resistance (AMR) is a global health threat due to the widespread use of antibacterial drugs. Pharmacokinetic/pharmacodynamic (PK/PD) studies of antibiotics are a preventive approach to delay AMR. We developed a method to determine 18 antibacterial drugs in human plasma for clinical therapeutic drug monitoring (TDM).
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Bruce R. Dalton
Summary: Therapeutic drug monitoring for vancomycin has shifted its focus from trough concentrations to area under the curve (AUC(24)). However, the evidence for this change is weak, with retrospective analyses and animal studies lacking conviction. In vitro data also present conflicting results. Therefore, the adoption of AUC(24):MIC based on animal experiments and in vitro evidence may be premature for vancomycin.
Review
Pediatrics
Ronaldo Morales Junior, Gabriela Otofuji Pereira, Gustavo Magno Baldin Tiguman, Vanessa D'Amaro Juodinis, Joao Paulo Telles, Daniela Carla de Souza, Silvia Regina Cavani Jorge Santos
Summary: This study conducted a literature review to explore therapeutic targets and strategies for beta-lactam antibiotics in pediatric patients with sepsis. The findings suggest that individualized antimicrobial therapy and monitoring of beta-lactam serum concentrations can improve treatment outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Emergency Medicine
Emma L. Chee-How, Nicole M. Acquisto, Y. Victoria Zhang
Summary: The study evaluated the appropriateness of serum sample timing for tacrolimus measurement in the emergency department, finding that many initial TAC measurements were collected inappropriately, resulting in the need for additional measurements within 24 hours and increased unnecessary healthcare costs.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Medical Laboratory Technology
Stephanie E. Reuter, Sophie L. Stocker, Jan-Willem C. Alffenaar, Sara Baldelli, Dario Cattaneo, Graham Jones, Birgit C. P. Koch, Danijela Kocic, Sumith K. Mathew, Mariadelfina Molinaro, Michael Neely, Indy Sandaradura, Deborah J. E. Marriott
Summary: Individualized vancomycin dosing based on therapeutic drug monitoring (TDM) data is proven to be more effective than fixed or empirical dosing strategies. Area-under-the-curve (AUC(24))-guided TDM is increasingly supported for vancomycin dosing decisions in patients receiving treatment for more than 48 hours. However, institutional barriers may hinder the implementation of AUC(24)-guided dosing, requiring additional effort to transition from trough-based strategies. Proper documentation, storage, transport, laboratory analysis, and data reporting are essential for appropriate interpretation of TDM data to guide vancomycin dosing recommendations. The International Association of Therapeutic Drug Monitoring and Clinical Toxicology provides recommendations for best clinical practice in vancomycin TDM.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Pharmacology & Pharmacy
Sarah Baklouti, Peggy Gandia, Didier Concordet
Summary: This article proposes a methodology to correct the bias and improve the precision of empirical Bayes estimates (EBEs) used in therapeutic drug monitoring (TDM). The method, based on a bias correction and selection of the lambda parameter, outperforms EBE in terms of bias and precision. The results demonstrate the effectiveness of this approach for different drugs.
CLINICAL PHARMACOKINETICS
(2022)
Review
Infectious Diseases
Amy Legg, Sinead Carmichael, Ming G. Chai, Jason A. Roberts, Menino O. Cotta
Summary: Beta-lactam antibiotics are commonly used in critically ill patients to treat infections, but the optimal exposure targets for these drugs are still debated. Overcoming pharmacokinetic and pharmacodynamic challenges in the intensive care unit is necessary to achieve desired exposures. Therapeutic drug monitoring has shown promise for determining if the desired exposures are reached, but more research is needed to determine its impact on infection-related outcomes. Improving the efficiency of sampling and reporting results in at-risk patients is important for an ideal beta-lactam TDM service.
Article
Immunology
J. Beck, M. Oellerich, U. Schulz, V. Schauerte, L. Reinhard, U. Fuchs, C. Knabbe, A. Zittermann, C. Olbricht, J. F. Gummert, M. Shipkova, I. Birschmann, E. Wieland, E. Schuetz
TRANSPLANTATION PROCEEDINGS
(2015)
Article
Medical Laboratory Technology
Maria Shipkova, Dobrin Svinarov
CLINICAL BIOCHEMISTRY
(2016)
Editorial Material
Medical Laboratory Technology
Maria Shipkova, Eberhard Wieland
CLINICAL BIOCHEMISTRY
(2016)
Article
Medical Laboratory Technology
Maria Metzker, Maria Shipkova, Nicolas von Ahsen, Rainer Andag, Manabu Abe, Ortrun Canzler, Corinne Klett, Simone Leicht, Christoph Olbricht, Eberhard Wieland
CLINICAL BIOCHEMISTRY
(2016)
Article
Medical Laboratory Technology
Eberhard Wieland, Maria Shipkova
CLINICAL BIOCHEMISTRY
(2016)
Article
Medical Laboratory Technology
Emaad Abdel-Kahaar, Mariana Kabakchiev, Bertram Hartmann, Eberhard Wieland, Maria Shipkova
CLINICAL BIOCHEMISTRY
(2016)
Article
Medical Laboratory Technology
Henar Valbuena, Maria Shipkova, Sophie-Maria Kliesch, Simon Mueller, Eberhard Wieland
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2016)
Article
Medicine, Research & Experimental
Olesja Rissling, Steffen Bauer, Maria Shipkova, Petra Glander, Marco Mai, Pia Hambach, Klemens Budde
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2016)
Review
Medical Laboratory Technology
Christoph Seger, Maria Shipkova, Uwe Christians, Elaine M. Billaud, Ping Wang, David W. Holt, Merce Brunet, Pawel K. Kunicki, Thomasz Pawinski, Loralie J. Langman, Pierre Marquet, Michael Oellerich, Eberhard Wieland, Pierre Wallemacq
THERAPEUTIC DRUG MONITORING
(2016)
Review
Medical Laboratory Technology
Maria Shipkova, Olga Millan Lopez, Nicolas Picard, Ofelia Noceti, Claudia Sommerer, Uwe Christians, Eberhard Wieland
THERAPEUTIC DRUG MONITORING
(2016)
Review
Medical Laboratory Technology
Eberhard Wieland, Maria Shipkova
THERAPEUTIC DRUG MONITORING
(2016)
Review
Medical Laboratory Technology
Maria Shipkova, Dennis A. Hesselink, David W. Holt, Eliane M. Billaud, Teun van Gelder, Pawel K. Kunicki, Merce Brunet, Klemens Budde, Markus J. Barten, Paolo De Simone, Eberhard Wieland, Olga Millan Lopez, Satohiro Masuda, Christoph Seger, Nicolas Picard, Michael Oellerich, Loralie J. Langman, Pierre Wallemacq, Raymond G. Morris, Carol Thompson, Pierre Marquet
THERAPEUTIC DRUG MONITORING
(2016)
Article
Medical Laboratory Technology
Emaad Abdel-Kahaar, Thomas Giese, Claudia Sommerer, Hannah Rieger, Maria Shipkova, Eberhard Wieland
THERAPEUTIC DRUG MONITORING
(2016)
Review
Medical Laboratory Technology
Merce Brunet, Maria Shipkova, Teun van Gelder, Eberhard Wieland, Claudia Sommerer, Klemens Budde, Vincent Haufroid, Uwe Christians, Marcos Lopez-Hoyos, Markus J. Barten, Stein Bergan, Nicolas Picard, Olga Millan Lopez, Pierre Marquet, Dennis A. Hesselink, Ofelia Noceti, Tomasz Pawinski, Pierre Wallemacq, Michael Oellerich
THERAPEUTIC DRUG MONITORING
(2016)
Article
Medical Laboratory Technology
Maria Shipkova, Michael Vogeser, Pedro Alia Ramos, Alain G. Verstraete, Matthias Orth, Christian Schneider, Pierre Wallemacq
CLINICAL BIOCHEMISTRY
(2014)